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Protein

Fanconi anemia group B protein homolog

Gene

Fancb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

DNA repair protein required for FANCD2 ubiquitination.By similarity

GO - Biological processi

  • cellular response to camptothecin Source: MGI
  • cellular response to drug Source: MGI
  • negative regulation of double-strand break repair via homologous recombination Source: MGI
  • positive regulation of double-strand break repair via homologous recombination Source: MGI
  • replication-born double-strand break repair via sister chromatid exchange Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia group B protein homolog
Short name:
Protein FACB
Gene namesi
Name:Fancb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2448558. Fancb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 703703Fanconi anemia group B protein homologPRO_0000087182Add
BLAST

Proteomic databases

MaxQBiQ5XJY6.
PaxDbiQ5XJY6.
PRIDEiQ5XJY6.

PTM databases

PhosphoSiteiQ5XJY6.

Expressioni

Gene expression databases

CleanExiMM_FANCB.

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128141.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IEYY. Eukaryota.
ENOG410YMW2. LUCA.
HOVERGENiHBG080307.
InParanoidiQ5XJY6.
KOiK10889.

Family and domain databases

InterProiIPR033333. FANCB.
[Graphical view]
PANTHERiPTHR28450. PTHR28450. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XJY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQSSCAIM GKSLSFSLSR GERADLEMPT DPLVLGVKRM MFDRETSTFL
60 70 80 90 100
LISTVFLNIN EKDSHLKILC CNCVSDLRTR INLPCVLIQC RKYNSEAFKY
110 120 130 140 150
CILLLHNLNR VERLLSFELN HALDENTKIF DGPIVFWQYL NQFFYISSAI
160 170 180 190 200
GKVTTISLML SSIEWIGEIE NFGLGFLGLA EPSEDKCTQK LSESDYEFSN
210 220 230 240 250
SSLCAYALKS QEMLSNGYLI PLAYSTMVTH VHVWAAEMVD HQLRTSLIAL
260 270 280 290 300
TRKNQLILFQ NGIPVRACQL PFPGPRSVQI LDAGKRNRFF IVSFPSKACA
310 320 330 340 350
VSEKKFKVVA KWEQLSLVLV NDFAGVGTEQ VLVVFEDSLD ADQLTSFTVT
360 370 380 390 400
DFVKIWYSTK PLDCCEDPLA EEEHENYYLV LPALEGQLDN SFIFLNKIQQ
410 420 430 440 450
HISFKDKFIA KSWKALLNAV YGKGDSLPSD EMVKLDQDGL VPFCDEGEDS
460 470 480 490 500
VPTPEENLPD NFPEPEHIVE QTWCHVLDDD LVVGAKVTSL KESNEMTLSL
510 520 530 540 550
IMNQGNRSSF HLMKCHSQVW LLKHMKCERI QECTEIYLYK KLRNCGALFS
560 570 580 590 600
WEQRTASEGI LTIYCRSQGV LFQCLDHLIK VLPEICSFKY LKVENEDFLV
610 620 630 640 650
DHLSSTLEAE LVTFCSVSTS AFEYVRGGYN CRIRRTDNRA MTFLGRRAKI
660 670 680 690 700
RQSKRKVQRE RILKHLNMTV NGSSYAEMTL ALAEIQLKSD LIVKTLANFV

IAL
Length:703
Mass (Da):80,088
Last modified:October 25, 2005 - v2
Checksum:i8160AF95C02C876B
GO

Sequence cautioni

The sequence AAH83151 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083151 mRNA. Translation: AAH83151.1. Different initiation.
RefSeqiNP_001139553.1. NM_001146081.1.
NP_778192.3. NM_175027.4.
UniGeneiMm.336317.

Genome annotation databases

GeneIDi237211.
KEGGimmu:237211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083151 mRNA. Translation: AAH83151.1. Different initiation.
RefSeqiNP_001139553.1. NM_001146081.1.
NP_778192.3. NM_175027.4.
UniGeneiMm.336317.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128141.

PTM databases

PhosphoSiteiQ5XJY6.

Proteomic databases

MaxQBiQ5XJY6.
PaxDbiQ5XJY6.
PRIDEiQ5XJY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi237211.
KEGGimmu:237211.

Organism-specific databases

CTDi2187.
MGIiMGI:2448558. Fancb.

Phylogenomic databases

eggNOGiENOG410IEYY. Eukaryota.
ENOG410YMW2. LUCA.
HOVERGENiHBG080307.
InParanoidiQ5XJY6.
KOiK10889.

Miscellaneous databases

PROiQ5XJY6.
SOURCEiSearch...

Gene expression databases

CleanExiMM_FANCB.

Family and domain databases

InterProiIPR033333. FANCB.
[Graphical view]
PANTHERiPTHR28450. PTHR28450. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFANCB_MOUSE
AccessioniPrimary (citable) accession number: Q5XJY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: September 7, 2016
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.