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Protein

Nucleoprotein

Gene

NP

Organism
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
Protein N
Gene namesi
Name:NP
OrganismiSudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
Taxonomic identifieri386033 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
ProteomesiUP000000277 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738NucleoproteinPRO_0000245053Add
BLAST

Post-translational modificationi

Phosphorylated and O-glycosylated by host.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid. Also interacts with VP24 and VP40 (By similarity).By similarity

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili334 – 36330Sequence AnalysisAdd
BLAST

Domaini

This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half.By similarity

Sequence similaritiesi

Belongs to the filoviruses nucleoprotein family.Curated

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR008609. Ebola_NP.
[Graphical view]
PfamiPF05505. Ebola_NP. 1 hit.
[Graphical view]
PIRSFiPIRSF003900. N_FiloV. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XX08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKRVRGSWA LGGQSEVDLD YHKILTAGLS VQQGIVRQRV IPVYVVSDLE
60 70 80 90 100
GICQHIIQAF EAGVDFQDNA DSFLLLLCLH HAYQGDHRLF LKSDAVQYLE
110 120 130 140 150
GHGFRFEVRE KENVHRLDEL LPNVTGGKNL RRTLAAMPEE ETTEANAGQF
160 170 180 190 200
LSFASLFLPK LVVGEKACLE KVQRQIQVHA EQGLIQYPTS WQSVGHMMVI
210 220 230 240 250
FRLMRTNFLI KFLLIHQGMH MVAGHDANDT VISNSVAQAR FSGLLIVKTV
260 270 280 290 300
LDHILQKTDL GVRLHPLART AKVKNEVSSF KAALGSLAKH GEYAPFARLL
310 320 330 340 350
NLSGVNNLEH GLYPQLSAIA LGVATAHGST LAGVNVGEQY QQLREAATEA
360 370 380 390 400
EKQLQQYAET RELDNLGLDE QEKKILMSFH QKKNEISFQQ TNAMVTLRKE
410 420 430 440 450
RLAKLTEAIT TASKIKVGDR YPDDNDIPFP GPIYDETHPN PSDDNPDDSR
460 470 480 490 500
DTTIPGGVVD PYDDESNNYP DYEDSAEGTT GDLDLFNLDD DDDDSQPGPP
510 520 530 540 550
DRGQSKERAA RTHGLQDPTL DGAKKVPELT PGSHQPGNLH ITKPGSNTNQ
560 570 580 590 600
PQGNMSSTLQ SMTPIQEESE PDDQKDDDDE SLTSLDSEGD EDVESVSGEN
610 620 630 640 650
NPTVAPPAPV YKDTGVDTNQ QNGPSNAVDG QGSESEALPI NPEKGSALEE
660 670 680 690 700
TYYHLLKTQG PFEAINYYHL MSDEPIAFST ESGKEYIFPD SLEEAYPPWL
710 720 730
SEKEALEKEN RYLVIDGQQF LWPVMSLQDK FLAVLQHD
Length:738
Mass (Da):81,805
Last modified:November 23, 2004 - v1
Checksum:i41BF3D7CC985711C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY729654 Genomic RNA. Translation: AAU43883.1.
RefSeqiYP_138520.1. NC_006432.1.

Genome annotation databases

GeneIDi3160777.
KEGGivg:3160777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY729654 Genomic RNA. Translation: AAU43883.1.
RefSeqiYP_138520.1. NC_006432.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3160777.
KEGGivg:3160777.

Family and domain databases

InterProiIPR008609. Ebola_NP.
[Graphical view]
PfamiPF05505. Ebola_NP. 1 hit.
[Graphical view]
PIRSFiPIRSF003900. N_FiloV. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda."
    Sanchez A., Rollin P.E.
    Virus Res. 113:16-25(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNCAP_EBOSU
AccessioniPrimary (citable) accession number: Q5XX08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 23, 2004
Last modified: April 29, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.