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Q5XQP9

- TRPF_SACK1

UniProt

Q5XQP9 - TRPF_SACK1

Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

TRP1

Organism
Saccharomyces kudriavzevii (strain ATCC MYA-4449 / AS 2.2408 / CBS 8840 / NBRC 1802 / NCYC 2889) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00035; UER00042.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Gene namesi
    Name:TRP1
    OrganismiSaccharomyces kudriavzevii (strain ATCC MYA-4449 / AS 2.2408 / CBS 8840 / NBRC 1802 / NCYC 2889) (Yeast)
    Taxonomic identifieri226230 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002753: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154336Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XQP9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpF family.Curated

    Phylogenomic databases

    OrthoDBiEOG76MKM7.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00697. PRAI. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5XQP9-1 [UniParc]FASTAAdd to Basket

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    MSFVNIRSSR GPVVKVCGLQ SLKAAQCALD SDADLLGIIC VPGRERTVDP    50
    VVAMEISALV RACRTSMSTP KYLVGVFRNQ SKEDVLRIAN DYGIDIVQLH 100
    GDEPWQEYQK FLGLPVIKRL VFPRDCDILL STPSEKTHLF MPLFDSEAGG 150
    TGELLDWNSI SDWFAEQGNP ECLQFMLAGG LTPENVSDAL QLHGVIGVDV 200
    SGGVETNGMK DMDKITNFVR NAKKES 226
    Length:226
    Mass (Da):24,791
    Last modified:November 23, 2004 - v1
    Checksum:i79E79FF6030BF5AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY740027 Genomic DNA. Translation: AAU43745.1.
    AACI03000993 Genomic DNA. Translation: EJT43161.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY740027 Genomic DNA. Translation: AAU43745.1 .
    AACI03000993 Genomic DNA. Translation: EJT43161.1 .

    3D structure databases

    ProteinModelPortali Q5XQP9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG76MKM7.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00042 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00697. PRAI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Parallel inactivation of multiple GAL pathway genes and ecological diversification in yeasts."
      Hittinger C.T., Rokas A., Carroll S.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:14144-14149(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC MYA-4449 / AS 2.2408 / CBS 8840 / NBRC 1802 / NCYC 2889.
    2. "Finding functional features in Saccharomyces genomes by phylogenetic footprinting."
      Cliften P.F., Sudarsanam P., Desikan A., Fulton L., Fulton B., Majors J., Waterston R., Cohen B.A., Johnston M.
      Science 301:71-76(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4449 / AS 2.2408 / CBS 8840 / NBRC 1802 / NCYC 2889.
    3. "The awesome power of yeast evolutionary genetics: New genome sequences and strain resources for the Saccharomyces sensu stricto genus."
      Scannell D.R., Zill O.A., Rokas A., Payen C., Dunham M.J., Eisen M.B., Rine J., Johnston M., Hittinger C.T.
      G3 (Bethesda) 1:11-25(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: ATCC MYA-4449 / AS 2.2408 / CBS 8840 / NBRC 1802 / NCYC 2889.

    Entry informationi

    Entry nameiTRPF_SACK1
    AccessioniPrimary (citable) accession number: Q5XQP9
    Secondary accession number(s): J5RY70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3