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Protein

Myosin-binding protein C, fast-type

Gene

Mybpc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role (By similarity).By similarity

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: MGI

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • muscle contraction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-MMU-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-binding protein C, fast-type
Short name:
Fast MyBP-C
Alternative name(s):
C-protein, skeletal muscle fast isoform
Gene namesi
Name:Mybpc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1336170. Mybpc2.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: MGI
  • myosin filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11361136Myosin-binding protein C, fast-typePRO_0000253051Add
BLAST

Proteomic databases

MaxQBiQ5XKE0.
PaxDbiQ5XKE0.
PeptideAtlasiQ5XKE0.
PRIDEiQ5XKE0.

PTM databases

iPTMnetiQ5XKE0.
PhosphoSiteiQ5XKE0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038670.
CleanExiMM_MYBPC2.
GenevisibleiQ5XKE0. MM.

Interactioni

Protein-protein interaction databases

BioGridi231385. 2 interactions.
STRINGi10090.ENSMUSP00000130127.

Structurei

Secondary structure

1
1136
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi436 – 4383Combined sources
Beta strandi443 – 4486Combined sources
Beta strandi456 – 4583Combined sources
Beta strandi463 – 4708Combined sources
Beta strandi480 – 4845Combined sources
Beta strandi487 – 4948Combined sources
Turni497 – 4993Combined sources
Beta strandi503 – 5086Combined sources
Beta strandi518 – 5214Combined sources
Beta strandi736 – 7438Combined sources
Beta strandi745 – 7539Combined sources
Beta strandi765 – 7728Combined sources
Beta strandi779 – 7846Combined sources
Beta strandi786 – 7949Combined sources
Beta strandi802 – 8109Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X5YNMR-A731-828[»]
2DLTNMR-A433-525[»]
ProteinModelPortaliQ5XKE0.
SMRiQ5XKE0. Positions 40-153, 208-241, 248-338, 340-525, 731-929.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5XKE0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 149104Ig-like C2-type 1Add
BLAST
Domaini250 – 33990Ig-like C2-type 2Add
BLAST
Domaini340 – 43293Ig-like C2-type 3Add
BLAST
Domaini433 – 533101Ig-like C2-type 4Add
BLAST
Domaini534 – 633100Ig-like C2-type 5Add
BLAST
Domaini636 – 73297Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini734 – 82996Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini833 – 92795Ig-like C2-type 6Add
BLAST
Domaini930 – 102596Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini1043 – 113694Ig-like C2-type 7Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. MyBP family.Curated
Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IFCI. Eukaryota.
ENOG4110AYI. LUCA.
GeneTreeiENSGT00840000129685.
HOGENOMiHOG000220906.
HOVERGENiHBG052560.
InParanoidiQ5XKE0.
KOiK12558.
OMAiKEHDFRT.
OrthoDBiEOG091G00ND.
PhylomeDBiQ5XKE0.
TreeFamiTF351819.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 7 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 7 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XKE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEAKPAAKK ASKGKDAPKE APAKQTPEEP PKEAPPEDQS PTAEEPTGIF
60 70 80 90 100
LKKPDSVSVE TGKDAVILAK VNGKELPGKP TIKWFKGKWQ ELGSKSGARF
110 120 130 140 150
IFKESHDSTS NVYTVELHIG KVVLGDRGDY RLEIKAKDVC DSCSFNVDVE
160 170 180 190 200
APRQDSSGQS LESFKRSGDG KSEDAGELDF SGLLKKREVV EEEKKKKKDD
210 220 230 240 250
DDLGIPPEIW ELLKGAKKSE YEKIAFQYGI TDLRGMLKRL KKAKVEVKKS
260 270 280 290 300
AAFTKKLDPA YQVDRGNKIK LVVEISDPDL PLKWFKNGQE IKPSSKYVFE
310 320 330 340 350
NVGKKRILTI NKCTLADDAA YEVAVQDEKC FTELFVKEPP VLIVTPLEDQ
360 370 380 390 400
QVFVGDRVEM SVEVSEEGAQ VMWMKDGVEM TREDSYKARY RFKKDGKRHI
410 420 430 440 450
LIYSDVAQED GGRYQVITNG GQCEAELIVE EKQLEVLQDI ADLTVKAAEQ
460 470 480 490 500
AVFKCEVSDE KVTGKWYKNG VEVRPSKRIT ISHVGRFHKL VIDDVRPEDE
510 520 530 540 550
GDYTFVPDGY ALSLSAKLNF LEIKVEYVPK QEPPKIHLDC SGKTSDNSIV
560 570 580 590 600
VVAGNKLRLD VAITGEPPPT ATWLRGDEVF TATEGRTHIE QRPDCSSFVI
610 620 630 640 650
ESAERSDEGR YTIKVTNPVG EDVASIFLRV VDVPDPPEAV RVTSVGEDWA
660 670 680 690 700
ILVWEPPKYD GGQPVTGYLM ERKKKGSQRW MKINFEVFTD TTYESTKMIE
710 720 730 740 750
GVLYEMRVFA VNAIGVSQPS MNTKPFMPIA PTSAPQHLTV EDVTDTTTTL
760 770 780 790 800
KWRPPDRIGA GGIDGYLVEY CLEGSEEWVP ANKEPVERCG FTVKDLPTGA
810 820 830 840 850
RILFRVVGVN IAGRSEPATL LQPVTIREIV EQPKIRLPRH LRQTYIRKVG
860 870 880 890 900
EALNLVIPFQ GKPRPQVVWT KGGAPLDTSR VNVRTSDFDT VFFVRQAARS
910 920 930 940 950
DSGEYELSVQ IENMKDTATI RIRVVEKAGP AENVMVKEVW GTNALVEWQP
960 970 980 990 1000
PKDDGNSEIT GYFVQKADKK TMEWFNVYEH NRHTSCTVSD LIVGNEYYFR
1010 1020 1030 1040 1050
IFSENICGLS DSPGVSKNTA RILKTGITLK PLEYKEHDFR TAPKFLTPLM
1060 1070 1080 1090 1100
DRVVVAGYTA ALNCAVRGHP KPKVVWMKNK MEIHEDPKFL ITNYQGILTL
1110 1120 1130
NIRRPSPFDA GTYSCRAFNE LGEALAECKL DVRVPQ
Length:1,136
Mass (Da):127,352
Last modified:November 23, 2004 - v1
Checksum:iD79F73721397DE0D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti619 – 6191V → A in AAH29762 (PubMed:15489334).Curated
Sequence conflicti648 – 6481D → N in BAC26371 (PubMed:16141072).Curated
Sequence conflicti900 – 9001S → T in BAC26371 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029282 mRNA. Translation: BAC26371.1.
BC029762 mRNA. Translation: AAH29762.1.
BC039184 mRNA. Translation: AAH39184.1.
CCDSiCCDS52233.1.
RefSeqiNP_666301.2. NM_146189.3.
UniGeneiMm.358888.

Genome annotation databases

EnsembliENSMUST00000165208; ENSMUSP00000130127; ENSMUSG00000038670.
GeneIDi233199.
KEGGimmu:233199.
UCSCiuc009gpv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029282 mRNA. Translation: BAC26371.1.
BC029762 mRNA. Translation: AAH29762.1.
BC039184 mRNA. Translation: AAH39184.1.
CCDSiCCDS52233.1.
RefSeqiNP_666301.2. NM_146189.3.
UniGeneiMm.358888.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X5YNMR-A731-828[»]
2DLTNMR-A433-525[»]
ProteinModelPortaliQ5XKE0.
SMRiQ5XKE0. Positions 40-153, 208-241, 248-338, 340-525, 731-929.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231385. 2 interactions.
STRINGi10090.ENSMUSP00000130127.

PTM databases

iPTMnetiQ5XKE0.
PhosphoSiteiQ5XKE0.

Proteomic databases

MaxQBiQ5XKE0.
PaxDbiQ5XKE0.
PeptideAtlasiQ5XKE0.
PRIDEiQ5XKE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165208; ENSMUSP00000130127; ENSMUSG00000038670.
GeneIDi233199.
KEGGimmu:233199.
UCSCiuc009gpv.2. mouse.

Organism-specific databases

CTDi4606.
MGIiMGI:1336170. Mybpc2.

Phylogenomic databases

eggNOGiENOG410IFCI. Eukaryota.
ENOG4110AYI. LUCA.
GeneTreeiENSGT00840000129685.
HOGENOMiHOG000220906.
HOVERGENiHBG052560.
InParanoidiQ5XKE0.
KOiK12558.
OMAiKEHDFRT.
OrthoDBiEOG091G00ND.
PhylomeDBiQ5XKE0.
TreeFamiTF351819.

Enzyme and pathway databases

ReactomeiR-MMU-390522. Striated Muscle Contraction.

Miscellaneous databases

EvolutionaryTraceiQ5XKE0.
PROiQ5XKE0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038670.
CleanExiMM_MYBPC2.
GenevisibleiQ5XKE0. MM.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 7 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 7 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYPC2_MOUSE
AccessioniPrimary (citable) accession number: Q5XKE0
Secondary accession number(s): Q8C109, Q8K2V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.