Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5XX03

- VP30_EBOSU

UniProt

Q5XX03 - VP30_EBOSU

Protein

Minor nucleoprotein VP30

Gene

VP30

Organism
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri72 – 9019C3H1-type; atypicalAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    Metal-binding, RNA-binding, Viral nucleoprotein, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Minor nucleoprotein VP30
    Alternative name(s):
    Transcription activator VP30
    Gene namesi
    Name:VP30
    OrganismiSudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
    Taxonomic identifieri386033 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
    Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
    Homo sapiens (Human) [TaxID: 9606]
    Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
    ProteomesiUP000000277: Genome

    Subcellular locationi

    Virion. Host cytoplasm By similarity

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Host cytoplasm, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Minor nucleoprotein VP30PRO_0000245073Add
    BLAST

    Post-translational modificationi

    Phosphorylated by host. Phosphorylation negatively regulates the transcription activation By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homohexamer or homodimer. Interacts with the nucleoprotein By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XX03.
    SMRiQ5XX03. Positions 142-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 4444Intrinsically disorderedSequence AnalysisAdd
    BLAST
    Regioni26 – 4015RNA-bindingBy similarityAdd
    BLAST
    Regioni94 – 11219OligomerizationBy similarityAdd
    BLAST
    Regioni121 – 14020Intrinsically disorderedSequence AnalysisAdd
    BLAST
    Regioni180 – 19718Interaction with the nucleoproteinBy similarityAdd
    BLAST
    Regioni268 – 28821Intrinsically disorderedSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C3H1-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri72 – 9019C3H1-type; atypicalAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Family and domain databases

    InterProiIPR014459. VP30_FiloV.
    [Graphical view]
    PfamiPF11507. Transcript_VP30. 1 hit.
    [Graphical view]
    PIRSFiPIRSF011356. VP30_FiloV. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5XX03-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERGRERGRS RNSRADQQNS TGPQFRTRSI SRDKTTTDYR SSRSTSQVRV    50
    PTVFHKKGTG TLTVPPAPKD VCPTLRKGFL CDSNFCKKDH QLESLTDREL 100
    LLLIARKTCG STDSSLNIAA PKDLRLANPT ADDFKQDGSP KLTLKLLVET 150
    AEFWANQNIN EVDDAKLRAL LTLSAVLVRK FSKSQLSQLC ESHLRRENLG 200
    QDQAESVLEV YQRLHSDKGG AFEAALWQQW DRQSLTMFIS AFLHVALQLS 250
    CESSTVVISG LRLLAPPSVN EGLPPAPGEY TWSEDSTT 288
    Length:288
    Mass (Da):32,107
    Last modified:November 23, 2004 - v1
    Checksum:i456599DB1654839E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY729654 Genomic RNA. Translation: AAU43888.1.
    RefSeqiYP_138525.1. NC_006432.1.

    Genome annotation databases

    GeneIDi3160773.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY729654 Genomic RNA. Translation: AAU43888.1 .
    RefSeqi YP_138525.1. NC_006432.1.

    3D structure databases

    ProteinModelPortali Q5XX03.
    SMRi Q5XX03. Positions 142-266.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3160773.

    Family and domain databases

    InterProi IPR014459. VP30_FiloV.
    [Graphical view ]
    Pfami PF11507. Transcript_VP30. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF011356. VP30_FiloV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda."
      Sanchez A., Rollin P.E.
      Virus Res. 113:16-25(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP30_EBOSU
    AccessioniPrimary (citable) accession number: Q5XX03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3