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Protein

Glycerol-3-phosphate dehydrogenase 1-like protein

Gene

gpd1l

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in regulating cardiac sodium current.By similarity

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981NADBy similarity
Binding sitei121 – 1211SubstrateBy similarity
Binding sitei154 – 1541NAD; via amide nitrogenBy similarity
Active sitei205 – 2051Proton acceptorBy similarity
Binding sitei271 – 2711NADBy similarity
Binding sitei298 – 2981NAD; via amide nitrogenBy similarity
Binding sitei300 – 3001NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADBy similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_317406. Triglyceride Biosynthesis.
REACT_338865. Synthesis of PA.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase 1-like protein (EC:1.1.1.8)
Gene namesi
Name:gpd1l
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-041010-220. gpd1l.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Glycerol-3-phosphate dehydrogenase 1-like proteinPRO_0000286514Add
BLAST

Proteomic databases

PRIDEiQ5XIZ6.

Expressioni

Gene expression databases

BgeeiQ5XIZ6.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000058549.

Structurei

3D structure databases

ProteinModelPortaliQ5XIZ6.
SMRiQ5XIZ6. Positions 3-346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni271 – 2722Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
HOVERGENiHBG003669.
InParanoidiQ5XIZ6.
KOiK00006.
OMAiFEEDISG.
OrthoDBiEOG7ZKSBS.
PhylomeDBiQ5XIZ6.
TreeFamiTF300836.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XIZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPLKVCIV GSGNWGSAIA RIIGSNAQKL QCFATTVKMW VYEEMVNGKK
60 70 80 90 100
LSEIINTEHE NVKYLPGYKL PENVVAVPQL RDAADGADLL VFVVPHQFIR
110 120 130 140 150
KLCDEMMGCV SERARGITLI KGIDEGPEGL KLISDIIREK MGIDVSVLMG
160 170 180 190 200
ANIANEVAAE KFCESTIGSK VLENGLLFKD LLQTPNFRIT VVDDADTVEL
210 220 230 240 250
CGALKNIVAV GAGFCDGLQC GDNTKAAVIR LGLMEMIAFA KLFSKDDSVS
260 270 280 290 300
SATFLESCGV ADLITTCYGG RNRRVAEAFA KTGKSIEELE KEMLNGQKLQ
310 320 330 340 350
GPLTSAEVYH ILKQKGLVEK FPLFTAVYQI CFEDKPVRDM ITCLQSHPEH

L
Length:351
Mass (Da):38,285
Last modified:November 23, 2004 - v1
Checksum:i13392C6CE9204871
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083522 mRNA. Translation: AAH83522.1.
RefSeqiNP_001005934.1. NM_001005934.1.
XP_009290808.1. XM_009292533.1.
UniGeneiDr.80185.

Genome annotation databases

EnsembliENSDART00000058550; ENSDARP00000058549; ENSDARG00000040024.
ENSDART00000133642; ENSDARP00000123149; ENSDARG00000040024.
GeneIDi449663.
KEGGidre:449663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083522 mRNA. Translation: AAH83522.1.
RefSeqiNP_001005934.1. NM_001005934.1.
XP_009290808.1. XM_009292533.1.
UniGeneiDr.80185.

3D structure databases

ProteinModelPortaliQ5XIZ6.
SMRiQ5XIZ6. Positions 3-346.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000058549.

Proteomic databases

PRIDEiQ5XIZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000058550; ENSDARP00000058549; ENSDARG00000040024.
ENSDART00000133642; ENSDARP00000123149; ENSDARG00000040024.
GeneIDi449663.
KEGGidre:449663.

Organism-specific databases

CTDi23171.
ZFINiZDB-GENE-041010-220. gpd1l.

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
HOVERGENiHBG003669.
InParanoidiQ5XIZ6.
KOiK00006.
OMAiFEEDISG.
OrthoDBiEOG7ZKSBS.
PhylomeDBiQ5XIZ6.
TreeFamiTF300836.

Enzyme and pathway databases

ReactomeiREACT_317406. Triglyceride Biosynthesis.
REACT_338865. Synthesis of PA.

Miscellaneous databases

NextBioi20832764.
PROiQ5XIZ6.

Gene expression databases

BgeeiQ5XIZ6.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGPD1L_DANRE
AccessioniPrimary (citable) accession number: Q5XIZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 23, 2004
Last modified: April 1, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.