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Protein

Myosin-binding protein C, fast-type

Gene

Mybpc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role (By similarity).By similarity

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: MGI

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • muscle contraction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-MMU-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-binding protein C, fast-type
Short name:
Fast MyBP-C
Alternative name(s):
C-protein, skeletal muscle fast isoform
Gene namesi
Name:Mybpc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1336170. Mybpc2.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: MGI
  • myosin filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002530511 – 1136Myosin-binding protein C, fast-typeAdd BLAST1136

Proteomic databases

MaxQBiQ5XKE0.
PaxDbiQ5XKE0.
PeptideAtlasiQ5XKE0.
PRIDEiQ5XKE0.

PTM databases

iPTMnetiQ5XKE0.
PhosphoSitePlusiQ5XKE0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038670.
CleanExiMM_MYBPC2.
ExpressionAtlasiQ5XKE0. baseline and differential.
GenevisibleiQ5XKE0. MM.

Interactioni

Protein-protein interaction databases

BioGridi231385. 2 interactors.
STRINGi10090.ENSMUSP00000130127.

Structurei

Secondary structure

11136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi436 – 438Combined sources3
Beta strandi443 – 448Combined sources6
Beta strandi456 – 458Combined sources3
Beta strandi463 – 470Combined sources8
Beta strandi480 – 484Combined sources5
Beta strandi487 – 494Combined sources8
Turni497 – 499Combined sources3
Beta strandi503 – 508Combined sources6
Beta strandi518 – 521Combined sources4
Beta strandi736 – 743Combined sources8
Beta strandi745 – 753Combined sources9
Beta strandi765 – 772Combined sources8
Beta strandi779 – 784Combined sources6
Beta strandi786 – 794Combined sources9
Beta strandi802 – 810Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X5YNMR-A731-828[»]
2DLTNMR-A433-525[»]
ProteinModelPortaliQ5XKE0.
SMRiQ5XKE0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5XKE0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 149Ig-like C2-type 1Add BLAST104
Domaini250 – 339Ig-like C2-type 2Add BLAST90
Domaini340 – 432Ig-like C2-type 3Add BLAST93
Domaini433 – 533Ig-like C2-type 4Add BLAST101
Domaini534 – 633Ig-like C2-type 5Add BLAST100
Domaini636 – 732Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST97
Domaini734 – 829Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini833 – 927Ig-like C2-type 6Add BLAST95
Domaini930 – 1025Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini1043 – 1136Ig-like C2-type 7Add BLAST94

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. MyBP family.Curated
Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IFCI. Eukaryota.
ENOG4110AYI. LUCA.
GeneTreeiENSGT00860000133685.
HOGENOMiHOG000220906.
HOVERGENiHBG052560.
InParanoidiQ5XKE0.
KOiK12558.
OMAiKEHDFRT.
OrthoDBiEOG091G00ND.
PhylomeDBiQ5XKE0.
TreeFamiTF351819.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 7 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 7 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XKE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEAKPAAKK ASKGKDAPKE APAKQTPEEP PKEAPPEDQS PTAEEPTGIF
60 70 80 90 100
LKKPDSVSVE TGKDAVILAK VNGKELPGKP TIKWFKGKWQ ELGSKSGARF
110 120 130 140 150
IFKESHDSTS NVYTVELHIG KVVLGDRGDY RLEIKAKDVC DSCSFNVDVE
160 170 180 190 200
APRQDSSGQS LESFKRSGDG KSEDAGELDF SGLLKKREVV EEEKKKKKDD
210 220 230 240 250
DDLGIPPEIW ELLKGAKKSE YEKIAFQYGI TDLRGMLKRL KKAKVEVKKS
260 270 280 290 300
AAFTKKLDPA YQVDRGNKIK LVVEISDPDL PLKWFKNGQE IKPSSKYVFE
310 320 330 340 350
NVGKKRILTI NKCTLADDAA YEVAVQDEKC FTELFVKEPP VLIVTPLEDQ
360 370 380 390 400
QVFVGDRVEM SVEVSEEGAQ VMWMKDGVEM TREDSYKARY RFKKDGKRHI
410 420 430 440 450
LIYSDVAQED GGRYQVITNG GQCEAELIVE EKQLEVLQDI ADLTVKAAEQ
460 470 480 490 500
AVFKCEVSDE KVTGKWYKNG VEVRPSKRIT ISHVGRFHKL VIDDVRPEDE
510 520 530 540 550
GDYTFVPDGY ALSLSAKLNF LEIKVEYVPK QEPPKIHLDC SGKTSDNSIV
560 570 580 590 600
VVAGNKLRLD VAITGEPPPT ATWLRGDEVF TATEGRTHIE QRPDCSSFVI
610 620 630 640 650
ESAERSDEGR YTIKVTNPVG EDVASIFLRV VDVPDPPEAV RVTSVGEDWA
660 670 680 690 700
ILVWEPPKYD GGQPVTGYLM ERKKKGSQRW MKINFEVFTD TTYESTKMIE
710 720 730 740 750
GVLYEMRVFA VNAIGVSQPS MNTKPFMPIA PTSAPQHLTV EDVTDTTTTL
760 770 780 790 800
KWRPPDRIGA GGIDGYLVEY CLEGSEEWVP ANKEPVERCG FTVKDLPTGA
810 820 830 840 850
RILFRVVGVN IAGRSEPATL LQPVTIREIV EQPKIRLPRH LRQTYIRKVG
860 870 880 890 900
EALNLVIPFQ GKPRPQVVWT KGGAPLDTSR VNVRTSDFDT VFFVRQAARS
910 920 930 940 950
DSGEYELSVQ IENMKDTATI RIRVVEKAGP AENVMVKEVW GTNALVEWQP
960 970 980 990 1000
PKDDGNSEIT GYFVQKADKK TMEWFNVYEH NRHTSCTVSD LIVGNEYYFR
1010 1020 1030 1040 1050
IFSENICGLS DSPGVSKNTA RILKTGITLK PLEYKEHDFR TAPKFLTPLM
1060 1070 1080 1090 1100
DRVVVAGYTA ALNCAVRGHP KPKVVWMKNK MEIHEDPKFL ITNYQGILTL
1110 1120 1130
NIRRPSPFDA GTYSCRAFNE LGEALAECKL DVRVPQ
Length:1,136
Mass (Da):127,352
Last modified:November 23, 2004 - v1
Checksum:iD79F73721397DE0D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti619V → A in AAH29762 (PubMed:15489334).Curated1
Sequence conflicti648D → N in BAC26371 (PubMed:16141072).Curated1
Sequence conflicti900S → T in BAC26371 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029282 mRNA. Translation: BAC26371.1.
BC029762 mRNA. Translation: AAH29762.1.
BC039184 mRNA. Translation: AAH39184.1.
CCDSiCCDS52233.1.
RefSeqiNP_666301.2. NM_146189.3.
UniGeneiMm.358888.

Genome annotation databases

EnsembliENSMUST00000165208; ENSMUSP00000130127; ENSMUSG00000038670.
GeneIDi233199.
KEGGimmu:233199.
UCSCiuc009gpv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029282 mRNA. Translation: BAC26371.1.
BC029762 mRNA. Translation: AAH29762.1.
BC039184 mRNA. Translation: AAH39184.1.
CCDSiCCDS52233.1.
RefSeqiNP_666301.2. NM_146189.3.
UniGeneiMm.358888.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X5YNMR-A731-828[»]
2DLTNMR-A433-525[»]
ProteinModelPortaliQ5XKE0.
SMRiQ5XKE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231385. 2 interactors.
STRINGi10090.ENSMUSP00000130127.

PTM databases

iPTMnetiQ5XKE0.
PhosphoSitePlusiQ5XKE0.

Proteomic databases

MaxQBiQ5XKE0.
PaxDbiQ5XKE0.
PeptideAtlasiQ5XKE0.
PRIDEiQ5XKE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165208; ENSMUSP00000130127; ENSMUSG00000038670.
GeneIDi233199.
KEGGimmu:233199.
UCSCiuc009gpv.2. mouse.

Organism-specific databases

CTDi4606.
MGIiMGI:1336170. Mybpc2.

Phylogenomic databases

eggNOGiENOG410IFCI. Eukaryota.
ENOG4110AYI. LUCA.
GeneTreeiENSGT00860000133685.
HOGENOMiHOG000220906.
HOVERGENiHBG052560.
InParanoidiQ5XKE0.
KOiK12558.
OMAiKEHDFRT.
OrthoDBiEOG091G00ND.
PhylomeDBiQ5XKE0.
TreeFamiTF351819.

Enzyme and pathway databases

ReactomeiR-MMU-390522. Striated Muscle Contraction.

Miscellaneous databases

EvolutionaryTraceiQ5XKE0.
PROiQ5XKE0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038670.
CleanExiMM_MYBPC2.
ExpressionAtlasiQ5XKE0. baseline and differential.
GenevisibleiQ5XKE0. MM.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 7 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 7 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYPC2_MOUSE
AccessioniPrimary (citable) accession number: Q5XKE0
Secondary accession number(s): Q8C109, Q8K2V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 23, 2004
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.