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Protein

Membrane-associated progesterone receptor component 2

Gene

Pgrmc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for steroids.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated progesterone receptor component 2
Gene namesi
Name:Pgrmc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1308804. Pgrmc2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6223HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Membrane-associated progesterone receptor component 2PRO_0000121745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei84 – 841PhosphoserineBy similarity
Modified residuei98 – 981PhosphoserineCombined sources
Modified residuei202 – 2021PhosphoserineCombined sources
Modified residuei204 – 2041PhosphotyrosineBy similarity
Modified residuei205 – 2051PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XIU9.
PRIDEiQ5XIU9.

PTM databases

iPTMnetiQ5XIU9.
PhosphoSiteiQ5XIU9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014051.
GenevisibleiQ5XIU9. RN.

Interactioni

Protein-protein interaction databases

IntActiQ5XIU9. 1 interaction.
MINTiMINT-4579023.
STRINGi10116.ENSRNOP00000018796.

Structurei

3D structure databases

ProteinModelPortaliQ5XIU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 195100Cytochrome b5 heme-bindingAdd
BLAST

Domaini

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 131 and 155.By similarity

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
HOVERGENiHBG059971.
InParanoidiQ5XIU9.
KOiK17278.
OMAiKDHSKQD.
OrthoDBiEOG091G0PXT.
PhylomeDBiQ5XIU9.
TreeFamiTF314562.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5XIU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGDGDVKL STLGSGGERG GDGSPGGAGA TAARSSWVAA LLATGGEMLL
60 70 80 90 100
NVALVALVLL GAYRLWVRWG RRGLCSGPGA GEESPAATLP RMKKRDFSLE
110 120 130 140 150
QLRQYDGART PRILLAVNGK VFDVTKGSKF YGPAGPYGIF AGRDASRGLA
160 170 180 190 200
TFCLDKDALR DEYDDLSDLN AVQMESVREW EMQFKEKYDY VGRLLKPGEE
210
PSEYTDEEDT KDHSKQD
Length:217
Mass (Da):23,403
Last modified:November 23, 2004 - v1
Checksum:iF70E1B00DDAC71F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083571 mRNA. Translation: AAH83571.1.
RefSeqiNP_001008375.1. NM_001008374.1.
UniGeneiRn.7685.

Genome annotation databases

EnsembliENSRNOT00000018796; ENSRNOP00000018796; ENSRNOG00000014051.
GeneIDi361940.
KEGGirno:361940.
UCSCiRGD:1308804. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083571 mRNA. Translation: AAH83571.1.
RefSeqiNP_001008375.1. NM_001008374.1.
UniGeneiRn.7685.

3D structure databases

ProteinModelPortaliQ5XIU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5XIU9. 1 interaction.
MINTiMINT-4579023.
STRINGi10116.ENSRNOP00000018796.

PTM databases

iPTMnetiQ5XIU9.
PhosphoSiteiQ5XIU9.

Proteomic databases

PaxDbiQ5XIU9.
PRIDEiQ5XIU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018796; ENSRNOP00000018796; ENSRNOG00000014051.
GeneIDi361940.
KEGGirno:361940.
UCSCiRGD:1308804. rat.

Organism-specific databases

CTDi10424.
RGDi1308804. Pgrmc2.

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
HOVERGENiHBG059971.
InParanoidiQ5XIU9.
KOiK17278.
OMAiKDHSKQD.
OrthoDBiEOG091G0PXT.
PhylomeDBiQ5XIU9.
TreeFamiTF314562.

Miscellaneous databases

PROiQ5XIU9.

Gene expression databases

BgeeiENSRNOG00000014051.
GenevisibleiQ5XIU9. RN.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPGRC2_RAT
AccessioniPrimary (citable) accession number: Q5XIU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.