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Protein

Palmitoyltransferase ZDHHC18

Gene

Zdhhc18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has palmitoyltransferase activity towards HRAS and LCK.1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei214 – 2141S-palmitoyl cysteine intermediateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri184 – 23451DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cellular protein localization Source: MGI
  • protein palmitoylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC18 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 18
Short name:
DHHC-18
Gene namesi
Name:Zdhhc18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3527792. Zdhhc18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei83 – 10321HelicalSequence analysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence analysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence analysisAdd
BLAST
Transmembranei270 – 29021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Palmitoyltransferase ZDHHC18PRO_0000212903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5Y5T2.
MaxQBiQ5Y5T2.
PaxDbiQ5Y5T2.
PRIDEiQ5Y5T2.

PTM databases

iPTMnetiQ5Y5T2.
PhosphoSiteiQ5Y5T2.
SwissPalmiQ5Y5T2.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ5Y5T2.
CleanExiMM_ZDHHC18.
GenevisibleiQ5Y5T2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081260.

Structurei

3D structure databases

ProteinModelPortaliQ5Y5T2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 4232Pro-richAdd
BLAST

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri184 – 23451DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000242943.
HOVERGENiHBG056239.
InParanoidiQ5Y5T2.
KOiK16675.
OMAiPRATICE.
OrthoDBiEOG700882.
PhylomeDBiQ5Y5T2.
TreeFamiTF312923.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5Y5T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDCEYQQIS PGAAPPPASP GARRPGPAAP PAPSPGPAPG APRWSGSGSG
60 70 80 90 100
SGSLGRRPRR KWEVFPGRNR FYCGGRLMLA GHGGVFALTL LLILSTTILF
110 120 130 140 150
FVFDCPYLAR TLTLAIPIIA AILFFFVMSC LLQTSFTDPG ILPRATICEA
160 170 180 190 200
AALEKQIDNT GSSTYRPPPR TREVMINGQT VKLKYCFTCK MFRPPRTSHC
210 220 230 240 250
SVCDNCVERF DHHCPWVGNC VGRRNYRFFY AFILSLSFLT AFIFACVVTH
260 270 280 290 300
LTLLSQGSNF LSALKKTPAS VLELVICFFS IWSILGLSGF HTYLVASNLT
310 320 330 340 350
TNEDIKGSWS SKRGGEASVN PYSHKSIITN CCAVLCGPLP PSLIDRRGFV
360 370 380
QSDTALPSPI RSDDPACGAK PDASMVGGHP
Length:380
Mass (Da):41,148
Last modified:June 10, 2008 - v4
Checksum:i91311320F4AE505C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627228, BX537327 Genomic DNA. Translation: CAM14825.1.
BX537327, AL627228 Genomic DNA. Translation: CAM25149.1.
BF582271 mRNA. No translation available.
CJ065144 mRNA. No translation available.
AY668950 mRNA. Translation: AAU89704.1.
CCDSiCCDS38906.1.
RefSeqiNP_001017968.2. NM_001017968.2.
UniGeneiMm.331948.

Genome annotation databases

EnsembliENSMUST00000084238; ENSMUSP00000081260; ENSMUSG00000037553.
GeneIDi503610.
KEGGimmu:503610.
UCSCiuc008vde.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627228, BX537327 Genomic DNA. Translation: CAM14825.1.
BX537327, AL627228 Genomic DNA. Translation: CAM25149.1.
BF582271 mRNA. No translation available.
CJ065144 mRNA. No translation available.
AY668950 mRNA. Translation: AAU89704.1.
CCDSiCCDS38906.1.
RefSeqiNP_001017968.2. NM_001017968.2.
UniGeneiMm.331948.

3D structure databases

ProteinModelPortaliQ5Y5T2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081260.

PTM databases

iPTMnetiQ5Y5T2.
PhosphoSiteiQ5Y5T2.
SwissPalmiQ5Y5T2.

Proteomic databases

EPDiQ5Y5T2.
MaxQBiQ5Y5T2.
PaxDbiQ5Y5T2.
PRIDEiQ5Y5T2.

Protocols and materials databases

DNASUi503610.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084238; ENSMUSP00000081260; ENSMUSG00000037553.
GeneIDi503610.
KEGGimmu:503610.
UCSCiuc008vde.1. mouse.

Organism-specific databases

CTDi84243.
MGIiMGI:3527792. Zdhhc18.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000242943.
HOVERGENiHBG056239.
InParanoidiQ5Y5T2.
KOiK16675.
OMAiPRATICE.
OrthoDBiEOG700882.
PhylomeDBiQ5Y5T2.
TreeFamiTF312923.

Miscellaneous databases

NextBioi411848.
PROiQ5Y5T2.
SOURCEiSearch...

Gene expression databases

BgeeiQ5Y5T2.
CleanExiMM_ZDHHC18.
GenevisibleiQ5Y5T2. MM.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-380.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-227.
  4. "Identification of PSD-95 palmitoylating enzymes."
    Fukata M., Fukata Y., Adesnik H., Nicoll R.A., Bredt D.S.
    Neuron 44:987-996(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 128-380, FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Brain.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZDH18_MOUSE
AccessioniPrimary (citable) accession number: Q5Y5T2
Secondary accession number(s): A2A9F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 10, 2008
Last modified: March 16, 2016
This is version 92 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.