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Q5XXA6

- ANO1_HUMAN

UniProt

Q5XXA6 - ANO1_HUMAN

Protein

Anoctamin-1

Gene

ANO1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.4 Publications

    Enzyme regulationi

    ATP and calmodulin are essential for its activation. Channel activity is inhibited by CFTR protein and by chloride inhibitors such as niflumic acid (NFA) and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS).1 Publication

    GO - Molecular functioni

    1. calcium activated cation channel activity Source: UniProt
    2. intracellular calcium activated chloride channel activity Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. cation transport Source: UniProt
    2. chloride transmembrane transport Source: GOC
    3. chloride transport Source: UniProtKB
    4. ion transmembrane transport Source: Reactome
    5. multicellular organismal development Source: UniProtKB-KW
    6. regulation of membrane potential Source: Ensembl
    7. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Chloride channel, Developmental protein, Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Calcium, Chloride

    Enzyme and pathway databases

    ReactomeiREACT_160189. Stimuli-sensing channels.

    Protein family/group databases

    TCDBi1.A.17.1.1. the calcium-dependent chloride channel (ca-clc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anoctamin-1
    Alternative name(s):
    Discovered on gastrointestinal stromal tumors protein 1
    Oral cancer overexpressed protein 2
    Transmembrane protein 16A
    Tumor-amplified and overexpressed sequence 2
    Gene namesi
    Name:ANO1
    Synonyms:DOG1, ORAOV2, TAOS2, TMEM16A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:21625. ANO1.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Cytoplasm
    Note: Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors.

    GO - Cellular componenti

    1. chloride channel complex Source: UniProtKB-KW
    2. cytoplasm Source: UniProtKB-SubCell
    3. extracellular vesicular exosome Source: UniProt
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164715378.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 986986Anoctamin-1PRO_0000288435Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi832 – 8321N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ5XXA6.
    PaxDbiQ5XXA6.
    PRIDEiQ5XXA6.

    PTM databases

    PhosphoSiteiQ5XXA6.

    Expressioni

    Tissue specificityi

    Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles.2 Publications

    Gene expression databases

    ArrayExpressiQ5XXA6.
    BgeeiQ5XXA6.
    CleanExiHS_ANO1.
    GenevestigatoriQ5XXA6.

    Organism-specific databases

    HPAiHPA032148.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with CFTR.2 Publications

    Protein-protein interaction databases

    BioGridi120417. 1 interaction.
    IntActiQ5XXA6. 1 interaction.
    STRINGi9606.ENSP00000347454.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XXA6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 333333CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini355 – 40248ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini424 – 51996CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini541 – 56525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini587 – 60620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini628 – 731104ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini753 – 79139CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini813 – 88270ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini904 – 98683CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei334 – 35421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei403 – 42321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei520 – 54021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei566 – 58621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei607 – 62721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei732 – 75221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei792 – 81221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei883 – 90321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.By similarity

    Sequence similaritiesi

    Belongs to the anoctamin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320103.
    HOGENOMiHOG000006509.
    HOVERGENiHBG069519.
    InParanoidiQ5XXA6.
    OMAiDYEGENV.
    OrthoDBiEOG7BS48W.
    PhylomeDBiQ5XXA6.
    TreeFamiTF314265.

    Family and domain databases

    InterProiIPR007632. Anoctamin.
    [Graphical view]
    PANTHERiPTHR12308. PTHR12308. 1 hit.
    PfamiPF04547. Anoctamin. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5XXA6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRVNEKYSTL PAEDRSVHII NICAIEDIGY LPSEGTLLNS LSVDPDAECK    50
    YGLYFRDGRR KVDYILVYHH KRPSGNRTLV RRVQHSDTPS GARSVKQDHP 100
    LPGKGASLDA GSGEPPMDYH EDDKRFRREE YEGNLLEAGL ELERDEDTKI 150
    HGVGFVKIHA PWNVLCREAE FLKLKMPTKK MYHINETRGL LKKINSVLQK 200
    ITDPIQPKVA EHRPQTMKRL SYPFSREKQH LFDLSDKDSF FDSKTRSTIV 250
    YEILKRTTCT KAKYSMGITS LLANGVYAAA YPLHDGDYNG ENVEFNDRKL 300
    LYEEWARYGV FYKYQPIDLV RKYFGEKIGL YFAWLGVYTQ MLIPASIVGI 350
    IVFLYGCATM DENIPSMEMC DQRHNITMCP LCDKTCSYWK MSSACATARA 400
    SHLFDNPATV FFSVFMALWA ATFMEHWKRK QMRLNYRWDL TGFEEEEEAV 450
    KDHPRAEYEA RVLEKSLKKE SRNKEKRRHI PEESTNKWKQ RVKTAMAGVK 500
    LTDKVKLTWR DRFPAYLTNL VSIIFMIAVT FAIVLGVIIY RISMAAALAM 550
    NSSPSVRSNI RVTVTATAVI INLVVIILLD EVYGCIARWL TKIEVPKTEK 600
    SFEERLIFKA FLLKFVNSYT PIFYVAFFKG RFVGRPGDYV YIFRSFRMEE 650
    CAPGGCLMEL CIQLSIIMLG KQLIQNNLFE IGIPKMKKLI RYLKLKQQSP 700
    PDHEECVKRK QRYEVDYNLE PFAGLTPEYM EMIIQFGFVT LFVASFPLAP 750
    LFALLNNIIE IRLDAKKFVT ELRRPVAVRA KDIGIWYNIL RGIGKLAVII 800
    NAFVISFTSD FIPRLVYLYM YSKNGTMHGF VNHTLSSFNV SDFQNGTAPN 850
    DPLDLGYEVQ ICRYKDYREP PWSENKYDIS KDFWAVLAAR LAFVIVFQNL 900
    VMFMSDFVDW VIPDIPKDIS QQIHKEKVLM VELFMREEQD KQQLLETWME 950
    KERQKDEPPC NHHNTKACPD SLGSPAPSHA YHGGVL 986
    Length:986
    Mass (Da):114,078
    Last modified:November 23, 2004 - v1
    Checksum:iE30A02F91EF36FC2
    GO
    Isoform 2 (identifier: Q5XXA6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-116: Missing.
         448-451: Missing.
         476-501: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:840
    Mass (Da):97,736
    Checksum:i43B0D18B6FD82C3A
    GO
    Isoform 3 (identifier: Q5XXA6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-28: Missing.
         29-36: GYLPSEGT → MLTRPSQV
         448-451: Missing.
         476-501: Missing.
         651-700: CAPGGCLMEL...RYLKLKQQSP → VTEILFISGS...SFLLETFLFP
         701-986: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:642
    Mass (Da):74,369
    Checksum:i6F7B524B54FD032B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti202 – 2021T → A in BAF85777. (PubMed:14702039)Curated
    Sequence conflicti801 – 8011N → D in AAH33036. (PubMed:15489334)Curated
    Sequence conflicti948 – 9481W → C in AAH33036. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti608 – 6081F → S.
    Corresponds to variant rs2186797 [ dbSNP | Ensembl ].
    VAR_032417
    Natural varianti983 – 9831G → R.
    Corresponds to variant rs3740722 [ dbSNP | Ensembl ].
    VAR_032418

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 116116Missing in isoform 2. 1 PublicationVSP_025665Add
    BLAST
    Alternative sequencei1 – 2828Missing in isoform 3. 1 PublicationVSP_025666Add
    BLAST
    Alternative sequencei29 – 368GYLPSEGT → MLTRPSQV in isoform 3. 1 PublicationVSP_025667
    Alternative sequencei448 – 4514Missing in isoform 2 and isoform 3. 2 PublicationsVSP_025668
    Alternative sequencei476 – 50126Missing in isoform 2 and isoform 3. 2 PublicationsVSP_025669Add
    BLAST
    Alternative sequencei651 – 70050CAPGG…KQQSP → VTEILFISGSPFCLAYDLST PCTWEKQLQHICSAKSSRFL SFLLETFLFP in isoform 3. 1 PublicationVSP_025670Add
    BLAST
    Alternative sequencei701 – 986286Missing in isoform 3. 1 PublicationVSP_025671Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY728143 mRNA. Translation: AAU82085.1.
    AK097619 mRNA. Translation: BAC05123.1.
    AK293088 mRNA. Translation: BAF85777.1.
    BC033036 mRNA. Translation: AAH33036.2.
    CCDSiCCDS44663.1. [Q5XXA6-1]
    RefSeqiNP_060513.5. NM_018043.5. [Q5XXA6-1]
    XP_006718668.1. XM_006718605.1. [Q5XXA6-2]
    UniGeneiHs.503074.

    Genome annotation databases

    EnsembliENST00000316296; ENSP00000319477; ENSG00000131620. [Q5XXA6-3]
    ENST00000355303; ENSP00000347454; ENSG00000131620. [Q5XXA6-1]
    ENST00000530676; ENSP00000435797; ENSG00000131620. [Q5XXA6-2]
    GeneIDi55107.
    KEGGihsa:55107.
    UCSCiuc001opj.3. human. [Q5XXA6-1]
    uc001opk.1. human. [Q5XXA6-3]

    Polymorphism databases

    DMDMi74708278.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY728143 mRNA. Translation: AAU82085.1 .
    AK097619 mRNA. Translation: BAC05123.1 .
    AK293088 mRNA. Translation: BAF85777.1 .
    BC033036 mRNA. Translation: AAH33036.2 .
    CCDSi CCDS44663.1. [Q5XXA6-1 ]
    RefSeqi NP_060513.5. NM_018043.5. [Q5XXA6-1 ]
    XP_006718668.1. XM_006718605.1. [Q5XXA6-2 ]
    UniGenei Hs.503074.

    3D structure databases

    ProteinModelPortali Q5XXA6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120417. 1 interaction.
    IntActi Q5XXA6. 1 interaction.
    STRINGi 9606.ENSP00000347454.

    Chemistry

    ChEMBLi CHEMBL2046267.
    DrugBanki DB04941. Crofelemer.
    GuidetoPHARMACOLOGYi 708.

    Protein family/group databases

    TCDBi 1.A.17.1.1. the calcium-dependent chloride channel (ca-clc) family.

    PTM databases

    PhosphoSitei Q5XXA6.

    Polymorphism databases

    DMDMi 74708278.

    Proteomic databases

    MaxQBi Q5XXA6.
    PaxDbi Q5XXA6.
    PRIDEi Q5XXA6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316296 ; ENSP00000319477 ; ENSG00000131620 . [Q5XXA6-3 ]
    ENST00000355303 ; ENSP00000347454 ; ENSG00000131620 . [Q5XXA6-1 ]
    ENST00000530676 ; ENSP00000435797 ; ENSG00000131620 . [Q5XXA6-2 ]
    GeneIDi 55107.
    KEGGi hsa:55107.
    UCSCi uc001opj.3. human. [Q5XXA6-1 ]
    uc001opk.1. human. [Q5XXA6-3 ]

    Organism-specific databases

    CTDi 55107.
    GeneCardsi GC11P069927.
    HGNCi HGNC:21625. ANO1.
    HPAi HPA032148.
    MIMi 610108. gene.
    neXtProti NX_Q5XXA6.
    PharmGKBi PA164715378.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320103.
    HOGENOMi HOG000006509.
    HOVERGENi HBG069519.
    InParanoidi Q5XXA6.
    OMAi DYEGENV.
    OrthoDBi EOG7BS48W.
    PhylomeDBi Q5XXA6.
    TreeFami TF314265.

    Enzyme and pathway databases

    Reactomei REACT_160189. Stimuli-sensing channels.

    Miscellaneous databases

    GeneWikii ANO1.
    GenomeRNAii 55107.
    NextBioi 58717.
    PROi Q5XXA6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5XXA6.
    Bgeei Q5XXA6.
    CleanExi HS_ANO1.
    Genevestigatori Q5XXA6.

    Family and domain databases

    InterProi IPR007632. Anoctamin.
    [Graphical view ]
    PANTHERi PTHR12308. PTHR12308. 1 hit.
    Pfami PF04547. Anoctamin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comprehensive genome and transcriptome analysis of the 11q13 amplicon in human oral cancer and synteny to the 7F5 amplicon in murine oral carcinoma."
      Huang X., Godfrey T.E., Gooding W.E., McCarty K.S. Jr., Gollin S.M.
      Genes Chromosomes Cancer 45:1058-1069(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Testis and Uterus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. "FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products."
      Katoh M., Katoh M.
      Int. J. Oncol. 22:1375-1381(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TOPOLOGY.
    5. "The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status."
      West R.B., Corless C.L., Chen X., Rubin B.P., Subramanian S., Montgomery K., Zhu S., Ball C.A., Nielsen T.O., Patel R., Goldblum J.R., Brown P.O., Heinrich M.C., van de Rijn M.
      Am. J. Pathol. 165:107-113(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    6. "Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display."
      Carles A., Millon R., Cromer A., Ganguli G., Lemaire F., Young J., Wasylyk C., Muller D., Schultz I., Rabouel Y., Dembele D., Zhao C., Marchal P., Ducray C., Bracco L., Abecassis J., Poch O., Wasylyk B.
      Oncogene 25:1821-1831(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. Cited for: FUNCTION, SUBCELLULAR LOCATION.
    8. "TMEM16A protein: a new identity for Ca(2+)-dependent Cl? channels."
      Ferrera L., Caputo A., Galietta L.J.
      Physiology (Bethesda) 25:357-363(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    9. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"
      Duran C., Hartzell H.C.
      Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "CFTR and TMEM16A are separate but functionally related Cl-channels."
      Ousingsawat J., Kongsuphol P., Schreiber R., Kunzelmann K.
      Cell. Physiol. Biochem. 28:715-724(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CFTR, ENZYME REGULATION.
    12. "Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A."
      Sheridan J.T., Worthington E.N., Yu K., Gabriel S.E., Hartzell H.C., Tarran R.
      J. Biol. Chem. 286:1381-1388(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    13. Cited for: REVIEW.
    14. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."
      Winpenny J.P., Gray M.A.
      Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    15. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."
      Scudieri P., Sondo E., Ferrera L., Galietta L.J.
      Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW, FUNCTION, SUBCELLULAR LOCATION.
    16. Cited for: REVIEW.
    17. "Anoctamins are a family of Ca2+ activated Cl- channels."
      Tian Y., Schreiber R., Kunzelmann K.
      J. Cell Sci. 125:4991-4998(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiANO1_HUMAN
    AccessioniPrimary (citable) accession number: Q5XXA6
    Secondary accession number(s): A8KAM3, Q8IYY8, Q8N7V3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3