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Protein

Membrane-associated progesterone receptor component 2

Gene

Pgrmc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for steroids.Curated

GO - Molecular functioni

Keywordsi

Molecular functionReceptor
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated progesterone receptor component 2
Gene namesi
Name:Pgrmc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1308804. Pgrmc2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 62HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001217451 – 217Membrane-associated progesterone receptor component 2Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84PhosphoserineBy similarity1
Modified residuei98PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei204PhosphotyrosineBy similarity1
Modified residuei205PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XIU9.
PRIDEiQ5XIU9.

PTM databases

iPTMnetiQ5XIU9.
PhosphoSitePlusiQ5XIU9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014051.
GenevisibleiQ5XIU9. RN.

Interactioni

Protein-protein interaction databases

IntActiQ5XIU9. 1 interactor.
MINTiMINT-4579023.
STRINGi10116.ENSRNOP00000018796.

Structurei

3D structure databases

ProteinModelPortaliQ5XIU9.
SMRiQ5XIU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 195Cytochrome b5 heme-bindingAdd BLAST100

Domaini

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 131 and 155.By similarity

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
HOVERGENiHBG059971.
InParanoidiQ5XIU9.
KOiK17278.
OMAiRLWVRWG.
OrthoDBiEOG091G0PXT.
PhylomeDBiQ5XIU9.
TreeFamiTF314562.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiView protein in InterPro
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR036400. Cyt_B5-like_heme/steroid_sf.
PfamiView protein in Pfam
PF00173. Cyt-b5. 1 hit.
SMARTiView protein in SMART
SM01117. Cyt-b5. 1 hit.
SUPFAMiSSF55856. SSF55856. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XIU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGDGDVKL STLGSGGERG GDGSPGGAGA TAARSSWVAA LLATGGEMLL
60 70 80 90 100
NVALVALVLL GAYRLWVRWG RRGLCSGPGA GEESPAATLP RMKKRDFSLE
110 120 130 140 150
QLRQYDGART PRILLAVNGK VFDVTKGSKF YGPAGPYGIF AGRDASRGLA
160 170 180 190 200
TFCLDKDALR DEYDDLSDLN AVQMESVREW EMQFKEKYDY VGRLLKPGEE
210
PSEYTDEEDT KDHSKQD
Length:217
Mass (Da):23,403
Last modified:November 23, 2004 - v1
Checksum:iF70E1B00DDAC71F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083571 mRNA. Translation: AAH83571.1.
RefSeqiNP_001008375.1. NM_001008374.1.
UniGeneiRn.7685.

Genome annotation databases

EnsembliENSRNOT00000018796; ENSRNOP00000018796; ENSRNOG00000014051.
GeneIDi361940.
KEGGirno:361940.
UCSCiRGD:1308804. rat.

Similar proteinsi

Entry informationi

Entry nameiPGRC2_RAT
AccessioniPrimary (citable) accession number: Q5XIU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: November 22, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families