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Q5XX02

- VP24_EBOSU

UniProt

Q5XX02 - VP24_EBOSU

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Protein
Membrane-associated protein VP24
Gene
VP24
Organism
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Interferon antiviral system evasion

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated protein VP24
Gene namesi
Name:VP24
OrganismiSudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
Taxonomic identifieri386033 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
ProteomesiUP000000277: Genome

Subcellular locationi

Virion membrane; Peripheral membrane protein By similarity. Host cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Host endomembrane system; Peripheral membrane protein By similarity
Note: In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place By similarity.

GO - Cellular componenti

  1. host cell endomembrane system Source: UniProtKB-SubCell
  2. host cell plasma membrane Source: UniProtKB-SubCell
  3. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Membrane-associated protein VP24
PRO_0000245069Add
BLAST

Interactioni

Subunit structurei

Binds to host importin alpha-1/KPNA1 By similarity.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 2712
Beta strandi30 – 334
Beta strandi35 – 428
Beta strandi45 – 506
Helixi54 – 618
Helixi67 – 693
Helixi70 – 756
Helixi77 – 804
Beta strandi85 – 873
Helixi90 – 10314
Helixi115 – 12814
Helixi139 – 1446
Helixi147 – 16519
Beta strandi172 – 1743
Beta strandi178 – 1825
Beta strandi187 – 1926
Beta strandi194 – 2029
Helixi207 – 2093
Beta strandi211 – 2133
Beta strandi217 – 2237
Turni224 – 2274
Helixi228 – 2303

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VNEX-ray2.00A9-232[»]
3VNFX-ray2.10A13-228[»]

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR009433. Filo_VP24.
[Graphical view]
PfamiPF06389. Filo_VP24. 1 hit.
[Graphical view]
PIRSFiPIRSF011355. VP24. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XX02-1 [UniParc]FASTAAdd to Basket

« Hide

MAKATGRYNL VTPKRELEQG VVFSDLCNFL VTPTVQGWKV YWAGLEFDVN    50
QKGITLLNRL KVNDFAPAWA MTRNLFPHLF KNQQSEVQTP IWALRVILAA 100
GILDQLMDHS LIEPLSGALN LIADWLLTTS TNHFNMRTQR VKDQLSMRML 150
SLIRSNIINF INKLETLHVV NYKGLLSSVE IGTPSYAIII TRTNMGYLVE 200
VQEPDKSAMD IRHPGPVKFS LLHESTLKPV ATPKPSSITS LIMEFNSSLA 250
I 251
Length:251
Mass (Da):28,277
Last modified:November 23, 2004 - v1
Checksum:i1378EDBB6829875A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY729654 Genomic RNA. Translation: AAU43889.1.
RefSeqiYP_138526.1. NC_006432.1.

Genome annotation databases

GeneIDi3160772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY729654 Genomic RNA. Translation: AAU43889.1 .
RefSeqi YP_138526.1. NC_006432.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VNE X-ray 2.00 A 9-232 [» ]
3VNF X-ray 2.10 A 13-228 [» ]
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3160772.

Family and domain databases

InterProi IPR009433. Filo_VP24.
[Graphical view ]
Pfami PF06389. Filo_VP24. 1 hit.
[Graphical view ]
PIRSFi PIRSF011355. VP24. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda."
    Sanchez A., Rollin P.E.
    Virus Res. 113:16-25(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP24_EBOSU
AccessioniPrimary (citable) accession number: Q5XX02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 23, 2004
Last modified: October 31, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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