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Q5XTS1

- PLPL8_RABIT

UniProt

Q5XTS1 - PLPL8_RABIT

Protein

Calcium-independent phospholipase A2-gamma

Gene

PNPLA8

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by E-6-bromomethylene-3-1-naphthalenyl-2H-tetrahydropyran-2-one (BEL).

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-independent phospholipase A2-gamma (EC:3.1.1.5)
    Alternative name(s):
    Group VIB calcium-independent phospholipase A2
    Intracellular membrane-associated calcium-independent phospholipase A2 gamma
    Short name:
    iPLA2-gamma
    Patatin-like phospholipase domain-containing protein 8
    Gene namesi
    Name:PNPLA8
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    Endoplasmic reticulum membrane Curated; Single-pass membrane protein Curated. Golgi apparatus membrane Curated; Single-pass membrane protein Curated. Cytoplasmperinuclear region 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 786786Calcium-independent phospholipase A2-gammaPRO_0000303216Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Modified residuei740 – 7401N6-succinyllysineBy similarity

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed in kidney, heart and brain.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000019643.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XTS1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei483 – 50321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini449 – 644196PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi485 – 4895GXSXGBy similarity

    Sequence similaritiesi

    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3621.
    HOGENOMiHOG000115579.
    HOVERGENiHBG102100.

    Family and domain databases

    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR002641. Patatin/PLipase_A2-rel.
    [Graphical view]
    PfamiPF01734. Patatin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5XTS1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSINLTIDIC IYLLSNARNL CGKHRSKQLH LVCSPNHCWK IRHVSLQRGL    50
    HPHKVRCKWT KSETHSCSKH YYSPSNHGLH IGILKLSTSA PKGLTKVSIR 100
    MSRIKSTLNS VSKAVFGSQN EMISRLAQFK PSSRILRKVS DSGWLKQESI 150
    KQAIRSLKKY SDKSTEKSPV PEGRNHIIDK EDDIGKQSLF HYTGNITTKF 200
    GESFYFLSNH INSYFKRAEK MSQDKENSHF QEKSELEGKK VEEGKSSSLD 250
    PGILTSQADK PDPKSSAGTM DKATSPSGTP ESLPISTKQS IANFLSRPTE 300
    GVQALVGGYI GGLVPKLKYD SKSQAEEQEE PAKSEPAGSK DKTVEEKKHL 350
    SLQREKIIAR VSIDNRTRAL VQALRRTADP KLCITRVEEL TFHLLEFPEG 400
    KGVAVKERLI PCLLRLRQMK DETLQAAVRE ILALIGYVDP VKGRGIRILT 450
    IDGGGTRGVV ALQTLRKLVE LTQKPVHQLF DYICGVSTGA ILAFMLGLFH 500
    LPLDECEELY RKLGSDIFSQ NVIVGTVKMS WSHAFYDSQT WEKILKERMG 550
    SALMIETARN PMCPKVAAVS TIVNRGSTPK AFVFRNYGHF PGSQSHYLGG 600
    CQYKMWQAIR ASSAAPGYFA EYALGNDLHQ DGGLLLNNPS ALAMHECKCL 650
    WPDAPLECIV SLGTGRYESD VRNNTTYTSL KTKLSNVINS ATDTEEVHIM 700
    LDGLLPPDTY FRFNPVMCEN IPLDESRNEK LDQLQLEGSK YIERNEHKMK 750
    KVAKILSQEK TTLQKINDWI KLKTDMYEGL PFFSKL 786
    Length:786
    Mass (Da):88,177
    Last modified:November 23, 2004 - v1
    Checksum:iAB130C143E718367
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY738591 mRNA. Translation: AAU85256.1.
    RefSeqiNP_001164743.1. NM_001171272.1.
    UniGeneiOcu.3212.

    Genome annotation databases

    GeneIDi100328577.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY738591 mRNA. Translation: AAU85256.1 .
    RefSeqi NP_001164743.1. NM_001171272.1.
    UniGenei Ocu.3212.

    3D structure databases

    ProteinModelPortali Q5XTS1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000019643.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100328577.

    Organism-specific databases

    CTDi 50640.

    Phylogenomic databases

    eggNOGi COG3621.
    HOGENOMi HOG000115579.
    HOVERGENi HBG102100.

    Family and domain databases

    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002641. Patatin/PLipase_A2-rel.
    [Graphical view ]
    Pfami PF01734. Patatin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, CHARACTERIZATION.
      Tissue: Heart.

    Entry informationi

    Entry nameiPLPL8_RABIT
    AccessioniPrimary (citable) accession number: Q5XTS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3