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Protein

Probable palmitoyltransferase ZDHHC20

Gene

Zdhhc20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC20 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 20
Short name:
DHHC-20
Gene namesi
Name:Zdhhc20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1923215. Zdhhc20.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129071 – 380Probable palmitoyltransferase ZDHHC20Add BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei320PhosphoserineBy similarity1
Modified residuei345PhosphoserineBy similarity1
Modified residuei354PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ5Y5T1.
PeptideAtlasiQ5Y5T1.
PRIDEiQ5Y5T1.

PTM databases

iPTMnetiQ5Y5T1.
PhosphoSitePlusiQ5Y5T1.
SwissPalmiQ5Y5T1.

Expressioni

Tissue specificityi

Highest levels in lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000021969.
CleanExiMM_ZDHHC20.
GenevisibleiQ5Y5T1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086900.

Structurei

3D structure databases

ProteinModelPortaliQ5Y5T1.
SMRiQ5Y5T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 176DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1315. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00850000132259.
HOGENOMiHOG000234777.
HOVERGENiHBG055108.
InParanoidiQ5Y5T1.
KOiK20028.
OMAiFRAPMFS.
OrthoDBiEOG091G0AXR.
PhylomeDBiQ5Y5T1.
TreeFamiTF316044.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5Y5T1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPWTLWRCC QRVVGWVPVL FITFVVVWSY YAYVVELCVS TISRTGEKGK
60 70 80 90 100
TVVYLVAFHL FFVMFVWSYW MTIFTSPASP SKEFYLSNSE KERYEKEFSQ
110 120 130 140 150
ERQQDILRRA ARDLPIYTTS ASKAIRYCEK CQLIKPDRAH HCSACDRCVL
160 170 180 190 200
KMDHHCPWVN NCVGFTNYKF FMLFLLYSLL YCLFVAATVL EYFIKFWTLC
210 220 230 240 250
RRKSTENCPK NEPTVLNFPS AKFHVLFLFF VSAMFFVSVL SLFSYHCWLV
260 270 280 290 300
GKNRTTIESF RAPMFSYGID GNGFSLGCSK NWRQVFGDEK KYWLVPIFSS
310 320 330 340 350
LGDGCSFPAR LVGMDPEQAS VANQSDYVRS IGSNQPFPIK PLSESKNRLL
360 370 380
DSESQWLENG AEEGVTKSGT NNHVTVEIEN
Length:380
Mass (Da):43,976
Last modified:November 23, 2004 - v1
Checksum:i3ECD9E424185BF01
GO
Isoform 2 (identifier: Q5Y5T1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     199-210: Missing.

Show »
Length:368
Mass (Da):42,559
Checksum:iFD1C012E3CFE7A1E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130K → R in BAE41590 (PubMed:16141072).Curated1
Sequence conflicti243F → Y in BAB30620 (PubMed:16141072).Curated1
Sequence conflicti370T → I in BAE41590 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016278199 – 210Missing in isoform 2. 2 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY668951 mRNA. Translation: AAU89705.1.
AK017158 mRNA. Translation: BAB30620.1.
AK031184 mRNA. Translation: BAC27294.1.
AK049270 mRNA. Translation: BAC33648.1.
AK140182 mRNA. Translation: BAE24268.1.
AK163174 mRNA. Translation: BAE37221.1.
AK170139 mRNA. Translation: BAE41590.1.
BC019536 mRNA. Translation: AAH19536.1.
CCDSiCCDS27162.1. [Q5Y5T1-2]
RefSeqiNP_083768.4. NM_029492.4. [Q5Y5T1-2]
UniGeneiMm.29044.

Genome annotation databases

EnsembliENSMUST00000089473; ENSMUSP00000086900; ENSMUSG00000021969. [Q5Y5T1-2]
GeneIDi75965.
KEGGimmu:75965.
UCSCiuc007udr.1. mouse. [Q5Y5T1-2]
uc007uds.1. mouse. [Q5Y5T1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY668951 mRNA. Translation: AAU89705.1.
AK017158 mRNA. Translation: BAB30620.1.
AK031184 mRNA. Translation: BAC27294.1.
AK049270 mRNA. Translation: BAC33648.1.
AK140182 mRNA. Translation: BAE24268.1.
AK163174 mRNA. Translation: BAE37221.1.
AK170139 mRNA. Translation: BAE41590.1.
BC019536 mRNA. Translation: AAH19536.1.
CCDSiCCDS27162.1. [Q5Y5T1-2]
RefSeqiNP_083768.4. NM_029492.4. [Q5Y5T1-2]
UniGeneiMm.29044.

3D structure databases

ProteinModelPortaliQ5Y5T1.
SMRiQ5Y5T1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086900.

PTM databases

iPTMnetiQ5Y5T1.
PhosphoSitePlusiQ5Y5T1.
SwissPalmiQ5Y5T1.

Proteomic databases

PaxDbiQ5Y5T1.
PeptideAtlasiQ5Y5T1.
PRIDEiQ5Y5T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089473; ENSMUSP00000086900; ENSMUSG00000021969. [Q5Y5T1-2]
GeneIDi75965.
KEGGimmu:75965.
UCSCiuc007udr.1. mouse. [Q5Y5T1-2]
uc007uds.1. mouse. [Q5Y5T1-1]

Organism-specific databases

CTDi253832.
MGIiMGI:1923215. Zdhhc20.

Phylogenomic databases

eggNOGiKOG1315. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00850000132259.
HOGENOMiHOG000234777.
HOVERGENiHBG055108.
InParanoidiQ5Y5T1.
KOiK20028.
OMAiFRAPMFS.
OrthoDBiEOG091G0AXR.
PhylomeDBiQ5Y5T1.
TreeFamiTF316044.

Miscellaneous databases

PROiPR:Q5Y5T1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021969.
CleanExiMM_ZDHHC20.
GenevisibleiQ5Y5T1. MM.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZDH20_MOUSE
AccessioniPrimary (citable) accession number: Q5Y5T1
Secondary accession number(s): Q3TDL1, Q8VCL6, Q9D3Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 23, 2004
Last modified: March 15, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.