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Q5Y4N8

- EMR1_RAT

UniProt

Q5Y4N8 - EMR1_RAT

Protein

EGF-like module-containing mucin-like hormone receptor-like 1

Gene

Emr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Could be involved in cell-cell interactions.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EGF-like module-containing mucin-like hormone receptor-like 1
    Alternative name(s):
    EGF-like module receptor 1
    EMR1 hormone receptor
    Gene namesi
    Name:Emr1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi1359214. Emr1.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 932917EGF-like module-containing mucin-like hormone receptor-like 1PRO_0000250959Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi36 ↔ 48PROSITE-ProRule annotation
    Disulfide bondi42 ↔ 57PROSITE-ProRule annotation
    Disulfide bondi85 ↔ 98PROSITE-ProRule annotation
    Disulfide bondi92 ↔ 107PROSITE-ProRule annotation
    Disulfide bondi137 ↔ 149PROSITE-ProRule annotation
    Disulfide bondi143 ↔ 158PROSITE-ProRule annotation
    Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi160 ↔ 171PROSITE-ProRule annotation
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi177 ↔ 189PROSITE-ProRule annotation
    Disulfide bondi183 ↔ 198PROSITE-ProRule annotation
    Disulfide bondi226 ↔ 239PROSITE-ProRule annotation
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi233 ↔ 248PROSITE-ProRule annotation
    Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi276 ↔ 286PROSITE-ProRule annotation
    Disulfide bondi280 ↔ 295PROSITE-ProRule annotation
    Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi323 ↔ 336PROSITE-ProRule annotation
    Disulfide bondi330 ↔ 345PROSITE-ProRule annotation
    Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi363 – 3631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi405 – 4051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi707 – 7071N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ5Y4N8.

    PTM databases

    PhosphoSiteiQ5Y4N8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5Y4N8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5Y4N8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini16 – 652637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini674 – 6818CytoplasmicSequence Analysis
    Topological domaini703 – 71917ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini741 – 75616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini778 – 79518ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini817 – 84933CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini871 – 8722ExtracellularSequence Analysis
    Topological domaini894 – 93239CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei653 – 67321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei682 – 70221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei720 – 74021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei757 – 77721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei796 – 81621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei850 – 87021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei873 – 89321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 6938EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini81 – 11939EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini133 – 17240EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini173 – 21038EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini222 – 26039EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini272 – 30736EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini319 – 35436EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini593 – 64250GPSPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi507 – 5093Cell attachment siteSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi768 – 7714Poly-Val

    Sequence similaritiesi

    Contains 7 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 GPS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00710000106562.
    HOVERGENiHBG048917.
    KOiK04591.
    OMAiRNHNTYL.
    OrthoDBiEOG7WHH8Q.
    PhylomeDBiQ5Y4N8.

    Family and domain databases

    InterProiIPR026823. cEGF.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR017981. GPCR_2-like.
    IPR001740. GPCR_2_EMR1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF12662. cEGF. 1 hit.
    PF07645. EGF_CA. 5 hits.
    PF01825. GPS. 1 hit.
    [Graphical view]
    PRINTSiPR01128. EMR1HORMONER.
    PR00249. GPCRSECRETIN.
    SMARTiSM00181. EGF. 1 hit.
    SM00179. EGF_CA. 6 hits.
    SM00303. GPS. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 3 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 6 hits.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 7 hits.
    PS01187. EGF_CA. 5 hits.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5Y4N8-1 [UniParc]FASTAAdd to Basket

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    MWGFWLLLFW GFSGTHRWGM TTLAILGQRL NGVNECQDTT TCPAYATCTD    50
    TTESYYCTCK QGFLPSNGQT NFQGPGVECQ DVNECLRSDS PCGSNSVCTN 100
    IPGRARCSCL SGFSSSAGGS WILGSPGHFL CTDVDECLTI GICPKNSNCS 150
    NSVGSYSCTC QSGFVSNGST CEDEDECVTR NACPEHATCH NTLGSYYCTC 200
    NEGLEFSGGG PMFQGLEESC EDVDECSRNS TLCGPSFICI NTLGSYSCSC 250
    PAGFSLSTFQ IPGHPADGNC TDIDECDDIC PSNSSCTNTL GSYFCTCHPG 300
    FASSNGQLNF TDQEVTCEDI DECTQDPFRC GRNSSCTNVP GSYNCSCLPD 350
    FRMDPGGSQA HGNFTCKRIP FKCKEDLIPK SEQIEQCQAG QGRNLDYTSF 400
    CTFVNATFTI LDNTCENKSA PVSLQSAATS VSLMLEQAST WFEFSREETS 450
    TLGTILLETV ESTMLAALLT PSGNASQTIR TEYLEIESKV INEECNEENV 500
    SINLKARGDK MDVGCFIIKE SESTGTPGVA FVSFAHMDSV LDERFFEDGQ 550
    ASWKLRMNSH VVGGTVTGER KEDFSKPIVY TLQHIQPKQK SERSICVSWN 600
    TDVEDGRWTP SGCETVEASE THTVCSCNRM TNLAIIMASG ELTMEFSLYI 650
    ISYVGTVISL VCLALAIATF LLFRAVQNHN TYLHLHLCVC LFLAKILFLT 700
    GIDKTDNQTA CAIIAGFLHY LFLACFFWML VEAVMLFLMV RNLKVVNYFS 750
    SRNIKMLHLC AFGYGLPVVV VIISATVHPW GYGMHNRCWL NTETGFIWSF 800
    LGPVCMIITI NSALLAWTLW VLRQKLCSVN SEVSKLKDTR LLTFKAIAQI 850
    FILGCSWVLG IFQIGPLASI MAYLFTTINS LQGAFIFLIH CLLNRQVRDE 900
    YRKLLTRKTD LSSHSQTSGI LLSSMPSTSK TG 932
    Length:932
    Mass (Da):102,308
    Last modified:November 23, 2004 - v1
    Checksum:i99C4B11C721EF8DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY686632 mRNA. Translation: AAU95564.1.
    RefSeqiNP_001007558.1. NM_001007557.1.
    UniGeneiRn.205884.

    Genome annotation databases

    EnsembliENSRNOT00000073926; ENSRNOP00000067220; ENSRNOG00000046254.
    GeneIDi316137.
    KEGGirno:316137.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY686632 mRNA. Translation: AAU95564.1 .
    RefSeqi NP_001007558.1. NM_001007557.1.
    UniGenei Rn.205884.

    3D structure databases

    ProteinModelPortali Q5Y4N8.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q5Y4N8.

    Proteomic databases

    PRIDEi Q5Y4N8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000073926 ; ENSRNOP00000067220 ; ENSRNOG00000046254 .
    GeneIDi 316137.
    KEGGi rno:316137.

    Organism-specific databases

    CTDi 2015.
    RGDi 1359214. Emr1.

    Phylogenomic databases

    GeneTreei ENSGT00710000106562.
    HOVERGENi HBG048917.
    KOi K04591.
    OMAi RNHNTYL.
    OrthoDBi EOG7WHH8Q.
    PhylomeDBi Q5Y4N8.

    Miscellaneous databases

    NextBioi 670479.
    PROi Q5Y4N8.

    Gene expression databases

    Genevestigatori Q5Y4N8.

    Family and domain databases

    InterProi IPR026823. cEGF.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR017981. GPCR_2-like.
    IPR001740. GPCR_2_EMR1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF12662. cEGF. 1 hit.
    PF07645. EGF_CA. 5 hits.
    PF01825. GPS. 1 hit.
    [Graphical view ]
    PRINTSi PR01128. EMR1HORMONER.
    PR00249. GPCRSECRETIN.
    SMARTi SM00181. EGF. 1 hit.
    SM00179. EGF_CA. 6 hits.
    SM00303. GPS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 3 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 6 hits.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 7 hits.
    PS01187. EGF_CA. 5 hits.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Brown Norway.

    Entry informationi

    Entry nameiEMR1_RAT
    AccessioniPrimary (citable) accession number: Q5Y4N8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3