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Protein

Keratin, type II cytoskeletal 79

Gene

KRT79

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei395 – 3951Stutter

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 79
Alternative name(s):
Cytokeratin-79
Short name:
CK-79
Keratin-6-like
Short name:
Keratin-6L
Keratin-79
Short name:
K79
Type-II keratin Kb38
Gene namesi
Name:KRT79
Synonyms:K6L, KB38, KRT6L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28930. KRT79.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393725.

Polymorphism and mutation databases

BioMutaiKRT79.
DMDMi296434550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535Keratin, type II cytoskeletal 79PRO_0000314893Add
BLAST

Proteomic databases

EPDiQ5XKE5.
MaxQBiQ5XKE5.
PaxDbiQ5XKE5.
PeptideAtlasiQ5XKE5.
PRIDEiQ5XKE5.

PTM databases

iPTMnetiQ5XKE5.
PhosphoSiteiQ5XKE5.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, skin and scalp, but not in any other tissues or organs examined.1 Publication

Gene expression databases

BgeeiQ5XKE5.
CleanExiHS_KRT79.
ExpressionAtlasiQ5XKE5. baseline and differential.
GenevisibleiQ5XKE5. HS.

Organism-specific databases

HPAiHPA059347.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT13A1A4E93EBI-2514135,EBI-10171552
KRT15P190123EBI-2514135,EBI-739566
KRT31Q153233EBI-2514135,EBI-948001
KRT33BQ145253EBI-2514135,EBI-1049638
KRT38O760153EBI-2514135,EBI-1047263
USHBP1Q8N6Y03EBI-2514135,EBI-739895

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi130796. 22 interactions.
IntActiQ5XKE5. 12 interactions.
STRINGi9606.ENSP00000328358.

Structurei

3D structure databases

ProteinModelPortaliQ5XKE5.
SMRiQ5XKE5. Positions 139-283, 310-451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 141141HeadAdd
BLAST
Regioni142 – 453312RodAdd
BLAST
Regioni142 – 17736Coil 1AAdd
BLAST
Regioni178 – 19821Linker 1Add
BLAST
Regioni199 – 29092Coil 1BAdd
BLAST
Regioni291 – 31424Linker 12Add
BLAST
Regioni315 – 453139Coil 2Add
BLAST
Regioni454 – 53582TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEK5. Eukaryota.
ENOG410XUTQ. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ5XKE5.
KOiK07605.
OMAiHLYEMEL.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ5XKE5.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 2 hits.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XKE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSSVSRQTY STKGGFSSNS ASGGSGSQAR TSFSSVTVSR SSGSGGGAHC
60 70 80 90 100
GPGTGGFGSR SLYNLGGHKS ISVSVAGGAL LGRALGGFGF GSRAFMGQGA
110 120 130 140 150
GRQTFGPACP PGGIQEVTVN QSLLTPLHVE IDPEIQRVRT QEREQIKTLN
160 170 180 190 200
NKFASFIDKV RFLEQQNKVL ETKWALLQEQ GQNLGVTRNN LEPLFEAYLG
210 220 230 240 250
SMRSTLDRLQ SERGRLDSEL RNVQDLVEDF KNKYEDEINK HTAAENEFVV
260 270 280 290 300
LKKDVDAAYM GRMDLHGKVG TLTQEIDFLQ QLYEMELSQV QTHVSNTNVV
310 320 330 340 350
LSMDNNRNLD LDSIIAEVKA QYELIAQRSR AEAEAWYQTK YEELQVTAGK
360 370 380 390 400
HGDNLRDTKN EIAELTRTIQ RLQGEADAAK KQCQQLQTAI AEAEQRGELA
410 420 430 440 450
LKDAQKKLGD LDVALHQAKE DLTRLLRDYQ ELMNVKLALD VEIATYRKLL
460 470 480 490 500
ESEESRMSGE CPSAVSISVT GNSTTVCGGG AASFGGGISL GGSGGATKGG
510 520 530
FSTNVGYSTV KGGPVSAGTS ILRKTTTVKT SSQRY
Length:535
Mass (Da):57,836
Last modified:May 18, 2010 - v2
Checksum:iB25A71327186A1C4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811L → S.2 Publications
Corresponds to variant rs2638497 [ dbSNP | Ensembl ].
VAR_038113
Natural varianti195 – 1951F → L.1 Publication
Corresponds to variant rs17855862 [ dbSNP | Ensembl ].
VAR_038114
Natural varianti266 – 2661H → R.
Corresponds to variant rs17688672 [ dbSNP | Ensembl ].
VAR_038115
Natural varianti393 – 3931A → V.
Corresponds to variant rs17688627 [ dbSNP | Ensembl ].
VAR_038116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564105 mRNA. Translation: CAD91893.1.
AC107016 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96648.1.
BC039148 mRNA. Translation: AAH39148.1.
BC063648 mRNA. Translation: AAH63648.1.
BK000976 Genomic DNA. Translation: DAA00403.1.
CCDSiCCDS8839.1.
RefSeqiNP_787028.1. NM_175834.2.
UniGeneiHs.711471.

Genome annotation databases

EnsembliENST00000330553; ENSP00000328358; ENSG00000185640.
GeneIDi338785.
KEGGihsa:338785.
UCSCiuc001sbb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564105 mRNA. Translation: CAD91893.1.
AC107016 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96648.1.
BC039148 mRNA. Translation: AAH39148.1.
BC063648 mRNA. Translation: AAH63648.1.
BK000976 Genomic DNA. Translation: DAA00403.1.
CCDSiCCDS8839.1.
RefSeqiNP_787028.1. NM_175834.2.
UniGeneiHs.711471.

3D structure databases

ProteinModelPortaliQ5XKE5.
SMRiQ5XKE5. Positions 139-283, 310-451.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130796. 22 interactions.
IntActiQ5XKE5. 12 interactions.
STRINGi9606.ENSP00000328358.

PTM databases

iPTMnetiQ5XKE5.
PhosphoSiteiQ5XKE5.

Polymorphism and mutation databases

BioMutaiKRT79.
DMDMi296434550.

Proteomic databases

EPDiQ5XKE5.
MaxQBiQ5XKE5.
PaxDbiQ5XKE5.
PeptideAtlasiQ5XKE5.
PRIDEiQ5XKE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330553; ENSP00000328358; ENSG00000185640.
GeneIDi338785.
KEGGihsa:338785.
UCSCiuc001sbb.4. human.

Organism-specific databases

CTDi338785.
GeneCardsiKRT79.
H-InvDBHIX0201906.
HGNCiHGNC:28930. KRT79.
HPAiHPA059347.
MIMi611160. gene.
neXtProtiNX_Q5XKE5.
PharmGKBiPA162393725.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEK5. Eukaryota.
ENOG410XUTQ. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ5XKE5.
KOiK07605.
OMAiHLYEMEL.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ5XKE5.
TreeFamiTF317854.

Miscellaneous databases

GeneWikiiKRT79.
GenomeRNAii338785.
NextBioi97155.
PROiQ5XKE5.
SOURCEiSearch...

Gene expression databases

BgeeiQ5XKE5.
CleanExiHS_KRT79.
ExpressionAtlasiQ5XKE5. baseline and differential.
GenevisibleiQ5XKE5. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 2 hits.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13."
    Rogers M.A., Edler L., Winter H., Langbein L., Beckmann I., Schweizer J.
    J. Invest. Dermatol. 124:536-544(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Skin.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-81.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-81 AND LEU-195.
    Tissue: Skin.
  5. "Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18."
    Hesse M., Magin T.M., Weber K.
    J. Cell Sci. 114:2569-2575(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiK2C79_HUMAN
AccessioniPrimary (citable) accession number: Q5XKE5
Secondary accession number(s): Q6P465, Q7Z793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: May 11, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.