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Q5Y4Q8

- COX1_BOSMU

UniProt

Q5Y4Q8 - COX1_BOSMU

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Protein

Cytochrome c oxidase subunit 1

Gene

MT-CO1

Organism
Bos mutus grunniens (Wild yak) (Bos grunniens)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Iron (heme A axial ligand)Curated
Metal bindingi244 – 2441Copper BCurated
Metal bindingi290 – 2901Copper BCurated
Metal bindingi291 – 2911Copper BCurated
Metal bindingi376 – 3761Iron (heme A3 axial ligand)Curated
Metal bindingi378 – 3781Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. hydrogen ion transmembrane transport Source: GOC
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded oniMitochondrion
OrganismiBos mutus grunniens (Wild yak) (Bos grunniens)
Taxonomic identifieri30521 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei12 – 4029Helical; Name=IBy similarityAdd
BLAST
Topological domaini41 – 5010Mitochondrial intermembraneBy similarity
Transmembranei51 – 8636Helical; Name=IIBy similarityAdd
BLAST
Topological domaini87 – 948Mitochondrial matrixBy similarity
Transmembranei95 – 11723Helical; Name=IIIBy similarityAdd
BLAST
Topological domaini118 – 14023Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei141 – 17030Helical; Name=IVBy similarityAdd
BLAST
Topological domaini171 – 18212Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei183 – 21230Helical; Name=VBy similarityAdd
BLAST
Topological domaini213 – 22715Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei228 – 26134Helical; Name=VIBy similarityAdd
BLAST
Topological domaini262 – 2698Mitochondrial matrixBy similarity
Transmembranei270 – 28617Helical; Name=VIIBy similarityAdd
BLAST
Topological domaini287 – 29812Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei299 – 32729Helical; Name=VIIIBy similarityAdd
BLAST
Topological domaini328 – 3358Mitochondrial matrixBy similarity
Transmembranei336 – 35722Helical; Name=IXBy similarityAdd
BLAST
Topological domaini358 – 37013Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei371 – 40030Helical; Name=XBy similarityAdd
BLAST
Topological domaini401 – 4066Mitochondrial matrixBy similarity
Transmembranei407 – 43327Helical; Name=XIBy similarityAdd
BLAST
Topological domaini434 – 44613Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei447 – 47832Helical; Name=XIIBy similarityAdd
BLAST
Topological domaini479 – 51436Mitochondrial matrixBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Cytochrome c oxidase subunit 1PRO_0000253786Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5Y4Q8.
SMRiQ5Y4Q8. Positions 1-514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG003841.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5Y4Q8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFINRWLFST NHKDIGTLYL LFGAWAGMVG TALSLLIRAE LGQPGTLLGD
60 70 80 90 100
DQIYNVVVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM
110 120 130 140 150
SFWLLPPSFL LLLASSMVEA GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL
160 170 180 190 200
HLAGVSSILG AINFITTIIN MKPPAMSQYQ TPLFVWSVMI TAVLLLLSLP
210 220 230 240 250
VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG
260 270 280 290 300
FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD
310 320 330 340 350
TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMMW ALGFIFLFTV
360 370 380 390 400
GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFVHWFPLF
410 420 430 440 450
SGYTLNDTWA KIHFAIMFVG VNMTFFPQHF LGLSGMPRRS PDYPDAYTMW
460 470 480 490 500
NTVSSMGSFI SLTAVMLMVF IIWEALASKR EVLTVDLTTT NLEWLNGCPP
510
PYHTFEEPTY VNLK
Length:514
Mass (Da):56,918
Last modified:November 23, 2004 - v1
Checksum:i9D7FD418DE78EDC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY684273 Genomic DNA. Translation: AAU89108.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY684273 Genomic DNA. Translation: AAU89108.1 .

3D structure databases

ProteinModelPortali Q5Y4Q8.
SMRi Q5Y4Q8. Positions 1-514.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG003841.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of the Yak (Bos grunniens.) mitochondrial genome and its genetic relationship with related species."
    Gu Z., Zhao X., Li N., Wu C.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_BOSMU
AccessioniPrimary (citable) accession number: Q5Y4Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3