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Protein

Homeobox protein orthopedia

Gene

OTP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in the differentiation of hypothalamic neuroendocrine cells.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi104 – 16360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. forebrain neuron differentiation Source: Ensembl
  2. hypothalamus cell differentiation Source: Ensembl
  3. neurohypophysis development Source: Ensembl
  4. positive regulation of neuroblast proliferation Source: Ensembl
  5. regulation of transcription, DNA-templated Source: UniProtKB-KW
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein orthopedia
Gene namesi
Name:OTP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8518. OTP.

Subcellular locationi

Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32844.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Homeobox protein orthopediaPRO_0000292432Add
BLAST

Proteomic databases

PaxDbiQ5XKR4.
PRIDEiQ5XKR4.

Expressioni

Developmental stagei

Present in fetal hypothalamus at 19 weeks of gestation (at protein level).1 Publication

Gene expression databases

BgeeiQ5XKR4.
CleanExiHS_OTP.
GenevestigatoriQ5XKR4.

Organism-specific databases

HPAiHPA039365.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302814.

Structurei

3D structure databases

ProteinModelPortaliQ5XKR4.
SMRiQ5XKR4. Positions 105-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi306 – 31914OARAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi187 – 1948Poly-Ala
Compositional biasi210 – 2134Poly-Ala

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG256838.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000039976.
HOVERGENiHBG001617.
InParanoidiQ5XKR4.
OMAiWATAGMP.
OrthoDBiEOG7FJH11.
PhylomeDBiQ5XKR4.
TreeFamiTF351614.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XKR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSHADLLDA RLGMKDAAEL LGHREAVKCR LGVGGSDPGG HPGDLAPNSD
60 70 80 90 100
PVEGATLLPG EDITTVGSTP ASLAVSAKDP DKQPGPQGGP NPSQAGQQQG
110 120 130 140 150
QQKQKRHRTR FTPAQLNELE RSFAKTHYPD IFMREELALR IGLTESRVQV
160 170 180 190 200
WFQNRRAKWK KRKKTTNVFR APGTLLPTPG LPQFPSAAAA AAAAMGDSLC
210 220 230 240 250
SFHANDTRWA AAAMPGVSQL PLPPALGRQQ AMAQSLSQCS LAAGPPPNSM
260 270 280 290 300
GLSNSLAGSN GAGLQSHLYQ PAFPGMVPAS LPGPSNVSGS PQLCSSPDSS
310 320
DVWRGTSIAS LRRKALEHTV SMSFT
Length:325
Mass (Da):34,159
Last modified:November 23, 2004 - v1
Checksum:i429E3A91E0A9BA5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001800 mRNA. Translation: AAH01800.1.
CCDSiCCDS4039.1.
RefSeqiNP_115485.1. NM_032109.2.
UniGeneiHs.202247.

Genome annotation databases

EnsembliENST00000306422; ENSP00000302814; ENSG00000171540.
GeneIDi23440.
KEGGihsa:23440.
UCSCiuc003kfg.3. human.

Polymorphism databases

DMDMi74762283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001800 mRNA. Translation: AAH01800.1.
CCDSiCCDS4039.1.
RefSeqiNP_115485.1. NM_032109.2.
UniGeneiHs.202247.

3D structure databases

ProteinModelPortaliQ5XKR4.
SMRiQ5XKR4. Positions 105-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302814.

Polymorphism databases

DMDMi74762283.

Proteomic databases

PaxDbiQ5XKR4.
PRIDEiQ5XKR4.

Protocols and materials databases

DNASUi23440.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306422; ENSP00000302814; ENSG00000171540.
GeneIDi23440.
KEGGihsa:23440.
UCSCiuc003kfg.3. human.

Organism-specific databases

CTDi23440.
GeneCardsiGC05M076924.
HGNCiHGNC:8518. OTP.
HPAiHPA039365.
MIMi604529. gene.
neXtProtiNX_Q5XKR4.
PharmGKBiPA32844.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG256838.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000039976.
HOVERGENiHBG001617.
InParanoidiQ5XKR4.
OMAiWATAGMP.
OrthoDBiEOG7FJH11.
PhylomeDBiQ5XKR4.
TreeFamiTF351614.

Miscellaneous databases

ChiTaRSiOTP. human.
GenomeRNAii23440.
NextBioi45713.
PROiQ5XKR4.
SOURCEiSearch...

Gene expression databases

BgeeiQ5XKR4.
CleanExiHS_OTP.
GenevestigatoriQ5XKR4.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  2. "Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP)."
    Lin X., State M.W., Vaccarino F.M., Greally J., Hass M., Leckman J.F.
    Genomics 60:96-104(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiOTP_HUMAN
AccessioniPrimary (citable) accession number: Q5XKR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 23, 2004
Last modified: February 4, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.