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Q5XZD9 (FTHS_EUBAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Synonyms:thf
OrganismEubacterium acidaminophilum
Taxonomic identifier1731 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199348

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5XZD9 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: C76CAAAA272D0986

FASTA55659,161
        10         20         30         40         50         60 
MKTDVQIAQE AKMLPIMEVA KQIGLGEDDI ELYGKYKAKI SLDVYKRLAD KPDGKLVLVT 

        70         80         90        100        110        120 
AINPTPAGEG KTTTNVGLSM GLNKIGKKTI TALNEPSLGP CFGVKGGAAG GGYAQVVPMD 

       130        140        150        160        170        180 
DINLHFTGDI HAITTAHNLL AALMDNHIKQ GNALGIDINK ITWKRVLDMN DRALRDIVIG 

       190        200        210        220        230        240 
LGGTANGIPR QDGFDITVAS EIMAIMCLAT SLSDLKDRLS RMIVGYTSRR LAVTADSLTL 

       250        260        270        280        290        300 
RGALALLLKD ALKPNLVQTL ENTPAIIHGG PFANIAHGCN SVTTTKTALK IADYVVTEAG 

       310        320        330        340        350        360 
FGADLGAEKF FDIKCRFADL KPDVAVIVAT VRALKNHGGV AKANLGAENM KALEDGFGNL 

       370        380        390        400        410        420 
ERHIENVHKF GVPAVVAINA FPTDTEKELK FVEDACRKLG ADVVLSEVWA KGGEGGVELA 

       430        440        450        460        470        480 
KKVVEVTEKG AAKFKPLYPA EMPLKQKIET IAKEIYRADG VEFSAKASKE LDKFEKLGFG 

       490        500        510        520        530        540 
NLPICVAKTQ YSFSDNPNLK GAPKGFTVSV SNARISAGAG FIVVLTGDIM TMPGLPKVPA 

       550 
ANHMDVLESG EIVGLF 

« Hide

References

[1]"Genes involved in glycine decarboxylation reaction of Eubacterium acidaminophilum."
Poehlein A., Lechel A., Groebe D., Andreesen J.R.
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY722711 Genomic DNA. Translation: AAU84895.1.

3D structure databases

ProteinModelPortalQ5XZD9.
SMRQ5XZD9. Positions 4-554.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_EUBAC
AccessionPrimary (citable) accession number: Q5XZD9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways