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Q5XKR4 (OTP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein orthopedia
Gene names
Name:OTP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably involved in the differentiation of hypothalamic neuroendocrine cells.

Subcellular location

Nucleus Ref.2.

Developmental stage

Present in fetal hypothalamus at 19 weeks of gestation (at protein level). Ref.2

Sequence similarities

Belongs to the paired homeobox family. Bicoid subfamily.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Homeobox protein orthopedia
PRO_0000292432

Regions

DNA binding104 – 16360Homeobox
Motif306 – 31914OAR
Compositional bias187 – 1948Poly-Ala
Compositional bias210 – 2134Poly-Ala

Sequences

Sequence LengthMass (Da)Tools
Q5XKR4 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 429E3A91E0A9BA5F

FASTA32534,159
        10         20         30         40         50         60 
MLSHADLLDA RLGMKDAAEL LGHREAVKCR LGVGGSDPGG HPGDLAPNSD PVEGATLLPG 

        70         80         90        100        110        120 
EDITTVGSTP ASLAVSAKDP DKQPGPQGGP NPSQAGQQQG QQKQKRHRTR FTPAQLNELE 

       130        140        150        160        170        180 
RSFAKTHYPD IFMREELALR IGLTESRVQV WFQNRRAKWK KRKKTTNVFR APGTLLPTPG 

       190        200        210        220        230        240 
LPQFPSAAAA AAAAMGDSLC SFHANDTRWA AAAMPGVSQL PLPPALGRQQ AMAQSLSQCS 

       250        260        270        280        290        300 
LAAGPPPNSM GLSNSLAGSN GAGLQSHLYQ PAFPGMVPAS LPGPSNVSGS PQLCSSPDSS 

       310        320 
DVWRGTSIAS LRRKALEHTV SMSFT 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[2]"Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP)."
Lin X., State M.W., Vaccarino F.M., Greally J., Hass M., Leckman J.F.
Genomics 60:96-104(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC001800 mRNA. Translation: AAH01800.1.
RefSeqNP_115485.1. NM_032109.2.
UniGeneHs.202247.

3D structure databases

ProteinModelPortalQ5XKR4.
SMRQ5XKR4. Positions 105-158.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000302814.

Polymorphism databases

DMDM74762283.

Proteomic databases

PaxDbQ5XKR4.
PRIDEQ5XKR4.

Protocols and materials databases

DNASU23440.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306422; ENSP00000302814; ENSG00000171540.
GeneID23440.
KEGGhsa:23440.
UCSCuc003kfg.3. human.

Organism-specific databases

CTD23440.
GeneCardsGC05M076960.
HGNCHGNC:8518. OTP.
HPAHPA039365.
MIM604529. gene.
neXtProtNX_Q5XKR4.
PharmGKBPA32844.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256838.
HOGENOMHOG000039976.
HOVERGENHBG001617.
InParanoidQ5XKR4.
OMARWATAGM.
OrthoDBEOG7FJH11.
PhylomeDBQ5XKR4.
TreeFamTF351614.

Gene expression databases

BgeeQ5XKR4.
CleanExHS_OTP.
GenevestigatorQ5XKR4.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003654. OAR_dom.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
PRINTSPR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi23440.
NextBio45713.
PROQ5XKR4.
SOURCESearch...

Entry information

Entry nameOTP_HUMAN
AccessionPrimary (citable) accession number: Q5XKR4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 23, 2004
Last modified: February 19, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM