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Protein

Caspase recruitment domain-containing protein 17

Gene

CARD17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.1 Publication

GO - Molecular functioni

  • caspase binding Source: UniProtKB
  • cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW
  • identical protein binding Source: UniProtKB

GO - Biological processi

  • cellular response to lipopolysaccharide Source: UniProtKB
  • negative regulation of interleukin-1 beta secretion Source: UniProtKB
  • regulation of apoptotic process Source: InterPro

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 17
Alternative name(s):
Caspase-1 inhibitor INCA
Inhibitory caspase recruitment domain protein
Gene namesi
Name:CARD17
Synonyms:INCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000255221.2.
HGNCiHGNC:33827. CARD17.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi440068.
OpenTargetsiENSG00000255221.
PharmGKBiPA164717641.

Polymorphism and mutation databases

BioMutaiCARD17.
DMDMi74724394.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003445041 – 110Caspase recruitment domain-containing protein 17Add BLAST110

Proteomic databases

PaxDbiQ5XLA6.
PeptideAtlasiQ5XLA6.
PRIDEiQ5XLA6.

PTM databases

iPTMnetiQ5XLA6.
PhosphoSitePlusiQ5XLA6.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Inductioni

By IFNG/IFN-gamma in monocytic cell lines.1 Publication

Gene expression databases

BgeeiENSG00000255221.
CleanExiHS_CARD17.

Interactioni

Subunit structurei

Interacts with pro-CASP1.1 Publication

GO - Molecular functioni

  • caspase binding Source: UniProtKB
  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-61990N.
STRINGi9606.ENSP00000364859.

Structurei

3D structure databases

ProteinModelPortaliQ5XLA6.
SMRiQ5XLA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 91CARDPROSITE-ProRule annotationAdd BLAST91

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00510000049857.
HOGENOMiHOG000111301.
HOVERGENiHBG006113.
InParanoidiQ5XLA6.
KOiK12806.
OMAiPACQICI.
OrthoDBiEOG091G0XYK.
PhylomeDBiQ5XLA6.
TreeFamiTF330675.

Family and domain databases

InterProiView protein in InterPro
IPR001315. CARD.
IPR011029. DEATH-like_dom.
PfamiView protein in Pfam
PF00619. CARD. 1 hit.
SMARTiView protein in SMART
SM00114. CARD. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50209. CARD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XLA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKVLKEKR KQFIRSVGEG TINGLLGELL ETRVLSQEEI EIVKCENATV
60 70 80 90 100
MDKARALLDS VIRKGAPACQ ICITYICEED SHLAGTLGLS AGPTSGNHLT
110
TQDSQIVLPS
Length:110
Mass (Da):11,868
Last modified:November 23, 2004 - v1
Checksum:i84B5BAE7345E32B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY761064 mRNA. Translation: AAV28630.1.
CCDSiCCDS31662.1.
RefSeqiNP_001007233.1. NM_001007232.1.
UniGeneiHs.732627.

Genome annotation databases

EnsembliENST00000375707; ENSP00000364859; ENSG00000255221.
GeneIDi440068.
KEGGihsa:440068.
UCSCiuc001pir.1. human.

Similar proteinsi

Entry informationi

Entry nameiCAR17_HUMAN
AccessioniPrimary (citable) accession number: Q5XLA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: November 23, 2004
Last modified: September 27, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot