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Q5XX08 (NCAP_EBOSU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name=Protein N
Gene names
Name:NP
OrganismSudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus) [Complete proteome]
Taxonomic identifier386033 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]

Protein attributes

Sequence length738 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases By similarity.

Subunit structure

Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid. Also interacts with VP24 and VP40 By similarity.

Subcellular location

Virion. Host cytoplasm By similarity.

Domain

This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half By similarity.

Post-translational modification

Phosphorylated and O-glycosylated by host By similarity.

Sequence similarities

Belongs to the filoviruses nucleoprotein family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 738738Nucleoprotein
PRO_0000245053

Regions

Coiled coil334 – 36330 Potential

Sequences

Sequence LengthMass (Da)Tools
Q5XX08 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 41BF3D7CC985711C

FASTA73881,805
        10         20         30         40         50         60 
MDKRVRGSWA LGGQSEVDLD YHKILTAGLS VQQGIVRQRV IPVYVVSDLE GICQHIIQAF 

        70         80         90        100        110        120 
EAGVDFQDNA DSFLLLLCLH HAYQGDHRLF LKSDAVQYLE GHGFRFEVRE KENVHRLDEL 

       130        140        150        160        170        180 
LPNVTGGKNL RRTLAAMPEE ETTEANAGQF LSFASLFLPK LVVGEKACLE KVQRQIQVHA 

       190        200        210        220        230        240 
EQGLIQYPTS WQSVGHMMVI FRLMRTNFLI KFLLIHQGMH MVAGHDANDT VISNSVAQAR 

       250        260        270        280        290        300 
FSGLLIVKTV LDHILQKTDL GVRLHPLART AKVKNEVSSF KAALGSLAKH GEYAPFARLL 

       310        320        330        340        350        360 
NLSGVNNLEH GLYPQLSAIA LGVATAHGST LAGVNVGEQY QQLREAATEA EKQLQQYAET 

       370        380        390        400        410        420 
RELDNLGLDE QEKKILMSFH QKKNEISFQQ TNAMVTLRKE RLAKLTEAIT TASKIKVGDR 

       430        440        450        460        470        480 
YPDDNDIPFP GPIYDETHPN PSDDNPDDSR DTTIPGGVVD PYDDESNNYP DYEDSAEGTT 

       490        500        510        520        530        540 
GDLDLFNLDD DDDDSQPGPP DRGQSKERAA RTHGLQDPTL DGAKKVPELT PGSHQPGNLH 

       550        560        570        580        590        600 
ITKPGSNTNQ PQGNMSSTLQ SMTPIQEESE PDDQKDDDDE SLTSLDSEGD EDVESVSGEN 

       610        620        630        640        650        660 
NPTVAPPAPV YKDTGVDTNQ QNGPSNAVDG QGSESEALPI NPEKGSALEE TYYHLLKTQG 

       670        680        690        700        710        720 
PFEAINYYHL MSDEPIAFST ESGKEYIFPD SLEEAYPPWL SEKEALEKEN RYLVIDGQQF 

       730 
LWPVMSLQDK FLAVLQHD 

« Hide

References

[1]"Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda."
Sanchez A., Rollin P.E.
Virus Res. 113:16-25(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY729654 Genomic RNA. Translation: AAU43883.1.
RefSeqYP_138520.1. NC_006432.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3160777.

Family and domain databases

InterProIPR008609. Ebola_NP.
[Graphical view]
PfamPF05505. Ebola_NP. 1 hit.
[Graphical view]
PIRSFPIRSF003900. N_FiloV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNCAP_EBOSU
AccessionPrimary (citable) accession number: Q5XX08
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 23, 2004
Last modified: October 16, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families