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Q5XX03 (VP30_EBOSU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Minor nucleoprotein VP30
Alternative name(s):
Transcription activator VP30
Gene names
Name:VP30
OrganismSudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus) [Complete proteome]
Taxonomic identifier386033 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA By similarity.

Subunit structure

Homohexamer or homodimer. Interacts with the nucleoprotein By similarity.

Subcellular location

Virion. Host cytoplasm By similarity.

Post-translational modification

Phosphorylated by host. Phosphorylation negatively regulates the transcription activation By similarity.

Sequence similarities

Belongs to the filoviridae minor nucleoprotein VP30 family.

Contains 1 C3H1-type zinc finger.

Ontologies

Keywords
   Biological processTranscription
   Cellular componentHost cytoplasm
Virion
   DomainZinc-finger
   LigandMetal-binding
RNA-binding
Viral nucleoprotein
Zinc
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

viral nucleocapsid

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Minor nucleoprotein VP30
PRO_0000245073

Regions

Zinc finger72 – 9019C3H1-type; atypical
Region1 – 4444Intrinsically disordered Potential
Region26 – 4015RNA-binding By similarity
Region94 – 11219Oligomerization By similarity
Region121 – 14020Intrinsically disordered Potential
Region180 – 19718Interaction with the nucleoprotein By similarity
Region268 – 28821Intrinsically disordered Potential

Sequences

Sequence LengthMass (Da)Tools
Q5XX03 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 456599DB1654839E

FASTA28832,107
        10         20         30         40         50         60 
MERGRERGRS RNSRADQQNS TGPQFRTRSI SRDKTTTDYR SSRSTSQVRV PTVFHKKGTG 

        70         80         90        100        110        120 
TLTVPPAPKD VCPTLRKGFL CDSNFCKKDH QLESLTDREL LLLIARKTCG STDSSLNIAA 

       130        140        150        160        170        180 
PKDLRLANPT ADDFKQDGSP KLTLKLLVET AEFWANQNIN EVDDAKLRAL LTLSAVLVRK 

       190        200        210        220        230        240 
FSKSQLSQLC ESHLRRENLG QDQAESVLEV YQRLHSDKGG AFEAALWQQW DRQSLTMFIS 

       250        260        270        280 
AFLHVALQLS CESSTVVISG LRLLAPPSVN EGLPPAPGEY TWSEDSTT 

« Hide

References

[1]"Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda."
Sanchez A., Rollin P.E.
Virus Res. 113:16-25(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY729654 Genomic RNA. Translation: AAU43888.1.
RefSeqYP_138525.1. NC_006432.1.

3D structure databases

ProteinModelPortalQ5XX03.
SMRQ5XX03. Positions 142-266.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3160773.

Family and domain databases

InterProIPR014459. VP30_FiloV.
[Graphical view]
PfamPF11507. Transcript_VP30. 1 hit.
[Graphical view]
PIRSFPIRSF011356. VP30_FiloV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameVP30_EBOSU
AccessionPrimary (citable) accession number: Q5XX03
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 23, 2004
Last modified: March 19, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families