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Q5XIX0

- DJC14_RAT

UniProt

Q5XIX0 - DJC14_RAT

Protein

DnaJ homolog subfamily C member 14

Gene

Dnajc14

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.1 Publication

    GO - Molecular functioni

    1. dopamine receptor binding Source: RGD
    2. G-protein coupled receptor binding Source: RGD

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DnaJ homolog subfamily C member 14
    Alternative name(s):
    Dopamine receptor-interacting protein of 78 kDa
    Short name:
    DRiP78
    Gene namesi
    Name:Dnajc14
    Synonyms:Drip78
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi620489. Dnajc14.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi538 – 5381C → S: Loss of interaction with DRD1. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 703703DnaJ homolog subfamily C member 14PRO_0000247495Add
    BLAST

    Proteomic databases

    PRIDEiQ5XIX0.

    Expressioni

    Tissue specificityi

    Detected in heart, brain, lung, liver, skeletal muscle, kidney and testis.1 Publication

    Gene expression databases

    GenevestigatoriQ5XIX0.

    Interactioni

    Subunit structurei

    Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal domain.1 Publication

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000029946.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XIX0.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei254 – 27421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei327 – 34721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini444 – 50865JPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi149 – 1524Poly-Ser

    Sequence similaritiesi

    Contains 1 J domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0484.
    GeneTreeiENSGT00670000097756.
    HOGENOMiHOG000290199.
    HOVERGENiHBG059561.
    InParanoidiQ5XIX0.
    KOiK09534.
    OMAiPPGQMSN.
    OrthoDBiEOG7HTHGK.
    PhylomeDBiQ5XIX0.
    TreeFamiTF105173.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    InterProiIPR001623. DnaJ_domain.
    [Graphical view]
    PfamiPF00226. DnaJ. 1 hit.
    [Graphical view]
    PRINTSiPR00625. JDOMAIN.
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    PROSITEiPS50076. DNAJ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5XIX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQKHPGERG LCGVHHSGGS SLITSGSSVD PEILSFSGLR DSKETAPNGT    50
    RCLKEHSDPK CTQPPNPAHW SDPSHGPPRG PGPPREGGYP DESETCSEES 100
    GVDQELSREN ETGYQEDGSP SFLPIPSACN CQGSPGVPEG TCSEEGDGSS 150
    SSFCHHCTSP ALGEDEELEE EYDDEEPLKF PSDFSRVSSG KKPPSRRQRH 200
    RFLTKEDVRD SGRRDPKAPG RHRLARKRSQ TDKRRGLGLW GVEELCQLGQ 250
    AGFWWLIELL VLVGEYVETC GYLIYACRKL KGSDLDLFRI WVGVWARRLG 300
    GWARVMFQFL SQSFFSVAGL FIRLLRVVGA FLLLALALFL GCLQLGWRFL 350
    VGLGDRLGWR GKAAWLFSWL DSPALHHFLT LLKDSRPWQQ LVRVIQWGWL 400
    ELPWVKQRTQ RQGTAHVASG RYCQPEEEVA RLLTMAGVPE DELNPFHVLG 450
    VEATASDIEL KKAYRQLAVM VHPDKNHHPR AEEAFKVLRA AWDIVSNPER 500
    RKEYEMKRMA ENELSRSVNE FLSKLQDDLK EAMNTMMCSR CQGKHRRFEM 550
    DREPKSARYC AECNRLHPAE EGDFWAESSM LGLKITYFAL MDGKVYDITE 600
    WAGCQRVGIS PDTHRVPYHI SFGSRVPGTS GRQRATPESP PADLQDFLSR 650
    IFQVPPGPMS NGNFFAAPHP GPGTTSTSRP NSSVPKGEAK PKRRKKVRRP 700
    FQR 703
    Length:703
    Mass (Da):79,017
    Last modified:November 23, 2004 - v1
    Checksum:i5D282F8A78DA2B08
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti65 – 651P → S in AAK56240. (PubMed:11331877)Curated
    Sequence conflicti226 – 23510RKRSQTDKRR → EVRQITPE in AAK56240. (PubMed:11331877)Curated
    Sequence conflicti244 – 2441E → G in AAK56240. (PubMed:11331877)Curated
    Sequence conflicti416 – 4183HVA → NVP in AAK56240. (PubMed:11331877)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF351783 mRNA. Translation: AAK56240.1.
    BC083549 mRNA. Translation: AAH83549.1.
    RefSeqiNP_446142.2. NM_053690.2.
    XP_006240788.1. XM_006240726.1.
    XP_006240789.1. XM_006240727.1.
    UniGeneiRn.114340.

    Genome annotation databases

    EnsembliENSRNOT00000037332; ENSRNOP00000029946; ENSRNOG00000006844.
    GeneIDi114481.
    KEGGirno:114481.
    UCSCiRGD:620489. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF351783 mRNA. Translation: AAK56240.1 .
    BC083549 mRNA. Translation: AAH83549.1 .
    RefSeqi NP_446142.2. NM_053690.2.
    XP_006240788.1. XM_006240726.1.
    XP_006240789.1. XM_006240727.1.
    UniGenei Rn.114340.

    3D structure databases

    ProteinModelPortali Q5XIX0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000029946.

    Proteomic databases

    PRIDEi Q5XIX0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000037332 ; ENSRNOP00000029946 ; ENSRNOG00000006844 .
    GeneIDi 114481.
    KEGGi rno:114481.
    UCSCi RGD:620489. rat.

    Organism-specific databases

    CTDi 85406.
    RGDi 620489. Dnajc14.

    Phylogenomic databases

    eggNOGi COG0484.
    GeneTreei ENSGT00670000097756.
    HOGENOMi HOG000290199.
    HOVERGENi HBG059561.
    InParanoidi Q5XIX0.
    KOi K09534.
    OMAi PPGQMSN.
    OrthoDBi EOG7HTHGK.
    PhylomeDBi Q5XIX0.
    TreeFami TF105173.

    Miscellaneous databases

    NextBioi 618477.
    PROi Q5XIX0.

    Gene expression databases

    Genevestigatori Q5XIX0.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    InterProi IPR001623. DnaJ_domain.
    [Graphical view ]
    Pfami PF00226. DnaJ. 1 hit.
    [Graphical view ]
    PRINTSi PR00625. JDOMAIN.
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    PROSITEi PS50076. DNAJ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein."
      Bermak J.C., Li M., Bullock C.M., Zhou Q.-Y.
      Nat. Cell Biol. 3:492-498(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH DRD1, MUTAGENESIS OF CYS-538, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiDJC14_RAT
    AccessioniPrimary (citable) accession number: Q5XIX0
    Secondary accession number(s): Q925G7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3