Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5XIZ6

- GPD1L_DANRE

UniProt

Q5XIZ6 - GPD1L_DANRE

Protein

Glycerol-3-phosphate dehydrogenase 1-like protein

Gene

gpd1l

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays a role in regulating cardiac sodium current.By similarity

    Catalytic activityi

    sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei98 – 981NADBy similarity
    Binding sitei121 – 1211SubstrateBy similarity
    Binding sitei154 – 1541NAD; via amide nitrogenBy similarity
    Active sitei205 – 2051Proton acceptorBy similarity
    Binding sitei271 – 2711NADBy similarity
    Binding sitei298 – 2981NAD; via amide nitrogenBy similarity
    Binding sitei300 – 3001NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADBy similarity

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. glycerol-3-phosphate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    ReactomeiREACT_181620. Synthesis of PA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase 1-like protein (EC:1.1.1.8)
    Gene namesi
    Name:gpd1l
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 16

    Organism-specific databases

    ZFINiZDB-GENE-041010-220. gpd1l.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Glycerol-3-phosphate dehydrogenase 1-like proteinPRO_0000286514Add
    BLAST

    Proteomic databases

    PRIDEiQ5XIZ6.

    Expressioni

    Gene expression databases

    BgeeiQ5XIZ6.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000058549.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XIZ6.
    SMRiQ5XIZ6. Positions 3-346.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni271 – 2722Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0240.
    GeneTreeiENSGT00390000003114.
    HOGENOMiHOG000246855.
    HOVERGENiHBG003669.
    InParanoidiQ5XIZ6.
    KOiK00006.
    OMAiTEMIAFA.
    OrthoDBiEOG7ZKSBS.
    PhylomeDBiQ5XIZ6.
    TreeFamiTF300836.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR017751. G3P_DH_NAD-dep_euk.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11728. PTHR11728. 1 hit.
    PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSiPR00077. GPDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5XIZ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPLKVCIV GSGNWGSAIA RIIGSNAQKL QCFATTVKMW VYEEMVNGKK    50
    LSEIINTEHE NVKYLPGYKL PENVVAVPQL RDAADGADLL VFVVPHQFIR 100
    KLCDEMMGCV SERARGITLI KGIDEGPEGL KLISDIIREK MGIDVSVLMG 150
    ANIANEVAAE KFCESTIGSK VLENGLLFKD LLQTPNFRIT VVDDADTVEL 200
    CGALKNIVAV GAGFCDGLQC GDNTKAAVIR LGLMEMIAFA KLFSKDDSVS 250
    SATFLESCGV ADLITTCYGG RNRRVAEAFA KTGKSIEELE KEMLNGQKLQ 300
    GPLTSAEVYH ILKQKGLVEK FPLFTAVYQI CFEDKPVRDM ITCLQSHPEH 350
    L 351
    Length:351
    Mass (Da):38,285
    Last modified:November 23, 2004 - v1
    Checksum:i13392C6CE9204871
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083522 mRNA. Translation: AAH83522.1.
    RefSeqiNP_001005934.1. NM_001005934.1.
    UniGeneiDr.80185.

    Genome annotation databases

    EnsembliENSDART00000058550; ENSDARP00000058549; ENSDARG00000040024.
    ENSDART00000133642; ENSDARP00000123149; ENSDARG00000040024.
    GeneIDi449663.
    KEGGidre:449663.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083522 mRNA. Translation: AAH83522.1 .
    RefSeqi NP_001005934.1. NM_001005934.1.
    UniGenei Dr.80185.

    3D structure databases

    ProteinModelPortali Q5XIZ6.
    SMRi Q5XIZ6. Positions 3-346.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000058549.

    Proteomic databases

    PRIDEi Q5XIZ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000058550 ; ENSDARP00000058549 ; ENSDARG00000040024 .
    ENSDART00000133642 ; ENSDARP00000123149 ; ENSDARG00000040024 .
    GeneIDi 449663.
    KEGGi dre:449663.

    Organism-specific databases

    CTDi 23171.
    ZFINi ZDB-GENE-041010-220. gpd1l.

    Phylogenomic databases

    eggNOGi COG0240.
    GeneTreei ENSGT00390000003114.
    HOGENOMi HOG000246855.
    HOVERGENi HBG003669.
    InParanoidi Q5XIZ6.
    KOi K00006.
    OMAi TEMIAFA.
    OrthoDBi EOG7ZKSBS.
    PhylomeDBi Q5XIZ6.
    TreeFami TF300836.

    Enzyme and pathway databases

    Reactomei REACT_181620. Synthesis of PA.

    Miscellaneous databases

    NextBioi 20832764.
    PROi Q5XIZ6.

    Gene expression databases

    Bgeei Q5XIZ6.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR017751. G3P_DH_NAD-dep_euk.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11728. PTHR11728. 1 hit.
    Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSi PR00077. GPDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiGPD1L_DANRE
    AccessioniPrimary (citable) accession number: Q5XIZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3