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Q5XIX3

- DCR1C_RAT

UniProt

Q5XIX3 - DCR1C_RAT

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Protein

Protein artemis

Gene

Dclre1c

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation, and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (By similarity).By similarity

GO - Molecular functioni

  1. 5'-3' exonuclease activity Source: Ensembl
  2. single-stranded DNA endodeoxyribonuclease activity Source: Ensembl

GO - Biological processi

  1. B cell differentiation Source: Ensembl
  2. DNA recombination Source: UniProtKB-KW
  3. double-strand break repair Source: Ensembl
  4. response to ionizing radiation Source: Ensembl
  5. telomere maintenance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Adaptive immunity, DNA damage, DNA recombination, DNA repair, Immunity

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein artemis (EC:3.1.-.-)
Alternative name(s):
DNA cross-link repair 1C protein
SNM1-like protein
Gene namesi
Name:Dclre1c
Synonyms:Snm1l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi708574. Dclre1c.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698Protein artemisPRO_0000209125Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei650 – 6501Phosphoserine; by ATMBy similarity

Post-translational modificationi

Phosphorylation on undefined residues by PRKDC may stimulate endonucleolytic activity on 5' and 3' hairpins and overhangs. PRKDC must remain present, even after phosphorylation, for efficient hairpin opening. Also phosphorylated by ATM in response to ionizing radiation (IR) and by ATR in response to ultraviolet (UV) radiation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5XIX3.

PTM databases

PhosphoSiteiQ5XIX3.

Expressioni

Gene expression databases

GenevestigatoriQ5XIX3.

Interactioni

Subunit structurei

Interacts with ATM, BRCA1, PRKDC and TP53BP1. Also exhibits ATM- and phosphorylation-dependent interaction with the MRN complex, composed of MRE11A/MRE11, RAD50, and NBN (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021506.

Structurei

3D structure databases

ProteinModelPortaliQ5XIX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1236.
GeneTreeiENSGT00530000063183.
HOGENOMiHOG000231568.
HOVERGENiHBG081421.
InParanoidiQ5XIX3.
KOiK10887.
OMAiMFRNMPD.
OrthoDBiEOG70CR8F.
PhylomeDBiQ5XIX3.
TreeFamiTF329572.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR011084. DRMBL.
[Graphical view]
PfamiPF07522. DRMBL. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XIX3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSFQGQMEE YPTISIDRFD RENLKARAYF LSHCHKDHMK GLRAPSMKRR
60 70 80 90 100
LECSLKVFLY CSPVTKELLL TSPKYKFWEN RIIAIEIETP TQVSLVDEAS
110 120 130 140 150
GEKEEVVVTL LPAGHCPGSV MFLFQGSNGT VLYTGDFRLA KGEVSRMELL
160 170 180 190 200
HSGGRVKDIQ SVYLDTTFCD PRFYQIPSRE ECLRGVLELV RSWITRSPKH
210 220 230 240 250
VVWLNCKAAY GYEYLFTNLS EELGVQVHVD KLDMFKNMPD ILHHLTTDRN
260 270 280 290 300
TQIHACRHPK AEEYFQWNKL PCGMASKTKT VLHTISIKPS TMWFGERTRK
310 320 330 340 350
TNVIVRTGES SYRACFSFHS SYSEIKDFLS YICPVNAYPN VIPIGLTVDK
360 370 380 390 400
VMDFLKPLCR SSQCAEPKYK PLGKLKRART VHLDSEEDDD LFDDPLLTHS
410 420 430 440 450
RRKVPYQVTL HPEVFSMKAL PLDQPELGQS PGCCKAESMP SPSLANFVDC
460 470 480 490 500
DESNSDSEGE LETPPSLQGG LGPTTLPQQN ADPDVDVPRW EVFFKRKDEI
510 520 530 540 550
TDECLENLPS SIETGGSQSP KRFSDSPKLG SDSDGESTHI SSQNSSQSTH
560 570 580 590 600
ITDQGSQGWD SQCDTVLLSS QEKSGGDSTS LNKDTYKPKP KDSISASQIE
610 620 630 640 650
QNALCPQDTH CDLKSGAEVN GVPCIEEPDT VSGRKSSPEK TSLTSTQADS
660 670 680 690
QSSSDFEIPS TPEAELPKPE HLQFLYGKLA TGESIVLKKE NVHSQIFK
Length:698
Mass (Da):78,189
Last modified:November 23, 2004 - v1
Checksum:i28D2F15EAA5ADF85
GO

Sequence cautioni

The sequence AAM89124.1 differs from that shown. Reason: Frameshift at position 686.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti623 – 6231P → S in AAM89124. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF395746 mRNA. Translation: AAM89124.1. Frameshift.
BC083546 mRNA. Translation: AAH83546.1.
RefSeqiNP_671486.2. NM_147145.2.
UniGeneiRn.204346.

Genome annotation databases

EnsembliENSRNOT00000021506; ENSRNOP00000021506; ENSRNOG00000015980.
GeneIDi259171.
KEGGirno:259171.
UCSCiRGD:708574. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF395746 mRNA. Translation: AAM89124.1 . Frameshift.
BC083546 mRNA. Translation: AAH83546.1 .
RefSeqi NP_671486.2. NM_147145.2.
UniGenei Rn.204346.

3D structure databases

ProteinModelPortali Q5XIX3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021506.

PTM databases

PhosphoSitei Q5XIX3.

Proteomic databases

PRIDEi Q5XIX3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021506 ; ENSRNOP00000021506 ; ENSRNOG00000015980 .
GeneIDi 259171.
KEGGi rno:259171.
UCSCi RGD:708574. rat.

Organism-specific databases

CTDi 64421.
RGDi 708574. Dclre1c.

Phylogenomic databases

eggNOGi COG1236.
GeneTreei ENSGT00530000063183.
HOGENOMi HOG000231568.
HOVERGENi HBG081421.
InParanoidi Q5XIX3.
KOi K10887.
OMAi MFRNMPD.
OrthoDBi EOG70CR8F.
PhylomeDBi Q5XIX3.
TreeFami TF329572.

Miscellaneous databases

NextBioi 624222.
PROi Q5XIX3.

Gene expression databases

Genevestigatori Q5XIX3.

Family and domain databases

Gene3Di 3.60.15.10. 1 hit.
InterProi IPR001279. Beta-lactamas-like.
IPR011084. DRMBL.
[Graphical view ]
Pfami PF07522. DRMBL. 1 hit.
[Graphical view ]
SUPFAMi SSF56281. SSF56281. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse and rat SNM1-like genes, cloning, expression and mapping."
    Li L., Zhou Y., Xie G., Cowan M.J.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiDCR1C_RAT
AccessioniPrimary (citable) accession number: Q5XIX3
Secondary accession number(s): Q8K4H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3