SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5XZD9

- FTHS_EUBAC

UniProt

Q5XZD9 - FTHS_EUBAC

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Formate--tetrahydrofolate ligase
Gene
fhs, thf
Organism
Eubacterium acidaminophilum
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Synonyms:thf
OrganismiEubacterium acidaminophilum
Taxonomic identifieri1731 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199348Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5XZD9.
SMRiQ5XZD9. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XZD9-1 [UniParc]FASTAAdd to Basket

« Hide

MKTDVQIAQE AKMLPIMEVA KQIGLGEDDI ELYGKYKAKI SLDVYKRLAD    50
KPDGKLVLVT AINPTPAGEG KTTTNVGLSM GLNKIGKKTI TALNEPSLGP 100
CFGVKGGAAG GGYAQVVPMD DINLHFTGDI HAITTAHNLL AALMDNHIKQ 150
GNALGIDINK ITWKRVLDMN DRALRDIVIG LGGTANGIPR QDGFDITVAS 200
EIMAIMCLAT SLSDLKDRLS RMIVGYTSRR LAVTADSLTL RGALALLLKD 250
ALKPNLVQTL ENTPAIIHGG PFANIAHGCN SVTTTKTALK IADYVVTEAG 300
FGADLGAEKF FDIKCRFADL KPDVAVIVAT VRALKNHGGV AKANLGAENM 350
KALEDGFGNL ERHIENVHKF GVPAVVAINA FPTDTEKELK FVEDACRKLG 400
ADVVLSEVWA KGGEGGVELA KKVVEVTEKG AAKFKPLYPA EMPLKQKIET 450
IAKEIYRADG VEFSAKASKE LDKFEKLGFG NLPICVAKTQ YSFSDNPNLK 500
GAPKGFTVSV SNARISAGAG FIVVLTGDIM TMPGLPKVPA ANHMDVLESG 550
EIVGLF 556
Length:556
Mass (Da):59,161
Last modified:November 23, 2004 - v1
Checksum:iC76CAAAA272D0986
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY722711 Genomic DNA. Translation: AAU84895.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY722711 Genomic DNA. Translation: AAU84895.1 .

3D structure databases

ProteinModelPortali Q5XZD9.
SMRi Q5XZD9. Positions 4-554.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genes involved in glycine decarboxylation reaction of Eubacterium acidaminophilum."
    Poehlein A., Lechel A., Groebe D., Andreesen J.R.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiFTHS_EUBAC
AccessioniPrimary (citable) accession number: Q5XZD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi