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Q5XIZ6 (GPD1L_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase 1-like protein
EC=1.1.1.8
Gene names
Name:gpd1l
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in regulating cardiac sodium current By similarity.

Catalytic activity

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Glycerol-3-phosphate dehydrogenase 1-like protein
PRO_0000286514

Regions

Nucleotide binding11 – 166NAD By similarity
Region271 – 2722Substrate binding By similarity

Sites

Active site2051Proton acceptor By similarity
Binding site981NAD By similarity
Binding site1211Substrate By similarity
Binding site1541NAD; via amide nitrogen By similarity
Binding site2711NAD By similarity
Binding site2981NAD; via amide nitrogen By similarity
Binding site3001NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5XIZ6 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 13392C6CE9204871

FASTA35138,285
        10         20         30         40         50         60 
MAAPLKVCIV GSGNWGSAIA RIIGSNAQKL QCFATTVKMW VYEEMVNGKK LSEIINTEHE 

        70         80         90        100        110        120 
NVKYLPGYKL PENVVAVPQL RDAADGADLL VFVVPHQFIR KLCDEMMGCV SERARGITLI 

       130        140        150        160        170        180 
KGIDEGPEGL KLISDIIREK MGIDVSVLMG ANIANEVAAE KFCESTIGSK VLENGLLFKD 

       190        200        210        220        230        240 
LLQTPNFRIT VVDDADTVEL CGALKNIVAV GAGFCDGLQC GDNTKAAVIR LGLMEMIAFA 

       250        260        270        280        290        300 
KLFSKDDSVS SATFLESCGV ADLITTCYGG RNRRVAEAFA KTGKSIEELE KEMLNGQKLQ 

       310        320        330        340        350 
GPLTSAEVYH ILKQKGLVEK FPLFTAVYQI CFEDKPVRDM ITCLQSHPEH L

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC083522 mRNA. Translation: AAH83522.1.
IPIIPI00506940.
RefSeqNP_001005934.1. NM_001005934.1.
UniGeneDr.80185.

3D structure databases

ProteinModelPortalQ5XIZ6.
SMRQ5XIZ6. Positions 3-346.
ModBaseSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000058549.

Proteomic databases

PRIDEQ5XIZ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000058550; ENSDARP00000058549; ENSDARG00000040024.
ENSDART00000133642; ENSDARP00000123149; ENSDARG00000040024.
GeneID449663.
KEGGdre:449663.

Organism-specific databases

CTD23171.
ZFINZDB-GENE-041010-220. gpd1l.

Phylogenomic databases

eggNOGCOG0240.
GeneTreeENSGT00390000003114.
HOGENOMHOG000246855.
HOVERGENHBG003669.
InParanoidQ5XIZ6.
KOK00006.
OMAKPVQEML.
OrthoDBEOG4WQ12X.

Gene expression databases

BgeeQ5XIZ6.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11728. PTHR11728. 1 hit.
PfamPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSPR00077. GPDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR03376. glycerol3P_DH. 1 hit.
PROSITEPS00957. NAD_G3PDH. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio20832764.

Entry information

Entry nameGPD1L_DANRE
AccessionPrimary (citable) accession number: Q5XIZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 23, 2004
Last modified: May 29, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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