Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5XLA6

- CAR17_HUMAN

UniProt

Q5XLA6 - CAR17_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Caspase recruitment domain-containing protein 17

Gene

CARD17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.1 Publication

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of apoptotic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 17
Alternative name(s):
Caspase-1 inhibitor INCA
Inhibitory caspase recruitment domain protein
Gene namesi
Name:CARD17
Synonyms:INCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:33827. CARD17.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717641.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 110110Caspase recruitment domain-containing protein 17PRO_0000344504Add
BLAST

Proteomic databases

PaxDbiQ5XLA6.
PRIDEiQ5XLA6.

PTM databases

PhosphoSiteiQ5XLA6.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Inductioni

By IFNG/IFN-gamma in monocytic cell lines.1 Publication

Gene expression databases

BgeeiQ5XLA6.
CleanExiHS_CARD17.
GenevestigatoriQ5XLA6.

Interactioni

Subunit structurei

Interacts with pro-CASP1.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ5XLA6.
SMRiQ5XLA6. Positions 2-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9191CARDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG326166.
GeneTreeiENSGT00510000049857.
HOGENOMiHOG000111301.
HOVERGENiHBG006113.
InParanoidiQ5XLA6.
OMAiNGKREND.
OrthoDBiEOG7J1812.
PhylomeDBiQ5XLA6.
TreeFamiTF330675.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XLA6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADKVLKEKR KQFIRSVGEG TINGLLGELL ETRVLSQEEI EIVKCENATV
60 70 80 90 100
MDKARALLDS VIRKGAPACQ ICITYICEED SHLAGTLGLS AGPTSGNHLT
110
TQDSQIVLPS
Length:110
Mass (Da):11,868
Last modified:November 23, 2004 - v1
Checksum:i84B5BAE7345E32B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY761064 mRNA. Translation: AAV28630.1.
CCDSiCCDS31662.1.
RefSeqiNP_001007233.1. NM_001007232.1.
UniGeneiHs.732627.

Genome annotation databases

EnsembliENST00000375707; ENSP00000364859; ENSG00000255221.
GeneIDi440068.
KEGGihsa:440068.
UCSCiuc001pir.1. human.

Polymorphism databases

DMDMi74724394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY761064 mRNA. Translation: AAV28630.1 .
CCDSi CCDS31662.1.
RefSeqi NP_001007233.1. NM_001007232.1.
UniGenei Hs.732627.

3D structure databases

ProteinModelPortali Q5XLA6.
SMRi Q5XLA6. Positions 2-89.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q5XLA6.

Polymorphism databases

DMDMi 74724394.

Proteomic databases

PaxDbi Q5XLA6.
PRIDEi Q5XLA6.

Protocols and materials databases

DNASUi 440068.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375707 ; ENSP00000364859 ; ENSG00000255221 .
GeneIDi 440068.
KEGGi hsa:440068.
UCSCi uc001pir.1. human.

Organism-specific databases

CTDi 440068.
GeneCardsi GC11M104963.
HGNCi HGNC:33827. CARD17.
MIMi 609490. gene.
neXtProti NX_Q5XLA6.
PharmGKBi PA164717641.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG326166.
GeneTreei ENSGT00510000049857.
HOGENOMi HOG000111301.
HOVERGENi HBG006113.
InParanoidi Q5XLA6.
OMAi NGKREND.
OrthoDBi EOG7J1812.
PhylomeDBi Q5XLA6.
TreeFami TF330675.

Miscellaneous databases

GenomeRNAii 440068.
NextBioi 108895.
PROi Q5XLA6.
SOURCEi Search...

Gene expression databases

Bgeei Q5XLA6.
CleanExi HS_CARD17.
Genevestigatori Q5XLA6.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
InterProi IPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
[Graphical view ]
SMARTi SM00114. CARD. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation."
    Lamkanfi M., Denecker G., Kalai M., D'hondt K., Meeus A., Declercq W., Saelens X., Vandenabeele P.
    J. Biol. Chem. 279:51729-51738(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CASP1, INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCAR17_HUMAN
AccessioniPrimary (citable) accession number: Q5XLA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3