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Protein

U4/U6.U5 tri-snRNP-associated protein 1

Gene

Sart1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-RNO-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U4/U6.U5 tri-snRNP-associated protein 1
Alternative name(s):
Squamous cell carcinoma antigen recognized by T-cells 1
Short name:
SART-1
Short name:
rSART-1
Gene namesi
Name:Sart1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi61930. Sart1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806U4/U6.U5 tri-snRNP-associated protein 1PRO_0000223310Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki141 – 141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki141 – 141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki147 – 147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki188 – 188Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei189 – 1891PhosphothreonineBy similarity
Modified residuei321 – 3211PhosphoserineBy similarity
Modified residuei348 – 3481PhosphoserineBy similarity
Modified residuei431 – 4311PhosphothreonineBy similarity
Modified residuei481 – 4811PhosphoserineCombined sources
Modified residuei527 – 5271PhosphoserineBy similarity
Modified residuei597 – 5971PhosphoserineCombined sources
Modified residuei602 – 6021PhosphoserineCombined sources
Modified residuei604 – 6041PhosphoserineCombined sources
Modified residuei627 – 6271PhosphoserineBy similarity
Modified residuei701 – 7011PhosphothreonineBy similarity
Modified residuei767 – 7671PhosphoserineBy similarity
Modified residuei770 – 7701PhosphothreonineBy similarity
Modified residuei795 – 7951PhosphoserineBy similarity

Post-translational modificationi

Sumoylated with SUMO2.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5XIW8.
PRIDEiQ5XIW8.

PTM databases

iPTMnetiQ5XIW8.
PhosphoSiteiQ5XIW8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020475.
GenevisibleiQ5XIW8. RN.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027812.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili157 – 23175Sequence analysisAdd
BLAST
Coiled coili495 – 54046Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SNU66/SART1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2217. Eukaryota.
ENOG410XSTT. LUCA.
GeneTreeiENSGT00390000007071.
HOGENOMiHOG000046291.
HOVERGENiHBG052942.
InParanoidiQ5XIW8.
KOiK11984.
OMAiFVRAITY.
OrthoDBiEOG091G04IE.
PhylomeDBiQ5XIW8.
TreeFamiTF318828.

Family and domain databases

InterProiIPR005011. SNU66/SART1.
[Graphical view]
PANTHERiPTHR14152:SF5. PTHR14152:SF5. 1 hit.
PfamiPF03343. SART-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSKKHRGE KEAAGTTAAA GTGGTTEQPP RHREHKKHKH RSSGGGSSGG
60 70 80 90 100
ERRKRSRERG AERGSGRRGA EAEARSGAHG RERSQAEPSE RRVKREKRDE
110 120 130 140 150
GYEAAASSKA SSGDASSLSI EETNKLRAKL GLKPLEVNAV KKEAGTKEEP
160 170 180 190 200
VAADVINPMA LRQREELREK LAAAKEKRLL NQKLGKIKTL GEDDPWLDDT
210 220 230 240 250
AAWIERSRQL QKEKDLAEKR AKLLEEMDQE FGVSTLVEEE FEQRRQDLYS
260 270 280 290 300
ARDLQGLTVE HAIDSFREGE TVVLTLKDKG VLQEGEDVLV NVNMVDKERA
310 320 330 340 350
DKNVELRKKK PDYLPYAEDE SVDDLAQQKP RSILAKYDEE LEGERPHSFR
360 370 380 390 400
LEQGGMADGL RERELEEIRT KLRLQAQSLN TVGPRLASEY LSPEEMVTFK
410 420 430 440 450
KTKRRVKKIR KKEKEVIMRA DDLLPLGEDQ TQDGDFGSRL RGRGRRRVPE
460 470 480 490 500
VEEEALEDEE KDPVAQPPPS DDTRVENMDI SDEEDGGALP SGPPELEEDE
510 520 530 540 550
AELELQKQLE KGRRLRQLQQ LQQLRDSGEK VLEIVKKLES RQRGWEEEED
560 570 580 590 600
PERKGTIVFN ATSEFCRTLG EIPTYGLAGN REEQEELMDF ERDEERSANG
610 620 630 640 650
GSESDGEENI GWSTVNLDEE KQHQDFSASS TTILDEEPIV NRGLAAALLL
660 670 680 690 700
CQNKGLLETT VQKVARVKAP NKSLPSAVYC IEDKMAIDDK YSRREEYRGF
710 720 730 740 750
TQDFKEKDGY KPDVKIEYVD ETGRKLTPKE AFRQLSHRFH GKGSGKMKTE
760 770 780 790 800
RRMKKLDEEA LLKKMSSSDT PLGTVALLQE KQKAQKTPYI VLSGSGKSMN

ANTITK
Length:806
Mass (Da):91,011
Last modified:November 23, 2004 - v1
Checksum:iC8A1BCADC07544E9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti317 – 3171A → V in BAA36584 (PubMed:9765622).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014722 mRNA. Translation: BAA36584.1.
BC083551 mRNA. Translation: AAH83551.1.
RefSeqiNP_113784.1. NM_031596.1.
UniGeneiRn.25144.

Genome annotation databases

EnsembliENSRNOT00000027811; ENSRNOP00000027812; ENSRNOG00000020475.
GeneIDi29678.
KEGGirno:29678.
UCSCiRGD:61930. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014722 mRNA. Translation: BAA36584.1.
BC083551 mRNA. Translation: AAH83551.1.
RefSeqiNP_113784.1. NM_031596.1.
UniGeneiRn.25144.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027812.

PTM databases

iPTMnetiQ5XIW8.
PhosphoSiteiQ5XIW8.

Proteomic databases

PaxDbiQ5XIW8.
PRIDEiQ5XIW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027811; ENSRNOP00000027812; ENSRNOG00000020475.
GeneIDi29678.
KEGGirno:29678.
UCSCiRGD:61930. rat.

Organism-specific databases

CTDi9092.
RGDi61930. Sart1.

Phylogenomic databases

eggNOGiKOG2217. Eukaryota.
ENOG410XSTT. LUCA.
GeneTreeiENSGT00390000007071.
HOGENOMiHOG000046291.
HOVERGENiHBG052942.
InParanoidiQ5XIW8.
KOiK11984.
OMAiFVRAITY.
OrthoDBiEOG091G04IE.
PhylomeDBiQ5XIW8.
TreeFamiTF318828.

Enzyme and pathway databases

ReactomeiR-RNO-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiQ5XIW8.

Gene expression databases

BgeeiENSRNOG00000020475.
GenevisibleiQ5XIW8. RN.

Family and domain databases

InterProiIPR005011. SNU66/SART1.
[Graphical view]
PANTHERiPTHR14152:SF5. PTHR14152:SF5. 1 hit.
PfamiPF03343. SART-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNUT1_RAT
AccessioniPrimary (citable) accession number: Q5XIW8
Secondary accession number(s): Q9Z314
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.