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Protein

Caspase recruitment domain-containing protein 17

Gene

CARD17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.1 Publication

GO - Molecular functioni

  • caspase binding Source: UniProtKB
  • cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW
  • identical protein binding Source: UniProtKB

GO - Biological processi

  • cellular response to lipopolysaccharide Source: UniProtKB
  • negative regulation of interleukin-1 beta secretion Source: UniProtKB
  • regulation of apoptotic process Source: InterPro

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 17
Alternative name(s):
Caspase-1 inhibitor INCA
Inhibitory caspase recruitment domain protein
Gene namesi
Name:CARD17
Synonyms:INCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000255221.2
HGNCiHGNC:33827 CARD17
MIMi609490 gene
neXtProtiNX_Q5XLA6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi440068
OpenTargetsiENSG00000255221
PharmGKBiPA164717641

Polymorphism and mutation databases

BioMutaiCARD17
DMDMi74724394

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003445041 – 110Caspase recruitment domain-containing protein 17Add BLAST110

Proteomic databases

PaxDbiQ5XLA6
PeptideAtlasiQ5XLA6
PRIDEiQ5XLA6

PTM databases

iPTMnetiQ5XLA6
PhosphoSitePlusiQ5XLA6

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Inductioni

By IFNG/IFN-gamma in monocytic cell lines.1 Publication

Gene expression databases

BgeeiENSG00000255221
CleanExiHS_CARD17

Interactioni

Subunit structurei

Interacts with pro-CASP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CASP1P294663EBI-16203934,EBI-516667

GO - Molecular functioni

  • caspase binding Source: UniProtKB
  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-61990N
IntActiQ5XLA6, 1 interactor
STRINGi9606.ENSP00000364859

Structurei

3D structure databases

ProteinModelPortaliQ5XLA6
SMRiQ5XLA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 91CARDPROSITE-ProRule annotationAdd BLAST91

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00510000049857
HOGENOMiHOG000111301
HOVERGENiHBG006113
InParanoidiQ5XLA6
KOiK12806
OMAiPACQICI
OrthoDBiEOG091G0XYK
PhylomeDBiQ5XLA6
TreeFamiTF330675

Family and domain databases

InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
PfamiView protein in Pfam
PF00619 CARD, 1 hit
SMARTiView protein in SMART
SM00114 CARD, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XLA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKVLKEKR KQFIRSVGEG TINGLLGELL ETRVLSQEEI EIVKCENATV
60 70 80 90 100
MDKARALLDS VIRKGAPACQ ICITYICEED SHLAGTLGLS AGPTSGNHLT
110
TQDSQIVLPS
Length:110
Mass (Da):11,868
Last modified:November 23, 2004 - v1
Checksum:i84B5BAE7345E32B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY761064 mRNA Translation: AAV28630.1
CCDSiCCDS31662.1
RefSeqiNP_001007233.1, NM_001007232.1
UniGeneiHs.732627

Genome annotation databases

EnsembliENST00000375707; ENSP00000364859; ENSG00000255221
GeneIDi440068
KEGGihsa:440068
UCSCiuc001pir.1 human

Similar proteinsi

Entry informationi

Entry nameiCAR17_HUMAN
AccessioniPrimary (citable) accession number: Q5XLA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: November 23, 2004
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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