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Q5Y7A7

- 2B1D_HUMAN

UniProt

Q5Y7A7 - 2B1D_HUMAN

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Protein

HLA class II histocompatibility antigen, DRB1-13 beta chain

Gene

HLA-DRB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. cytokine-mediated signaling pathway Source: Reactome
  3. interferon-gamma-mediated signaling pathway Source: Reactome
  4. T cell costimulation Source: Reactome
  5. T cell receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.
REACT_25078. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DRB1-13 beta chain
Alternative name(s):
MHC class II antigen DRB1*13
Short name:
DR-13
Short name:
DR13
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4948. HLA-DRB1.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Golgi apparatustrans-Golgi network membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Lysosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Late endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei228 – 24821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. clathrin-coated endocytic vesicle membrane Source: Reactome
  2. endocytic vesicle membrane Source: Reactome
  3. ER to Golgi transport vesicle membrane Source: Reactome
  4. Golgi membrane Source: Reactome
  5. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  6. late endosome membrane Source: UniProtKB
  7. lysosomal membrane Source: UniProtKB
  8. MHC class II protein complex Source: UniProtKB-KW
  9. plasma membrane Source: Reactome
  10. trans-Golgi network membrane Source: Reactome
  11. transport vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 266237HLA class II histocompatibility antigen, DRB1-13 beta chainPRO_0000392290Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi146 ↔ 202PROSITE-ProRule annotation
Cross-linki254 – 254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ5Y7A7.
PRIDEiQ5Y7A7.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

Structurei

3D structure databases

ProteinModelPortaliQ5Y7A7.
SMRiQ5Y7A7. Positions 34-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 21489Ig-like C1-typeAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012730.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5Y7A7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TSECHFFNGT
60 70 80 90 100
ERVRFLDRYF HNQEENVRFD SDVGEFRAVT ELGRPDAEYW NSQKDILEDE
110 120 130 140 150
RAAVDTYCRH NYGVVESFTV QRRVHPKVTV YPSKTQPLQH HNLLVCSVSG
160 170 180 190 200
FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG DWTFQTLVML ETVPRSGEVY
210 220 230 240 250
TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF
260
RNQKGHSGLQ PRGFLS
Length:266
Mass (Da):30,008
Last modified:November 23, 2004 - v1
Checksum:i17731F784445CC39
GO

Sequence cautioni

The sequence CAB40418.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041V → L in CAA04628. 1 PublicationCurated
Sequence conflicti121 – 1211Q → H in AAC05271. (PubMed:16634878)Curated
Sequence conflicti124 – 1241V → G in BAA06216. (PubMed:17767557)Curated

Polymorphismi

The following alleles of DRB1-13 are known: DRB1*13:01, DRB1*13:02, DRB1*13:03, DRB1*13:04, DRB1*13:05, DRB1*13:06, DRB1*13:07, DRB1*13:08, DRB1*13:09, DRB1*13:10, DRB1*13:11, DRB1*13:12, DRB1*13:13, DRB1*13:14, DRB1*13:15, DRB1*13:16, DRB1*13:17, DRB1*13:18, DRB1*13:19, DRB1*13:20, DRB1*13:21, DRB1*13:22, DRB1*13:23, DRB1*13:24, DRB1*13:25, DRB1*13:26, DRB1*13:27, DRB1*13:28, DRB1*13:29, DRB1*13:30, DRB1*13:31, DRB1*13:32, DRB1*13:33, DRB1*13:34, DRB1*13:35, DRB1*13:36, DRB1*13:37, DRB1*13:38, DRB1*13:39, DRB1*13:40, DRB1*13:41, DRB1*13:42, DRB1*13:43, DRB1*13:44, DRB1*13:45, DRB1*13:46, DRB1*13:47, DRB1*13:48, DRB1*13:49, DRB1*13:50, DRB1*13:51, DRB1*13:52, DRB1*13:53, DRB1*13:54, DRB1*13:55, DRB1*13:56, DRB1*13:57, DRB1*13:58, DRB1*13:59, DRB1*13:60, DRB1*13:61, DRB1*13:62, DRB1*13:63, DRB1*13:64, DRB1*13:65, DRB1*13:66, DRB1*13:67, DRB1*13:68, DRB1*13:69, DRB1*13:70, DRB1*13:71, DRB1*13:72, DRB1*13:73, DRB1*13:74, DRB1*13:75, DRB1*13:76, DRB1*13:77, DRB1*13:78, DRB1*13:79, DRB1*13:80, DRB1*13:81, DRB1*13:82, DRB1*13:83, DRB1*13:84, DRB1*13:85, DRB1*13:86, DRB1*13:87 and DRB1*13:88. The sequence shown is that of DRB1*13:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391Y → L in allele DRB1*13:67; requires 2 nucleotide substitutions.
VAR_062866
Natural varianti40 – 401S → L in allele DRB1*13:67.
VAR_062867
Natural varianti41 – 411T → K in allele DRB1*13:67.
VAR_062868
Natural varianti42 – 421S → G in allele DRB1*13:17.
VAR_062869
Natural varianti45 – 451H → Q in allele DRB1*13:72.
VAR_062871
Natural varianti45 – 451H → Y in allele DRB1*13:17.
VAR_062870
Natural varianti54 – 541R → L in allele DRB1*13:73.
VAR_062872
Natural varianti55 – 551F → Y in allele DRB1*13:27, allele DRB1*13:41 and allele DRB1*13:71.
VAR_062873
Natural varianti56 – 561L → Q in allele DRB1*13:59.
VAR_062874
Natural varianti57 – 571D → E in allele DRB1*13:15, allele DRB1*13:19, allele DRB1*13:26, allele DRB1*13:53, allele DRB1*13:57, allele DRB1*13:85 and allele DRB1*13:86.
VAR_062875
Natural varianti61 – 611H → Y in allele DRB1*13:03, allele DRB1*13:07, allele DRB1*13:04, allele DRB1*13:11, allele DRB1*13:12, allele DRB1*13:13, allele DRB1*13:14, allele DRB1*13:17, allele DRB1*13:21, allele DRB1*13:22, allele DRB1*13:23, allele DRB1*13:24, allele DRB1*13:25, allele DRB1*13:30, allele DRB1*13:33, allele DRB1*13:37, allele DRB1*13:38, allele DRB1*13:44, allele DRB1*13:45, allele DRB1*13:46, allele DRB1*13:47, allele DRB1*13:48, allele DRB1*13:49, allele DRB1*13:50, allele DRB1*13:54, allele DRB1*13:55, allele DRB1*13:58, allele DRB1*13:60, allele DRB1*13:62, allele DRB1*13:66, allele DRB1*13:69, allele DRB1*13:70, allele DRB1*13:75, allele DRB1*13:81, allele DRB1*13:82, allele DRB1*13:86 and allele DRB1*13:88.
VAR_062876
Natural varianti66 – 661N → D in allele DRB1*13:62 and allele DRB1*13:68.
VAR_062880
Natural varianti66 – 661N → F in allele DRB1*13:08, allele DRB1*13:19, allele DRB1*13:57, allele DRB1*13:64, allele DRB1*13:72, allele DRB1*13:76 and allele DRB1*13:83; requires 2 nucleotide substitutions.
VAR_062878
Natural varianti66 – 661N → I in allele DRB1*13:87.
VAR_062881
Natural varianti66 – 661N → S in allele DRB1*13:60 and allele DRB1*13:84.
VAR_062879
Natural varianti66 – 661N → Y in allele DRB1*13:03, allele DRB1*13:07, allele DRB1*13:04, allele DRB1*13:11, allele DRB1*13:12, allele DRB1*13:13, allele DRB1*13:14, allele DRB1*13:17, allele DRB1*13:21, allele DRB1*13:22, allele DRB1*13:23, allele DRB1*13:24, allele DRB1*13:25, allele DRB1*13:30, allele DRB1*13:33, allele DRB1*13:37, allele DRB1*13:38, allele DRB1*13:44, allele DRB1*13:45, allele DRB1*13:46, allele DRB1*13:47, allele DRB1*13:48, allele DRB1*13:49, allele DRB1*13:52, allele DRB1*13:54, allele DRB1*13:55, allele DRB1*13:58, allele DRB1*13:66, allele DRB1*13:70, allele DRB1*13:75, allele DRB1*13:81, allele DRB1*13:82, allele DRB1*13:86 and allele DRB1*13:88.
VAR_062877
Natural varianti67 – 671V → L in allele DRB1*13:34, allele DRB1*13:62 and allele DRB1*13:64.
VAR_062882
Natural varianti76 – 761F → Y in allele DRB1*13:03, allele DRB1*13:07, allele DRB1*13:08, allele DRB1*13:12, allele DRB1*13:13, allele DRB1*13:19, allele DRB1*13:26, allele DRB1*13:32, allele DRB1*13:33, allele DRB1*13:36, allele DRB1*13:37, allele DRB1*13:38, allele DRB1*13:40, allele DRB1*13:47, allele DRB1*13:48, allele DRB1*13:49, allele DRB1*13:53, allele DRB1*13:55, allele DRB1*13:58, allele DRB1*13:60, allele DRB1*13:65, allele DRB1*13:70, allele DRB1*13:72, allele DRB1*13:76, allele DRB1*13:81, allele DRB1*13:84, allele DRB1*13:85 and allele DRB1*13:88.
VAR_062883
Natural varianti77 – 771R → L in allele DRB1*13:35.
VAR_062884
Natural varianti77 – 771R → W in allele DRB1*13:80.
VAR_062885
Natural varianti79 – 791V → L in allele DRB1*13:51.
VAR_062886
Natural varianti86 – 861D → A in allele DRB1*13:43 and allele DRB1*13:45.
VAR_062889
Natural varianti86 – 861D → S in allele DRB1*13:03, allele DRB1*13:04, allele DRB1*13:12, allele DRB1*13:13, allele DRB1*13:21, allele DRB1*13:30, allele DRB1*13:32, allele DRB1*13:33, allele DRB1*13:38, allele DRB1*13:48, allele DRB1*13:49, allele DRB1*13:55, allele DRB1*13:58, allele DRB1*13:65, allele DRB1*13:66, allele DRB1*13:75, allele DRB1*13:81 and allele DRB1*13:88; requires 2 nucleotide substitutions.
VAR_062887
Natural varianti86 – 861D → V in allele DRB1*13:31, allele DRB1*13:46, allele DRB1*13:54 and allele DRB1*13:77.
VAR_062888
Natural varianti89 – 891Y → H in allele DRB1*13:43 and allele DRB1*13:45.
VAR_062891
Natural varianti89 – 891Y → S in allele DRB1*13:39, allele DRB1*13:54, allele DRB1*13:77, allele DRB1*13:78 and allele DRB1*13:79.
VAR_062890
Natural varianti96 – 961I → F in allele DRB1*13:07, allele DRB1*13:05, allele DRB1*13:11, allele DRB1*13:14, allele DRB1*13:18, allele DRB1*13:21, allele DRB1*13:24, allele DRB1*13:26, allele DRB1*13:42, allele DRB1*13:46, allele DRB1*13:47, allele DRB1*13:49, allele DRB1*13:50, allele DRB1*13:54, allele DRB1*13:55, allele DRB1*13:62, allele DRB1*13:63 and allele DRB1*13:75.
VAR_062892
Natural varianti96 – 961I → L in allele DRB1*13:20, allele DRB1*13:25, allele DRB1*13:29, allele DRB1*13:43, allele DRB1*13:44, allele DRB1*13:56, allele DRB1*13:60, allele DRB1*13:71, allele DRB1*13:78, allele DRB1*13:86 and allele DRB1*13:88.
VAR_062893
Natural varianti97 – 971L → R in allele DRB1*13:74.
VAR_062894
Natural varianti99 – 991D → Q in allele DRB1*13:09, allele DRB1*13:44 and allele DRB1*13:86; requires 2 nucleotide substitutions.
VAR_062895
Natural varianti100 – 1001E → A in allele DRB1*13:09.
VAR_062898
Natural varianti100 – 1001E → K in allele DRB1*13:03, allele DRB1*13:10, allele DRB1*13:33, allele DRB1*13:37, allele DRB1*13:66, allele DRB1*13:81, allele DRB1*13:85 and allele DRB1*13:88.
VAR_062897
Natural varianti100 – 1001E → R in allele DRB1*13:07, allele DRB1*13:05, allele DRB1*13:06, allele DRB1*13:11, allele DRB1*13:12, allele DRB1*13:13, allele DRB1*13:14, allele DRB1*13:18, allele DRB1*13:21, allele DRB1*13:25, allele DRB1*13:26, allele DRB1*13:30, allele DRB1*13:42, allele DRB1*13:44, allele DRB1*13:46, allele DRB1*13:47, allele DRB1*13:49, allele DRB1*13:50, allele DRB1*13:55, allele DRB1*13:56, allele DRB1*13:58, allele DRB1*13:60, allele DRB1*13:62, allele DRB1*13:77, allele DRB1*13:82 and allele DRB1*13:86; requires 2 nucleotide substitutions.
VAR_062896
Natural varianti103 – 1031A → E in allele DRB1*13:76.
VAR_062900
Natural varianti103 – 1031A → L in allele DRB1*13:13, allele DRB1*13:18, allele DRB1*13:47 and allele DRB1*13:55; requires 2 nucleotide substitutions.
VAR_062899
Natural varianti106 – 1061T → N in allele DRB1*13:33 and allele DRB1*13:61.
VAR_062901
Natural varianti113 – 1131G → R in allele DRB1*13:28.
VAR_062902
Natural varianti114 – 1141V → A in allele DRB1*13:58 and allele DRB1*13:81.
VAR_062903
Natural varianti115 – 1151V → D in allele DRB1*13:16.
VAR_062905
Natural varianti115 – 1151V → G in allele DRB1*13:02, allele DRB1*13:03, allele DRB1*13:07, allele DRB1*13:05, allele DRB1*13:12, allele DRB1*13:13, allele DRB1*13:14, allele DRB1*13:21, allele DRB1*13:23, allele DRB1*13:25, allele DRB1*13:26, allele DRB1*13:29, allele DRB1*13:30, allele DRB1*13:31, allele DRB1*13:33, allele DRB1*13:34, allele DRB1*13:36, allele DRB1*13:37, allele DRB1*13:38, allele DRB1*13:39, allele DRB1*13:41, allele DRB1*13:45, allele DRB1*13:46, allele DRB1*13:47, allele DRB1*13:49, allele DRB1*13:50, allele DRB1*13:55, allele DRB1*13:56, allele DRB1*13:60, allele DRB1*13:62, allele DRB1*13:63, allele DRB1*13:65, allele DRB1*13:66, allele DRB1*13:67, allele DRB1*13:73, allele DRB1*13:74, allele DRB1*13:82, allele DRB1*13:85, allele DRB1*13:86 and allele DRB1*13:88.
VAR_062904

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY663413 Genomic DNA. Translation: AAU88029.1.
AY663415 Genomic DNA. Translation: AAU88035.1.
AJ697893 mRNA. Translation: CAG27026.1.
AY961069 mRNA. Translation: AAX63457.1.
AY961070 mRNA. Translation: AAX63458.2.
L76133 mRNA. Translation: AAL40069.1.
AK293020 mRNA. Translation: BAF85709.1.
BC007920 mRNA. Translation: AAH07920.1.
L41992 Genomic DNA. Translation: AAA65914.1.
U17381 mRNA. Translation: AAC50167.1.
M59803 mRNA. Translation: AAA64237.1.
FM196526 Genomic DNA. Translation: CAQ86517.1.
AM109988 Genomic DNA. Translation: CAJ33595.1.
AM109989 Genomic DNA. Translation: CAJ33596.1.
AM109990 Genomic DNA. Translation: CAJ33597.1.
AM109991 Genomic DNA. Translation: CAJ33598.1.
AM109992 Genomic DNA. Translation: CAJ33599.1.
AM109993 Genomic DNA. Translation: CAJ33600.1.
AM109994 Genomic DNA. Translation: CAJ33601.1.
AM109995 Genomic DNA. Translation: CAJ33602.1.
AM109996 Genomic DNA. Translation: CAJ33603.1.
AM109997 Genomic DNA. Translation: CAJ33604.1.
D29836 Genomic DNA. Translation: BAA06216.1.
Z48631 Genomic DNA. No translation available.
X86326 Genomic DNA. No translation available.
AF136155 Genomic DNA. Translation: AAD27646.1.
AF164346 Genomic DNA. Translation: AAD47814.1.
AF169239 Genomic DNA. Translation: AAD51315.1.
AF243537 Genomic DNA. Translation: AAG00414.1.
AF243538 Genomic DNA. Translation: AAG00415.1.
AF352295 Genomic DNA. Translation: AAK27712.1.
AF306862 Genomic DNA. Translation: AAG42258.1.
AF247533 Genomic DNA. Translation: AAF99607.1.
AY178845 Genomic DNA. Translation: AAO18733.1.
AJ555156 Genomic DNA. Translation: CAD87537.1.
AY048687 Genomic DNA. Translation: AAL12226.1.
AF441789 Genomic DNA. Translation: AAL35834.1.
AY765349 Genomic DNA. Translation: AAV35213.1.
AJ634529 Genomic DNA. Translation: CAG25408.1.
AY963587 Genomic DNA. Translation: AAX51706.1.
AM086025 Genomic DNA. Translation: CAJ30431.1.
AM494414 Genomic DNA. Translation: CAM36736.1.
EF053230 Genomic DNA. Translation: ABK33462.1.
AM158254 Genomic DNA. Translation: CAJ43560.1.
EF196873 Genomic DNA. Translation: ABM69041.1.
AM904556 Genomic DNA. Translation: CAP17407.1.
U97554 Genomic DNA. Translation: AAB58309.1.
AF048688 Genomic DNA. Translation: AAC05271.1.
AF170582 Genomic DNA. Translation: AAD50971.1.
AJ245717 Genomic DNA. Translation: CAB53346.1.
AJ249591 Genomic DNA. Translation: CAB56840.1.
AJ401236 Genomic DNA. Translation: CAB96577.1.
AB049459 Genomic DNA. Translation: BAB16298.1.
AF305212 Genomic DNA. Translation: AAG22826.1.
AJ271206 Genomic DNA. Translation: CAC27122.1.
AY178184 Genomic DNA. Translation: AAO21939.1.
AY277392 Genomic DNA. Translation: AAP34696.1.
AY225520 Genomic DNA. Translation: AAO67727.1.
AY259126 Genomic DNA. Translation: AAP21612.1.
AB112913 Genomic DNA. Translation: BAD02944.1.
AY339247 Genomic DNA. Translation: AAQ18914.1.
AY379480 Genomic DNA. Translation: AAQ85128.1.
AY502108 Genomic DNA. Translation: AAR89455.1.
AJ627565 Genomic DNA. Translation: CAF28889.1.
AJ783982 Genomic DNA. Translation: CAH04455.1.
AJ853708 Genomic DNA. Translation: CAH68606.1.
AM279417 Genomic DNA. Translation: CAK50561.1.
EF493833 Genomic DNA. Translation: ABP68561.1.
EF493832 Genomic DNA. Translation: ABP68560.1.
AM931066 Genomic DNA. Translation: CAP62371.1.
DQ473293 Genomic DNA. Translation: ABF18979.1.
DQ514602 Genomic DNA. Translation: ABF60565.1.
DQ525629 Genomic DNA. Translation: ABF74594.1.
EU029803 Genomic DNA. Translation: ABU86862.1.
EU071684 Genomic DNA. Translation: ABS87343.1.
EU812541 Genomic DNA. Translation: ACE88700.1.
EU826130 Genomic DNA. Translation: ACF36162.1.
EU826129 Genomic DNA. Translation: ACF36161.1.
FJ688163 Genomic DNA. Translation: ACN56340.1.
U36827 Genomic DNA. Translation: AAC51629.1.
U36825 Genomic DNA. Translation: AAC51628.1.
U79025 Genomic DNA. Translation: AAB52235.1.
AF499445 Genomic DNA. Translation: AAP68877.1.
X93924 Genomic DNA. No translation available.
AJ001254 Genomic DNA. Translation: CAA04628.1.
AJ237964 Genomic DNA. Translation: CAB40418.1. Sequence problems.
AJ488066 Genomic DNA. Translation: CAD32373.1.
AY174182 Genomic DNA. Translation: AAO17054.1.
AY179366 Genomic DNA. Translation: AAO23237.1.
L23534 Genomic DNA. Translation: AAA62591.1.
U72264 Genomic DNA. Translation: AAB17276.1.
X97407 Genomic DNA. Translation: CAA66060.1.
X96396 Genomic DNA. Translation: CAA65260.1.
AJ276873 Genomic DNA. Translation: CAB82169.1.
PIRiD25239.
I38899.
I59647.
I72484.
PH0155.
S03439.
UniGeneiHs.485130.
Hs.534322.
Hs.696211.
Hs.716081.
Hs.723344.
Hs.736560.

Genome annotation databases

EnsembliENST00000328980; ENSP00000331343; ENSG00000206306.
ENST00000399450; ENSP00000382378; ENSG00000206240.
ENST00000415796; ENSP00000412168; ENSG00000206306.
ENST00000428566; ENSP00000392280; ENSG00000206240.

Polymorphism databases

DMDMi74757225.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY663413 Genomic DNA. Translation: AAU88029.1 .
AY663415 Genomic DNA. Translation: AAU88035.1 .
AJ697893 mRNA. Translation: CAG27026.1 .
AY961069 mRNA. Translation: AAX63457.1 .
AY961070 mRNA. Translation: AAX63458.2 .
L76133 mRNA. Translation: AAL40069.1 .
AK293020 mRNA. Translation: BAF85709.1 .
BC007920 mRNA. Translation: AAH07920.1 .
L41992 Genomic DNA. Translation: AAA65914.1 .
U17381 mRNA. Translation: AAC50167.1 .
M59803 mRNA. Translation: AAA64237.1 .
FM196526 Genomic DNA. Translation: CAQ86517.1 .
AM109988 Genomic DNA. Translation: CAJ33595.1 .
AM109989 Genomic DNA. Translation: CAJ33596.1 .
AM109990 Genomic DNA. Translation: CAJ33597.1 .
AM109991 Genomic DNA. Translation: CAJ33598.1 .
AM109992 Genomic DNA. Translation: CAJ33599.1 .
AM109993 Genomic DNA. Translation: CAJ33600.1 .
AM109994 Genomic DNA. Translation: CAJ33601.1 .
AM109995 Genomic DNA. Translation: CAJ33602.1 .
AM109996 Genomic DNA. Translation: CAJ33603.1 .
AM109997 Genomic DNA. Translation: CAJ33604.1 .
D29836 Genomic DNA. Translation: BAA06216.1 .
Z48631 Genomic DNA. No translation available.
X86326 Genomic DNA. No translation available.
AF136155 Genomic DNA. Translation: AAD27646.1 .
AF164346 Genomic DNA. Translation: AAD47814.1 .
AF169239 Genomic DNA. Translation: AAD51315.1 .
AF243537 Genomic DNA. Translation: AAG00414.1 .
AF243538 Genomic DNA. Translation: AAG00415.1 .
AF352295 Genomic DNA. Translation: AAK27712.1 .
AF306862 Genomic DNA. Translation: AAG42258.1 .
AF247533 Genomic DNA. Translation: AAF99607.1 .
AY178845 Genomic DNA. Translation: AAO18733.1 .
AJ555156 Genomic DNA. Translation: CAD87537.1 .
AY048687 Genomic DNA. Translation: AAL12226.1 .
AF441789 Genomic DNA. Translation: AAL35834.1 .
AY765349 Genomic DNA. Translation: AAV35213.1 .
AJ634529 Genomic DNA. Translation: CAG25408.1 .
AY963587 Genomic DNA. Translation: AAX51706.1 .
AM086025 Genomic DNA. Translation: CAJ30431.1 .
AM494414 Genomic DNA. Translation: CAM36736.1 .
EF053230 Genomic DNA. Translation: ABK33462.1 .
AM158254 Genomic DNA. Translation: CAJ43560.1 .
EF196873 Genomic DNA. Translation: ABM69041.1 .
AM904556 Genomic DNA. Translation: CAP17407.1 .
U97554 Genomic DNA. Translation: AAB58309.1 .
AF048688 Genomic DNA. Translation: AAC05271.1 .
AF170582 Genomic DNA. Translation: AAD50971.1 .
AJ245717 Genomic DNA. Translation: CAB53346.1 .
AJ249591 Genomic DNA. Translation: CAB56840.1 .
AJ401236 Genomic DNA. Translation: CAB96577.1 .
AB049459 Genomic DNA. Translation: BAB16298.1 .
AF305212 Genomic DNA. Translation: AAG22826.1 .
AJ271206 Genomic DNA. Translation: CAC27122.1 .
AY178184 Genomic DNA. Translation: AAO21939.1 .
AY277392 Genomic DNA. Translation: AAP34696.1 .
AY225520 Genomic DNA. Translation: AAO67727.1 .
AY259126 Genomic DNA. Translation: AAP21612.1 .
AB112913 Genomic DNA. Translation: BAD02944.1 .
AY339247 Genomic DNA. Translation: AAQ18914.1 .
AY379480 Genomic DNA. Translation: AAQ85128.1 .
AY502108 Genomic DNA. Translation: AAR89455.1 .
AJ627565 Genomic DNA. Translation: CAF28889.1 .
AJ783982 Genomic DNA. Translation: CAH04455.1 .
AJ853708 Genomic DNA. Translation: CAH68606.1 .
AM279417 Genomic DNA. Translation: CAK50561.1 .
EF493833 Genomic DNA. Translation: ABP68561.1 .
EF493832 Genomic DNA. Translation: ABP68560.1 .
AM931066 Genomic DNA. Translation: CAP62371.1 .
DQ473293 Genomic DNA. Translation: ABF18979.1 .
DQ514602 Genomic DNA. Translation: ABF60565.1 .
DQ525629 Genomic DNA. Translation: ABF74594.1 .
EU029803 Genomic DNA. Translation: ABU86862.1 .
EU071684 Genomic DNA. Translation: ABS87343.1 .
EU812541 Genomic DNA. Translation: ACE88700.1 .
EU826130 Genomic DNA. Translation: ACF36162.1 .
EU826129 Genomic DNA. Translation: ACF36161.1 .
FJ688163 Genomic DNA. Translation: ACN56340.1 .
U36827 Genomic DNA. Translation: AAC51629.1 .
U36825 Genomic DNA. Translation: AAC51628.1 .
U79025 Genomic DNA. Translation: AAB52235.1 .
AF499445 Genomic DNA. Translation: AAP68877.1 .
X93924 Genomic DNA. No translation available.
AJ001254 Genomic DNA. Translation: CAA04628.1 .
AJ237964 Genomic DNA. Translation: CAB40418.1 . Sequence problems.
AJ488066 Genomic DNA. Translation: CAD32373.1 .
AY174182 Genomic DNA. Translation: AAO17054.1 .
AY179366 Genomic DNA. Translation: AAO23237.1 .
L23534 Genomic DNA. Translation: AAA62591.1 .
U72264 Genomic DNA. Translation: AAB17276.1 .
X97407 Genomic DNA. Translation: CAA66060.1 .
X96396 Genomic DNA. Translation: CAA65260.1 .
AJ276873 Genomic DNA. Translation: CAB82169.1 .
PIRi D25239.
I38899.
I59647.
I72484.
PH0155.
S03439.
UniGenei Hs.485130.
Hs.534322.
Hs.696211.
Hs.716081.
Hs.723344.
Hs.736560.

3D structure databases

ProteinModelPortali Q5Y7A7.
SMRi Q5Y7A7. Positions 34-220.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 74757225.

Proteomic databases

MaxQBi Q5Y7A7.
PRIDEi Q5Y7A7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328980 ; ENSP00000331343 ; ENSG00000206306 .
ENST00000399450 ; ENSP00000382378 ; ENSG00000206240 .
ENST00000415796 ; ENSP00000412168 ; ENSG00000206306 .
ENST00000428566 ; ENSP00000392280 ; ENSG00000206240 .

Organism-specific databases

GeneCardsi GC06M032546.
GC06Mj32477.
GC06Mn32480.
HGNCi HGNC:4948. HLA-DRB1.
MIMi 142857. gene.
neXtProti NX_Q5Y7A7.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG012730.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.
REACT_25078. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSi HLA-DRB1. human.
SOURCEi Search...

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view ]
ProDomi PD000328. MHC_II_b_N. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DRB1*13:01 AND DRB1*13:02).
  2. "Complete coding sequences and haplotypic associations of HLA-B*0707, -B*1524, -B*4405, -B*4802, -DRB1*0409, -DRB1*0411, -DRB1*1115, - DRB1*1305, and the novel allele -DRB1*0709. Group-specific amplification of cDNA from DRB1 alleles associated to DRB3 and DRB4."
    Vilches C., Sepulveda S., Balas A., Solis R., Aviles M.J., Estefania E., Gomez-Lozano N., Vicario J.L., DePablo R.
    Tissue Antigens 65:529-538(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*13:05).
  3. "Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113."
    Balas A., Vilches C., Rodriguez M.A., Fernandez B., Martinez M.P., de Pablo R., Garcia-Sanchez F., Vicario J.L.
    Hum. Immunol. 67:1008-1016(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DRB1*13:27 AND DRB1*13:56).
  4. "New complete sequences of MHC-DR in Spanish family with systemic lupus erythematosus."
    Arnaiz-Villena A., Martinez-Quiles N., De Juan-Echavarri D., Martin-Villa M., Martinez-Laso J.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*13:02).
    Tissue: Blood.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DRB1*13:01).
    Tissue: Uterus.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DRB1*13:02).
    Tissue: B-cell.
  7. Maurer D.H.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-148 (ALLELE DRB1*13:21).
    Tissue: Leukocyte.
  8. "Direct sequencing of SSP-PCR-amplified cDNA to identify new alleles in the DR52-associated DRB1 group: identification of DRB1*1115, DRB1*1117 and DRB1*1319."
    Robbins F., Tang T., Yao H., Ng J., Hartzman R.J., Hurley C.K.
    Tissue Antigens 45:302-308(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-123 (ALLELE DRB1*13:19).
    Tissue: Blood.
  9. "Two divergent routes of evolution gave rise to the DRw13 haplotypes."
    Lee K.W., Johnson A.H., Hurley C.K.
    J. Immunol. 145:3119-3125(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-130 (ALLELE DRB1*13:04).
  10. "A novel HLA-DRB1*13 allele identified by sequence-based typing."
    Ogrzewalla K., Tillmann G., Scheibelhut N., Lauber J., Enczmann J.
    Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-217 (ALLELE DRB1*13:87).
  11. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-216 (ALLELES DRB1*13:03; DRB1*13:06; DRB1*13:08; DRB1*13:10; DRB1*13:11; DRB1*13:14; DRB1*13:17; DRB1*13:20; DRB1*13:29 AND DRB1*13:36).
    Tissue: Peripheral blood.
  12. "DR variant with a DR5-like-haplotype found in Taiwan."
    Hu C.J.
    Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-124 (ALLELE DRB1*13:12).
  13. "A new HLA-DRB1(*)13 allele (DRB1(*)1318) with a short DRB1(*)08 sequence."
    Dormoy A., Delbosc A., Galy-Floc'h M., Tongio M.M.
    Immunogenetics 43:240-241(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:18).
  14. "Two newly identified HLA-DRB1 alleles: DRB1*1322 and DRB1*1327."
    Duran K.J., Maeda H., Otten H.G., Vries R.D., Schreuder G.M., Tilanus M.G.
    Immunogenetics 46:442-443(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:22).
  15. "Description of fourteen new DRB alleles found in a stem cell donor registry."
    Tang T.F., Lin Y.-S., Robbins F.M., Li L., Sintasath D., Coquillard G., Huang A., Heine U., Ng J., Hartzman R.J., Hurley C.K.
    Tissue Antigens 59:63-65(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*13:42 AND DRB1*13:43), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELES DRB1*13:35; DRB1*13:37 AND DRB1*13:49), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB1*13:38).
  16. "Novel HLA-DRB1 alleles discovered during routine sequencing based typing, DRB1*03052, DRB1*04032, DRB1*1139 and DRB1*1346."
    Greville W.D., Chapman G., Hogbin J.-P., Kennedy A., Dunckley H.
    Tissue Antigens 59:154-156(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:46).
  17. "Identification of two new HLA-DRB1 alleles, DRB1*1138 and DRB1*1344."
    Kennedy A., Le T., Chapman G., Greville W.D., Dunckley H.
    Tissue Antigens 59:157-158(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:44).
  18. "Identification of a new allele, HLA-DRB1*1360, on a DRB5 haplotype in a Brazilian individual."
    Testa G.V., Bunce M., Sheldon M.H., Dunn P.P., Day S., Marques S.B.
    Tissue Antigens 63:617-618(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:60).
  19. "A novel HLA-DRB1*13 allele (DRB1*1357) identified by polymerase chain reaction with sequence-specific primers and direct sequencing."
    Danzer M., Leitner D., Gangl E., Fae I., Fischer G.F., Gabriel C.
    Tissue Antigens 64:213-214(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:57).
  20. "Identification of two new HLA-DRB1 alleles: HLA-DRB1*1350 and DRB1*140502."
    Chen Z.X., Tsan S.G., Dang C.W., Chu C.C., Lin M., Lee Y.J.
    Tissue Antigens 64:300-303(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:50).
  21. "Two novel HLA-DRB1 alleles identified using a sequence-based typing: HLA-DRB1*1443 and HLA-DRB1*1351*."
    Chu C.C., Lee H.L., Hsieh N.K., Trejaut J., Lin M.
    Tissue Antigens 64:308-310(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:51).
  22. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:66).
  23. "Description and characterization of two new HLA alleles, B*4051 and DRB1*1364, identified by sequence-based typing."
    Czachurski D., Scollo A., Skambraks A., Perichon A.M., Scherer S., Tran T.H., Opelz G., Grappiolo I., Mytilineos J.
    Tissue Antigens 66:151-155(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:64).
    Tissue: Peripheral blood.
  24. "Identification of a novel human DRB1*13 allele by sequence-based DRB typing."
    Caggiari L., Simula M.P., Marzotto A., Caragnano A., Luchetti M., Gabrielli A., De Re V.
    Tissue Antigens 66:246-247(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:68).
  25. "Novel HLA-DRB1*1370 allele identified in a cord blood donor and her mother."
    Horn P.A., Zingsem J., Eckstein R., Blasczyk R.
    Tissue Antigens 67:345-347(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:70).
    Tissue: Peripheral blood.
  26. "Identification of three novel DRB1 alleles."
    Tavoularis S., Conrod V., Ribeiro E.
    Hum. Immunol. 68:S63-S63(2007)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:77).
    Tissue: Blood.
  27. "A new human leukocyte antigen DRB1 allele, HLA-DRB1*1375."
    Sanchez-Gordo F., Balas A., Ortiz M., Prat I., Vicario J.L.
    Tissue Antigens 69:204-205(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:75).
  28. "Description of HLA-DRB1*1371 allele, which has the 3' intron 1 sequence and HLA-DQB1 association normally seen with a DRB1*0301 allele."
    McWhinnie A.J., Shah A., Peat J., Tavarozzi F., Little A.M.
    Tissue Antigens 69:284-285(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:71).
  29. "Identification of three novel alleles of HLA-DRB1 and HLA-A in the Brazilian population."
    Abdeen H., McErlean C., Moraes M.E., Torres M., Campiotto S., Galvao S., Gouvea C., Middleton D.
    Tissue Antigens 69:607-610(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:76).
  30. "Thirty-six novel HLA alleles: 7 HLA-A, 11 HLA-B, 15 HLA-C and 3 HLA-DRB1."
    Anholts J.D., Aneq M., Dirks H.L., Tas A., Verduyn W., Oudshoorn M.
    Tissue Antigens 74:424-428(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:82).
    Tissue: Blood.
  31. "A new DRB1*13 allele detected by PCR-SSOP and confirmed by sequencing."
    Lester S., Laham N., Humphreys I., McCluskey J.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:32).
    Tissue: Peripheral blood.
  32. Erne G., Schmid C., Schwarz K., Woelpl A.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:34).
  33. "A new HLA-DRB1*13 allele in a Korean individual."
    Park M.H., Whang D.H., Kang S.J.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:39).
  34. "Sequence confirmation of HLA-DRB1*1314."
    Guttridge M.G.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:14).
    Tissue: Peripheral blood.
  35. "Characterization of a new HLA-DRB1*13 class II allele."
    Bois M., Dormoy A., Alcalay D.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:41).
  36. "A new HLA DRB1* allele close to DRB1*1304."
    Moine A.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:48).
    Tissue: Peripheral blood.
  37. "HLA-DRB1-1307V for exon2."
    Kashiwase K., Shimizu M., Juji T., Tanaka H., Ishikawa Y.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:47).
  38. "New HLA-DRB1*13."
    Tamouza R., Keyhani M., Poirier J.C., Schaeffer V., Fortier C., Labie D., Charron D.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:07).
  39. "New HLA DRB1*13 allele identified by sequence-based typing."
    Voorter C.E., van den Berg-Loonen E.M.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:01).
  40. "Complete exon 2 sequence for HLA-DRB1*1316."
    Rizzo M., Gedil M.A., Steiner N.K., Hurley C.K.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*13:01 AND DRB1*13:16).
  41. "Novel HLA-DRB1*1301 Variant."
    Rodriguez-Marino S., Coquillard G.J.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:69).
  42. "Novel HLA-DRB1*13 alleles detected by PCR-SSOP and confirmed by single allele specific sequencing."
    Chen D.-F., Dong L., Janzen M., Rabson A., Fraser P.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:58).
  43. "A new HLA-DR12V allele detected by PCR-RFLP."
    Ono A.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:54).
  44. Lazaro A.M., Gedil M.A., Rizzo M., Hurley C.K.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:61).
  45. "Characterization of a new HLA-DRB1 allele by direct sequencing."
    Hirv K., Krauss A., Schwarz K.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*13:62 AND DRB1*13:63).
  46. "Rare DRB1*1359 alleles confirmatory testing."
    Bendukidze N.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:59).
  47. "Hochaufloesende Typisierung von HLA-Klasse I und Klasse II mittels Sequenzanalyse. Einfluss auf das Transplantatueberleben."
    Czachurski D.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:65).
  48. "A new HLA-DRB1*13 variant similar to DRB1*130201 and DRB3*020101."
    Binder T.M.C., Mosebach M., Kuehnl P., Heim M.U., Blasczyk R., Eiermann T.H.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:67).
    Tissue: Peripheral blood.
  49. "Sequence of new HLA-DRB1*13 allele DRB1*13XX."
    Dunne C., Crowley J.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:74).
    Tissue: Peripheral blood.
  50. "New DRB1*13 allele found in cord blood."
    Duignan P., Varney M., Holdsworth R.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:79).
    Tissue: Blood.
  51. "New HLA DR13 sequence found in bone marrow donor."
    Moore J., Bowman S., Varney M., Tait B.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:78).
  52. "A novel HLA-DRB1*13 allele."
    Horn P.A., Blasczyk R.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*13:83).
  53. "Novel HLA-class II allele."
    Lazaro A.M., Xiao Y., Cao K., Shan X., Zhang B., Masaberg C., Hurley C.K.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB1*13:31; DRB1*13:72; DRB1*13:73; DRB1*13:80; DRB1*13:81; DRB1*13:84; DRB1*13:85; DRB1*13:86 AND DRB1*13:88).
  54. "Identification of four new DR52-associated DRB1 alleles: DRB1*1424, *1425, *1323 and *1324."
    Ellis J.M., Robbins F., Wang J., Tang T., Heine U., Mason J.M., Sese D., Milford E., Hurley C.K.
    Tissue Antigens 50:42-46(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELES DRB1*13:23 AND DRB1*13:24).
  55. "DRB1*1313."
    Hurley C.K., Noreen H., Lin Y.S.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-120 (ALLELE DRB1*13:13).
    Tissue: Blood.
  56. "Characterization of a new DRB1*13011 variant allele."
    Rodriguez-Marino S., Coquillard G.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-120 (ALLELE DRB1*13:52).
  57. "Identification of a new DRB1 allele (DRB1*1325) by PCR-SSP and DNA sequencing."
    Poli F., Bianchi P., Crespiatico L., Sirchia G.
    Tissue Antigens 48:714-716(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-116 (ALLELE DRB1*13:25).
  58. "Identification of novel DRB1*13 (DRB1*1333), DRB1*04 (DRB1*0426) and DRB5* (DRB5*0109) alleles."
    Buyse I.M., Ouellet S., Hashemi-Tavoularis S.
    Tissue Antigens 51:658-662(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB1*13:33).
    Tissue: Blood.
  59. "Identification of a novel allele, DRB1*1340, in two Brazilian individuals."
    Maciag P.C., Junes K.S., Villa L.L., Petzl-Erler M.L.
    Tissue Antigens 56:194-196(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-123 (ALLELE DRB1*13:40).
    Tissue: Cervix.
  60. "Identification of a new HLA DRB1*13 by SBT."
    Poli F., Longhi E., Frison S.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-123 (ALLELE DRB1*13:53).
    Tissue: Peripheral blood.
  61. "Confirmatory Sequence of HLA Class II DRB1*1315."
    Lo B.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-123 (ALLELES DRB1*13:15 AND DRB1*13:55).
  62. "Characterization of a new DRB1 allele, DRB1*1309, by PCR-SSOP and sequencing."
    Yunis J.J., Kineke E., Yunis E.J.
    Tissue Antigens 43:54-57(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-120 (ALLELE DRB1*13:09).
    Tissue: Blood.
  63. "New HLA class II (DRB1) allele from Melbourne BTS."
    Greville W.D., Bowman S.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-119 (ALLELE DRB1*13:30).
  64. "Identification of a novel DPB allele."
    Varney M.D., Tait B.D.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-119 (ALLELE DRB1*13:28).
  65. "Identification of a new HLA-DRB1*13 allele (DRB1*1326) with a short DRB1*16 sequence."
    Voorter C.E.M., de Bruyn-Geraets D., Verduyn W., Schreuder G.M.T., van den Berg-Loonen E.M.
    Tissue Antigens 49:88-91(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-116 (ALLELE DRB1*13:26).
  66. "Identification of a novel HLA DRB1 exon 2 sequence, DRB1*1345."
    Bengtsson M., Jansson I.E., Danielsson F., Henrysson H., Kallsten K.
    Tissue Antigens 59:159-161(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-116 (ALLELE DRB1*13:45).
  67. "Invariant chain structure and MHC class II function."
    Cresswell P.
    Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  68. "Presentation of antigens by MHC class II molecules: getting the most out of them."
    Villadangos J.A.
    Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  69. "Autophagy in MHC class II presentation: sampling from within."
    Menendez-Benito V., Neefjes J.
    Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  70. "MHC class II molecules on the move for successful antigen presentation."
    Rocha N., Neefjes J.
    EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  71. "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation."
    De Gassart A., Camosseto V., Thibodeau J., Ceppi M., Catalan N., Pierre P., Gatti E.
    Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION BY MARCH1, SUBCELLULAR LOCATION.
  72. "MHC class II transport at a glance."
    Berger A.C., Roche P.A.
    J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  73. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
    Beswick E.J., Reyes V.E.
    World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry namei2B1D_HUMAN
AccessioniPrimary (citable) accession number: Q5Y7A7
Secondary accession number(s): A0MWF2
, A2ICT1, A4ZXA5, A4ZXA6, A7UHG2, A7X5K7, A8YQE9, B0BK85, B3VTQ3, B5A8Y2, B5A8Y3, B5B9V6, B5QSK8, C0LAB5, O02930, O62889, O78047, P79545, Q14280, Q14QT2, Q19K86, Q1G0Z9, Q1KLJ6, Q29673, Q29720, Q29722, Q29806, Q29833, Q29874, Q29886, Q2MF40, Q2YHQ2, Q30112, Q3LA93, Q3LA94, Q3LA95, Q3LA96, Q3LA97, Q3LA98, Q3LA99, Q3LAA0, Q3LAA1, Q3LAA2, Q3MQ60, Q53IG1, Q56FP2, Q56FP3, Q58F52, Q5K3W2, Q5UBA2, Q5W3L4, Q6REE2, Q6U387, Q701T1, Q70Q85, Q768U2, Q7YP03, Q7YQ26, Q7YQA3, Q860E5, Q860H8, Q860Z3, Q861G6, Q861H0, Q861H4, Q8HWQ6, Q8WMA0, Q95389, Q95HL1, Q96HZ9, Q9BCP5, Q9BD21, Q9GIP3, Q9GJ25, Q9GJ60, Q9GJF8, Q9GJF9, Q9GJG0, Q9MY45, Q9MY56, Q9TPW3, Q9TPW9, Q9TPX4, Q9UBY1, Q9UIN0, Q9XRX1, Q9Y453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: November 23, 2004
Last modified: October 1, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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