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Protein
Submitted name:

Nuclear receptor coactivator 6

Gene

Ncoa6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiR-MMU-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear receptor coactivator 6Imported
Gene namesi
Name:Ncoa6Imported
ORF Names:mCG_21081Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1929915. Ncoa6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045386.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 189143Nucleic_acid_bdInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili260 – 29637Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IK20. Eukaryota.
ENOG410XW4F. LUCA.
GeneTreeiENSGT00730000111114.
HOGENOMiHOG000113745.
HOVERGENiHBG052586.
KOiK14971.
OMAiMEAAFPM.
TreeFamiTF332639.

Family and domain databases

InterProiIPR026638. NCOA6.
IPR032715. NCOA6_nucleic_acid-bd.
[Graphical view]
PANTHERiPTHR15690:SF0. PTHR15690:SF0. 2 hits.
PfamiPF13820. Nucleic_acid_bd. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XJV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLDDLPNFE DIYTSLCSST MGDSEVEFDS GLEDDDTKSD SILEDSTIFV
60 70 80 90 100
AFKGNIDDKD FKWKLDAILK NVPNLLHMES SKLKVQKVEP WNSVRVTFNI
110 120 130 140 150
PREAAERLRI LAQSNNQQLR DLGILSVQIE GEGAINLALG QNRSQDVRMN
160 170 180 190 200
GPVASGNSVR MEAGFPMASG PGLIRMTSPA AVMTPQGGNM SSSMMAPGPN
210 220 230 240 250
PELQPRTPRP ASQSDAMDPL LSGLHIQQQS HPSGSLPPAH HSMQPVPVNR
260 270 280 290 300
QMNPANFPQL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQLQTRPLQQ
310 320 330 340 350
HQQQPQGIRP QFTAPTQVPV PPGWNQLPSG ALQPPPAQGS LGTMTTNQGW
360 370 380 390 400
KKAPLPSPMQ AQLQARPSLA TVQTPSHPPP PYPFGSQQAS QAHTNFPQMS
410 420 430 440 450
NPGQFTAPQM KGLQGGPSRV PTPLQQPHLT NKSPASSPSS FQQGSPASSP
460 470 480 490 500
TVNQTQQQMG PRPPQNNPLS QGFQQPVSSP GRNPMVQQGN VPPNFMVMQQ
510 520 530 540 550
QPPNQGPQSL HPGLGGMPKR LPPGFSAGQA NPNFMQGQVP STTAATPGNS
560 570 580 590 600
GALQLQANQN VQHAGGQGAG PPQNQMQVSH GPPNMMQPSL MGIHGNINNQ
610 620 630 640 650
QAGSSGVPQV TLGNMQGQPQ QGPPSQLMGM HQQIVPSQGQ MAQQQGTLNP
660 670 680 690 700
QNPMILSRAQ LMPQGQMMVN AQNQNLGPSP QRMTPPKQML PQQGPQMMAP
710 720 730 740 750
HNQMMGPQGQ VLLQQNPMIE QIMTNQMQGN KAQFNSQNQS NVMPGPAQIM
760 770 780 790 800
RGPTPNMQGN MVQFTGQMSG QMLPQQGPVN NSPSQVMGIQ GQVLRPPGPS
810 820 830 840 850
PHMAQQHNDP VTTANNDVNL SQMMPDVSMQ QASMVPPHVQ SMQGNSASGS
860 870 880 890 900
HFSGHGVSFN APFGGAPNGS QMSCGQNPGF PVNKDVTLTS PLLVNLLQSD
910 920 930 940 950
ISAGHFGVNN KQNNTNANKP KKKKPPRKKK NCHQDLNTPD NRPTGLEEVD
960 970 980 990 1000
QQSLPGEQGI NLDTTGPKLP DFSNRPPGYP TQPVEQRPLP QMPPQLMQHV
1010 1020 1030 1040 1050
APPPQPPQQQ PQPQLPQQQQ PPPPSQPQSQ QQQQQQQMMM MLMMQQDPKS
1060 1070 1080 1090 1100
IRLPVSQNVH PPRGPLNPDS QRMPVQQSGN VPVMVGLQGP ASVPPSPDKQ
1110 1120 1130 1140 1150
RMPMSVNTPM GSNSRKMVYQ ENPQNSSSSP LGEMSSLPEA SGSEVPSVAG
1160 1170 1180 1190 1200
GPNNMPSHLV VSQNQLMMTG PKPGPSPLSA TQGATPQQPP VNSLPSSHGH
1210 1220 1230 1240 1250
HFPNVAAPTQ TSRPKTPNRA SPRPYYPQTP NNRPPSTEPS EISLSPERLN
1260 1270 1280 1290 1300
ASIAGLFPPQ INIPLPPRPN LNRGFDQQGL NPTTLKAIGQ APSNLTITNP
1310 1320 1330 1340 1350
PNFAAPQAHK LDSVVVNSGK QSNPGTTKRA SPSNSRRSSP GSSRKTTPSP
1360 1370 1380 1390 1400
GRQNSKAPKL TLASQTSTTM LQNMELPRNV LVGPTPLANP PLPGSFPNNT
1410 1420 1430 1440 1450
GLNPQNPTVP VPAMGTVLED NKESVNIPQD SDCQNAQGRK EQVNTELKVV
1460 1470 1480 1490 1500
PTQEAKMAVP EDQSKKDGQP LDPNKLPSVE ENKNLMSPAM REAPTSLSQL
1510 1520 1530 1540 1550
LDNSGAPNVT IKPPGLTDLE VTPPVVSGED LRKASVIPTL QDPPSKEPST
1560 1570 1580 1590 1600
SLSSPHSSEP CSTLARSELS EVSSNTAPSI PPVMSRPVSS SSISTPLPPN
1610 1620 1630 1640 1650
QITVFVTSNP ITTSSNTSAA LPTHLQSALM STVVTMPNVG NKVMVSEGQS
1660 1670 1680 1690 1700
AAQSNARPQF ITPVFINSSS IIQVMKGSQP STIPATPLTT NSGLMPPSVA
1710 1720 1730 1740 1750
VVGPLHIPQN IKFSSAPVTP NVPSSSPAPN IQTGRPLVLS SRATPVQLPS
1760 1770 1780 1790 1800
PPCTSSPVVA PNPSVQQVKE LNPDEASPQT NTSADQSTLP PSQPTTVVSP
1810 1820 1830 1840 1850
LLTNSPGSSA NRRSPVSSSK GKGKVDKIGQ ILLTKACKKV TGSLEKGEEQ
1860 1870 1880 1890 1900
YGADGETEGP GLEITTPGLM GTEQCSTELD SKTPTPSAPT LLKMTSSPMG
1910 1920 1930 1940 1950
PSSTSTGPIL PGGALPTSVR SIVTTLVPSE LISTAPTTKG NHGGVTSEPL
1960 1970 1980 1990 2000
AGGLVEEKVG SHPELLPSIA PSQNLAPKET PATALQGSVA RPELEANAAI
2010 2020 2030 2040 2050
ASGQSCEPKE IVEKSKTLTS RRNSRTEEPT MASESVENGH RKRSSRPASA
2060
SSSTKDITGA VQSKRRKSK
Length:2,069
Mass (Da):219,958
Last modified:November 23, 2004 - v1
Checksum:i018B0C0F6886A200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844852 Genomic DNA. No translation available.
AL845325 Genomic DNA. No translation available.
BC083187 mRNA. Translation: AAH83187.1.
CH466551 Genomic DNA. Translation: EDL06121.1.
RefSeqiNP_001229487.1. NM_001242558.1.
NP_062799.2. NM_019825.3.
XP_006499990.1. XM_006499927.1.
XP_006499991.1. XM_006499928.1.
XP_011238010.1. XM_011239708.1.
UniGeneiMm.27592.

Genome annotation databases

EnsembliENSMUST00000043126; ENSMUSP00000045386; ENSMUSG00000038369.
ENSMUST00000109670; ENSMUSP00000105295; ENSMUSG00000038369.
GeneIDi56406.
KEGGimmu:56406.
UCSCiuc008nkm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844852 Genomic DNA. No translation available.
AL845325 Genomic DNA. No translation available.
BC083187 mRNA. Translation: AAH83187.1.
CH466551 Genomic DNA. Translation: EDL06121.1.
RefSeqiNP_001229487.1. NM_001242558.1.
NP_062799.2. NM_019825.3.
XP_006499990.1. XM_006499927.1.
XP_006499991.1. XM_006499928.1.
XP_011238010.1. XM_011239708.1.
UniGeneiMm.27592.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045386.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043126; ENSMUSP00000045386; ENSMUSG00000038369.
ENSMUST00000109670; ENSMUSP00000105295; ENSMUSG00000038369.
GeneIDi56406.
KEGGimmu:56406.
UCSCiuc008nkm.2. mouse.

Organism-specific databases

CTDi23054.
MGIiMGI:1929915. Ncoa6.

Phylogenomic databases

eggNOGiENOG410IK20. Eukaryota.
ENOG410XW4F. LUCA.
GeneTreeiENSGT00730000111114.
HOGENOMiHOG000113745.
HOVERGENiHBG052586.
KOiK14971.
OMAiMEAAFPM.
TreeFamiTF332639.

Enzyme and pathway databases

ReactomeiR-MMU-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Miscellaneous databases

ChiTaRSiNcoa6. mouse.
SOURCEiSearch...

Family and domain databases

InterProiIPR026638. NCOA6.
IPR032715. NCOA6_nucleic_acid-bd.
[Graphical view]
PANTHERiPTHR15690:SF0. PTHR15690:SF0. 2 hits.
PfamiPF13820. Nucleic_acid_bd. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQ5XJV5_MOUSE
AccessioniPrimary (citable) accession number: Q5XJV5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.