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Protein

MICOS complex subunit MIC13

Gene

MIC13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MINOS1/MIC10 into the MICOS complex.1 Publication

GO - Biological processi

  • cristae formation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit MIC13Curated
Alternative name(s):
Protein P1171 Publication
Gene namesi
Name:MIC131 Publication
Synonyms:C19orf70Imported, QIL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33702. C19orf70.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2619HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • MICOS complex Source: UniProtKB
  • mitochondrial crista junction Source: UniProtKB
  • mitochondrial inner membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162378863.

Polymorphism and mutation databases

BioMutaiQIL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118MICOS complex subunit MIC13PRO_0000289985Add
BLAST

Proteomic databases

EPDiQ5XKP0.
MaxQBiQ5XKP0.
PaxDbiQ5XKP0.
PeptideAtlasiQ5XKP0.
PRIDEiQ5XKP0.
TopDownProteomicsiQ5XKP0.

PTM databases

iPTMnetiQ5XKP0.
PhosphoSiteiQ5XKP0.

Expressioni

Gene expression databases

BgeeiQ5XKP0.
CleanExiHS_C19orf70.
ExpressionAtlasiQ5XKP0. baseline and differential.
GenevisibleiQ5XKP0. HS.

Organism-specific databases

HPAiHPA042672.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOO/MIC26, QIL1/MIC13, APOOL/MIC27 and IMMT/MIC60. The complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2, and with HSPA9.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PELOQ9BRX21EBI-1053887,EBI-1043580

Protein-protein interaction databases

BioGridi125943. 9 interactions.
IntActiQ5XKP0. 6 interactions.
STRINGi9606.ENSP00000309561.

Structurei

3D structure databases

ProteinModelPortaliQ5XKP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MICOS complex subunit Mic13 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J44B. Eukaryota.
ENOG410YRP1. LUCA.
GeneTreeiENSGT00390000002629.
HOGENOMiHOG000154052.
HOVERGENiHBG107278.
InParanoidiQ5XKP0.
OrthoDBiEOG70ZZQZ.
PhylomeDBiQ5XKP0.
TreeFamiTF343386.

Family and domain databases

InterProiIPR026769. Mic13.
[Graphical view]
PANTHERiPTHR31816. PTHR31816. 1 hit.
PfamiPF15884. QIL1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XKP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVARVWSLMR FLIKGSVAGG AVYLVYDQEL LGPSDKSQAA LQKAGEVVPP
60 70 80 90 100
AMYQFSQYVC QQTGLQIPQL PAPPKIYFPI RDSWNAGIMT VMSALSVAPS
110
KAREYSKEGW EYVKARTK
Length:118
Mass (Da):13,087
Last modified:November 23, 2004 - v1
Checksum:i3E85936D77715415
GO

Sequence cautioni

The sequence AC011499 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence EAW69159.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201G → V in AAH42386 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB167391 Genomic DNA. Translation: BAE80091.1.
AC011499 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69159.1. Sequence problems.
BC009557 mRNA. Translation: AAH09557.1.
BC042386 mRNA. Translation: AAH42386.1.
CCDSiCCDS12143.1.
RefSeqiNP_001295169.1. NM_001308240.1.
NP_991330.1. NM_205767.2.
UniGeneiHs.356626.

Genome annotation databases

EnsembliENST00000309324; ENSP00000309561; ENSG00000174917.
GeneIDi125988.
KEGGihsa:125988.
UCSCiuc002mch.2. human.
uc060sbv.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB167391 Genomic DNA. Translation: BAE80091.1.
AC011499 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69159.1. Sequence problems.
BC009557 mRNA. Translation: AAH09557.1.
BC042386 mRNA. Translation: AAH42386.1.
CCDSiCCDS12143.1.
RefSeqiNP_001295169.1. NM_001308240.1.
NP_991330.1. NM_205767.2.
UniGeneiHs.356626.

3D structure databases

ProteinModelPortaliQ5XKP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125943. 9 interactions.
IntActiQ5XKP0. 6 interactions.
STRINGi9606.ENSP00000309561.

PTM databases

iPTMnetiQ5XKP0.
PhosphoSiteiQ5XKP0.

Polymorphism and mutation databases

BioMutaiQIL1.

Proteomic databases

EPDiQ5XKP0.
MaxQBiQ5XKP0.
PaxDbiQ5XKP0.
PeptideAtlasiQ5XKP0.
PRIDEiQ5XKP0.
TopDownProteomicsiQ5XKP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309324; ENSP00000309561; ENSG00000174917.
GeneIDi125988.
KEGGihsa:125988.
UCSCiuc002mch.2. human.
uc060sbv.1. human.

Organism-specific databases

CTDi125988.
GeneCardsiC19orf70.
H-InvDBHIX0202768.
HGNCiHGNC:33702. C19orf70.
HPAiHPA042672.
MIMi616658. gene.
neXtProtiNX_Q5XKP0.
PharmGKBiPA162378863.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J44B. Eukaryota.
ENOG410YRP1. LUCA.
GeneTreeiENSGT00390000002629.
HOGENOMiHOG000154052.
HOVERGENiHBG107278.
InParanoidiQ5XKP0.
OrthoDBiEOG70ZZQZ.
PhylomeDBiQ5XKP0.
TreeFamiTF343386.

Miscellaneous databases

ChiTaRSiC19orf70. human.
GenomeRNAii125988.
PROiQ5XKP0.
SOURCEiSearch...

Gene expression databases

BgeeiQ5XKP0.
CleanExiHS_C19orf70.
ExpressionAtlasiQ5XKP0. baseline and differential.
GenevisibleiQ5XKP0. HS.

Family and domain databases

InterProiIPR026769. Mic13.
[Graphical view]
PANTHERiPTHR31816. PTHR31816. 1 hit.
PfamiPF15884. QIL1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel retroposon P117 in the intergenic region of alpha-globin genes in macaques."
    Takenaka A., Kawamoto S., Varavudhi P., Kawamoto Y., Suzuki J., Eakavibatha C., Terao K., Nakamura S., Hirai H., Takenaka O.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Pancreas.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology."
    Guarani V., McNeill E.M., Paulo J.A., Huttlin E.L., Froehlich F., Gygi S.P., Van Vactor D., Harper J.W.
    Elife 4:0-0(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MICOS COMPLEX.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMIC13_HUMAN
AccessioniPrimary (citable) accession number: Q5XKP0
Secondary accession number(s): A0A0B4J2A5, K7EKR0, Q86YE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.