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Q5Y4N8

- EMR1_RAT

UniProt

Q5Y4N8 - EMR1_RAT

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Protein
EGF-like module-containing mucin-like hormone receptor-like 1
Gene
Emr1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Could be involved in cell-cell interactions By similarity.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
EGF-like module-containing mucin-like hormone receptor-like 1
Alternative name(s):
EGF-like module receptor 1
EMR1 hormone receptor
Gene namesi
Name:Emr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1359214. Emr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini16 – 652637Extracellular Reviewed prediction
Add
BLAST
Transmembranei653 – 67321Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini674 – 6818Cytoplasmic Reviewed prediction
Transmembranei682 – 70221Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini703 – 71917Extracellular Reviewed prediction
Add
BLAST
Transmembranei720 – 74021Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini741 – 75616Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei757 – 77721Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini778 – 79518Extracellular Reviewed prediction
Add
BLAST
Transmembranei796 – 81621Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini817 – 84933Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei850 – 87021Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini871 – 8722Extracellular Reviewed prediction
Transmembranei873 – 89321Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini894 – 93239Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed prediction
Add
BLAST
Chaini16 – 932917EGF-like module-containing mucin-like hormone receptor-like 1
PRO_0000250959Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 48 By similarity
Disulfide bondi42 ↔ 57 By similarity
Disulfide bondi85 ↔ 98 By similarity
Disulfide bondi92 ↔ 107 By similarity
Disulfide bondi137 ↔ 149 By similarity
Disulfide bondi143 ↔ 158 By similarity
Glycosylationi148 – 1481N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi160 ↔ 171 By similarity
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi177 ↔ 189 By similarity
Disulfide bondi183 ↔ 198 By similarity
Disulfide bondi226 ↔ 239 By similarity
Glycosylationi229 – 2291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi233 ↔ 248 By similarity
Glycosylationi269 – 2691N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi276 ↔ 286 By similarity
Disulfide bondi280 ↔ 295 By similarity
Glycosylationi283 – 2831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi309 – 3091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi323 ↔ 336 By similarity
Disulfide bondi330 ↔ 345 By similarity
Glycosylationi333 – 3331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi344 – 3441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi363 – 3631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi405 – 4051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi417 – 4171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi474 – 4741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi499 – 4991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi707 – 7071N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ5Y4N8.

PTM databases

PhosphoSiteiQ5Y4N8.

Expressioni

Gene expression databases

GenevestigatoriQ5Y4N8.

Structurei

3D structure databases

ProteinModelPortaliQ5Y4N8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 6938EGF-like 1
Add
BLAST
Domaini81 – 11939EGF-like 2
Add
BLAST
Domaini133 – 17240EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST
Domaini173 – 21038EGF-like 4; calcium-binding Reviewed prediction
Add
BLAST
Domaini222 – 26039EGF-like 5; calcium-binding Reviewed prediction
Add
BLAST
Domaini272 – 30736EGF-like 6; calcium-binding Reviewed prediction
Add
BLAST
Domaini319 – 35436EGF-like 7; calcium-binding Reviewed prediction
Add
BLAST
Domaini593 – 64250GPS
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi507 – 5093Cell attachment site Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi768 – 7714Poly-Val

Sequence similaritiesi

Contains 7 EGF-like domains.
Contains 1 GPS domain.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00710000106562.
HOVERGENiHBG048917.
KOiK04591.
OMAiRNHNTYL.
OrthoDBiEOG7WHH8Q.
PhylomeDBiQ5Y4N8.

Family and domain databases

InterProiIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF12662. cEGF. 1 hit.
PF07645. EGF_CA. 5 hits.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 6 hits.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 6 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 5 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5Y4N8-1 [UniParc]FASTAAdd to Basket

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MWGFWLLLFW GFSGTHRWGM TTLAILGQRL NGVNECQDTT TCPAYATCTD    50
TTESYYCTCK QGFLPSNGQT NFQGPGVECQ DVNECLRSDS PCGSNSVCTN 100
IPGRARCSCL SGFSSSAGGS WILGSPGHFL CTDVDECLTI GICPKNSNCS 150
NSVGSYSCTC QSGFVSNGST CEDEDECVTR NACPEHATCH NTLGSYYCTC 200
NEGLEFSGGG PMFQGLEESC EDVDECSRNS TLCGPSFICI NTLGSYSCSC 250
PAGFSLSTFQ IPGHPADGNC TDIDECDDIC PSNSSCTNTL GSYFCTCHPG 300
FASSNGQLNF TDQEVTCEDI DECTQDPFRC GRNSSCTNVP GSYNCSCLPD 350
FRMDPGGSQA HGNFTCKRIP FKCKEDLIPK SEQIEQCQAG QGRNLDYTSF 400
CTFVNATFTI LDNTCENKSA PVSLQSAATS VSLMLEQAST WFEFSREETS 450
TLGTILLETV ESTMLAALLT PSGNASQTIR TEYLEIESKV INEECNEENV 500
SINLKARGDK MDVGCFIIKE SESTGTPGVA FVSFAHMDSV LDERFFEDGQ 550
ASWKLRMNSH VVGGTVTGER KEDFSKPIVY TLQHIQPKQK SERSICVSWN 600
TDVEDGRWTP SGCETVEASE THTVCSCNRM TNLAIIMASG ELTMEFSLYI 650
ISYVGTVISL VCLALAIATF LLFRAVQNHN TYLHLHLCVC LFLAKILFLT 700
GIDKTDNQTA CAIIAGFLHY LFLACFFWML VEAVMLFLMV RNLKVVNYFS 750
SRNIKMLHLC AFGYGLPVVV VIISATVHPW GYGMHNRCWL NTETGFIWSF 800
LGPVCMIITI NSALLAWTLW VLRQKLCSVN SEVSKLKDTR LLTFKAIAQI 850
FILGCSWVLG IFQIGPLASI MAYLFTTINS LQGAFIFLIH CLLNRQVRDE 900
YRKLLTRKTD LSSHSQTSGI LLSSMPSTSK TG 932
Length:932
Mass (Da):102,308
Last modified:November 23, 2004 - v1
Checksum:i99C4B11C721EF8DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY686632 mRNA. Translation: AAU95564.1.
RefSeqiNP_001007558.1. NM_001007557.1.
UniGeneiRn.205884.

Genome annotation databases

EnsembliENSRNOT00000073926; ENSRNOP00000067220; ENSRNOG00000046254.
GeneIDi316137.
KEGGirno:316137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY686632 mRNA. Translation: AAU95564.1 .
RefSeqi NP_001007558.1. NM_001007557.1.
UniGenei Rn.205884.

3D structure databases

ProteinModelPortali Q5Y4N8.
ModBasei Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q5Y4N8.

Proteomic databases

PRIDEi Q5Y4N8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000073926 ; ENSRNOP00000067220 ; ENSRNOG00000046254 .
GeneIDi 316137.
KEGGi rno:316137.

Organism-specific databases

CTDi 2015.
RGDi 1359214. Emr1.

Phylogenomic databases

GeneTreei ENSGT00710000106562.
HOVERGENi HBG048917.
KOi K04591.
OMAi RNHNTYL.
OrthoDBi EOG7WHH8Q.
PhylomeDBi Q5Y4N8.

Miscellaneous databases

NextBioi 670479.
PROi Q5Y4N8.

Gene expression databases

Genevestigatori Q5Y4N8.

Family and domain databases

InterProi IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF12662. cEGF. 1 hit.
PF07645. EGF_CA. 5 hits.
PF01825. GPS. 1 hit.
[Graphical view ]
PRINTSi PR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 6 hits.
SM00303. GPS. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 3 hits.
PROSITEi PS00010. ASX_HYDROXYL. 6 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 5 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiEMR1_RAT
AccessioniPrimary (citable) accession number: Q5Y4N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi