Q5XKR4 (OTP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein orthopedia

Gene names

Name:

OTP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably involved in the differentiation of hypothalamic neuroendocrine cells.
Subcellular location	Nucleus Ref.2.
Developmental stage	Present in fetal hypothalamus at 19 weeks of gestation (at protein level). Ref.2
Sequence similarities	Belongs to the paired homeobox family. Bicoid subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	forebrain neuron differentiation Inferred from electronic annotation. Source: Compara hypothalamus cell differentiation Inferred from electronic annotation. Source: Compara neurohypophysis development Inferred from electronic annotation. Source: Compara positive regulation of neuroblast proliferation Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro transcription regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Homeobox protein orthopedia		PRO_0000292432
Regions
	DNA binding	104 – 163	60	Homeobox
	Motif	306 – 319	14	OAR
	Compositional bias	187 – 194	8	Poly-Ala
	Compositional bias	210 – 213	4	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	Q5XKR4 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 429E3A91E0A9BA5F	FASTA	325	34,159
	10 20 30 40 50 60 MLSHADLLDA RLGMKDAAEL LGHREAVKCR LGVGGSDPGG HPGDLAPNSD PVEGATLLPG 70 80 90 100 110 120 EDITTVGSTP ASLAVSAKDP DKQPGPQGGP NPSQAGQQQG QQKQKRHRTR FTPAQLNELE 130 140 150 160 170 180 RSFAKTHYPD IFMREELALR IGLTESRVQV WFQNRRAKWK KRKKTTNVFR APGTLLPTPG 190 200 210 220 230 240 LPQFPSAAAA AAAAMGDSLC SFHANDTRWA AAAMPGVSQL PLPPALGRQQ AMAQSLSQCS 250 260 270 280 290 300 LAAGPPPNSM GLSNSLAGSN GAGLQSHLYQ PAFPGMVPAS LPGPSNVSGS PQLCSSPDSS 310 320 DVWRGTSIAS LRRKALEHTV SMSFT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[2]	"Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP)." Lin X., State M.W., Vaccarino F.M., Greally J., Hass M., Leckman J.F. Genomics 60:96-104(1999) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC001800 mRNA. Translation: AAH01800.1.
IPI	IPI00029796.
RefSeq	NP_115485.1. NM_032109.2.
UniGene	Hs.202247.
3D structure databases
HSSP	HSSP built from PDB template 1FJL based on UniProtKB P06601.
ProteinModelPortal	Q5XKR4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000302814.
Polymorphism databases
DMDM	74762283.
Proteomic databases
PaxDb	Q5XKR4.
PRIDE	Q5XKR4.
Protocols and materials databases
DNASU	23440.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306422; ENSP00000302814; ENSG00000171540.
GeneID	23440.
KEGG	hsa:23440.
UCSC	uc003kfg.3. human.
Organism-specific databases
CTD	23440.
GeneCards	GC05M076960.
HGNC	HGNC:8518. OTP.
HPA	HPA039365.
MIM	604529. gene.
neXtProt	NX_Q5XKR4.
PharmGKB	PA32844.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG256838.
HOGENOM	HOG000039976.
HOVERGEN	HBG001617.
InParanoid	Q5XKR4.
OMA	RWATAGM.
OrthoDB	EOG4FXR8D.
PhylomeDB	Q5XKR4.
Gene expression databases
Bgee	Q5XKR4.
CleanEx	HS_OTP.
Genevestigator	Q5XKR4.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR000047. HTH_motif. IPR003654. OAR_dom. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. PF03826. OAR. 1 hit. [Graphical view]
PRINTS	PR00031. HTHREPRESSR.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS50803. OAR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23440.
NextBio	45713.
SOURCE	Search...

Entry information

Entry name

OTP_HUMAN

Accession

Primary (citable) accession number: Q5XKR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	November 23, 2004
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.