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Protein

PAX-interacting protein 1

Gene

paxip1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in DNA damage response. May function as transcriptional cofactor in TGF beta signaling. Accentuates Smad2-dependent transcription (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
PAX-interacting protein 1
Alternative name(s):
PAX transactivation activation domain-interacting protein
Gene namesi
Name:paxip1
ORF Names:zgc:92593
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-041010-214. paxip1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002962641 – 943PAX-interacting protein 1Add BLAST943

Proteomic databases

PaxDbiQ5XIY8.
PeptideAtlasiQ5XIY8.
PRIDEiQ5XIY8.

Interactioni

Subunit structurei

Interacts with smad2 via its last three BRCT domain-containing regions in an activin signal-dependent manner.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000113779.

Structurei

3D structure databases

ProteinModelPortaliQ5XIY8.
SMRiQ5XIY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 93BRCT 1PROSITE-ProRule annotationAdd BLAST86
Domaini94 – 182BRCT 2PROSITE-ProRule annotationAdd BLAST89
Domaini664 – 756BRCT 3PROSITE-ProRule annotationAdd BLAST93
Domaini763 – 851BRCT 4PROSITE-ProRule annotationAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi730 – 747Nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi379 – 646Gln-richAdd BLAST268

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2043. Eukaryota.
ENOG410XSGS. LUCA.
HOVERGENiHBG061191.
InParanoidiQ5XIY8.

Family and domain databases

CDDicd00027. BRCT. 4 hits.
Gene3Di3.40.50.10190. 4 hits.
InterProiView protein in InterPro
IPR001357. BRCT_dom.
PfamiView protein in Pfam
PF00533. BRCT. 1 hit.
PF12738. PTCB-BRCT. 2 hits.
SMARTiView protein in SMART
SM00292. BRCT. 4 hits.
SUPFAMiSSF52113. SSF52113. 4 hits.
PROSITEiView protein in PROSITE
PS50172. BRCT. 4 hits.

Sequencei

Sequence statusi: Complete.

Q5XIY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDDLKVPE ELFKDVKFYV VGDIDQKVVQ LLKSGKGKEV SYNALATHII
60 70 80 90 100
AEDGDNPEVG ESREVFDLPV VKPSWVILSV KCGDLLPVTG FSPESGQVFF
110 120 130 140 150
GVTACLPHLA EDLNALWAFI TFYGGDCQLH FNKKCTHLVV PEPKGAKYEC
160 170 180 190 200
ALRHNNIKIV TPEWILDSVK EKNRKDEMLY HPRLTLYDAP EEEGSEYENE
210 220 230 240 250
RSSRSEGSYS DRRSPHSRRS SPTSSRDASP AGRRSPSTKH ERKSELMFDD
260 270 280 290 300
SDDSSPEKED RNLNWTPAEV LPPGPAKRRL QPGKETGLIN LCANVPPVPG
310 320 330 340 350
SFGPPDARMV GAGAGAGGGV PMGVERLEVM SEWNSAARTL RNITNNTDTQ
360 370 380 390 400
QPSRPSNVAH IIQSFSASSK GVVDHMGNQG QSGIPNQLLL KAQQQLPPEA
410 420 430 440 450
QQQLLQQQQQ QSHQLQQQQQ QHQMAQQHPM MLPQVMQMHH HQQQQQHQPP
460 470 480 490 500
PQQQQQQQNQ QGFPQMPPQS HQFLQQQMHQ QMYSQHQQQQ QQQQQQQQQH
510 520 530 540 550
AFPQQMRPQQ LPRLPLQHQQ QHVLQQQLQL QQQHRLQLQL QQQQQQQQQQ
560 570 580 590 600
QQQQQQQQQQ QQQQQQQQQQ QQKQQQQQQQ NQQQMHQQYL QQQQHFLQQQ
610 620 630 640 650
LQQQHMQQLQ QQQQMQQQQQ QHLQNQQPLQ HQNQQVNPHQ TQTMLQPPIT
660 670 680 690 700
SAQLFGHEPG HDIPEEGFLV GCIFAIADYP EQMADKQLLA TWKRIIQLNG
710 720 730 740 750
GTVDSALNRC THLLCESQVS NTYLQALREG KRCVTAHWLN TVLKKKKMVP
760 770 780 790 800
PHRTLHLPFS FPPGAKPCAQ HIISVTGFVD SDRDDLKLMA YLAGARYTGY
810 820 830 840 850
LCRSNTVLIC KEPSGLKYEK AKEWRIPCVN AQWLCDILLG NFEALRQIQH
860 870 880 890 900
SKYTQFNLPD PLAPNHHLVH NLLSAWRIPV KISPEALASL RLQLKQKQAD
910 920 930 940
VSVQPPSKRP KLEELPTPTK SFHLIQHLTS FSQALNLCRL SST
Length:943
Mass (Da):108,033
Last modified:November 23, 2004 - v1
Checksum:i0EB659817675CD56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083530 mRNA. Translation: AAH83530.1.
UniGeneiDr.522.

Similar proteinsi

Entry informationi

Entry nameiPAXI1_DANRE
AccessioniPrimary (citable) accession number: Q5XIY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: November 23, 2004
Last modified: May 10, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome