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Protein

MICOS complex subunit MIC13

Gene

MIC13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MINOS1/MIC10 into the MICOS complex.1 Publication

GO - Biological processi

  • cristae formation Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit MIC13Curated
Alternative name(s):
Protein P1171 Publication
Gene namesi
Name:MIC131 Publication
Synonyms:C19orf70Imported, QIL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000174917.8
HGNCiHGNC:33702 C19orf70
MIMi616658 gene
neXtProtiNX_Q5XKP0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 26HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

MalaCardsiC19orf70
OpenTargetsiENSG00000174917
PharmGKBiPA162378863

Polymorphism and mutation databases

BioMutaiQIL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899851 – 118MICOS complex subunit MIC13Add BLAST118

Proteomic databases

EPDiQ5XKP0
MaxQBiQ5XKP0
PaxDbiQ5XKP0
PeptideAtlasiQ5XKP0
PRIDEiQ5XKP0
TopDownProteomicsiQ5XKP0

PTM databases

iPTMnetiQ5XKP0
PhosphoSitePlusiQ5XKP0

Expressioni

Gene expression databases

BgeeiENSG00000174917
CleanExiHS_C19orf70
ExpressionAtlasiQ5XKP0 baseline and differential
GenevisibleiQ5XKP0 HS

Organism-specific databases

HPAiHPA042672

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOO/MIC26, QIL1/MIC13, APOOL/MIC27 and IMMT/MIC60. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex.1 Publication

Protein-protein interaction databases

BioGridi125943, 20 interactors
CORUMiQ5XKP0
IntActiQ5XKP0, 12 interactors
MINTiQ5XKP0
STRINGi9606.ENSP00000309561

Structurei

3D structure databases

ProteinModelPortaliQ5XKP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MICOS complex subunit Mic13 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J44B Eukaryota
ENOG410YRP1 LUCA
GeneTreeiENSGT00390000002629
HOGENOMiHOG000154052
HOVERGENiHBG107278
InParanoidiQ5XKP0
PhylomeDBiQ5XKP0
TreeFamiTF343386

Family and domain databases

InterProiView protein in InterPro
IPR026769 Mic13
PANTHERiPTHR31816 PTHR31816, 1 hit
PfamiView protein in Pfam
PF15884 QIL1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XKP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVARVWSLMR FLIKGSVAGG AVYLVYDQEL LGPSDKSQAA LQKAGEVVPP
60 70 80 90 100
AMYQFSQYVC QQTGLQIPQL PAPPKIYFPI RDSWNAGIMT VMSALSVAPS
110
KAREYSKEGW EYVKARTK
Length:118
Mass (Da):13,087
Last modified:November 23, 2004 - v1
Checksum:i3E85936D77715415
GO

Sequence cautioni

The sequence AC011499 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAW69159 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20G → V in AAH42386 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB167391 Genomic DNA Translation: BAE80091.1
AC011499 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69159.1 Sequence problems.
BC009557 mRNA Translation: AAH09557.1
BC042386 mRNA Translation: AAH42386.1
CCDSiCCDS12143.1
RefSeqiNP_001295169.1, NM_001308240.1
NP_991330.1, NM_205767.2
XP_016881737.1, XM_017026248.1
UniGeneiHs.356626

Genome annotation databases

EnsembliENST00000309324; ENSP00000309561; ENSG00000174917
GeneIDi125988
KEGGihsa:125988
UCSCiuc002mch.2 human
uc060sbv.1 human

Similar proteinsi

Entry informationi

Entry nameiMIC13_HUMAN
AccessioniPrimary (citable) accession number: Q5XKP0
Secondary accession number(s): A0A0B4J2A5, K7EKR0, Q86YE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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