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Q5XIZ6

- GPD1L_DANRE

UniProt

Q5XIZ6 - GPD1L_DANRE

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Protein

Glycerol-3-phosphate dehydrogenase 1-like protein

Gene

gpd1l

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role in regulating cardiac sodium current.By similarity

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981NADBy similarity
Binding sitei121 – 1211SubstrateBy similarity
Binding sitei154 – 1541NAD; via amide nitrogenBy similarity
Active sitei205 – 2051Proton acceptorBy similarity
Binding sitei271 – 2711NADBy similarity
Binding sitei298 – 2981NAD; via amide nitrogenBy similarity
Binding sitei300 – 3001NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADBy similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_181620. Synthesis of PA.
REACT_238155. Triglyceride Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase 1-like protein (EC:1.1.1.8)
Gene namesi
Name:gpd1l
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-041010-220. gpd1l.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Glycerol-3-phosphate dehydrogenase 1-like proteinPRO_0000286514Add
BLAST

Proteomic databases

PRIDEiQ5XIZ6.

Expressioni

Gene expression databases

BgeeiQ5XIZ6.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000058549.

Structurei

3D structure databases

ProteinModelPortaliQ5XIZ6.
SMRiQ5XIZ6. Positions 3-346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni271 – 2722Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
HOVERGENiHBG003669.
InParanoidiQ5XIZ6.
KOiK00006.
OMAiTEMIAFA.
OrthoDBiEOG7ZKSBS.
PhylomeDBiQ5XIZ6.
TreeFamiTF300836.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XIZ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPLKVCIV GSGNWGSAIA RIIGSNAQKL QCFATTVKMW VYEEMVNGKK
60 70 80 90 100
LSEIINTEHE NVKYLPGYKL PENVVAVPQL RDAADGADLL VFVVPHQFIR
110 120 130 140 150
KLCDEMMGCV SERARGITLI KGIDEGPEGL KLISDIIREK MGIDVSVLMG
160 170 180 190 200
ANIANEVAAE KFCESTIGSK VLENGLLFKD LLQTPNFRIT VVDDADTVEL
210 220 230 240 250
CGALKNIVAV GAGFCDGLQC GDNTKAAVIR LGLMEMIAFA KLFSKDDSVS
260 270 280 290 300
SATFLESCGV ADLITTCYGG RNRRVAEAFA KTGKSIEELE KEMLNGQKLQ
310 320 330 340 350
GPLTSAEVYH ILKQKGLVEK FPLFTAVYQI CFEDKPVRDM ITCLQSHPEH

L
Length:351
Mass (Da):38,285
Last modified:November 23, 2004 - v1
Checksum:i13392C6CE9204871
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083522 mRNA. Translation: AAH83522.1.
RefSeqiNP_001005934.1. NM_001005934.1.
UniGeneiDr.80185.

Genome annotation databases

EnsembliENSDART00000058550; ENSDARP00000058549; ENSDARG00000040024.
ENSDART00000133642; ENSDARP00000123149; ENSDARG00000040024.
GeneIDi449663.
KEGGidre:449663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083522 mRNA. Translation: AAH83522.1 .
RefSeqi NP_001005934.1. NM_001005934.1.
UniGenei Dr.80185.

3D structure databases

ProteinModelPortali Q5XIZ6.
SMRi Q5XIZ6. Positions 3-346.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000058549.

Proteomic databases

PRIDEi Q5XIZ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000058550 ; ENSDARP00000058549 ; ENSDARG00000040024 .
ENSDART00000133642 ; ENSDARP00000123149 ; ENSDARG00000040024 .
GeneIDi 449663.
KEGGi dre:449663.

Organism-specific databases

CTDi 23171.
ZFINi ZDB-GENE-041010-220. gpd1l.

Phylogenomic databases

eggNOGi COG0240.
GeneTreei ENSGT00390000003114.
HOGENOMi HOG000246855.
HOVERGENi HBG003669.
InParanoidi Q5XIZ6.
KOi K00006.
OMAi TEMIAFA.
OrthoDBi EOG7ZKSBS.
PhylomeDBi Q5XIZ6.
TreeFami TF300836.

Enzyme and pathway databases

Reactomei REACT_181620. Synthesis of PA.
REACT_238155. Triglyceride Biosynthesis.

Miscellaneous databases

NextBioi 20832764.
PROi Q5XIZ6.

Gene expression databases

Bgeei Q5XIZ6.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGPD1L_DANRE
AccessioniPrimary (citable) accession number: Q5XIZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3