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Q5XX02 (VP24_EBOSU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 31, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.

Subunit structure

Binds to host importin alpha-1/KPNA1 By similarity.

Subcellular location

Virion membrane; Peripheral membrane protein By similarity. Host cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Host endomembrane system; Peripheral membrane protein By similarity. Note: In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place By similarity.

Sequence similarities

Belongs to the filoviridae membrane-associated protein VP24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Membrane-associated protein VP24
PRO_0000245069

Secondary structure

.......................................... 251
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q5XX02 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 1378EDBB6829875A

FASTA25128,277
        10         20         30         40         50         60 
MAKATGRYNL VTPKRELEQG VVFSDLCNFL VTPTVQGWKV YWAGLEFDVN QKGITLLNRL 

        70         80         90        100        110        120 
KVNDFAPAWA MTRNLFPHLF KNQQSEVQTP IWALRVILAA GILDQLMDHS LIEPLSGALN 

       130        140        150        160        170        180 
LIADWLLTTS TNHFNMRTQR VKDQLSMRML SLIRSNIINF INKLETLHVV NYKGLLSSVE 

       190        200        210        220        230        240 
IGTPSYAIII TRTNMGYLVE VQEPDKSAMD IRHPGPVKFS LLHESTLKPV ATPKPSSITS 

       250 
LIMEFNSSLA I 

« Hide

References

[1]"Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda."
Sanchez A., Rollin P.E.
Virus Res. 113:16-25(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY729654 Genomic RNA. Translation: AAU43889.1.
RefSeqYP_138526.1. NC_006432.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3VNEX-ray2.00A9-232[»]
3VNFX-ray2.10A13-228[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3160772.

Family and domain databases

InterProIPR009433. Filo_VP24.
[Graphical view]
PfamPF06389. Filo_VP24. 1 hit.
[Graphical view]
PIRSFPIRSF011355. VP24. 1 hit.
ProtoNetSearch...

Entry information

Entry nameVP24_EBOSU
AccessionPrimary (citable) accession number: Q5XX02
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 23, 2004
Last modified: October 31, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references