Q5XLA6 (CAR17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Caspase recruitment domain-containing protein 17

Alternative name(s):
Caspase-1 inhibitor INCA
Inhibitory caspase recruitment domain protein

Gene names

Name:	CARD17
Synonyms:	INCA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation. Ref.1
Subunit structure	Interacts with pro-CASP1. Ref.1
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Ubiquitous. Ref.1
Induction	By IFNG/IFN-gamma in monocytic cell lines. Ref.1
Sequence similarities	Contains 1 CARD domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Protease inhibitor Thiol protease inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: InterPro regulation of apoptotic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro cysteine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 110	110	Caspase recruitment domain-containing protein 17		PRO_0000344504
Regions
	Domain	1 – 91	91	CARD

Sequences

	Sequence		Length	Mass (Da)
	Q5XLA6 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 84B5BAE7345E32B3	FASTA	110	11,868
	10 20 30 40 50 60 MADKVLKEKR KQFIRSVGEG TINGLLGELL ETRVLSQEEI EIVKCENATV MDKARALLDS 70 80 90 100 110 VIRKGAPACQ ICITYICEED SHLAGTLGLS AGPTSGNHLT TQDSQIVLPS

References

[1]

"INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation." Lamkanfi M., Denecker G., Kalai M., D'hondt K., Meeus A., Declercq W., Saelens X., Vandenabeele P. J. Biol. Chem. 279:51729-51738(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CASP1, INDUCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY761064 mRNA. Translation: AAV28630.1.
IPI	IPI00478702.
RefSeq	NP_001007233.1. NM_001007232.1.
UniGene	Hs.732627.
3D structure databases
HSSP	HSSP built from PDB template 1DGN based on UniProtKB P57730.
ProteinModelPortal	Q5XLA6.
ModBase	Search...
PTM databases
PhosphoSite	Q5XLA6.
Polymorphism databases
DMDM	74724394.
Proteomic databases
PaxDb	Q5XLA6.
PRIDE	Q5XLA6.
Protocols and materials databases
DNASU	440068.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000375707; ENSP00000364859; ENSG00000255221.
GeneID	440068.
KEGG	hsa:440068.
UCSC	uc001pir.1. human.
Organism-specific databases
CTD	440068.
GeneCards	GC11M104963.
HGNC	HGNC:33827. CARD17.
MIM	609490. gene.
neXtProt	NX_Q5XLA6.
PharmGKB	PA164717641.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG326166.
HOGENOM	HOG000111301.
HOVERGEN	HBG006113.
InParanoid	Q5XLA6.
OMA	PACQICI.
Gene expression databases
Bgee	Q5XLA6.
CleanEx	HS_CARD17.
Genevestigator	Q5XLA6.
Family and domain databases
Gene3D	1.10.533.10. 1 hit.
InterPro	IPR001315. CARD. IPR011029. DEATH-like_dom. IPR002398. Pept_C14_p45. [Graphical view]
PANTHER	PTHR10454. PTHR10454. 1 hit.
Pfam	PF00619. CARD. 1 hit. [Graphical view]
SMART	SM00114. CARD. 1 hit. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 1 hit.
PROSITE	PS50209. CARD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	440068.
NextBio	108895.
SOURCE	Search...

Entry information

Entry name

CAR17_HUMAN

Accession

Primary (citable) accession number: Q5XLA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	November 23, 2004
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.