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Q5XLA6

- CAR17_HUMAN

UniProt

Q5XLA6 - CAR17_HUMAN

Protein

Caspase recruitment domain-containing protein 17

Gene

CARD17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.1 Publication

    GO - Molecular functioni

    1. cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of apoptotic process Source: InterPro

    Keywords - Molecular functioni

    Protease inhibitor, Thiol protease inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caspase recruitment domain-containing protein 17
    Alternative name(s):
    Caspase-1 inhibitor INCA
    Inhibitory caspase recruitment domain protein
    Gene namesi
    Name:CARD17
    Synonyms:INCA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:33827. CARD17.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164717641.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 110110Caspase recruitment domain-containing protein 17PRO_0000344504Add
    BLAST

    Proteomic databases

    PaxDbiQ5XLA6.
    PRIDEiQ5XLA6.

    PTM databases

    PhosphoSiteiQ5XLA6.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Inductioni

    By IFNG/IFN-gamma in monocytic cell lines.1 Publication

    Gene expression databases

    BgeeiQ5XLA6.
    CleanExiHS_CARD17.
    GenevestigatoriQ5XLA6.

    Interactioni

    Subunit structurei

    Interacts with pro-CASP1.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XLA6.
    SMRiQ5XLA6. Positions 2-89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9191CARDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CARD domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG326166.
    HOGENOMiHOG000111301.
    HOVERGENiHBG006113.
    InParanoidiQ5XLA6.
    OMAiNGKREND.
    OrthoDBiEOG7J1812.
    PhylomeDBiQ5XLA6.
    TreeFamiTF330675.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR001315. CARD.
    IPR011029. DEATH-like_dom.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    [Graphical view]
    SMARTiSM00114. CARD. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5XLA6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADKVLKEKR KQFIRSVGEG TINGLLGELL ETRVLSQEEI EIVKCENATV    50
    MDKARALLDS VIRKGAPACQ ICITYICEED SHLAGTLGLS AGPTSGNHLT 100
    TQDSQIVLPS 110
    Length:110
    Mass (Da):11,868
    Last modified:November 23, 2004 - v1
    Checksum:i84B5BAE7345E32B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY761064 mRNA. Translation: AAV28630.1.
    CCDSiCCDS31662.1.
    RefSeqiNP_001007233.1. NM_001007232.1.
    UniGeneiHs.732627.

    Genome annotation databases

    EnsembliENST00000375707; ENSP00000364859; ENSG00000255221.
    GeneIDi440068.
    KEGGihsa:440068.
    UCSCiuc001pir.1. human.

    Polymorphism databases

    DMDMi74724394.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY761064 mRNA. Translation: AAV28630.1 .
    CCDSi CCDS31662.1.
    RefSeqi NP_001007233.1. NM_001007232.1.
    UniGenei Hs.732627.

    3D structure databases

    ProteinModelPortali Q5XLA6.
    SMRi Q5XLA6. Positions 2-89.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q5XLA6.

    Polymorphism databases

    DMDMi 74724394.

    Proteomic databases

    PaxDbi Q5XLA6.
    PRIDEi Q5XLA6.

    Protocols and materials databases

    DNASUi 440068.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375707 ; ENSP00000364859 ; ENSG00000255221 .
    GeneIDi 440068.
    KEGGi hsa:440068.
    UCSCi uc001pir.1. human.

    Organism-specific databases

    CTDi 440068.
    GeneCardsi GC11M104963.
    HGNCi HGNC:33827. CARD17.
    MIMi 609490. gene.
    neXtProti NX_Q5XLA6.
    PharmGKBi PA164717641.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG326166.
    HOGENOMi HOG000111301.
    HOVERGENi HBG006113.
    InParanoidi Q5XLA6.
    OMAi NGKREND.
    OrthoDBi EOG7J1812.
    PhylomeDBi Q5XLA6.
    TreeFami TF330675.

    Miscellaneous databases

    GenomeRNAii 440068.
    NextBioi 108895.
    PROi Q5XLA6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5XLA6.
    CleanExi HS_CARD17.
    Genevestigatori Q5XLA6.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR001315. CARD.
    IPR011029. DEATH-like_dom.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    [Graphical view ]
    SMARTi SM00114. CARD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation."
      Lamkanfi M., Denecker G., Kalai M., D'hondt K., Meeus A., Declercq W., Saelens X., Vandenabeele P.
      J. Biol. Chem. 279:51729-51738(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CASP1, INDUCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCAR17_HUMAN
    AccessioniPrimary (citable) accession number: Q5XLA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3