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Q5XIX0

- DJC14_RAT

UniProt

Q5XIX0 - DJC14_RAT

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Protein
DnaJ homolog subfamily C member 14
Gene
Dnajc14, Drip78
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor binding Source: RGD
  2. dopamine receptor binding Source: RGD

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 14
Alternative name(s):
Dopamine receptor-interacting protein of 78 kDa
Short name:
DRiP78
Gene namesi
Name:Dnajc14
Synonyms:Drip78
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi620489. Dnajc14.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei254 – 27421Helical; Reviewed prediction
Add
BLAST
Transmembranei305 – 32521Helical; Reviewed prediction
Add
BLAST
Transmembranei327 – 34721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi538 – 5381C → S: Loss of interaction with DRD1. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 703703DnaJ homolog subfamily C member 14
PRO_0000247495Add
BLAST

Proteomic databases

PRIDEiQ5XIX0.

Expressioni

Tissue specificityi

Detected in heart, brain, lung, liver, skeletal muscle, kidney and testis.1 Publication

Gene expression databases

GenevestigatoriQ5XIX0.

Interactioni

Subunit structurei

Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal domain.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029946.

Structurei

3D structure databases

ProteinModelPortaliQ5XIX0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini444 – 50865J
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi149 – 1524Poly-Ser

Sequence similaritiesi

Contains 1 J domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0484.
GeneTreeiENSGT00670000097756.
HOGENOMiHOG000290199.
HOVERGENiHBG059561.
InParanoidiQ5XIX0.
KOiK09534.
OMAiPPGQMSN.
OrthoDBiEOG7HTHGK.
PhylomeDBiQ5XIX0.
TreeFamiTF105173.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIX0-1 [UniParc]FASTAAdd to Basket

« Hide

MAQKHPGERG LCGVHHSGGS SLITSGSSVD PEILSFSGLR DSKETAPNGT    50
RCLKEHSDPK CTQPPNPAHW SDPSHGPPRG PGPPREGGYP DESETCSEES 100
GVDQELSREN ETGYQEDGSP SFLPIPSACN CQGSPGVPEG TCSEEGDGSS 150
SSFCHHCTSP ALGEDEELEE EYDDEEPLKF PSDFSRVSSG KKPPSRRQRH 200
RFLTKEDVRD SGRRDPKAPG RHRLARKRSQ TDKRRGLGLW GVEELCQLGQ 250
AGFWWLIELL VLVGEYVETC GYLIYACRKL KGSDLDLFRI WVGVWARRLG 300
GWARVMFQFL SQSFFSVAGL FIRLLRVVGA FLLLALALFL GCLQLGWRFL 350
VGLGDRLGWR GKAAWLFSWL DSPALHHFLT LLKDSRPWQQ LVRVIQWGWL 400
ELPWVKQRTQ RQGTAHVASG RYCQPEEEVA RLLTMAGVPE DELNPFHVLG 450
VEATASDIEL KKAYRQLAVM VHPDKNHHPR AEEAFKVLRA AWDIVSNPER 500
RKEYEMKRMA ENELSRSVNE FLSKLQDDLK EAMNTMMCSR CQGKHRRFEM 550
DREPKSARYC AECNRLHPAE EGDFWAESSM LGLKITYFAL MDGKVYDITE 600
WAGCQRVGIS PDTHRVPYHI SFGSRVPGTS GRQRATPESP PADLQDFLSR 650
IFQVPPGPMS NGNFFAAPHP GPGTTSTSRP NSSVPKGEAK PKRRKKVRRP 700
FQR 703
Length:703
Mass (Da):79,017
Last modified:November 23, 2004 - v1
Checksum:i5D282F8A78DA2B08
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651P → S in AAK56240. 1 Publication
Sequence conflicti226 – 23510RKRSQTDKRR → EVRQITPE in AAK56240. 1 Publication
Sequence conflicti244 – 2441E → G in AAK56240. 1 Publication
Sequence conflicti416 – 4183HVA → NVP in AAK56240. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF351783 mRNA. Translation: AAK56240.1.
BC083549 mRNA. Translation: AAH83549.1.
RefSeqiNP_446142.2. NM_053690.2.
XP_006240788.1. XM_006240726.1.
XP_006240789.1. XM_006240727.1.
UniGeneiRn.114340.

Genome annotation databases

EnsembliENSRNOT00000037332; ENSRNOP00000029946; ENSRNOG00000006844.
GeneIDi114481.
KEGGirno:114481.
UCSCiRGD:620489. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF351783 mRNA. Translation: AAK56240.1 .
BC083549 mRNA. Translation: AAH83549.1 .
RefSeqi NP_446142.2. NM_053690.2.
XP_006240788.1. XM_006240726.1.
XP_006240789.1. XM_006240727.1.
UniGenei Rn.114340.

3D structure databases

ProteinModelPortali Q5XIX0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000029946.

Proteomic databases

PRIDEi Q5XIX0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000037332 ; ENSRNOP00000029946 ; ENSRNOG00000006844 .
GeneIDi 114481.
KEGGi rno:114481.
UCSCi RGD:620489. rat.

Organism-specific databases

CTDi 85406.
RGDi 620489. Dnajc14.

Phylogenomic databases

eggNOGi COG0484.
GeneTreei ENSGT00670000097756.
HOGENOMi HOG000290199.
HOVERGENi HBG059561.
InParanoidi Q5XIX0.
KOi K09534.
OMAi PPGQMSN.
OrthoDBi EOG7HTHGK.
PhylomeDBi Q5XIX0.
TreeFami TF105173.

Miscellaneous databases

NextBioi 618477.
PROi Q5XIX0.

Gene expression databases

Genevestigatori Q5XIX0.

Family and domain databases

Gene3Di 1.10.287.110. 1 hit.
InterProi IPR001623. DnaJ_domain.
[Graphical view ]
Pfami PF00226. DnaJ. 1 hit.
[Graphical view ]
PRINTSi PR00625. JDOMAIN.
SMARTi SM00271. DnaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF46565. SSF46565. 1 hit.
PROSITEi PS50076. DNAJ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein."
    Bermak J.C., Li M., Bullock C.M., Zhou Q.-Y.
    Nat. Cell Biol. 3:492-498(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH DRD1, MUTAGENESIS OF CYS-538, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiDJC14_RAT
AccessioniPrimary (citable) accession number: Q5XIX0
Secondary accession number(s): Q925G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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