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Protein

Palmitoyltransferase ZDHHC23

Gene

Zdhhc23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane (By similarity).By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri249 – 29951DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • protein localization to plasma membrane Source: MGI
  • protein palmitoylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC23 (EC:2.3.1.225)
Alternative name(s):
DHHC-containing protein 11
Zinc finger DHHC domain-containing protein 23
Short name:
DHHC-23
Short name:
zDHHC23
Gene namesi
Name:Zdhhc23
Synonyms:Gm779
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2685625. Zdhhc23.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei82 – 9918HelicalSequence analysisAdd
BLAST
Transmembranei103 – 12523HelicalSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence analysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Palmitoyltransferase ZDHHC23PRO_0000212913Add
BLAST

Proteomic databases

PaxDbiQ5Y5T3.
PRIDEiQ5Y5T3.

PTM databases

PhosphoSiteiQ5Y5T3.

Expressioni

Tissue specificityi

Expressed in the brain.1 Publication

Gene expression databases

BgeeiQ5Y5T3.
CleanExiMM_ZDHHC23.
ExpressionAtlasiQ5Y5T3. baseline and differential.

Interactioni

Subunit structurei

Interacts with NOS1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128650.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni422 – 4254Interaction with NOS1By similarity

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri249 – 29951DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000290638.
HOVERGENiHBG055654.
InParanoidiQ5Y5T3.
KOiK18932.
OMAiRWITCKS.
PhylomeDBiQ5Y5T3.
TreeFamiTF354316.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5Y5T3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPVKKKKTE EPELEPLCCC EYIDRNGEKN HVAACLCDCQ DLDEGCDRWL
60 70 80 90 100
TCQSLRPETC ERITDTISDR LRIPWLRGAK KVNISIVPPL VLLPVFLHVA
110 120 130 140 150
SWHFLLGVVV LTSLPMLALW YYYLTHRRKE QTLFFLSLGL FSLGYMYYVF
160 170 180 190 200
LREVVPQGRV GPTQLALLTC GLLLILLALY RAKKNPGYLS NDKSPSNSQI
210 220 230 240 250
ECPVKKGQEK TKGFPGTDAS GSLNNRTLKD DVRGSSRVGL DSPAKVKEDW
260 270 280 290 300
CAKCQLVRPA RAWHCRICGI CVRRMDHHCV WINSCVGESN HQAFILALSI
310 320 330 340 350
FLLTSVYGIS LTLNTICRDR SLFTALFYCP GVYANYSSAL SFTCVWYSVI
360 370 380 390 400
ITAGMAYIFL IQLINISYNV TEREVQQALR QKTGRRLLCG LIVDTGQYNR
410 420
GFLRNWLQFS TLGTHTVHTP AEDIV
Length:425
Mass (Da):48,150
Last modified:November 23, 2004 - v1
Checksum:i36004314B450A243
GO

Sequence cautioni

The sequence BAE27992.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti131 – 1311Q → E in BAE23368 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY668949 mRNA. Translation: AAU89703.1.
AK137472 mRNA. Translation: BAE23368.1.
AK147553 mRNA. Translation: BAE27992.1. Different initiation.
BC139052 mRNA. Translation: AAI39053.1.
BC145684 mRNA. Translation: AAI45685.1.
CCDSiCCDS28180.1.
RefSeqiNP_001007461.1. NM_001007460.1.
XP_006522373.1. XM_006522310.2.
XP_006522374.1. XM_006522311.2.
UniGeneiMm.327852.

Genome annotation databases

EnsembliENSMUST00000165648; ENSMUSP00000128650; ENSMUSG00000036304.
GeneIDi332175.
KEGGimmu:332175.
UCSCiuc007zgp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY668949 mRNA. Translation: AAU89703.1.
AK137472 mRNA. Translation: BAE23368.1.
AK147553 mRNA. Translation: BAE27992.1. Different initiation.
BC139052 mRNA. Translation: AAI39053.1.
BC145684 mRNA. Translation: AAI45685.1.
CCDSiCCDS28180.1.
RefSeqiNP_001007461.1. NM_001007460.1.
XP_006522373.1. XM_006522310.2.
XP_006522374.1. XM_006522311.2.
UniGeneiMm.327852.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128650.

PTM databases

PhosphoSiteiQ5Y5T3.

Proteomic databases

PaxDbiQ5Y5T3.
PRIDEiQ5Y5T3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165648; ENSMUSP00000128650; ENSMUSG00000036304.
GeneIDi332175.
KEGGimmu:332175.
UCSCiuc007zgp.1. mouse.

Organism-specific databases

CTDi254887.
MGIiMGI:2685625. Zdhhc23.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000290638.
HOVERGENiHBG055654.
InParanoidiQ5Y5T3.
KOiK18932.
OMAiRWITCKS.
PhylomeDBiQ5Y5T3.
TreeFamiTF354316.

Miscellaneous databases

NextBioi399854.
PROiQ5Y5T3.
SOURCEiSearch...

Gene expression databases

BgeeiQ5Y5T3.
CleanExiMM_ZDHHC23.
ExpressionAtlasiQ5Y5T3. baseline and differential.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of PSD-95 palmitoylating enzymes."
    Fukata M., Fukata Y., Adesnik H., Nicoll R.A., Bredt D.S.
    Neuron 44:987-996(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone and Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZDH23_MOUSE
AccessioniPrimary (citable) accession number: Q5Y5T3
Secondary accession number(s): A6H5Y4, Q3UH65, Q3UVA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 23, 2004
Last modified: February 17, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.