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Protein

Probable palmitoyltransferase ZDHHC8

Gene

Zdhhc8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1.1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei134S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-8963896 HDL assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC8 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 8
Short name:
DHHC-8
Gene namesi
Name:Zdhhc8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1338012 Zdhhc8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 52LumenalSequence analysisAdd BLAST18
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 148CytoplasmicSequence analysisAdd BLAST75
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 190LumenalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 762CytoplasmicSequence analysisAdd BLAST551

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice have normal brain morphology, but female have strong locomotor deficits in open field, due to a greater fear of new environments.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128781 – 762Probable palmitoyltransferase ZDHHC8Add BLAST762

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei335PhosphoserineCombined sources1
Modified residuei439Omega-N-methylarginineCombined sources1
Modified residuei603PhosphoserineBy similarity1
Modified residuei624PhosphoserineCombined sources1
Modified residuei672PhosphoserineCombined sources1
Modified residuei679PhosphoserineBy similarity1
Modified residuei722PhosphoserineBy similarity1
Modified residuei740PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ5Y5T5
PaxDbiQ5Y5T5
PRIDEiQ5Y5T5

PTM databases

iPTMnetiQ5Y5T5
PhosphoSitePlusiQ5Y5T5
SwissPalmiQ5Y5T5

Expressioni

Tissue specificityi

Expressed in brain cortex and hippocampus.1 Publication

Gene expression databases

BgeeiENSMUSG00000060166
CleanExiMM_ZDHHC8
GenevisibleiQ5Y5T5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076224

Structurei

3D structure databases

ProteinModelPortaliQ5Y5T5
SMRiQ5Y5T5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 154DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00550000074293
HOGENOMiHOG000234346
HOVERGENiHBG057186
InParanoidiQ5Y5T5
KOiK20030
OMAiFTRGCCG
OrthoDBiEOG091G02XW
PhylomeDBiQ5Y5T5
TreeFamiTF354263

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
IPR030291 ZDHHC8
PANTHERiPTHR12349:SF1 PTHR12349:SF1, 1 hit
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q5Y5T5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSPGTRLK PAKYIPVATA AALLVGSSTL FFVFTCPWLT RAVSPAIPVY
60 70 80 90 100
NGILFLFVLA NFSMATFMDP GVFPRADEDE DKEDDFRAPL YKNVDVRGIQ
110 120 130 140 150
VRMKWCATCH FYRPPRCSHC SVCDNCVEDF DHHCPWVNNC IGRRNYRYFF
160 170 180 190 200
LFLLSLSAHM VGVVAFGLLY VLNHSEGLGA AHTTITMAVM CVAGLFFIPV
210 220 230 240 250
IGLTGFHVVL VTRGRTTNEQ VTGKFRGGVN PFTRGCYGNV EHVLCSPLAP
260 270 280 290 300
RYVVEPPRMP LSVSLKPPFL RPELLERAVP LKVKLSDNGL KAGRSKSKGS
310 320 330 340 350
LDQLDEKPLD LGPPLPPKIE AGTFGRDLKT PRPGSAESAL SVQRTSPPTP
360 370 380 390 400
AMYKFRPAFS TGPKTPFCGP NEQVPGPDSL TLADDSTHSL DFVSEPSLDL
410 420 430 440 450
PDHGPGGLRP PYPPSPPLNT TDAFSGALRS LSLKAASRRG GDHMTLQPLR
460 470 480 490 500
SEGGPPTPHR SLFAPHALPN RNGSLSYDSL LNPGSPSGHA CPTHPSVGIA
510 520 530 540 550
SYHSPYLHPG PSDPPRPPPR SFSPVLGPRP REPSPVRYDN LSRTIMASIQ
560 570 580 590 600
ERKDREERER LLRSQTDSLF GDSGVYDTPS SYSLQQASVL TEGPRGSVLR
610 620 630 640 650
YGSRDDLVAG PGFGGARNPA LQTSLSSLSS SMSRAPRTSS SSLQADQANN
660 670 680 690 700
NAPGPRPGSG SHRSPARQGL PSPPGTPRSP SYTGSKAVAF IHTDLPDRQP
710 720 730 740 750
SLAMQRDHPQ LKTPPSKLNG QSPGMARLGP AASPMGPNAS PARHTLVKKV
760
SGVGGTTYEI SV
Length:762
Mass (Da):82,031
Last modified:November 23, 2004 - v1
Checksum:i28FC98CACA74B2E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY668947 mRNA Translation: AAU89701.1
BC055694 mRNA Translation: AAH55694.1
CCDSiCCDS28017.1
RefSeqiNP_742163.4, NM_172151.4
UniGeneiMm.326263

Genome annotation databases

EnsembliENSMUST00000076957; ENSMUSP00000076224; ENSMUSG00000060166
ENSMUST00000206884; ENSMUSP00000145843; ENSMUSG00000108733
GeneIDi27801
KEGGimmu:27801
UCSCiuc007ymx.1 mouse

Entry informationi

Entry nameiZDHC8_MOUSE
AccessioniPrimary (citable) accession number: Q5Y5T5
Secondary accession number(s): Q7TNF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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