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Protein

Caspase recruitment domain-containing protein 17

Gene

CARD17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 17
Alternative name(s):
Caspase-1 inhibitor INCA
Inhibitory caspase recruitment domain protein
Gene namesi
Name:CARD17
Synonyms:INCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:33827. CARD17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717641.

Polymorphism and mutation databases

BioMutaiCARD17.
DMDMi74724394.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 110110Caspase recruitment domain-containing protein 17PRO_0000344504Add
BLAST

Proteomic databases

PaxDbiQ5XLA6.
PRIDEiQ5XLA6.

PTM databases

PhosphoSiteiQ5XLA6.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Inductioni

By IFNG/IFN-gamma in monocytic cell lines.1 Publication

Gene expression databases

BgeeiQ5XLA6.
CleanExiHS_CARD17.

Interactioni

Subunit structurei

Interacts with pro-CASP1.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000364859.

Structurei

3D structure databases

ProteinModelPortaliQ5XLA6.
SMRiQ5XLA6. Positions 2-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9191CARDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG326166.
GeneTreeiENSGT00510000049857.
HOGENOMiHOG000111301.
HOVERGENiHBG006113.
InParanoidiQ5XLA6.
OMAiPACQICI.
OrthoDBiEOG7J1812.
PhylomeDBiQ5XLA6.
TreeFamiTF330675.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XLA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKVLKEKR KQFIRSVGEG TINGLLGELL ETRVLSQEEI EIVKCENATV
60 70 80 90 100
MDKARALLDS VIRKGAPACQ ICITYICEED SHLAGTLGLS AGPTSGNHLT
110
TQDSQIVLPS
Length:110
Mass (Da):11,868
Last modified:November 23, 2004 - v1
Checksum:i84B5BAE7345E32B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY761064 mRNA. Translation: AAV28630.1.
CCDSiCCDS31662.1.
RefSeqiNP_001007233.1. NM_001007232.1.
UniGeneiHs.732627.

Genome annotation databases

EnsembliENST00000375707; ENSP00000364859; ENSG00000255221.
GeneIDi440068.
KEGGihsa:440068.
UCSCiuc001pir.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY761064 mRNA. Translation: AAV28630.1.
CCDSiCCDS31662.1.
RefSeqiNP_001007233.1. NM_001007232.1.
UniGeneiHs.732627.

3D structure databases

ProteinModelPortaliQ5XLA6.
SMRiQ5XLA6. Positions 2-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000364859.

PTM databases

PhosphoSiteiQ5XLA6.

Polymorphism and mutation databases

BioMutaiCARD17.
DMDMi74724394.

Proteomic databases

PaxDbiQ5XLA6.
PRIDEiQ5XLA6.

Protocols and materials databases

DNASUi440068.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375707; ENSP00000364859; ENSG00000255221.
GeneIDi440068.
KEGGihsa:440068.
UCSCiuc001pir.1. human.

Organism-specific databases

CTDi440068.
GeneCardsiGC11M104963.
HGNCiHGNC:33827. CARD17.
MIMi609490. gene.
neXtProtiNX_Q5XLA6.
PharmGKBiPA164717641.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG326166.
GeneTreeiENSGT00510000049857.
HOGENOMiHOG000111301.
HOVERGENiHBG006113.
InParanoidiQ5XLA6.
OMAiPACQICI.
OrthoDBiEOG7J1812.
PhylomeDBiQ5XLA6.
TreeFamiTF330675.

Miscellaneous databases

GenomeRNAii440068.
NextBioi108895.
PROiQ5XLA6.
SOURCEiSearch...

Gene expression databases

BgeeiQ5XLA6.
CleanExiHS_CARD17.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation."
    Lamkanfi M., Denecker G., Kalai M., D'hondt K., Meeus A., Declercq W., Saelens X., Vandenabeele P.
    J. Biol. Chem. 279:51729-51738(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CASP1, INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCAR17_HUMAN
AccessioniPrimary (citable) accession number: Q5XLA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: November 23, 2004
Last modified: June 24, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.