Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho guanine nucleotide exchange factor 6

Gene

Arhgef6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a RAC1 guanine nucleotide exchange factor (GEF).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 6
Alternative name(s):
Rac/Cdc42 guanine nucleotide exchange factor 6
Gene namesi
Name:Arhgef6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359674. Arhgef6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 772772Rho guanine nucleotide exchange factor 6PRO_0000080919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei126 – 1261PhosphoserineBy similarity
Modified residuei133 – 1331PhosphothreonineBy similarity
Modified residuei225 – 2251PhosphoserineCombined sources
Modified residuei488 – 4881PhosphoserineBy similarity
Modified residuei640 – 6401PhosphoserineCombined sources
Modified residuei680 – 6801PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XXR3.
PRIDEiQ5XXR3.

PTM databases

iPTMnetiQ5XXR3.
PhosphoSiteiQ5XXR3.

Interactioni

Subunit structurei

Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Interacts with PARVB. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1. Interacts with BIN2. Identified in a complex with BIN2 and GIT2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001158.

Structurei

3D structure databases

ProteinModelPortaliQ5XXR3.
SMRiQ5XXR3. Positions 4-111, 161-222, 229-552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 110110CHPROSITE-ProRule annotationAdd
BLAST
Domaini160 – 21960SH3PROSITE-ProRule annotationAdd
BLAST
Domaini241 – 421181DHPROSITE-ProRule annotationAdd
BLAST
Domaini443 – 548106PHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi552 – 57221Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG2070. Eukaryota.
ENOG410XNNP. LUCA.
HOGENOMiHOG000231381.
HOVERGENiHBG050569.
InParanoidiQ5XXR3.
KOiK05729.
PhylomeDBiQ5XXR3.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR032409. GEF_CC.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF16523. betaPIX_CC. 1 hit.
PF00307. CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XXR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPEERVVTW LISLGVLESP KKTICDPEEF LKSSLKNGVV LCKLISRLLP
60 70 80 90 100
GSVEKYCQEP QTEADCIDNI NDFLKGCATL QVEVFEPDDL YSGANFSKVL
110 120 130 140 150
NTLLAVNKAT EDQLSERPCG RSSSLSATTS SQTNPQAAVP STTPEQQSEE
160 170 180 190 200
KAAEMTENGS HQLIVKARFN FKQTNEDELS VCKGDIIYVT RVEEGGWWEG
210 220 230 240 250
TLNGRTGWFP SNYVREIKPS ERPLSPKAVK GFDTAPLTKN YYTVVLQNIL
260 270 280 290 300
DTEKEYAKEL QSLLVTYLRP LQSNNNLSTV EFTCLLGNFE EVCTFQQTLC
310 320 330 340 350
QALEECSKSP ENQHKVGGCL LNLMPHFKSM YLAYCANHPS AVNVLTQHSD
360 370 380 390 400
DLERFMENQG ASSPGILILT TSLSKPFMRL EKYVTLLQEL ERHMEDTHPD
410 420 430 440 450
HQDILKAIIA FKSLMGQCQD LRKRKQLELQ ILSEPIQAWE GDDIKTLGNV
460 470 480 490 500
IFMSQVVMQH GACEEKEERY FLLFSSVLIM LSASPRMSGF MYQGKVPIAG
510 520 530 540 550
MVVTRLDEIE GNDCTFEITG STVERIVVHC NNNQDFQEWM EQLNRLTKGP
560 570 580 590 600
ASCSSLSKTS SSSCSTHSSF SSTGQPRGPL EPPQIIKPWS LSCLRPAPPL
610 620 630 640 650
RPSAALGYKE RMSYILKESS KSPKTMKKFL HKRKTERKTS EEEYVIRKST
660 670 680 690 700
AALEEDAQIL KVIEAYCTSA SFQQGTRKDS VPQVLLPEEE KLIIEETRSN
710 720 730 740 750
GQTIIEEKSL VDTVYALKDE VKELKQENKK MKQCLEEELK SRKDLEKLVR
760 770
KLLKQTDESI RAESSSKTSI LQ
Length:772
Mass (Da):87,013
Last modified:November 23, 2004 - v1
Checksum:i50FAEB59F70B09AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY725848 mRNA. Translation: AAU43636.1.
RefSeqiNP_001005565.1. NM_001005565.1.
UniGeneiRn.208975.

Genome annotation databases

GeneIDi363509.
KEGGirno:363509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY725848 mRNA. Translation: AAU43636.1.
RefSeqiNP_001005565.1. NM_001005565.1.
UniGeneiRn.208975.

3D structure databases

ProteinModelPortaliQ5XXR3.
SMRiQ5XXR3. Positions 4-111, 161-222, 229-552.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001158.

PTM databases

iPTMnetiQ5XXR3.
PhosphoSiteiQ5XXR3.

Proteomic databases

PaxDbiQ5XXR3.
PRIDEiQ5XXR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi363509.
KEGGirno:363509.

Organism-specific databases

CTDi9459.
RGDi1359674. Arhgef6.

Phylogenomic databases

eggNOGiKOG2070. Eukaryota.
ENOG410XNNP. LUCA.
HOGENOMiHOG000231381.
HOVERGENiHBG050569.
InParanoidiQ5XXR3.
KOiK05729.
PhylomeDBiQ5XXR3.

Miscellaneous databases

PROiQ5XXR3.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR032409. GEF_CC.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF16523. betaPIX_CC. 1 hit.
PF00307. CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARHG6_RAT
AccessioniPrimary (citable) accession number: Q5XXR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.