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Q5XIX0

- DJC14_RAT

UniProt

Q5XIX0 - DJC14_RAT

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Protein

DnaJ homolog subfamily C member 14

Gene

Dnajc14

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.1 Publication

GO - Molecular functioni

  1. dopamine receptor binding Source: RGD
  2. G-protein coupled receptor binding Source: RGD

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 14
Alternative name(s):
Dopamine receptor-interacting protein of 78 kDa
Short name:
DRiP78
Gene namesi
Name:Dnajc14
Synonyms:Drip78
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi620489. Dnajc14.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi538 – 5381C → S: Loss of interaction with DRD1. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 703703DnaJ homolog subfamily C member 14PRO_0000247495Add
BLAST

Proteomic databases

PRIDEiQ5XIX0.

Expressioni

Tissue specificityi

Detected in heart, brain, lung, liver, skeletal muscle, kidney and testis.1 Publication

Gene expression databases

GenevestigatoriQ5XIX0.

Interactioni

Subunit structurei

Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal domain.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029946.

Structurei

3D structure databases

ProteinModelPortaliQ5XIX0.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei254 – 27421HelicalSequence AnalysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence AnalysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini444 – 50865JPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi149 – 1524Poly-Ser

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0484.
GeneTreeiENSGT00670000097756.
HOGENOMiHOG000290199.
HOVERGENiHBG059561.
InParanoidiQ5XIX0.
KOiK09534.
OMAiPPGQMSN.
OrthoDBiEOG7HTHGK.
PhylomeDBiQ5XIX0.
TreeFamiTF105173.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIX0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQKHPGERG LCGVHHSGGS SLITSGSSVD PEILSFSGLR DSKETAPNGT
60 70 80 90 100
RCLKEHSDPK CTQPPNPAHW SDPSHGPPRG PGPPREGGYP DESETCSEES
110 120 130 140 150
GVDQELSREN ETGYQEDGSP SFLPIPSACN CQGSPGVPEG TCSEEGDGSS
160 170 180 190 200
SSFCHHCTSP ALGEDEELEE EYDDEEPLKF PSDFSRVSSG KKPPSRRQRH
210 220 230 240 250
RFLTKEDVRD SGRRDPKAPG RHRLARKRSQ TDKRRGLGLW GVEELCQLGQ
260 270 280 290 300
AGFWWLIELL VLVGEYVETC GYLIYACRKL KGSDLDLFRI WVGVWARRLG
310 320 330 340 350
GWARVMFQFL SQSFFSVAGL FIRLLRVVGA FLLLALALFL GCLQLGWRFL
360 370 380 390 400
VGLGDRLGWR GKAAWLFSWL DSPALHHFLT LLKDSRPWQQ LVRVIQWGWL
410 420 430 440 450
ELPWVKQRTQ RQGTAHVASG RYCQPEEEVA RLLTMAGVPE DELNPFHVLG
460 470 480 490 500
VEATASDIEL KKAYRQLAVM VHPDKNHHPR AEEAFKVLRA AWDIVSNPER
510 520 530 540 550
RKEYEMKRMA ENELSRSVNE FLSKLQDDLK EAMNTMMCSR CQGKHRRFEM
560 570 580 590 600
DREPKSARYC AECNRLHPAE EGDFWAESSM LGLKITYFAL MDGKVYDITE
610 620 630 640 650
WAGCQRVGIS PDTHRVPYHI SFGSRVPGTS GRQRATPESP PADLQDFLSR
660 670 680 690 700
IFQVPPGPMS NGNFFAAPHP GPGTTSTSRP NSSVPKGEAK PKRRKKVRRP

FQR
Length:703
Mass (Da):79,017
Last modified:November 23, 2004 - v1
Checksum:i5D282F8A78DA2B08
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651P → S in AAK56240. (PubMed:11331877)Curated
Sequence conflicti226 – 23510RKRSQTDKRR → EVRQITPE in AAK56240. (PubMed:11331877)Curated
Sequence conflicti244 – 2441E → G in AAK56240. (PubMed:11331877)Curated
Sequence conflicti416 – 4183HVA → NVP in AAK56240. (PubMed:11331877)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF351783 mRNA. Translation: AAK56240.1.
BC083549 mRNA. Translation: AAH83549.1.
RefSeqiNP_446142.2. NM_053690.2.
XP_006240788.1. XM_006240726.1.
XP_006240789.1. XM_006240727.1.
UniGeneiRn.114340.

Genome annotation databases

EnsembliENSRNOT00000037332; ENSRNOP00000029946; ENSRNOG00000006844.
GeneIDi114481.
KEGGirno:114481.
UCSCiRGD:620489. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF351783 mRNA. Translation: AAK56240.1 .
BC083549 mRNA. Translation: AAH83549.1 .
RefSeqi NP_446142.2. NM_053690.2.
XP_006240788.1. XM_006240726.1.
XP_006240789.1. XM_006240727.1.
UniGenei Rn.114340.

3D structure databases

ProteinModelPortali Q5XIX0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000029946.

Proteomic databases

PRIDEi Q5XIX0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000037332 ; ENSRNOP00000029946 ; ENSRNOG00000006844 .
GeneIDi 114481.
KEGGi rno:114481.
UCSCi RGD:620489. rat.

Organism-specific databases

CTDi 85406.
RGDi 620489. Dnajc14.

Phylogenomic databases

eggNOGi COG0484.
GeneTreei ENSGT00670000097756.
HOGENOMi HOG000290199.
HOVERGENi HBG059561.
InParanoidi Q5XIX0.
KOi K09534.
OMAi PPGQMSN.
OrthoDBi EOG7HTHGK.
PhylomeDBi Q5XIX0.
TreeFami TF105173.

Miscellaneous databases

NextBioi 618477.
PROi Q5XIX0.

Gene expression databases

Genevestigatori Q5XIX0.

Family and domain databases

Gene3Di 1.10.287.110. 1 hit.
InterProi IPR001623. DnaJ_domain.
[Graphical view ]
Pfami PF00226. DnaJ. 1 hit.
[Graphical view ]
PRINTSi PR00625. JDOMAIN.
SMARTi SM00271. DnaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF46565. SSF46565. 1 hit.
PROSITEi PS50076. DNAJ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein."
    Bermak J.C., Li M., Bullock C.M., Zhou Q.-Y.
    Nat. Cell Biol. 3:492-498(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH DRD1, MUTAGENESIS OF CYS-538, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiDJC14_RAT
AccessioniPrimary (citable) accession number: Q5XIX0
Secondary accession number(s): Q925G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3