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Q5Y4N8

- EMR1_RAT

UniProt

Q5Y4N8 - EMR1_RAT

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Protein

EGF-like module-containing mucin-like hormone receptor-like 1

Gene

Emr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Could be involved in cell-cell interactions.By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium

Protein family/group databases

MEROPSiI63.001.

Names & Taxonomyi

Protein namesi
Recommended name:
EGF-like module-containing mucin-like hormone receptor-like 1
Alternative name(s):
EGF-like module receptor 1
EMR1 hormone receptor
Gene namesi
Name:Emr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1359214. Emr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini16 – 652637ExtracellularSequence AnalysisAdd
BLAST
Transmembranei653 – 67321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini674 – 6818CytoplasmicSequence Analysis
Transmembranei682 – 70221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini703 – 71917ExtracellularSequence AnalysisAdd
BLAST
Transmembranei720 – 74021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini741 – 75616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei757 – 77721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini778 – 79518ExtracellularSequence AnalysisAdd
BLAST
Transmembranei796 – 81621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini817 – 84933CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei850 – 87021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini871 – 8722ExtracellularSequence Analysis
Transmembranei873 – 89321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini894 – 93239CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 932917EGF-like module-containing mucin-like hormone receptor-like 1PRO_0000250959Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 48PROSITE-ProRule annotation
Disulfide bondi42 ↔ 57PROSITE-ProRule annotation
Disulfide bondi85 ↔ 98PROSITE-ProRule annotation
Disulfide bondi92 ↔ 107PROSITE-ProRule annotation
Disulfide bondi137 ↔ 149PROSITE-ProRule annotation
Disulfide bondi143 ↔ 158PROSITE-ProRule annotation
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi160 ↔ 171PROSITE-ProRule annotation
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi177 ↔ 189PROSITE-ProRule annotation
Disulfide bondi183 ↔ 198PROSITE-ProRule annotation
Disulfide bondi226 ↔ 239PROSITE-ProRule annotation
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi233 ↔ 248PROSITE-ProRule annotation
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi276 ↔ 286PROSITE-ProRule annotation
Disulfide bondi280 ↔ 295PROSITE-ProRule annotation
Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi323 ↔ 336PROSITE-ProRule annotation
Disulfide bondi330 ↔ 345PROSITE-ProRule annotation
Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi363 – 3631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi405 – 4051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi707 – 7071N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ5Y4N8.

PTM databases

PhosphoSiteiQ5Y4N8.

Expressioni

Gene expression databases

GenevestigatoriQ5Y4N8.

Structurei

3D structure databases

ProteinModelPortaliQ5Y4N8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 6938EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini81 – 11939EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini133 – 17240EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini173 – 21038EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini222 – 26039EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini272 – 30736EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini319 – 35436EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini593 – 64250GPSPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi507 – 5093Cell attachment siteSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi768 – 7714Poly-Val

Sequence similaritiesi

Contains 7 EGF-like domains.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118787.
HOVERGENiHBG048917.
InParanoidiQ5Y4N8.
KOiK04591.
OMAiRNHNTYL.
OrthoDBiEOG7WHH8Q.
PhylomeDBiQ5Y4N8.

Family and domain databases

InterProiIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF12662. cEGF. 1 hit.
PF07645. EGF_CA. 5 hits.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 6 hits.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 6 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 5 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5Y4N8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWGFWLLLFW GFSGTHRWGM TTLAILGQRL NGVNECQDTT TCPAYATCTD
60 70 80 90 100
TTESYYCTCK QGFLPSNGQT NFQGPGVECQ DVNECLRSDS PCGSNSVCTN
110 120 130 140 150
IPGRARCSCL SGFSSSAGGS WILGSPGHFL CTDVDECLTI GICPKNSNCS
160 170 180 190 200
NSVGSYSCTC QSGFVSNGST CEDEDECVTR NACPEHATCH NTLGSYYCTC
210 220 230 240 250
NEGLEFSGGG PMFQGLEESC EDVDECSRNS TLCGPSFICI NTLGSYSCSC
260 270 280 290 300
PAGFSLSTFQ IPGHPADGNC TDIDECDDIC PSNSSCTNTL GSYFCTCHPG
310 320 330 340 350
FASSNGQLNF TDQEVTCEDI DECTQDPFRC GRNSSCTNVP GSYNCSCLPD
360 370 380 390 400
FRMDPGGSQA HGNFTCKRIP FKCKEDLIPK SEQIEQCQAG QGRNLDYTSF
410 420 430 440 450
CTFVNATFTI LDNTCENKSA PVSLQSAATS VSLMLEQAST WFEFSREETS
460 470 480 490 500
TLGTILLETV ESTMLAALLT PSGNASQTIR TEYLEIESKV INEECNEENV
510 520 530 540 550
SINLKARGDK MDVGCFIIKE SESTGTPGVA FVSFAHMDSV LDERFFEDGQ
560 570 580 590 600
ASWKLRMNSH VVGGTVTGER KEDFSKPIVY TLQHIQPKQK SERSICVSWN
610 620 630 640 650
TDVEDGRWTP SGCETVEASE THTVCSCNRM TNLAIIMASG ELTMEFSLYI
660 670 680 690 700
ISYVGTVISL VCLALAIATF LLFRAVQNHN TYLHLHLCVC LFLAKILFLT
710 720 730 740 750
GIDKTDNQTA CAIIAGFLHY LFLACFFWML VEAVMLFLMV RNLKVVNYFS
760 770 780 790 800
SRNIKMLHLC AFGYGLPVVV VIISATVHPW GYGMHNRCWL NTETGFIWSF
810 820 830 840 850
LGPVCMIITI NSALLAWTLW VLRQKLCSVN SEVSKLKDTR LLTFKAIAQI
860 870 880 890 900
FILGCSWVLG IFQIGPLASI MAYLFTTINS LQGAFIFLIH CLLNRQVRDE
910 920 930
YRKLLTRKTD LSSHSQTSGI LLSSMPSTSK TG
Length:932
Mass (Da):102,308
Last modified:November 23, 2004 - v1
Checksum:i99C4B11C721EF8DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY686632 mRNA. Translation: AAU95564.1.
RefSeqiNP_001007558.1. NM_001007557.1.
UniGeneiRn.205884.

Genome annotation databases

EnsembliENSRNOT00000073926; ENSRNOP00000067220; ENSRNOG00000046254.
GeneIDi316137.
KEGGirno:316137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY686632 mRNA. Translation: AAU95564.1 .
RefSeqi NP_001007558.1. NM_001007557.1.
UniGenei Rn.205884.

3D structure databases

ProteinModelPortali Q5Y4N8.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I63.001.
GPCRDBi Search...

PTM databases

PhosphoSitei Q5Y4N8.

Proteomic databases

PRIDEi Q5Y4N8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000073926 ; ENSRNOP00000067220 ; ENSRNOG00000046254 .
GeneIDi 316137.
KEGGi rno:316137.

Organism-specific databases

CTDi 2015.
RGDi 1359214. Emr1.

Phylogenomic databases

GeneTreei ENSGT00760000118787.
HOVERGENi HBG048917.
InParanoidi Q5Y4N8.
KOi K04591.
OMAi RNHNTYL.
OrthoDBi EOG7WHH8Q.
PhylomeDBi Q5Y4N8.

Miscellaneous databases

NextBioi 670479.
PROi Q5Y4N8.

Gene expression databases

Genevestigatori Q5Y4N8.

Family and domain databases

InterProi IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF12662. cEGF. 1 hit.
PF07645. EGF_CA. 5 hits.
PF01825. GPS. 1 hit.
[Graphical view ]
PRINTSi PR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 6 hits.
SM00303. GPS. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 3 hits.
PROSITEi PS00010. ASX_HYDROXYL. 6 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 5 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiEMR1_RAT
AccessioniPrimary (citable) accession number: Q5Y4N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3