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Q5XX02

- VP24_EBOSU

UniProt

Q5XX02 - VP24_EBOSU

Protein

Membrane-associated protein VP24

Gene

VP24

Organism
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. evasion or tolerance by virus of host immune response Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Interferon antiviral system evasion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane-associated protein VP24
    Gene namesi
    Name:VP24
    OrganismiSudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
    Taxonomic identifieri386033 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
    Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
    Homo sapiens (Human) [TaxID: 9606]
    Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
    ProteomesiUP000000277: Genome

    Subcellular locationi

    Virion membrane By similarity; Peripheral membrane protein By similarity. Host cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Host endomembrane system By similarity; Peripheral membrane protein By similarity
    Note: In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place By similarity.By similarity

    GO - Cellular componenti

    1. host cell endomembrane system Source: UniProtKB-SubCell
    2. host cell plasma membrane Source: UniProtKB-SubCell
    3. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 251251Membrane-associated protein VP24PRO_0000245069Add
    BLAST

    Interactioni

    Subunit structurei

    Binds to host importin alpha-1/KPNA1.By similarity

    Structurei

    Secondary structure

    1
    251
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 2712
    Beta strandi30 – 334
    Beta strandi35 – 428
    Beta strandi45 – 506
    Helixi54 – 618
    Helixi67 – 693
    Helixi70 – 756
    Helixi77 – 804
    Beta strandi85 – 873
    Helixi90 – 10314
    Helixi115 – 12814
    Helixi139 – 1446
    Helixi147 – 16519
    Beta strandi172 – 1743
    Beta strandi178 – 1825
    Beta strandi187 – 1926
    Beta strandi194 – 2029
    Helixi207 – 2093
    Beta strandi211 – 2133
    Beta strandi217 – 2237
    Turni224 – 2274
    Helixi228 – 2303

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3VNEX-ray2.00A9-232[»]
    3VNFX-ray2.10A13-228[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR009433. Filo_VP24.
    [Graphical view]
    PfamiPF06389. Filo_VP24. 1 hit.
    [Graphical view]
    PIRSFiPIRSF011355. VP24. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5XX02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKATGRYNL VTPKRELEQG VVFSDLCNFL VTPTVQGWKV YWAGLEFDVN    50
    QKGITLLNRL KVNDFAPAWA MTRNLFPHLF KNQQSEVQTP IWALRVILAA 100
    GILDQLMDHS LIEPLSGALN LIADWLLTTS TNHFNMRTQR VKDQLSMRML 150
    SLIRSNIINF INKLETLHVV NYKGLLSSVE IGTPSYAIII TRTNMGYLVE 200
    VQEPDKSAMD IRHPGPVKFS LLHESTLKPV ATPKPSSITS LIMEFNSSLA 250
    I 251
    Length:251
    Mass (Da):28,277
    Last modified:November 23, 2004 - v1
    Checksum:i1378EDBB6829875A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY729654 Genomic RNA. Translation: AAU43889.1.
    RefSeqiYP_138526.1. NC_006432.1.

    Genome annotation databases

    GeneIDi3160772.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY729654 Genomic RNA. Translation: AAU43889.1 .
    RefSeqi YP_138526.1. NC_006432.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3VNE X-ray 2.00 A 9-232 [» ]
    3VNF X-ray 2.10 A 13-228 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3160772.

    Family and domain databases

    InterProi IPR009433. Filo_VP24.
    [Graphical view ]
    Pfami PF06389. Filo_VP24. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF011355. VP24. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda."
      Sanchez A., Rollin P.E.
      Virus Res. 113:16-25(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP24_EBOSU
    AccessioniPrimary (citable) accession number: Q5XX02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3