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Protein

U3-agatoxin-Ao1d

Gene
N/A
Organism
Agelena orientalis (Spider)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
U3-agatoxin-Ao1d
Short name:
U3-AGTX-Ao1d
Alternative name(s):
Mu-2Aga_05Imported
OrganismiAgelena orientalis (Spider)
Taxonomic identifieri293813 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelena

Organism-specific databases

ArachnoServeriAS000083. U3-agatoxin-Ao1d.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_500009366121 – 34Sequence analysisAdd BLAST14
ChainiPRO_500009366235 – 72U3-agatoxin-Ao1dAdd BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 53By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi52 ↔ 68By similarity
Disulfide bondi60 ↔ 66By similarity
Modified residuei72Serine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliQ5Y4V5.
SMRiQ5Y4V5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR016328. Beta/delta-agatoxin_fam.
PIRSFiPIRSF001882. Curtatoxin. 1 hit.
PROSITEiView protein in PROSITE
PS60015. MU_AGATOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5Y4V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAAISLLLL SALLFVVIEA ITYEEGKELF QGERTDCVGD GQRCADWAGP
60 70
YCCSGYYCSC RSMPYCRCRS DSGK
Length:74
Mass (Da):8,190
Last modified:November 23, 2004 - v1
Checksum:i5C6D518A888550B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY681329 mRNA. Translation: AAU87889.1.

Similar proteinsi

Entry informationi

Entry nameiT3G1D_AGEOR
AccessioniPrimary (citable) accession number: Q5Y4V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 23, 2004
Last modified: July 5, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families