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Protein

Secretagogin

Gene

scgn

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi21 – 32121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi114 – 125122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi158 – 169123PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi206 – 217124PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi250 – 261125PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • brain development Source: ZFIN
  • regulation of cytosolic calcium ion concentration Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Secretagogin
Gene namesi
Name:scgn
ORF Names:zgc:100843
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-041010-82. scgn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272SecretagoginPRO_0000330627Add
BLAST

Proteomic databases

PaxDbiQ5XJX1.

Expressioni

Gene expression databases

BgeeiQ5XJX1.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076090.

Structurei

Secondary structure

1
272
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 2011Combined sources
Beta strandi26 – 294Combined sources
Helixi30 – 323Combined sources
Helixi33 – 4412Combined sources
Helixi52 – 6211Combined sources
Helixi65 – 684Combined sources
Beta strandi72 – 754Combined sources
Helixi76 – 838Combined sources
Helixi86 – 9712Combined sources
Helixi103 – 11311Combined sources
Beta strandi119 – 1224Combined sources
Helixi123 – 1253Combined sources
Helixi126 – 13611Combined sources
Helixi143 – 15715Combined sources
Beta strandi162 – 1665Combined sources
Helixi167 – 1704Combined sources
Helixi171 – 1733Combined sources
Helixi188 – 20518Combined sources
Beta strandi211 – 2144Combined sources
Helixi216 – 22914Combined sources
Beta strandi230 – 2323Combined sources
Helixi235 – 24915Combined sources
Beta strandi251 – 2533Combined sources
Beta strandi256 – 2583Combined sources
Helixi259 – 2657Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BE4X-ray2.10A2-272[»]
2Q4UX-ray2.10A2-272[»]
ProteinModelPortaliQ5XJX1.
SMRiQ5XJX1. Positions 3-272.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5XJX1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 4336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini53 – 8937EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini101 – 13636EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini145 – 18036EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini193 – 22836EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini237 – 27236EF-hand 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiQ5XJX1.
OMAiHHKKAIS.
OrthoDBiEOG71G9VB.
PhylomeDBiQ5XJX1.
TreeFamiTF325083.

Family and domain databases

Gene3Di1.10.238.10. 5 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XJX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSAFANLDA AGFLQIWQHF DADDNGYIEG KELDDFFRHM LKKLQPKDKI
60 70 80 90 100
TDERVQQIKK SFMSAYDATF DGRLQIEELA NMILPQEENF LLIFRREAPL
110 120 130 140 150
DNSVEFMKIW RKYDADSSGY ISAAELKNFL KDLFLQHKKK IPPNKLDEYT
160 170 180 190 200
DAMMKIFDKN KDGRLDLNDL ARILALQENF LLQFKMDASS QVERKRDFEK
210 220 230 240 250
IFAHYDVSRT GALEGPEVDG FVKDMMELVR PSISGGDLDK FRECLLTHCD
260 270
MNKDGKIQKS ELALCLGLKH KP
Length:272
Mass (Da):31,578
Last modified:November 23, 2004 - v1
Checksum:iCD2AD9A80017CAE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083168 mRNA. Translation: AAH83168.1.
RefSeqiNP_001005776.1. NM_001005776.1.
UniGeneiDr.89417.

Genome annotation databases

EnsembliENSDART00000081649; ENSDARP00000076090; ENSDARG00000058732.
GeneIDi573010.
KEGGidre:573010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083168 mRNA. Translation: AAH83168.1.
RefSeqiNP_001005776.1. NM_001005776.1.
UniGeneiDr.89417.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BE4X-ray2.10A2-272[»]
2Q4UX-ray2.10A2-272[»]
ProteinModelPortaliQ5XJX1.
SMRiQ5XJX1. Positions 3-272.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076090.

Proteomic databases

PaxDbiQ5XJX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000081649; ENSDARP00000076090; ENSDARG00000058732.
GeneIDi573010.
KEGGidre:573010.

Organism-specific databases

CTDi10590.
ZFINiZDB-GENE-041010-82. scgn.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiQ5XJX1.
OMAiHHKKAIS.
OrthoDBiEOG71G9VB.
PhylomeDBiQ5XJX1.
TreeFamiTF325083.

Miscellaneous databases

EvolutionaryTraceiQ5XJX1.
PROiQ5XJX1.

Gene expression databases

BgeeiQ5XJX1.

Family and domain databases

Gene3Di1.10.238.10. 5 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  2. "X-ray structure of an EF-hand protein from Danio rerio DR.36843."
    Center for eukaryotic structural genomics (CESG)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).

Entry informationi

Entry nameiSEGN_DANRE
AccessioniPrimary (citable) accession number: Q5XJX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 23, 2004
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.