Q5XQP9 (TRPF_SACK1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase
Short name=PRAI
EC=5.3.1.24

Gene names

Name:

TRP1

Organism

Saccharomyces kudriavzevii (strain ATCC MYA-4449 / AS 2.2408 / CBS 8840 / NBRC 1802 / NCYC 2889) [Complete proteome]

Taxonomic identifier

226230 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces kudriavzevii

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.
Sequence similarities	Belongs to the TrpF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	phosphoribosylanthranilate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	N-(5'-phosphoribosyl)anthranilate isomerase		PRO_0000154336

Sequences

	Sequence		Length	Mass (Da)
	Q5XQP9 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 79E79FF6030BF5AC	FASTA	226	24,791
	10 20 30 40 50 60 MSFVNIRSSR GPVVKVCGLQ SLKAAQCALD SDADLLGIIC VPGRERTVDP VVAMEISALV 70 80 90 100 110 120 RACRTSMSTP KYLVGVFRNQ SKEDVLRIAN DYGIDIVQLH GDEPWQEYQK FLGLPVIKRL 130 140 150 160 170 180 VFPRDCDILL STPSEKTHLF MPLFDSEAGG TGELLDWNSI SDWFAEQGNP ECLQFMLAGG 190 200 210 220 LTPENVSDAL QLHGVIGVDV SGGVETNGMK DMDKITNFVR NAKKES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Parallel inactivation of multiple GAL pathway genes and ecological diversification in yeasts." Hittinger C.T., Rokas A., Carroll S.B. Proc. Natl. Acad. Sci. U.S.A. 101:14144-14149(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC MYA-4449 / AS 2.2408 / CBS 8840 / NBRC 1802 / NCYC 2889.
[2]	"Finding functional features in Saccharomyces genomes by phylogenetic footprinting." Cliften P.F., Sudarsanam P., Desikan A., Fulton L., Fulton B., Majors J., Waterston R., Cohen B.A., Johnston M. Science 301:71-76(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4449 / AS 2.2408 / CBS 8840 / NBRC 1802 / NCYC 2889.
[3]	"The awesome power of yeast evolutionary genetics: New genome sequences and strain resources for the Saccharomyces sensu stricto genus." Scannell D.R., Zill O.A., Rokas A., Payen C., Dunham M.J., Eisen M.B., Rine J., Johnston M., Hittinger C.T. G3 (Bethesda) 1:11-25(2011) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: ATCC MYA-4449 / AS 2.2408 / CBS 8840 / NBRC 1802 / NCYC 2889.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY740027 Genomic DNA. Translation: AAU43745.1. AACI03000993 Genomic DNA. Translation: EJT43161.1.
3D structure databases
ProteinModelPortal	Q5XQP9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00035; UER00042.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR001240. PRAI. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00697. PRAI. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPF_SACK1

Accession

Primary (citable) accession number: Q5XQP9
Secondary accession number(s): J5RY70

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	November 23, 2004
Last modified:	April 3, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program