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Q5Y4Q8

- COX1_BOSMU

UniProt

Q5Y4Q8 - COX1_BOSMU

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Protein

Cytochrome c oxidase subunit 1

Gene
MT-CO1, COI, COXI, MTCO1
Organism
Bos mutus grunniens (Wild yak) (Bos grunniens)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Iron (heme A axial ligand) Inferred
Metal bindingi244 – 2441Copper B Inferred
Metal bindingi290 – 2901Copper B Inferred
Metal bindingi291 – 2911Copper B Inferred
Metal bindingi376 – 3761Iron (heme A3 axial ligand) Inferred
Metal bindingi378 – 3781Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. hydrogen ion transmembrane transport Source: GOC
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded oniMitochondrion
OrganismiBos mutus grunniens (Wild yak) (Bos grunniens)
Taxonomic identifieri30521 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111Mitochondrial matrix By similarityAdd
BLAST
Transmembranei12 – 4029Helical; Name=I; By similarityAdd
BLAST
Topological domaini41 – 5010Mitochondrial intermembrane By similarity
Transmembranei51 – 8636Helical; Name=II; By similarityAdd
BLAST
Topological domaini87 – 948Mitochondrial matrix By similarity
Transmembranei95 – 11723Helical; Name=III; By similarityAdd
BLAST
Topological domaini118 – 14023Mitochondrial intermembrane By similarityAdd
BLAST
Transmembranei141 – 17030Helical; Name=IV; By similarityAdd
BLAST
Topological domaini171 – 18212Mitochondrial matrix By similarityAdd
BLAST
Transmembranei183 – 21230Helical; Name=V; By similarityAdd
BLAST
Topological domaini213 – 22715Mitochondrial intermembrane By similarityAdd
BLAST
Transmembranei228 – 26134Helical; Name=VI; By similarityAdd
BLAST
Topological domaini262 – 2698Mitochondrial matrix By similarity
Transmembranei270 – 28617Helical; Name=VII; By similarityAdd
BLAST
Topological domaini287 – 29812Mitochondrial intermembrane By similarityAdd
BLAST
Transmembranei299 – 32729Helical; Name=VIII; By similarityAdd
BLAST
Topological domaini328 – 3358Mitochondrial matrix By similarity
Transmembranei336 – 35722Helical; Name=IX; By similarityAdd
BLAST
Topological domaini358 – 37013Mitochondrial intermembrane By similarityAdd
BLAST
Transmembranei371 – 40030Helical; Name=X; By similarityAdd
BLAST
Topological domaini401 – 4066Mitochondrial matrix By similarity
Transmembranei407 – 43327Helical; Name=XI; By similarityAdd
BLAST
Topological domaini434 – 44613Mitochondrial intermembrane By similarityAdd
BLAST
Transmembranei447 – 47832Helical; Name=XII; By similarityAdd
BLAST
Topological domaini479 – 51436Mitochondrial matrix By similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Cytochrome c oxidase subunit 1PRO_0000253786Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5Y4Q8.
SMRiQ5Y4Q8. Positions 1-514.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG003841.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5Y4Q8-1 [UniParc]FASTAAdd to Basket

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MFINRWLFST NHKDIGTLYL LFGAWAGMVG TALSLLIRAE LGQPGTLLGD    50
DQIYNVVVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM 100
SFWLLPPSFL LLLASSMVEA GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL 150
HLAGVSSILG AINFITTIIN MKPPAMSQYQ TPLFVWSVMI TAVLLLLSLP 200
VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG 250
FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD 300
TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMMW ALGFIFLFTV 350
GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFVHWFPLF 400
SGYTLNDTWA KIHFAIMFVG VNMTFFPQHF LGLSGMPRRS PDYPDAYTMW 450
NTVSSMGSFI SLTAVMLMVF IIWEALASKR EVLTVDLTTT NLEWLNGCPP 500
PYHTFEEPTY VNLK 514
Length:514
Mass (Da):56,918
Last modified:November 23, 2004 - v1
Checksum:i9D7FD418DE78EDC0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY684273 Genomic DNA. Translation: AAU89108.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY684273 Genomic DNA. Translation: AAU89108.1 .

3D structure databases

ProteinModelPortali Q5Y4Q8.
SMRi Q5Y4Q8. Positions 1-514.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG003841.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of the Yak (Bos grunniens.) mitochondrial genome and its genetic relationship with related species."
    Gu Z., Zhao X., Li N., Wu C.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_BOSMU
AccessioniPrimary (citable) accession number: Q5Y4Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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