Q5XJ54 (GLRX3_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutaredoxin 3

Gene names

Name:	glrx3
Synonyms:	txnl2

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity By similarity.
Subcellular location	Cytoplasm › cell cortex By similarity.
Domain	The thioredoxin domain lacks the two redox-active cysteines. This strongly suggests that it lacks thioredoxin activity.
Sequence similarities	Contains 2 glutaredoxin domains. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	cell cortex Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Glutaredoxin 3		PRO_0000348927
Regions
	Domain	1 – 108	108	Thioredoxin
	Domain	125 – 227	103	Glutaredoxin 1
	Domain	227 – 326	100	Glutaredoxin 2

Sequences

	Sequence		Length	Mass (Da)
	Q5XJ54 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 2DC664A390D94FD5	FASTA	326	36,335
	10 20 30 40 50 60 MANFTDAASL QQFDELLKNN SKSLTVVHFH APWAPQCSQM NDVMAELAKE HKHTMFVKLE 70 80 90 100 110 120 AEAVPEVSEK YEITSVPTFL FFKGGEKIDR LDGAHAPELT NKVQRLGSGG GGAVGAGDVP 130 140 150 160 170 180 KEDLNQRLKR LINAAPCMLF MKGSPQEPRC GFSRQIIQIL KDHNVQYSSF DILSDEEVRQ 190 200 210 220 230 240 GLKTYSNWPT YPQVYVSGEL IGGLDIVKEL VESGELENTF PKTVSLENRL KSLINKSPVM 250 260 270 280 290 300 LFMKGNKEAA KCGFSRQILE IMNNTGVEYD TFDILEDEEV RQGLKTYSNW PTFPQLYVKG 310 320 DLIGGLDIVK ELLEGGELVS VLKGEN

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Larva.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC083453 mRNA. Translation: AAH83453.1. BC153570 mRNA. Translation: AAI53571.1.
IPI	IPI00480956.
RefSeq	NP_001005950.1. NM_001005950.1.
UniGene	Dr.36959.
3D structure databases
HSSP	HSSP built from PDB template 1WIK based on UniProtKB Q9CQM9.
ProteinModelPortal	Q5XJ54.
SMR	Q5XJ54. Positions 9-110, 128-216, 230-326.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5XJ54.
Proteomic databases
PRIDE	Q5XJ54.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	449777.
KEGG	dre:449777.
Organism-specific databases
CTD	10539.
ZFIN	ZDB-GENE-041010-22. glrx3.
Phylogenomic databases
eggNOG	fiNOG14939.
GeneTree	ENSGT00550000075030.
HOGENOM	HBG327968.
HOVERGEN	HBG054719.
InParanoid	Q5XJ54.
OrthoDB	EOG4V9TR0.
PhylomeDB	Q5XJ54.
Gene expression databases
ArrayExpress	Q5XJ54.
Bgee	Q5XJ54.
Family and domain databases
InterPro	IPR002109. Glutaredoxin. IPR004480. Monothiol_GRX-rel. IPR012336. Thioredoxin-like_fold. IPR013766. Thioredoxin_domain. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 3 hits.
PANTHER	PTHR10293. Glutredox-rel. 1 hit.
Pfam	PF00462. Glutaredoxin. 2 hits. PF00085. Thioredoxin. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 3 hits.
TIGRFAMs	TIGR00365. TIGR00365. 2 hits.
PROSITE	PS51354. GLUTAREDOXIN_2. 2 hits. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX3_DANRE

Accession

Primary (citable) accession number: Q5XJ54

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	November 23, 2004
Last modified:	September 21, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program