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Protein

Steroidogenic acute regulatory protein, mitochondrial

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.UniRule annotation

Pathwayi: cholesterol metabolism

This protein is involved in the pathway cholesterol metabolism, which is part of Steroid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway cholesterol metabolism and in Steroid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transportUniRule annotation, SteroidogenesisUniRule annotation, Transport
LigandLipid-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00296

Names & Taxonomyi

Protein namesi
Recommended name:
Steroidogenic acute regulatory protein, mitochondrialUniRule annotation
Short name:
StARUniRule annotation
Alternative name(s):
START domain-containing protein 1UniRule annotation
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MitochondrionUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5XUN6
SMRiQ5XUN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 279STARTInterPro annotationAdd BLAST214

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG3845 Eukaryota
ENOG41100B5 LUCA
HOVERGENiHBG010529

Family and domain databases

CDDicd08905 START_STARD1-like, 1 hit
Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR029866 StAR
IPR000799 StAR-like
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom
PANTHERiPTHR12136:SF9 PTHR12136:SF9, 1 hit
PfamiView protein in Pfam
PF01852 START, 1 hit
PRINTSiPR00978 STARPROTEIN
SMARTiView protein in SMART
SM00234 START, 1 hit
PROSITEiView protein in PROSITE
PS50848 START, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XUN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLATFKLCA GSSYRHMRNM KGLRHQAVLA IGQELNRRAL GDPSPGWMGQ
60 70 80 90 100
VRRRSSLLGS QLEATLYSDQ ELSYIQQGEE AMQKALGILN NQEGWKKESQ
110 120 130 140 150
QENGDEVLSK VVPGVGKVFR LEVLLDQPMD RLYEELVDRM EAMGEWNPNV
160 170 180 190 200
KEIKVLKKIG KDTVITHELR AAAAGNLVGP RDFVSVRCTK RRGSTCVLAG
210 220 230 240 250
MATHFGEMPE QSGVIRAEHG PTCMVLHPLA GSPSKTKLTW LLSIDLKGWL
260 270 280
PKTIINQVLS QTQIEFASHL RKRLESSPAS EAQC
Length:284
Mass (Da):31,620
Last modified:November 23, 2004 - v1
Checksum:iC2FE4E0984DA5DB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY736357 mRNA Translation: AAU84904.1
UniGeneiRn.11399

Similar proteinsi

Entry informationi

Entry nameiQ5XUN6_RAT
AccessioniPrimary (citable) accession number: Q5XUN6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health