Reviewed, UniProtKB/Swiss-Prot Q5XIZ6 (GPD1L_DANRE)

Names and origin

Protein names

Recommended name:
    Glycerol-3-phosphate dehydrogenase 1-like protein
    EC=1.1.1.8

Gene names

Name:

gpd1l

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.
Subcellular location	CytoplasmPotential.
Sequence similarities	Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate catabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	glycerol-3-phosphate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate dehydrogenase (NAD+) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Glycerol-3-phosphate dehydrogenase 1-like protein		PRO_0000286514
Regions
	Nucleotide binding	11 – 16	6	NAD By similarity
	Region	271 – 272	2	Substrate binding By similarity
Sites
	Active site	205	1	Proton acceptor By similarity
	Binding site	98	1	NAD By similarity
	Binding site	121	1	Substrate By similarity
	Binding site	154	1	NAD; via amide nitrogen By similarity
	Binding site	271	1	NAD By similarity
	Binding site	298	1	NAD; via amide nitrogen By similarity
	Binding site	300	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5XIZ6-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 13392C6CE9204871	FASTA	351	38,285
	10 20 30 40 50 60 MAAPLKVCIV GSGNWGSAIA RIIGSNAQKL QCFATTVKMW VYEEMVNGKK LSEIINTEHE 70 80 90 100 110 120 NVKYLPGYKL PENVVAVPQL RDAADGADLL VFVVPHQFIR KLCDEMMGCV SERARGITLI 130 140 150 160 170 180 KGIDEGPEGL KLISDIIREK MGIDVSVLMG ANIANEVAAE KFCESTIGSK VLENGLLFKD 190 200 210 220 230 240 LLQTPNFRIT VVDDADTVEL CGALKNIVAV GAGFCDGLQC GDNTKAAVIR LGLMEMIAFA 250 260 270 280 290 300 KLFSKDDSVS SATFLESCGV ADLITTCYGG RNRRVAEAFA KTGKSIEELE KEMLNGQKLQ 310 320 330 340 350 GPLTSAEVYH ILKQKGLVEK FPLFTAVYQI CFEDKPVRDM ITCLQSHPEH L

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC083522 mRNA. Translation: AAH83522.1.
RefSeq	NP_001005934.1.
UniGene	Dr.80185
3D structure databases
SMR	Q5XIZ6. Positions 3-346.
ModBase	Search...
Genome annotation databases
Ensembl	ENSDARG00000040024. Danio rerio. [Contig view]
GeneID	449663.
KEGG	dre:449663.
Organism-specific databases
ZFIN	ZDB-GENE-041010-220. gpd1l.
Phylogenomic databases
HOGENOM	Q5XIZ6.
HOVERGEN	Q5XIZ6.
Gene expression databases
ArrayExpress	Q5XIZ6.
Family and domain databases
InterPro	IPR013328. DHase_multihelical. IPR016040. NAD(P)-bd. IPR017751. NAD-dep_Gly3P_DH_euk. IPR006168. NAD-dep_Gly3P_DHase. IPR011128. NAD-dep_Gly3P_DHase_N. IPR006109. NAD_Gly3P_DHase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PANTHER	PTHR11728. NAD_Gly3P_DH. 1 hit.
Pfam	PF07479. NAD_Gly3P_dh_C. 1 hit. PF01210. NAD_Gly3P_dh_N. 1 hit. [Graphical view]
PIRSF	PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTS	PR00077. GPDHDRGNASE.
ProDom	PD001278. NAD_Gly3P_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00957. NAD_G3PDH. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPD1L_DANRE

Accession

Primary (citable) accession number: Q5XIZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	November 23, 2004
Last modified:	November 25, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project