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Protein

Gastric intrinsic factor

Gene

GIF

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei171CobalaminBy similarity1
Binding sitei222CobalaminBy similarity1
Binding sitei270CobalaminBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCobalt transport, Ion transport, Transport
LigandCobalt

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric intrinsic factor
Alternative name(s):
Intrinsic factor
Short name:
IF
Short name:
INF
Pancreatic intrinsic factor
Gene namesi
Name:GIF
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000555723 – 417Gastric intrinsic factorAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 246By similarity
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 288By similarity
Disulfide bondi143 ↔ 182By similarity
Modified residuei191PhosphoserineBy similarity1
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi413N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5XWD5.
PRIDEiQ5XWD5.

Interactioni

Subunit structurei

Interacts with CUBN (via CUB domains).By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000015184.

Structurei

3D structure databases

SMRiQ5XWD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni365 – 370Cobalamin bindingBy similarity6
Regioni386 – 395Cobalamin bindingBy similarity10

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVBN. Eukaryota.
ENOG410XSU1. LUCA.
HOGENOMiHOG000013214.
HOVERGENiHBG006133.
InParanoidiQ5XWD5.
KOiK14615.

Family and domain databases

InterProiView protein in InterPro
IPR002157. Cbl-bd_transpt_euk.
IPR027954. DUF4430.
PfamiView protein in Pfam
PF01122. Cobalamin_bind. 1 hit.
PF14478. DUF4430. 1 hit.
PROSITEiView protein in PROSITE
PS00468. COBALAMIN_BINDING. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XWD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWFSLHLLH LLWAAAGTST WARSSCSVPQ AAQHLVDGLQ VLLEDSVSSA
60 70 80 90 100
APPNPSVLIA MNLAGALSAE ARELLADRLG ASDSAGLSVG QLALTIMALN
110 120 130 140 150
SSCRDPGNKV SVLYGQMEAW PPSSPSAPAW TFYGPSLAVL ALCQEHPGRA
160 170 180 190 200
LPVAARLAKI LAAGLSPFNT DTGAMVTLAL TCMYNKIPEG SEEGYRTLFS
210 220 230 240 250
QVLKDVVENI SMRIKDNGII GDVYSTGLAM QALSVTPEPP NKEWDCKKTM
260 270 280 290 300
DTILKEIEQG KFHNPMSIAQ ILPSLKGKTY LDVPYVSCSP GHQVQPTLPS
310 320 330 340 350
QPSPVPTSAS NITVAYTINN QLKGVELVFN ETIDVSVKDG SVLLVVLEEA
360 370 380 390 400
QRRNPMFKFV TTMTSWGLVV SSINNIAESV HDRTYWQFLS GKTPLNEGVA
410
DYTPRDHEHI TANFTQY
Length:417
Mass (Da):44,982
Last modified:November 23, 2004 - v1
Checksum:iE94323452E889C16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY730674 mRNA. Translation: AAU44784.1.
RefSeqiNP_001005759.1. NM_001005759.1.
UniGeneiCfa.36216.

Genome annotation databases

GeneIDi449477.
KEGGicfa:449477.

Similar proteinsi

Entry informationi

Entry nameiIF_CANLF
AccessioniPrimary (citable) accession number: Q5XWD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: May 10, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families