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Protein

Secretagogin

Gene

scgn

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi114 – 1252PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi158 – 1693PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi206 – 2174PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi250 – 2615PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • brain development Source: ZFIN
  • regulation of cytosolic calcium ion concentration Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Secretagogin
Gene namesi
Name:scgn
ORF Names:zgc:100843
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-041010-82. scgn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003306271 – 272SecretagoginAdd BLAST272

Proteomic databases

PaxDbiQ5XJX1.

Expressioni

Gene expression databases

BgeeiENSDARG00000058732.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076090.

Structurei

Secondary structure

1272
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 20Combined sources11
Beta strandi26 – 29Combined sources4
Helixi30 – 32Combined sources3
Helixi33 – 44Combined sources12
Helixi52 – 62Combined sources11
Helixi65 – 68Combined sources4
Beta strandi72 – 75Combined sources4
Helixi76 – 83Combined sources8
Helixi86 – 97Combined sources12
Helixi103 – 113Combined sources11
Beta strandi119 – 122Combined sources4
Helixi123 – 125Combined sources3
Helixi126 – 136Combined sources11
Helixi143 – 157Combined sources15
Beta strandi162 – 166Combined sources5
Helixi167 – 170Combined sources4
Helixi171 – 173Combined sources3
Helixi188 – 205Combined sources18
Beta strandi211 – 214Combined sources4
Helixi216 – 229Combined sources14
Beta strandi230 – 232Combined sources3
Helixi235 – 249Combined sources15
Beta strandi251 – 253Combined sources3
Beta strandi256 – 258Combined sources3
Helixi259 – 265Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BE4X-ray2.10A2-272[»]
2Q4UX-ray2.10A2-272[»]
ProteinModelPortaliQ5XJX1.
SMRiQ5XJX1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5XJX1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini53 – 89EF-hand 2PROSITE-ProRule annotationAdd BLAST37
Domaini101 – 136EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini145 – 180EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini193 – 228EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini237 – 272EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiQ5XJX1.
OMAiHHKKAIS.
OrthoDBiEOG091G0GNH.
PhylomeDBiQ5XJX1.
TreeFamiTF325083.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 5 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XJX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSAFANLDA AGFLQIWQHF DADDNGYIEG KELDDFFRHM LKKLQPKDKI
60 70 80 90 100
TDERVQQIKK SFMSAYDATF DGRLQIEELA NMILPQEENF LLIFRREAPL
110 120 130 140 150
DNSVEFMKIW RKYDADSSGY ISAAELKNFL KDLFLQHKKK IPPNKLDEYT
160 170 180 190 200
DAMMKIFDKN KDGRLDLNDL ARILALQENF LLQFKMDASS QVERKRDFEK
210 220 230 240 250
IFAHYDVSRT GALEGPEVDG FVKDMMELVR PSISGGDLDK FRECLLTHCD
260 270
MNKDGKIQKS ELALCLGLKH KP
Length:272
Mass (Da):31,578
Last modified:November 23, 2004 - v1
Checksum:iCD2AD9A80017CAE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083168 mRNA. Translation: AAH83168.1.
RefSeqiNP_001005776.1. NM_001005776.1.
UniGeneiDr.89417.

Genome annotation databases

EnsembliENSDART00000081649; ENSDARP00000076090; ENSDARG00000058732.
GeneIDi573010.
KEGGidre:573010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083168 mRNA. Translation: AAH83168.1.
RefSeqiNP_001005776.1. NM_001005776.1.
UniGeneiDr.89417.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BE4X-ray2.10A2-272[»]
2Q4UX-ray2.10A2-272[»]
ProteinModelPortaliQ5XJX1.
SMRiQ5XJX1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076090.

Proteomic databases

PaxDbiQ5XJX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000081649; ENSDARP00000076090; ENSDARG00000058732.
GeneIDi573010.
KEGGidre:573010.

Organism-specific databases

CTDi10590.
ZFINiZDB-GENE-041010-82. scgn.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiQ5XJX1.
OMAiHHKKAIS.
OrthoDBiEOG091G0GNH.
PhylomeDBiQ5XJX1.
TreeFamiTF325083.

Miscellaneous databases

EvolutionaryTraceiQ5XJX1.
PROiQ5XJX1.

Gene expression databases

BgeeiENSDARG00000058732.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 5 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEGN_DANRE
AccessioniPrimary (citable) accession number: Q5XJX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 23, 2004
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.