Q5XX07 (VP35_EBOSU) Reviewed, UniProtKB/Swiss-Prot
Last modified April 16, 2014. Version 38. History...
Names and origin
|Protein names||Recommended name:|
Polymerase cofactor VP35
|Organism||Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus) [Complete proteome]|
|Taxonomic identifier||386033 [NCBI]|
|Taxonomic lineage||Viruses › ssRNA negative-strand viruses › Mononegavirales › Filoviridae › Ebolavirus ›|
|Virus host||Epomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]|
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
|Sequence length||329 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR By similarity.
Homooligomer. Homomultimerizes via the coiled coil domain. Found in a trimeric complex in which VP35 bridges L and the nucleoprotein By similarity. May interact with VP40. Interacts with host IKBKE and TBK1; the interactions lead to inhibition of cellular antiviral response by blocking necessary interactions of IKBKE and TBK1 with their substrate IRF3 By similarity.
Phosphorylated by host IKBKE By similarity.
Belongs to the filoviridae polymerase cofactor VP35 family.
Sequence annotation (Features)
|AY729654 Genomic RNA. Translation: AAU43884.1.|
|RefSeq||YP_138521.1. NC_006432.1. |
3D structure databases
Protocols and materials databases
Genome annotation databases
Family and domain databases
|InterPro||IPR002953. Filo_VP35. |
|Pfam||PF02097. Filo_VP35. 1 hit. |
|PIRSF||PIRSF018326. VP35_FiloV. 1 hit. |
|PRINTS||PR01240. FILOVP35. |
|Accession||Primary (citable) accession number: Q5XX07|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families