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Protein

Keratin, type II cytoskeletal 5

Gene

KRT5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei420StutterSequence analysis1

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 5
Alternative name(s):
Cytokeratin-5
Short name:
CK-5
Keratin-5
Short name:
K5
Type-II keratin Kb5
Gene namesi
Name:KRT5By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Involvement in diseasei

Defects in KRT5 are a cause of epidermolysis bullosa simplex [EBS]. EBS leads to loss of skin and mucosa from contact areas and inflammation, due to separation of the epidermis from the dermis.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637261 – 601Keratin, type II cytoskeletal 5Add BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Modified residuei26PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei64PhosphoserineBy similarity1
Modified residuei71PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XQN5.
PeptideAtlasiQ5XQN5.
PRIDEiQ5XQN5.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP (By similarity). Interacts with KEPPK1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021456.

Structurei

3D structure databases

ProteinModelPortaliQ5XQN5.
SMRiQ5XQN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 482IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 168HeadSequence analysisAdd BLAST168
Regioni169 – 204Coil 1ASequence analysisAdd BLAST36
Regioni205 – 223Linker 1Sequence analysisAdd BLAST19
Regioni224 – 316Coil 1BSequence analysisAdd BLAST93
Regioni317 – 339Linker 12Sequence analysisAdd BLAST23
Regioni340 – 478Coil 2Sequence analysisAdd BLAST139
Regioni479 – 601TailSequence analysisAdd BLAST123

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 140Gly-richSequence analysisAdd BLAST102
Compositional biasi502 – 581Gly-richSequence analysisAdd BLAST80
Compositional biasi542 – 601Ser-richSequence analysisAdd BLAST60

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ5XQN5.
KOiK07605.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
PRINTSiPR01276. TYPE2KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
PROSITEiView protein in PROSITE
PS00226. IF_ROD_1. 1 hit.
PS51842. IF_ROD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XQN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQSTVSFR SGGGRSFSTA SAITPSVSRT SFTSVSRSGG GGGGGFGRVS
60 70 80 90 100
LGGAYGAGGF GSRSLYNLGG SKRISISASG GGFRNRFGAG AGGGYGFGGG
110 120 130 140 150
AGSGFGFGGG AGGGGFGLGG GAGFGGGFGG PGFPVCPPGG IQEVTVNQSL
160 170 180 190 200
LTPLNLQIDP TIQRVRTEER EQIKTLNNKF ASFIDKVRFL EQQNKVLDTK
210 220 230 240 250
WALLQEQGTK TVRQNLEPLL EQYINNLRRQ LDGIVGERGR LDSELRNMQD
260 270 280 290 300
LVEDFKNKYE DEINKRTTAE NEFVMLKKDV DAAYMNKVEL EAKVDALMDE
310 320 330 340 350
INFMKMFFDA ELSQMQTHVS DTSVVLSMDN NRSLDLDSII AEVKAQYEDI
360 370 380 390 400
ANRSRTEAES WYQTKYEELQ QTAGRHGDDL RNTKHEISEM NRMIQRLRSE
410 420 430 440 450
IDNVKKQCAN LQNAIADAEQ RGELALKDAR SKLAELEDAL QKAKQDMARL
460 470 480 490 500
LREYQELMNT KLALDVEIAT YRKLLEGEEC RLSGEGVGPV NISVVTNTVS
510 520 530 540 550
SGYGGGSGFG GGLGGGLGGG LGGGLGGGLG GGLGSGLGGG GSSSFYSSSS
560 570 580 590 600
GGVGLGGGLS VGGSGFSASS GRSLGFGSGG GSSSSVKFVS TTSSSRKSFK

S
Length:601
Mass (Da):62,937
Last modified:November 23, 2004 - v1
Checksum:i62592254B22DE0A2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti478E → K in EBS. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY740402 Genomic DNA. Translation: AAU95600.1.
RefSeqiNP_001008663.1. NM_001008663.1.
UniGeneiBt.13162.

Genome annotation databases

GeneIDi281268.
KEGGibta:281268.

Similar proteinsi

Entry informationi

Entry nameiK2C5_BOVIN
AccessioniPrimary (citable) accession number: Q5XQN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 23, 2004
Last modified: October 25, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families