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Protein

F-box/WD repeat-containing protein 9

Gene

FBXW9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ5XUX1.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein 9
Alternative name(s):
F-box and WD-40 domain-containing protein 9
Gene namesi
Name:FBXW9
Synonyms:FBW9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28136. FBXW9.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132004.
PharmGKBiPA134910095.

Polymorphism and mutation databases

BioMutaiFBXW9.
DMDMi115311596.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509991 – 488F-box/WD repeat-containing protein 9Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei18PhosphoserineCombined sources1
Modified residuei55PhosphothreonineCombined sources1
Modified residuei59PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5XUX1.
MaxQBiQ5XUX1.
PeptideAtlasiQ5XUX1.
PRIDEiQ5XUX1.

PTM databases

iPTMnetiQ5XUX1.
PhosphoSitePlusiQ5XUX1.

Expressioni

Gene expression databases

BgeeiENSG00000132004.
CleanExiHS_FBXW9.
ExpressionAtlasiQ5XUX1. baseline and differential.
GenevisibleiQ5XUX1. HS.

Organism-specific databases

HPAiHPA042087.

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632084EBI-2322729,EBI-307486

Protein-protein interaction databases

BioGridi123988. 6 interactors.
IntActiQ5XUX1. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ5XUX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 123F-boxPROSITE-ProRule annotationAdd BLAST48
Repeati171 – 210WD 1Add BLAST40
Repeati220 – 261WD 2Add BLAST42
Repeati264 – 301WD 3Add BLAST38
Repeati335 – 372WD 4Add BLAST38
Repeati374 – 411WD 5Add BLAST38
Repeati417 – 454WD 6Add BLAST38
Repeati457 – 488WD 7Add BLAST32

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000006806.
HOGENOMiHOG000112556.
HOVERGENiHBG051598.
InParanoidiQ5XUX1.
KOiK10265.
OMAiQHLSRWA.
OrthoDBiEOG091G0AVG.
PhylomeDBiQ5XUX1.
TreeFamiTF313746.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5XUX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELPLGRCDD SRTWDDDSDP ESETDPDAQA KAYVARVLSP PKSGLAFSRP
60 70 80 90 100
SQLSTPAASP SASEPRAASR VSAVSEPGLL SLPPELLLEI CSYLDARLVL
110 120 130 140 150
HVLSRVCHAL RDLVSDHVTW RLRALRRVRA PYPVVEEKNF DWPAACIALE
160 170 180 190 200
QHLSRWAEDG RWVEYFCLAE GHVASVDSVL LLQGGSLCLS GSRDRNVNLW
210 220 230 240 250
DLRQLGTESN QVLIKTLGTK RNSTHEGWVW SLAAQDHRVC SGSWDSTVKL
260 270 280 290 300
WDMAADGQQF GEIKASSAVL CLSYLPDILV TGTYDKKVTI YDPRDRMETR
310 320 330 340 350
DALMGWGGPS RGSDIPPHRP ITHEAGPALL KHQQLHSRPV LTLLADDRHI
360 370 380 390 400
ISGSEDHTLV VVDRRANSVL QRLQLDSYLL CMSYQEPQLW AGDNQGLLHV
410 420 430 440 450
FANRNGCFQL IRSFDVGHSF PITGIQYSVG ALYTTSTDKT IRVHVPTDPP
460 470 480
RTICTRRHDN GLNRVCAEGN LVVAGSGDLS LEVWRLQA
Note: No experimental confirmation available.
Length:488
Mass (Da):54,115
Last modified:September 19, 2006 - v2
Checksum:i51859E94347015DE
GO
Isoform 2 (identifier: Q5XUX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-137: Missing.

Note: No experimental confirmation available.
Show »
Length:478
Mass (Da):52,975
Checksum:iBE6E669CA11E2107
GO
Isoform 3 (identifier: Q5XUX1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-324: Missing.

Show »
Length:458
Mass (Da):50,760
Checksum:iA2A5B378211A3D06
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05759970R → K.Corresponds to variant rs6511833dbSNPEnsembl.1
Natural variantiVAR_062097219T → A.Corresponds to variant rs10424623dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020428128 – 137Missing in isoform 2. 1 Publication10
Alternative sequenceiVSP_020429295 – 324Missing in isoform 3. 2 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY736034 mRNA. Translation: AAU50678.1.
AK123037 mRNA. Translation: BAG53859.1.
AC018761 Genomic DNA. No translation available.
BC004290 mRNA. No translation available.
CCDSiCCDS12278.2. [Q5XUX1-3]
RefSeqiNP_115677.2. NM_032301.2. [Q5XUX1-3]
UniGeneiHs.515154.

Genome annotation databases

EnsembliENST00000393261; ENSP00000376945; ENSG00000132004. [Q5XUX1-3]
ENST00000587955; ENSP00000465387; ENSG00000132004. [Q5XUX1-2]
GeneIDi84261.
KEGGihsa:84261.
UCSCiuc002mum.2. human. [Q5XUX1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY736034 mRNA. Translation: AAU50678.1.
AK123037 mRNA. Translation: BAG53859.1.
AC018761 Genomic DNA. No translation available.
BC004290 mRNA. No translation available.
CCDSiCCDS12278.2. [Q5XUX1-3]
RefSeqiNP_115677.2. NM_032301.2. [Q5XUX1-3]
UniGeneiHs.515154.

3D structure databases

ProteinModelPortaliQ5XUX1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123988. 6 interactors.
IntActiQ5XUX1. 3 interactors.

PTM databases

iPTMnetiQ5XUX1.
PhosphoSitePlusiQ5XUX1.

Polymorphism and mutation databases

BioMutaiFBXW9.
DMDMi115311596.

Proteomic databases

EPDiQ5XUX1.
MaxQBiQ5XUX1.
PeptideAtlasiQ5XUX1.
PRIDEiQ5XUX1.

Protocols and materials databases

DNASUi84261.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393261; ENSP00000376945; ENSG00000132004. [Q5XUX1-3]
ENST00000587955; ENSP00000465387; ENSG00000132004. [Q5XUX1-2]
GeneIDi84261.
KEGGihsa:84261.
UCSCiuc002mum.2. human. [Q5XUX1-1]

Organism-specific databases

CTDi84261.
GeneCardsiFBXW9.
HGNCiHGNC:28136. FBXW9.
HPAiHPA042087.
MIMi609074. gene.
neXtProtiNX_Q5XUX1.
OpenTargetsiENSG00000132004.
PharmGKBiPA134910095.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000006806.
HOGENOMiHOG000112556.
HOVERGENiHBG051598.
InParanoidiQ5XUX1.
KOiK10265.
OMAiQHLSRWA.
OrthoDBiEOG091G0AVG.
PhylomeDBiQ5XUX1.
TreeFamiTF313746.

Enzyme and pathway databases

ReactomeiR-HSA-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ5XUX1.

Miscellaneous databases

GenomeRNAii84261.
PROiQ5XUX1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132004.
CleanExiHS_FBXW9.
ExpressionAtlasiQ5XUX1. baseline and differential.
GenevisibleiQ5XUX1. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBXW9_HUMAN
AccessioniPrimary (citable) accession number: Q5XUX1
Secondary accession number(s): B3KVP7, Q9BT89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: September 19, 2006
Last modified: November 30, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.