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Protein

Adhesion G protein-coupled receptor E2

Gene

Adgre1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor involved in cell adhesion and probably in cell-cell interactions involved specifically cells of the immune system. May play a role in regulatory T-cells (Treg) development.By similarity

Miscellaneous

Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRE1 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processAdaptive immunity, Immunity
LigandCalcium

Protein family/group databases

MEROPSiP02.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor E2
Alternative name(s):
EGF-like module receptor 1
EGF-like module-containing mucin-like hormone receptor-like 1
EMR1 hormone receptor
Gene namesi
Name:Adgre1
Synonyms:Emr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1359214. Adgre1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini16 – 652ExtracellularCuratedAdd BLAST637
Transmembranei653 – 673Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini674 – 681CytoplasmicCurated8
Transmembranei682 – 702Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini703 – 719ExtracellularCuratedAdd BLAST17
Transmembranei720 – 740Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini741 – 756CytoplasmicCuratedAdd BLAST16
Transmembranei757 – 777Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini778 – 795ExtracellularCuratedAdd BLAST18
Transmembranei796 – 816Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini817 – 849CytoplasmicCuratedAdd BLAST33
Transmembranei850 – 870Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini871 – 872ExtracellularCurated2
Transmembranei873 – 893Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini894 – 932CytoplasmicCuratedAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000025095916 – 932Adhesion G protein-coupled receptor E2Add BLAST917

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 48PROSITE-ProRule annotation
Disulfide bondi42 ↔ 57PROSITE-ProRule annotation
Disulfide bondi85 ↔ 98PROSITE-ProRule annotation
Disulfide bondi92 ↔ 107PROSITE-ProRule annotation
Disulfide bondi137 ↔ 149PROSITE-ProRule annotation
Disulfide bondi143 ↔ 158PROSITE-ProRule annotation
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 171PROSITE-ProRule annotation
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi177 ↔ 189PROSITE-ProRule annotation
Disulfide bondi183 ↔ 198PROSITE-ProRule annotation
Disulfide bondi226 ↔ 239PROSITE-ProRule annotation
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi233 ↔ 248PROSITE-ProRule annotation
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi276 ↔ 286PROSITE-ProRule annotation
Disulfide bondi280 ↔ 295PROSITE-ProRule annotation
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi323 ↔ 336PROSITE-ProRule annotation
Disulfide bondi330 ↔ 345PROSITE-ProRule annotation
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi405N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi499N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi707N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5Y4N8.
PRIDEiQ5Y4N8.

PTM databases

iPTMnetiQ5Y4N8.
PhosphoSitePlusiQ5Y4N8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000046254.
GenevisibleiQ5Y4N8. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067220.

Structurei

3D structure databases

ProteinModelPortaliQ5Y4N8.
SMRiQ5Y4N8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 69EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini81 – 119EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Domaini133 – 172EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini173 – 210EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini222 – 260EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini272 – 307EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini319 – 354EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini593 – 642GPSPROSITE-ProRule annotationAdd BLAST50

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi507 – 509Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi768 – 771Poly-Val4

Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOVERGENiHBG048917.
InParanoidiQ5Y4N8.
KOiK04591.
OMAiCQVGFIS.
OrthoDBiEOG091G00GJ.
PhylomeDBiQ5Y4N8.

Family and domain databases

InterProiView protein in InterPro
IPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1-like_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
PF01825. GPS. 1 hit.
PRINTSiPR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTiView protein in SMART
SM00181. EGF. 7 hits.
SM00179. EGF_CA. 7 hits.
SM00303. GPS. 1 hit.
SUPFAMiSSF57184. SSF57184. 3 hits.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 6 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 5 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5Y4N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGFWLLLFW GFSGTHRWGM TTLAILGQRL NGVNECQDTT TCPAYATCTD
60 70 80 90 100
TTESYYCTCK QGFLPSNGQT NFQGPGVECQ DVNECLRSDS PCGSNSVCTN
110 120 130 140 150
IPGRARCSCL SGFSSSAGGS WILGSPGHFL CTDVDECLTI GICPKNSNCS
160 170 180 190 200
NSVGSYSCTC QSGFVSNGST CEDEDECVTR NACPEHATCH NTLGSYYCTC
210 220 230 240 250
NEGLEFSGGG PMFQGLEESC EDVDECSRNS TLCGPSFICI NTLGSYSCSC
260 270 280 290 300
PAGFSLSTFQ IPGHPADGNC TDIDECDDIC PSNSSCTNTL GSYFCTCHPG
310 320 330 340 350
FASSNGQLNF TDQEVTCEDI DECTQDPFRC GRNSSCTNVP GSYNCSCLPD
360 370 380 390 400
FRMDPGGSQA HGNFTCKRIP FKCKEDLIPK SEQIEQCQAG QGRNLDYTSF
410 420 430 440 450
CTFVNATFTI LDNTCENKSA PVSLQSAATS VSLMLEQAST WFEFSREETS
460 470 480 490 500
TLGTILLETV ESTMLAALLT PSGNASQTIR TEYLEIESKV INEECNEENV
510 520 530 540 550
SINLKARGDK MDVGCFIIKE SESTGTPGVA FVSFAHMDSV LDERFFEDGQ
560 570 580 590 600
ASWKLRMNSH VVGGTVTGER KEDFSKPIVY TLQHIQPKQK SERSICVSWN
610 620 630 640 650
TDVEDGRWTP SGCETVEASE THTVCSCNRM TNLAIIMASG ELTMEFSLYI
660 670 680 690 700
ISYVGTVISL VCLALAIATF LLFRAVQNHN TYLHLHLCVC LFLAKILFLT
710 720 730 740 750
GIDKTDNQTA CAIIAGFLHY LFLACFFWML VEAVMLFLMV RNLKVVNYFS
760 770 780 790 800
SRNIKMLHLC AFGYGLPVVV VIISATVHPW GYGMHNRCWL NTETGFIWSF
810 820 830 840 850
LGPVCMIITI NSALLAWTLW VLRQKLCSVN SEVSKLKDTR LLTFKAIAQI
860 870 880 890 900
FILGCSWVLG IFQIGPLASI MAYLFTTINS LQGAFIFLIH CLLNRQVRDE
910 920 930
YRKLLTRKTD LSSHSQTSGI LLSSMPSTSK TG
Length:932
Mass (Da):102,308
Last modified:November 23, 2004 - v1
Checksum:i99C4B11C721EF8DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY686632 mRNA. Translation: AAU95564.1.
RefSeqiNP_001007558.1. NM_001007557.1.
UniGeneiRn.205884.

Genome annotation databases

EnsembliENSRNOT00000073926; ENSRNOP00000067220; ENSRNOG00000046254.
GeneIDi316137.
KEGGirno:316137.

Similar proteinsi

Entry informationi

Entry nameiAGRE1_RAT
AccessioniPrimary (citable) accession number: Q5Y4N8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 23, 2004
Last modified: September 27, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families