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Protein

Membrane-associated protein VP24

Gene

VP24

Organism
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Interferon antiviral system evasion

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated protein VP24
Gene namesi
Name:VP24
OrganismiSudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
Taxonomic identifieri386033 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
Proteomesi
  • UP000000277 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002450691 – 251Membrane-associated protein VP24Add BLAST251

Interactioni

Subunit structurei

Binds to host importin alpha-1/KPNA1.By similarity

Structurei

Secondary structure

1251
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 27Combined sources12
Beta strandi30 – 33Combined sources4
Beta strandi35 – 42Combined sources8
Beta strandi45 – 50Combined sources6
Helixi54 – 61Combined sources8
Helixi67 – 69Combined sources3
Helixi70 – 75Combined sources6
Helixi77 – 80Combined sources4
Beta strandi85 – 87Combined sources3
Helixi90 – 103Combined sources14
Helixi115 – 128Combined sources14
Helixi139 – 144Combined sources6
Helixi147 – 165Combined sources19
Beta strandi172 – 174Combined sources3
Beta strandi178 – 182Combined sources5
Beta strandi187 – 192Combined sources6
Beta strandi194 – 202Combined sources9
Helixi207 – 209Combined sources3
Beta strandi211 – 213Combined sources3
Beta strandi217 – 223Combined sources7
Turni224 – 227Combined sources4
Helixi228 – 230Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VNEX-ray2.00A9-232[»]
3VNFX-ray2.10A13-228[»]
ProteinModelPortaliQ5XX02.
SMRiQ5XX02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR009433. Filo_VP24.
[Graphical view]
PfamiPF06389. Filo_VP24. 1 hit.
[Graphical view]
PIRSFiPIRSF011355. VP24. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XX02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKATGRYNL VTPKRELEQG VVFSDLCNFL VTPTVQGWKV YWAGLEFDVN
60 70 80 90 100
QKGITLLNRL KVNDFAPAWA MTRNLFPHLF KNQQSEVQTP IWALRVILAA
110 120 130 140 150
GILDQLMDHS LIEPLSGALN LIADWLLTTS TNHFNMRTQR VKDQLSMRML
160 170 180 190 200
SLIRSNIINF INKLETLHVV NYKGLLSSVE IGTPSYAIII TRTNMGYLVE
210 220 230 240 250
VQEPDKSAMD IRHPGPVKFS LLHESTLKPV ATPKPSSITS LIMEFNSSLA

I
Length:251
Mass (Da):28,277
Last modified:November 23, 2004 - v1
Checksum:i1378EDBB6829875A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY729654 Genomic RNA. Translation: AAU43889.1.
RefSeqiYP_138526.1. NC_006432.1.

Genome annotation databases

GeneIDi3160772.
KEGGivg:3160772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY729654 Genomic RNA. Translation: AAU43889.1.
RefSeqiYP_138526.1. NC_006432.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VNEX-ray2.00A9-232[»]
3VNFX-ray2.10A13-228[»]
ProteinModelPortaliQ5XX02.
SMRiQ5XX02.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3160772.
KEGGivg:3160772.

Family and domain databases

InterProiIPR009433. Filo_VP24.
[Graphical view]
PfamiPF06389. Filo_VP24. 1 hit.
[Graphical view]
PIRSFiPIRSF011355. VP24. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVP24_EBOSU
AccessioniPrimary (citable) accession number: Q5XX02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.