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Protein

Anoctamin-1

Gene

ANO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.4 Publications

Enzyme regulationi

ATP and calmodulin are essential for its activation. Channel activity is inhibited by CFTR protein and by chloride inhibitors such as niflumic acid (NFA) and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS).1 Publication

GO - Molecular functioni

  1. calcium activated cation channel activity Source: UniProtKB
  2. intracellular calcium activated chloride channel activity Source: UniProtKB

GO - Biological processi

  1. cation transmembrane transport Source: GOC
  2. cation transport Source: UniProtKB
  3. chloride transport Source: UniProtKB
  4. ion transmembrane transport Source: Reactome
  5. multicellular organismal development Source: UniProtKB-KW
  6. regulation of membrane potential Source: Ensembl
  7. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Developmental protein, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Chloride

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.
REACT_268444. Orphan transporters.

Protein family/group databases

TCDBi1.A.17.1.1. the calcium-dependent chloride channel (ca-clc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anoctamin-1
Alternative name(s):
Discovered on gastrointestinal stromal tumors protein 1
Oral cancer overexpressed protein 2
Transmembrane protein 16A
Tumor-amplified and overexpressed sequence 2
Gene namesi
Name:ANO1
Synonyms:DOG1, ORAOV2, TAOS2, TMEM16A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:21625. ANO1.

Subcellular locationi

  1. Cell membrane; Multi-pass membrane protein
  2. Cytoplasm

  3. Note: Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 333333CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei334 – 35421HelicalSequence AnalysisAdd
BLAST
Topological domaini355 – 40248ExtracellularSequence AnalysisAdd
BLAST
Transmembranei403 – 42321HelicalSequence AnalysisAdd
BLAST
Topological domaini424 – 51996CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei520 – 54021HelicalSequence AnalysisAdd
BLAST
Topological domaini541 – 56525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei566 – 58621HelicalSequence AnalysisAdd
BLAST
Topological domaini587 – 60620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei607 – 62721HelicalSequence AnalysisAdd
BLAST
Topological domaini628 – 731104ExtracellularSequence AnalysisAdd
BLAST
Transmembranei732 – 75221HelicalSequence AnalysisAdd
BLAST
Topological domaini753 – 79139CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei792 – 81221HelicalSequence AnalysisAdd
BLAST
Topological domaini813 – 88270ExtracellularSequence AnalysisAdd
BLAST
Transmembranei883 – 90321HelicalSequence AnalysisAdd
BLAST
Topological domaini904 – 98683CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. chloride channel complex Source: UniProtKB-KW
  3. cytoplasm Source: UniProtKB-SubCell
  4. external side of plasma membrane Source: Ensembl
  5. extracellular vesicular exosome Source: UniProtKB
  6. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164715378.

Chemistry

DrugBankiDB04941. Crofelemer.

Polymorphism and mutation databases

BioMutaiANO1.
DMDMi74708278.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 986986Anoctamin-1PRO_0000288435Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei107 – 1071Phosphoserine1 Publication
Modified residuei196 – 1961Phosphoserine1 Publication
Glycosylationi832 – 8321N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ5XXA6.
PaxDbiQ5XXA6.
PRIDEiQ5XXA6.

PTM databases

PhosphoSiteiQ5XXA6.

Expressioni

Tissue specificityi

Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles.2 Publications

Gene expression databases

BgeeiQ5XXA6.
CleanExiHS_ANO1.
ExpressionAtlasiQ5XXA6. baseline and differential.
GenevestigatoriQ5XXA6.

Organism-specific databases

HPAiHPA032148.

Interactioni

Subunit structurei

Homodimer. Interacts with CFTR.2 Publications

Protein-protein interaction databases

BioGridi120417. 1 interaction.
IntActiQ5XXA6. 1 interaction.
STRINGi9606.ENSP00000347454.

Structurei

3D structure databases

ProteinModelPortaliQ5XXA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.By similarity

Sequence similaritiesi

Belongs to the anoctamin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320103.
GeneTreeiENSGT00760000119015.
HOGENOMiHOG000006509.
HOVERGENiHBG069519.
InParanoidiQ5XXA6.
OMAiDPDAECK.
OrthoDBiEOG7BS48W.
PhylomeDBiQ5XXA6.
TreeFamiTF314265.

Family and domain databases

InterProiIPR007632. Anoctamin.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PfamiPF04547. Anoctamin. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5XXA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVNEKYSTL PAEDRSVHII NICAIEDIGY LPSEGTLLNS LSVDPDAECK
60 70 80 90 100
YGLYFRDGRR KVDYILVYHH KRPSGNRTLV RRVQHSDTPS GARSVKQDHP
110 120 130 140 150
LPGKGASLDA GSGEPPMDYH EDDKRFRREE YEGNLLEAGL ELERDEDTKI
160 170 180 190 200
HGVGFVKIHA PWNVLCREAE FLKLKMPTKK MYHINETRGL LKKINSVLQK
210 220 230 240 250
ITDPIQPKVA EHRPQTMKRL SYPFSREKQH LFDLSDKDSF FDSKTRSTIV
260 270 280 290 300
YEILKRTTCT KAKYSMGITS LLANGVYAAA YPLHDGDYNG ENVEFNDRKL
310 320 330 340 350
LYEEWARYGV FYKYQPIDLV RKYFGEKIGL YFAWLGVYTQ MLIPASIVGI
360 370 380 390 400
IVFLYGCATM DENIPSMEMC DQRHNITMCP LCDKTCSYWK MSSACATARA
410 420 430 440 450
SHLFDNPATV FFSVFMALWA ATFMEHWKRK QMRLNYRWDL TGFEEEEEAV
460 470 480 490 500
KDHPRAEYEA RVLEKSLKKE SRNKEKRRHI PEESTNKWKQ RVKTAMAGVK
510 520 530 540 550
LTDKVKLTWR DRFPAYLTNL VSIIFMIAVT FAIVLGVIIY RISMAAALAM
560 570 580 590 600
NSSPSVRSNI RVTVTATAVI INLVVIILLD EVYGCIARWL TKIEVPKTEK
610 620 630 640 650
SFEERLIFKA FLLKFVNSYT PIFYVAFFKG RFVGRPGDYV YIFRSFRMEE
660 670 680 690 700
CAPGGCLMEL CIQLSIIMLG KQLIQNNLFE IGIPKMKKLI RYLKLKQQSP
710 720 730 740 750
PDHEECVKRK QRYEVDYNLE PFAGLTPEYM EMIIQFGFVT LFVASFPLAP
760 770 780 790 800
LFALLNNIIE IRLDAKKFVT ELRRPVAVRA KDIGIWYNIL RGIGKLAVII
810 820 830 840 850
NAFVISFTSD FIPRLVYLYM YSKNGTMHGF VNHTLSSFNV SDFQNGTAPN
860 870 880 890 900
DPLDLGYEVQ ICRYKDYREP PWSENKYDIS KDFWAVLAAR LAFVIVFQNL
910 920 930 940 950
VMFMSDFVDW VIPDIPKDIS QQIHKEKVLM VELFMREEQD KQQLLETWME
960 970 980
KERQKDEPPC NHHNTKACPD SLGSPAPSHA YHGGVL
Length:986
Mass (Da):114,078
Last modified:November 23, 2004 - v1
Checksum:iE30A02F91EF36FC2
GO
Isoform 2 (identifier: Q5XXA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     448-451: Missing.
     476-501: Missing.

Note: No experimental confirmation available.

Show »
Length:840
Mass (Da):97,736
Checksum:i43B0D18B6FD82C3A
GO
Isoform 3 (identifier: Q5XXA6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
     29-36: GYLPSEGT → MLTRPSQV
     448-451: Missing.
     476-501: Missing.
     651-700: CAPGGCLMEL...RYLKLKQQSP → VTEILFISGS...SFLLETFLFP
     701-986: Missing.

Note: No experimental confirmation available.

Show »
Length:642
Mass (Da):74,369
Checksum:i6F7B524B54FD032B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti202 – 2021T → A in BAF85777 (PubMed:14702039).Curated
Sequence conflicti801 – 8011N → D in AAH33036 (PubMed:15489334).Curated
Sequence conflicti948 – 9481W → C in AAH33036 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti608 – 6081F → S.
Corresponds to variant rs2186797 [ dbSNP | Ensembl ].
VAR_032417
Natural varianti983 – 9831G → R.
Corresponds to variant rs3740722 [ dbSNP | Ensembl ].
VAR_032418

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 116116Missing in isoform 2. 1 PublicationVSP_025665Add
BLAST
Alternative sequencei1 – 2828Missing in isoform 3. 1 PublicationVSP_025666Add
BLAST
Alternative sequencei29 – 368GYLPSEGT → MLTRPSQV in isoform 3. 1 PublicationVSP_025667
Alternative sequencei448 – 4514Missing in isoform 2 and isoform 3. 2 PublicationsVSP_025668
Alternative sequencei476 – 50126Missing in isoform 2 and isoform 3. 2 PublicationsVSP_025669Add
BLAST
Alternative sequencei651 – 70050CAPGG…KQQSP → VTEILFISGSPFCLAYDLST PCTWEKQLQHICSAKSSRFL SFLLETFLFP in isoform 3. 1 PublicationVSP_025670Add
BLAST
Alternative sequencei701 – 986286Missing in isoform 3. 1 PublicationVSP_025671Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY728143 mRNA. Translation: AAU82085.1.
AK097619 mRNA. Translation: BAC05123.1.
AK293088 mRNA. Translation: BAF85777.1.
BC033036 mRNA. Translation: AAH33036.2.
CCDSiCCDS44663.1. [Q5XXA6-1]
RefSeqiNP_060513.5. NM_018043.5. [Q5XXA6-1]
XP_006718668.1. XM_006718605.1. [Q5XXA6-2]
UniGeneiHs.503074.

Genome annotation databases

EnsembliENST00000316296; ENSP00000319477; ENSG00000131620. [Q5XXA6-3]
ENST00000355303; ENSP00000347454; ENSG00000131620. [Q5XXA6-1]
ENST00000530676; ENSP00000435797; ENSG00000131620. [Q5XXA6-2]
GeneIDi55107.
KEGGihsa:55107.
UCSCiuc001opj.3. human. [Q5XXA6-1]
uc001opk.1. human. [Q5XXA6-3]

Polymorphism and mutation databases

BioMutaiANO1.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY728143 mRNA. Translation: AAU82085.1.
AK097619 mRNA. Translation: BAC05123.1.
AK293088 mRNA. Translation: BAF85777.1.
BC033036 mRNA. Translation: AAH33036.2.
CCDSiCCDS44663.1. [Q5XXA6-1]
RefSeqiNP_060513.5. NM_018043.5. [Q5XXA6-1]
XP_006718668.1. XM_006718605.1. [Q5XXA6-2]
UniGeneiHs.503074.

3D structure databases

ProteinModelPortaliQ5XXA6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120417. 1 interaction.
IntActiQ5XXA6. 1 interaction.
STRINGi9606.ENSP00000347454.

Chemistry

BindingDBiQ5XXA6.
ChEMBLiCHEMBL2046267.
DrugBankiDB04941. Crofelemer.
GuidetoPHARMACOLOGYi708.

Protein family/group databases

TCDBi1.A.17.1.1. the calcium-dependent chloride channel (ca-clc) family.

PTM databases

PhosphoSiteiQ5XXA6.

Polymorphism and mutation databases

BioMutaiANO1.
DMDMi74708278.

Proteomic databases

MaxQBiQ5XXA6.
PaxDbiQ5XXA6.
PRIDEiQ5XXA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316296; ENSP00000319477; ENSG00000131620. [Q5XXA6-3]
ENST00000355303; ENSP00000347454; ENSG00000131620. [Q5XXA6-1]
ENST00000530676; ENSP00000435797; ENSG00000131620. [Q5XXA6-2]
GeneIDi55107.
KEGGihsa:55107.
UCSCiuc001opj.3. human. [Q5XXA6-1]
uc001opk.1. human. [Q5XXA6-3]

Organism-specific databases

CTDi55107.
GeneCardsiGC11P069929.
HGNCiHGNC:21625. ANO1.
HPAiHPA032148.
MIMi610108. gene.
neXtProtiNX_Q5XXA6.
PharmGKBiPA164715378.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG320103.
GeneTreeiENSGT00760000119015.
HOGENOMiHOG000006509.
HOVERGENiHBG069519.
InParanoidiQ5XXA6.
OMAiDPDAECK.
OrthoDBiEOG7BS48W.
PhylomeDBiQ5XXA6.
TreeFamiTF314265.

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.
REACT_268444. Orphan transporters.

Miscellaneous databases

ChiTaRSiANO1. human.
GeneWikiiANO1.
GenomeRNAii55107.
NextBioi58717.
PROiQ5XXA6.
SOURCEiSearch...

Gene expression databases

BgeeiQ5XXA6.
CleanExiHS_ANO1.
ExpressionAtlasiQ5XXA6. baseline and differential.
GenevestigatoriQ5XXA6.

Family and domain databases

InterProiIPR007632. Anoctamin.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PfamiPF04547. Anoctamin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comprehensive genome and transcriptome analysis of the 11q13 amplicon in human oral cancer and synteny to the 7F5 amplicon in murine oral carcinoma."
    Huang X., Godfrey T.E., Gooding W.E., McCarty K.S. Jr., Gollin S.M.
    Genes Chromosomes Cancer 45:1058-1069(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Testis and Uterus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products."
    Katoh M., Katoh M.
    Int. J. Oncol. 22:1375-1381(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TOPOLOGY.
  5. "The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status."
    West R.B., Corless C.L., Chen X., Rubin B.P., Subramanian S., Montgomery K., Zhu S., Ball C.A., Nielsen T.O., Patel R., Goldblum J.R., Brown P.O., Heinrich M.C., van de Rijn M.
    Am. J. Pathol. 165:107-113(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display."
    Carles A., Millon R., Cromer A., Ganguli G., Lemaire F., Young J., Wasylyk C., Muller D., Schultz I., Rabouel Y., Dembele D., Zhao C., Marchal P., Ducray C., Bracco L., Abecassis J., Poch O., Wasylyk B.
    Oncogene 25:1821-1831(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. "TMEM16A protein: a new identity for Ca(2+)-dependent Cl? channels."
    Ferrera L., Caputo A., Galietta L.J.
    Physiology (Bethesda) 25:357-363(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"
    Duran C., Hartzell H.C.
    Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "CFTR and TMEM16A are separate but functionally related Cl-channels."
    Ousingsawat J., Kongsuphol P., Schreiber R., Kunzelmann K.
    Cell. Physiol. Biochem. 28:715-724(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CFTR, ENZYME REGULATION.
  12. "Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A."
    Sheridan J.T., Worthington E.N., Yu K., Gabriel S.E., Hartzell H.C., Tarran R.
    J. Biol. Chem. 286:1381-1388(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  13. Cited for: REVIEW.
  14. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."
    Winpenny J.P., Gray M.A.
    Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  15. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."
    Scudieri P., Sondo E., Ferrera L., Galietta L.J.
    Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, FUNCTION, SUBCELLULAR LOCATION.
  16. Cited for: REVIEW.
  17. "Anoctamins are a family of Ca2+ activated Cl- channels."
    Tian Y., Schreiber R., Kunzelmann K.
    J. Cell Sci. 125:4991-4998(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107 AND SER-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiANO1_HUMAN
AccessioniPrimary (citable) accession number: Q5XXA6
Secondary accession number(s): A8KAM3, Q8IYY8, Q8N7V3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 23, 2004
Last modified: April 29, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.