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Q5XKR4

- OTP_HUMAN

UniProt

Q5XKR4 - OTP_HUMAN

Protein

Homeobox protein orthopedia

Gene

OTP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Probably involved in the differentiation of hypothalamic neuroendocrine cells.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi104 – 16360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. forebrain neuron differentiation Source: Ensembl
    2. hypothalamus cell differentiation Source: Ensembl
    3. neurohypophysis development Source: Ensembl
    4. positive regulation of neuroblast proliferation Source: Ensembl
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein orthopedia
    Gene namesi
    Name:OTP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:8518. OTP.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32844.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Homeobox protein orthopediaPRO_0000292432Add
    BLAST

    Proteomic databases

    PaxDbiQ5XKR4.
    PRIDEiQ5XKR4.

    Expressioni

    Developmental stagei

    Present in fetal hypothalamus at 19 weeks of gestation (at protein level).1 Publication

    Gene expression databases

    BgeeiQ5XKR4.
    CleanExiHS_OTP.
    GenevestigatoriQ5XKR4.

    Organism-specific databases

    HPAiHPA039365.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000302814.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XKR4.
    SMRiQ5XKR4. Positions 105-158.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi306 – 31914OARAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi187 – 1948Poly-Ala
    Compositional biasi210 – 2134Poly-Ala

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG256838.
    HOGENOMiHOG000039976.
    HOVERGENiHBG001617.
    InParanoidiQ5XKR4.
    OMAiRWATAGM.
    OrthoDBiEOG7FJH11.
    PhylomeDBiQ5XKR4.
    TreeFamiTF351614.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    IPR003654. OAR_dom.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF03826. OAR. 1 hit.
    [Graphical view]
    PRINTSiPR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS50803. OAR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5XKR4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSHADLLDA RLGMKDAAEL LGHREAVKCR LGVGGSDPGG HPGDLAPNSD    50
    PVEGATLLPG EDITTVGSTP ASLAVSAKDP DKQPGPQGGP NPSQAGQQQG 100
    QQKQKRHRTR FTPAQLNELE RSFAKTHYPD IFMREELALR IGLTESRVQV 150
    WFQNRRAKWK KRKKTTNVFR APGTLLPTPG LPQFPSAAAA AAAAMGDSLC 200
    SFHANDTRWA AAAMPGVSQL PLPPALGRQQ AMAQSLSQCS LAAGPPPNSM 250
    GLSNSLAGSN GAGLQSHLYQ PAFPGMVPAS LPGPSNVSGS PQLCSSPDSS 300
    DVWRGTSIAS LRRKALEHTV SMSFT 325
    Length:325
    Mass (Da):34,159
    Last modified:November 23, 2004 - v1
    Checksum:i429E3A91E0A9BA5F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC001800 mRNA. Translation: AAH01800.1.
    CCDSiCCDS4039.1.
    RefSeqiNP_115485.1. NM_032109.2.
    UniGeneiHs.202247.

    Genome annotation databases

    EnsembliENST00000306422; ENSP00000302814; ENSG00000171540.
    GeneIDi23440.
    KEGGihsa:23440.
    UCSCiuc003kfg.3. human.

    Polymorphism databases

    DMDMi74762283.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC001800 mRNA. Translation: AAH01800.1 .
    CCDSi CCDS4039.1.
    RefSeqi NP_115485.1. NM_032109.2.
    UniGenei Hs.202247.

    3D structure databases

    ProteinModelPortali Q5XKR4.
    SMRi Q5XKR4. Positions 105-158.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000302814.

    Polymorphism databases

    DMDMi 74762283.

    Proteomic databases

    PaxDbi Q5XKR4.
    PRIDEi Q5XKR4.

    Protocols and materials databases

    DNASUi 23440.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306422 ; ENSP00000302814 ; ENSG00000171540 .
    GeneIDi 23440.
    KEGGi hsa:23440.
    UCSCi uc003kfg.3. human.

    Organism-specific databases

    CTDi 23440.
    GeneCardsi GC05M076960.
    HGNCi HGNC:8518. OTP.
    HPAi HPA039365.
    MIMi 604529. gene.
    neXtProti NX_Q5XKR4.
    PharmGKBi PA32844.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256838.
    HOGENOMi HOG000039976.
    HOVERGENi HBG001617.
    InParanoidi Q5XKR4.
    OMAi RWATAGM.
    OrthoDBi EOG7FJH11.
    PhylomeDBi Q5XKR4.
    TreeFami TF351614.

    Miscellaneous databases

    GenomeRNAii 23440.
    NextBioi 45713.
    PROi Q5XKR4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5XKR4.
    CleanExi HS_OTP.
    Genevestigatori Q5XKR4.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    IPR003654. OAR_dom.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF03826. OAR. 1 hit.
    [Graphical view ]
    PRINTSi PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS50803. OAR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    2. "Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP)."
      Lin X., State M.W., Vaccarino F.M., Greally J., Hass M., Leckman J.F.
      Genomics 60:96-104(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiOTP_HUMAN
    AccessioniPrimary (citable) accession number: Q5XKR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3