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Q5Y4N8 (EMR1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
EGF-like module-containing mucin-like hormone receptor-like 1
Alternative name(s):
EGF-like module receptor 1
EMR1 hormone receptor
Gene names
Name:Emr1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length932 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Could be involved in cell-cell interactions By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 7 EGF-like domains.

Contains 1 GPS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 932917EGF-like module-containing mucin-like hormone receptor-like 1
PRO_0000250959

Regions

Topological domain16 – 652637Extracellular Potential
Transmembrane653 – 67321Helical; Name=1; Potential
Topological domain674 – 6818Cytoplasmic Potential
Transmembrane682 – 70221Helical; Name=2; Potential
Topological domain703 – 71917Extracellular Potential
Transmembrane720 – 74021Helical; Name=3; Potential
Topological domain741 – 75616Cytoplasmic Potential
Transmembrane757 – 77721Helical; Name=4; Potential
Topological domain778 – 79518Extracellular Potential
Transmembrane796 – 81621Helical; Name=5; Potential
Topological domain817 – 84933Cytoplasmic Potential
Transmembrane850 – 87021Helical; Name=6; Potential
Topological domain871 – 8722Extracellular Potential
Transmembrane873 – 89321Helical; Name=7; Potential
Topological domain894 – 93239Cytoplasmic Potential
Domain32 – 6938EGF-like 1
Domain81 – 11939EGF-like 2
Domain133 – 17240EGF-like 3; calcium-binding Potential
Domain173 – 21038EGF-like 4; calcium-binding Potential
Domain222 – 26039EGF-like 5; calcium-binding Potential
Domain272 – 30736EGF-like 6; calcium-binding Potential
Domain319 – 35436EGF-like 7; calcium-binding Potential
Domain593 – 64250GPS
Motif507 – 5093Cell attachment site Potential
Compositional bias768 – 7714Poly-Val

Amino acid modifications

Glycosylation1481N-linked (GlcNAc...) Potential
Glycosylation1671N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential
Glycosylation2831N-linked (GlcNAc...) Potential
Glycosylation3091N-linked (GlcNAc...) Potential
Glycosylation3331N-linked (GlcNAc...) Potential
Glycosylation3441N-linked (GlcNAc...) Potential
Glycosylation3631N-linked (GlcNAc...) Potential
Glycosylation4051N-linked (GlcNAc...) Potential
Glycosylation4171N-linked (GlcNAc...) Potential
Glycosylation4741N-linked (GlcNAc...) Potential
Glycosylation4991N-linked (GlcNAc...) Potential
Glycosylation7071N-linked (GlcNAc...) Potential
Disulfide bond36 ↔ 48 By similarity
Disulfide bond42 ↔ 57 By similarity
Disulfide bond85 ↔ 98 By similarity
Disulfide bond92 ↔ 107 By similarity
Disulfide bond137 ↔ 149 By similarity
Disulfide bond143 ↔ 158 By similarity
Disulfide bond160 ↔ 171 By similarity
Disulfide bond177 ↔ 189 By similarity
Disulfide bond183 ↔ 198 By similarity
Disulfide bond226 ↔ 239 By similarity
Disulfide bond233 ↔ 248 By similarity
Disulfide bond276 ↔ 286 By similarity
Disulfide bond280 ↔ 295 By similarity
Disulfide bond323 ↔ 336 By similarity
Disulfide bond330 ↔ 345 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5Y4N8 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 99C4B11C721EF8DA

FASTA932102,308
        10         20         30         40         50         60 
MWGFWLLLFW GFSGTHRWGM TTLAILGQRL NGVNECQDTT TCPAYATCTD TTESYYCTCK 

        70         80         90        100        110        120 
QGFLPSNGQT NFQGPGVECQ DVNECLRSDS PCGSNSVCTN IPGRARCSCL SGFSSSAGGS 

       130        140        150        160        170        180 
WILGSPGHFL CTDVDECLTI GICPKNSNCS NSVGSYSCTC QSGFVSNGST CEDEDECVTR 

       190        200        210        220        230        240 
NACPEHATCH NTLGSYYCTC NEGLEFSGGG PMFQGLEESC EDVDECSRNS TLCGPSFICI 

       250        260        270        280        290        300 
NTLGSYSCSC PAGFSLSTFQ IPGHPADGNC TDIDECDDIC PSNSSCTNTL GSYFCTCHPG 

       310        320        330        340        350        360 
FASSNGQLNF TDQEVTCEDI DECTQDPFRC GRNSSCTNVP GSYNCSCLPD FRMDPGGSQA 

       370        380        390        400        410        420 
HGNFTCKRIP FKCKEDLIPK SEQIEQCQAG QGRNLDYTSF CTFVNATFTI LDNTCENKSA 

       430        440        450        460        470        480 
PVSLQSAATS VSLMLEQAST WFEFSREETS TLGTILLETV ESTMLAALLT PSGNASQTIR 

       490        500        510        520        530        540 
TEYLEIESKV INEECNEENV SINLKARGDK MDVGCFIIKE SESTGTPGVA FVSFAHMDSV 

       550        560        570        580        590        600 
LDERFFEDGQ ASWKLRMNSH VVGGTVTGER KEDFSKPIVY TLQHIQPKQK SERSICVSWN 

       610        620        630        640        650        660 
TDVEDGRWTP SGCETVEASE THTVCSCNRM TNLAIIMASG ELTMEFSLYI ISYVGTVISL 

       670        680        690        700        710        720 
VCLALAIATF LLFRAVQNHN TYLHLHLCVC LFLAKILFLT GIDKTDNQTA CAIIAGFLHY 

       730        740        750        760        770        780 
LFLACFFWML VEAVMLFLMV RNLKVVNYFS SRNIKMLHLC AFGYGLPVVV VIISATVHPW 

       790        800        810        820        830        840 
GYGMHNRCWL NTETGFIWSF LGPVCMIITI NSALLAWTLW VLRQKLCSVN SEVSKLKDTR 

       850        860        870        880        890        900 
LLTFKAIAQI FILGCSWVLG IFQIGPLASI MAYLFTTINS LQGAFIFLIH CLLNRQVRDE 

       910        920        930 
YRKLLTRKTD LSSHSQTSGI LLSSMPSTSK TG 

« Hide

References

[1]"The EGF-TM7 family of the rat."
Hamann J.
Immunogenetics 56:679-681(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Brown Norway.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY686632 mRNA. Translation: AAU95564.1.
RefSeqNP_001007558.1. NM_001007557.1.
UniGeneRn.205884.

3D structure databases

ProteinModelPortalQ5Y4N8.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ5Y4N8.

Proteomic databases

PRIDEQ5Y4N8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000073926; ENSRNOP00000067220; ENSRNOG00000046254.
GeneID316137.
KEGGrno:316137.

Organism-specific databases

CTD2015.
RGD1359214. Emr1.

Phylogenomic databases

GeneTreeENSGT00710000106562.
HOVERGENHBG048917.
KOK04591.
OMARNHNTYL.
OrthoDBEOG7WHH8Q.
PhylomeDBQ5Y4N8.

Gene expression databases

GenevestigatorQ5Y4N8.

Family and domain databases

InterProIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF12662. cEGF. 1 hit.
PF07645. EGF_CA. 5 hits.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSPR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTSM00181. EGF. 1 hit.
SM00179. EGF_CA. 6 hits.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 3 hits.
PROSITEPS00010. ASX_HYDROXYL. 6 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 5 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio670479.
PROQ5Y4N8.

Entry information

Entry nameEMR1_RAT
AccessionPrimary (citable) accession number: Q5Y4N8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries