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Q5XTS1

- PLPL8_RABIT

UniProt

Q5XTS1 - PLPL8_RABIT

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Protein

Calcium-independent phospholipase A2-gamma

Gene

PNPLA8

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by E-6-bromomethylene-3-1-naphthalenyl-2H-tetrahydropyran-2-one (BEL).

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-independent phospholipase A2-gamma (EC:3.1.1.5)
Alternative name(s):
Group VIB calcium-independent phospholipase A2
Intracellular membrane-associated calcium-independent phospholipase A2 gamma
Short name:
iPLA2-gamma
Patatin-like phospholipase domain-containing protein 8
Gene namesi
Name:PNPLA8
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Endoplasmic reticulum membrane Curated; Single-pass membrane protein Curated. Golgi apparatus membrane Curated; Single-pass membrane protein Curated. Cytoplasmperinuclear region 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. Golgi apparatus Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 786786Calcium-independent phospholipase A2-gammaPRO_0000303216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Modified residuei740 – 7401N6-succinyllysineBy similarity

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Expressed in kidney, heart and brain.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000019643.

Structurei

3D structure databases

ProteinModelPortaliQ5XTS1.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei483 – 50321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini449 – 644196PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi485 – 4895GXSXGBy similarity

Sequence similaritiesi

Contains 1 patatin domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3621.
HOGENOMiHOG000115579.
HOVERGENiHBG102100.
InParanoidiQ5XTS1.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002641. Patatin/PLipase_A2-rel.
[Graphical view]
PfamiPF01734. Patatin. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XTS1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSINLTIDIC IYLLSNARNL CGKHRSKQLH LVCSPNHCWK IRHVSLQRGL
60 70 80 90 100
HPHKVRCKWT KSETHSCSKH YYSPSNHGLH IGILKLSTSA PKGLTKVSIR
110 120 130 140 150
MSRIKSTLNS VSKAVFGSQN EMISRLAQFK PSSRILRKVS DSGWLKQESI
160 170 180 190 200
KQAIRSLKKY SDKSTEKSPV PEGRNHIIDK EDDIGKQSLF HYTGNITTKF
210 220 230 240 250
GESFYFLSNH INSYFKRAEK MSQDKENSHF QEKSELEGKK VEEGKSSSLD
260 270 280 290 300
PGILTSQADK PDPKSSAGTM DKATSPSGTP ESLPISTKQS IANFLSRPTE
310 320 330 340 350
GVQALVGGYI GGLVPKLKYD SKSQAEEQEE PAKSEPAGSK DKTVEEKKHL
360 370 380 390 400
SLQREKIIAR VSIDNRTRAL VQALRRTADP KLCITRVEEL TFHLLEFPEG
410 420 430 440 450
KGVAVKERLI PCLLRLRQMK DETLQAAVRE ILALIGYVDP VKGRGIRILT
460 470 480 490 500
IDGGGTRGVV ALQTLRKLVE LTQKPVHQLF DYICGVSTGA ILAFMLGLFH
510 520 530 540 550
LPLDECEELY RKLGSDIFSQ NVIVGTVKMS WSHAFYDSQT WEKILKERMG
560 570 580 590 600
SALMIETARN PMCPKVAAVS TIVNRGSTPK AFVFRNYGHF PGSQSHYLGG
610 620 630 640 650
CQYKMWQAIR ASSAAPGYFA EYALGNDLHQ DGGLLLNNPS ALAMHECKCL
660 670 680 690 700
WPDAPLECIV SLGTGRYESD VRNNTTYTSL KTKLSNVINS ATDTEEVHIM
710 720 730 740 750
LDGLLPPDTY FRFNPVMCEN IPLDESRNEK LDQLQLEGSK YIERNEHKMK
760 770 780
KVAKILSQEK TTLQKINDWI KLKTDMYEGL PFFSKL
Length:786
Mass (Da):88,177
Last modified:November 23, 2004 - v1
Checksum:iAB130C143E718367
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY738591 mRNA. Translation: AAU85256.1.
RefSeqiNP_001164743.1. NM_001171272.1.
UniGeneiOcu.3212.

Genome annotation databases

GeneIDi100328577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY738591 mRNA. Translation: AAU85256.1 .
RefSeqi NP_001164743.1. NM_001171272.1.
UniGenei Ocu.3212.

3D structure databases

ProteinModelPortali Q5XTS1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000019643.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100328577.

Organism-specific databases

CTDi 50640.

Phylogenomic databases

eggNOGi COG3621.
HOGENOMi HOG000115579.
HOVERGENi HBG102100.
InParanoidi Q5XTS1.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002641. Patatin/PLipase_A2-rel.
[Graphical view ]
Pfami PF01734. Patatin. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, CHARACTERIZATION.
    Tissue: Heart.

Entry informationi

Entry nameiPLPL8_RABIT
AccessioniPrimary (citable) accession number: Q5XTS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3