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Q5XIX3

- DCR1C_RAT

UniProt

Q5XIX3 - DCR1C_RAT

Protein

Protein artemis

Gene

Dclre1c

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation, and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ By similarity.By similarity

    GO - Molecular functioni

    1. 5'-3' exonuclease activity Source: Ensembl
    2. single-stranded DNA endodeoxyribonuclease activity Source: Ensembl

    GO - Biological processi

    1. B cell differentiation Source: Ensembl
    2. DNA recombination Source: UniProtKB-KW
    3. double-strand break repair Source: Ensembl
    4. response to ionizing radiation Source: Ensembl
    5. telomere maintenance Source: Ensembl

    Keywords - Molecular functioni

    Endonuclease, Exonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    Adaptive immunity, DNA damage, DNA recombination, DNA repair, Immunity

    Keywords - Ligandi

    Magnesium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein artemis (EC:3.1.-.-)
    Alternative name(s):
    DNA cross-link repair 1C protein
    SNM1-like protein
    Gene namesi
    Name:Dclre1c
    Synonyms:Snm1l
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi708574. Dclre1c.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 698698Protein artemisPRO_0000209125Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei650 – 6501Phosphoserine; by ATMBy similarity

    Post-translational modificationi

    Phosphorylation on undefined residues by PRKDC may stimulate endonucleolytic activity on 5' and 3' hairpins and overhangs. PRKDC must remain present, even after phosphorylation, for efficient hairpin opening. Also phosphorylated by ATM in response to ionizing radiation (IR) and by ATR in response to ultraviolet (UV) radiation By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ5XIX3.

    PTM databases

    PhosphoSiteiQ5XIX3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5XIX3.

    Interactioni

    Subunit structurei

    Interacts with ATM, BRCA1, PRKDC and TP53BP1. Also exhibits ATM- and phosphorylation-dependent interaction with the MRN complex, composed of MRE11A/MRE11, RAD50, and NBN By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000021506.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XIX3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1236.
    GeneTreeiENSGT00530000063183.
    HOGENOMiHOG000231568.
    HOVERGENiHBG081421.
    InParanoidiQ5XIX3.
    KOiK10887.
    OMAiMFRNMPD.
    OrthoDBiEOG70CR8F.
    PhylomeDBiQ5XIX3.
    TreeFamiTF329572.

    Family and domain databases

    Gene3Di3.60.15.10. 1 hit.
    InterProiIPR001279. Beta-lactamas-like.
    IPR011084. DRMBL.
    [Graphical view]
    PfamiPF07522. DRMBL. 1 hit.
    [Graphical view]
    SUPFAMiSSF56281. SSF56281. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5XIX3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSFQGQMEE YPTISIDRFD RENLKARAYF LSHCHKDHMK GLRAPSMKRR    50
    LECSLKVFLY CSPVTKELLL TSPKYKFWEN RIIAIEIETP TQVSLVDEAS 100
    GEKEEVVVTL LPAGHCPGSV MFLFQGSNGT VLYTGDFRLA KGEVSRMELL 150
    HSGGRVKDIQ SVYLDTTFCD PRFYQIPSRE ECLRGVLELV RSWITRSPKH 200
    VVWLNCKAAY GYEYLFTNLS EELGVQVHVD KLDMFKNMPD ILHHLTTDRN 250
    TQIHACRHPK AEEYFQWNKL PCGMASKTKT VLHTISIKPS TMWFGERTRK 300
    TNVIVRTGES SYRACFSFHS SYSEIKDFLS YICPVNAYPN VIPIGLTVDK 350
    VMDFLKPLCR SSQCAEPKYK PLGKLKRART VHLDSEEDDD LFDDPLLTHS 400
    RRKVPYQVTL HPEVFSMKAL PLDQPELGQS PGCCKAESMP SPSLANFVDC 450
    DESNSDSEGE LETPPSLQGG LGPTTLPQQN ADPDVDVPRW EVFFKRKDEI 500
    TDECLENLPS SIETGGSQSP KRFSDSPKLG SDSDGESTHI SSQNSSQSTH 550
    ITDQGSQGWD SQCDTVLLSS QEKSGGDSTS LNKDTYKPKP KDSISASQIE 600
    QNALCPQDTH CDLKSGAEVN GVPCIEEPDT VSGRKSSPEK TSLTSTQADS 650
    QSSSDFEIPS TPEAELPKPE HLQFLYGKLA TGESIVLKKE NVHSQIFK 698
    Length:698
    Mass (Da):78,189
    Last modified:November 23, 2004 - v1
    Checksum:i28D2F15EAA5ADF85
    GO

    Sequence cautioni

    The sequence AAM89124.1 differs from that shown. Reason: Frameshift at position 686.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti623 – 6231P → S in AAM89124. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF395746 mRNA. Translation: AAM89124.1. Frameshift.
    BC083546 mRNA. Translation: AAH83546.1.
    RefSeqiNP_671486.2. NM_147145.2.
    UniGeneiRn.204346.

    Genome annotation databases

    EnsembliENSRNOT00000021506; ENSRNOP00000021506; ENSRNOG00000015980.
    GeneIDi259171.
    KEGGirno:259171.
    UCSCiRGD:708574. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF395746 mRNA. Translation: AAM89124.1 . Frameshift.
    BC083546 mRNA. Translation: AAH83546.1 .
    RefSeqi NP_671486.2. NM_147145.2.
    UniGenei Rn.204346.

    3D structure databases

    ProteinModelPortali Q5XIX3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000021506.

    PTM databases

    PhosphoSitei Q5XIX3.

    Proteomic databases

    PRIDEi Q5XIX3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021506 ; ENSRNOP00000021506 ; ENSRNOG00000015980 .
    GeneIDi 259171.
    KEGGi rno:259171.
    UCSCi RGD:708574. rat.

    Organism-specific databases

    CTDi 64421.
    RGDi 708574. Dclre1c.

    Phylogenomic databases

    eggNOGi COG1236.
    GeneTreei ENSGT00530000063183.
    HOGENOMi HOG000231568.
    HOVERGENi HBG081421.
    InParanoidi Q5XIX3.
    KOi K10887.
    OMAi MFRNMPD.
    OrthoDBi EOG70CR8F.
    PhylomeDBi Q5XIX3.
    TreeFami TF329572.

    Miscellaneous databases

    NextBioi 624222.
    PROi Q5XIX3.

    Gene expression databases

    Genevestigatori Q5XIX3.

    Family and domain databases

    Gene3Di 3.60.15.10. 1 hit.
    InterProi IPR001279. Beta-lactamas-like.
    IPR011084. DRMBL.
    [Graphical view ]
    Pfami PF07522. DRMBL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56281. SSF56281. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The mouse and rat SNM1-like genes, cloning, expression and mapping."
      Li L., Zhou Y., Xie G., Cowan M.J.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiDCR1C_RAT
    AccessioniPrimary (citable) accession number: Q5XIX3
    Secondary accession number(s): Q8K4H7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3