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Q5XX07

- VP35_EBOSU

UniProt

Q5XX07 - VP35_EBOSU

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Protein

Polymerase cofactor VP35

Gene

VP35

Organism
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR By similarity.By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. suppression by virus of host IKBKE activity Source: UniProtKB-KW
  2. suppression by virus of host IRF7 activity Source: UniProtKB-KW
  3. suppression by virus of host TBK1 activity Source: UniProtKB-KW
  4. suppression by virus of host toll-like receptor signaling pathway Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host IKBKE by virus, Inhibition of host innate immune response by virus, Inhibition of host IRF7 by virus, Inhibition of host RLR pathway by virus, Inhibition of host TBK1 by virus, Inhibition of host TLR pathway by virus, Interferon antiviral system evasion, Transcription, Viral immunoevasion, Viral RNA replication

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polymerase cofactor VP35
Gene namesi
Name:VP35
OrganismiSudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
Taxonomic identifieri386033 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
ProteomesiUP000000277: Genome

Subcellular locationi

Virion. Host cytoplasm By similarity

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Polymerase cofactor VP35PRO_0000245077Add
BLAST

Post-translational modificationi

Phosphorylated by host IKBKE.By similarity

Interactioni

Subunit structurei

Homooligomer. Homomultimerizes via the coiled coil domain. Found in a trimeric complex in which VP35 bridges L and the nucleoprotein By similarity. May interact with VP40. Interacts with host IKBKE and TBK1; the interactions lead to inhibition of cellular antiviral response by blocking necessary interactions of IKBKE and TBK1 with their substrate IRF3 By similarity.By similarity

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili84 – 10825Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR002953. Filo_VP35.
[Graphical view]
PfamiPF02097. Filo_VP35. 1 hit.
[Graphical view]
PIRSFiPIRSF018326. VP35_FiloV. 1 hit.
PRINTSiPR01240. FILOVP35.

Sequencei

Sequence statusi: Complete.

Q5XX07-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQQDRTYRHH GPEVSGWFSE QLMTGKIPLT EVFVDVENKP SPAPITIISK
60 70 80 90 100
NPKTTRKSDK QVQTDDASSL LTEEVKAAIN SVISAVRRQT NAIESLEGRV
110 120 130 140 150
TTLEASLKPV QDMAKTISSL NRSCAEMVAK YDLLVMTTGR ATATAAATEA
160 170 180 190 200
YWNEHGQAPP GPSLYEDDAI KAKLKDPNGK VPESVKQAYI NLDSTSALNE
210 220 230 240 250
ENFGRPYISA KDLKEIIYDH LPGFGTAFHQ LVQVICKIGK DNNILDIIHA
260 270 280 290 300
EFQASLAEGD SPQCALIQIT KRIPAFQDAS PPIVHIKSRG DIPKACQKSL
310 320
RPVPPSPKID RGWVCIFQFQ DGKALGLKI
Length:329
Mass (Da):36,116
Last modified:November 23, 2004 - v1
Checksum:i1B85B4EDF83FB011
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY729654 Genomic RNA. Translation: AAU43884.1.
RefSeqiYP_138521.1. NC_006432.1.

Genome annotation databases

GeneIDi3160776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY729654 Genomic RNA. Translation: AAU43884.1 .
RefSeqi YP_138521.1. NC_006432.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3160776.

Family and domain databases

InterProi IPR002953. Filo_VP35.
[Graphical view ]
Pfami PF02097. Filo_VP35. 1 hit.
[Graphical view ]
PIRSFi PIRSF018326. VP35_FiloV. 1 hit.
PRINTSi PR01240. FILOVP35.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda."
    Sanchez A., Rollin P.E.
    Virus Res. 113:16-25(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP35_EBOSU
AccessioniPrimary (citable) accession number: Q5XX07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3