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Protein

Minor nucleoprotein VP30

Gene

VP30

Organism
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri72 – 9019C3H1-type; atypicalAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

Metal-binding, RNA-binding, Viral nucleoprotein, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Minor nucleoprotein VP30
Alternative name(s):
Transcription activator VP30
Gene namesi
Name:VP30
OrganismiSudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
Taxonomic identifieri386033 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
ProteomesiUP000000277 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Minor nucleoprotein VP30PRO_0000245073Add
BLAST

Post-translational modificationi

Phosphorylated by host. Phosphorylation negatively regulates the transcription activation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homohexamer or homodimer. Interacts with the nucleoprotein (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5XX03.
SMRiQ5XX03. Positions 142-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4444Intrinsically disorderedSequence AnalysisAdd
BLAST
Regioni26 – 4015RNA-bindingBy similarityAdd
BLAST
Regioni94 – 11219OligomerizationBy similarityAdd
BLAST
Regioni121 – 14020Intrinsically disorderedSequence AnalysisAdd
BLAST
Regioni180 – 19718Interaction with the nucleoproteinBy similarityAdd
BLAST
Regioni268 – 28821Intrinsically disorderedSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri72 – 9019C3H1-type; atypicalAdd
BLAST

Keywords - Domaini

Zinc-finger

Family and domain databases

InterProiIPR014459. VP30_FiloV.
[Graphical view]
PfamiPF11507. Transcript_VP30. 1 hit.
[Graphical view]
PIRSFiPIRSF011356. VP30_FiloV. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XX03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERGRERGRS RNSRADQQNS TGPQFRTRSI SRDKTTTDYR SSRSTSQVRV
60 70 80 90 100
PTVFHKKGTG TLTVPPAPKD VCPTLRKGFL CDSNFCKKDH QLESLTDREL
110 120 130 140 150
LLLIARKTCG STDSSLNIAA PKDLRLANPT ADDFKQDGSP KLTLKLLVET
160 170 180 190 200
AEFWANQNIN EVDDAKLRAL LTLSAVLVRK FSKSQLSQLC ESHLRRENLG
210 220 230 240 250
QDQAESVLEV YQRLHSDKGG AFEAALWQQW DRQSLTMFIS AFLHVALQLS
260 270 280
CESSTVVISG LRLLAPPSVN EGLPPAPGEY TWSEDSTT
Length:288
Mass (Da):32,107
Last modified:November 23, 2004 - v1
Checksum:i456599DB1654839E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY729654 Genomic RNA. Translation: AAU43888.1.
RefSeqiYP_138525.1. NC_006432.1.

Genome annotation databases

GeneIDi3160773.
KEGGivg:3160773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY729654 Genomic RNA. Translation: AAU43888.1.
RefSeqiYP_138525.1. NC_006432.1.

3D structure databases

ProteinModelPortaliQ5XX03.
SMRiQ5XX03. Positions 142-266.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3160773.
KEGGivg:3160773.

Family and domain databases

InterProiIPR014459. VP30_FiloV.
[Graphical view]
PfamiPF11507. Transcript_VP30. 1 hit.
[Graphical view]
PIRSFiPIRSF011356. VP30_FiloV. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda."
    Sanchez A., Rollin P.E.
    Virus Res. 113:16-25(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP30_EBOSU
AccessioniPrimary (citable) accession number: Q5XX03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 23, 2004
Last modified: April 1, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.