ID   Q5XIU3_RAT              Unreviewed;       801 AA.
AC   Q5XIU3;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   23-NOV-2004, sequence version 1.
DT   27-MAR-2024, entry version 164.
DE   SubName: Full=Zinc finger and BTB domain containing 17 {ECO:0000313|EMBL:AAH83577.1};
GN   Name=Zbtb17 {ECO:0000313|EMBL:AAH83577.1, ECO:0000313|RGD:1307143};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:AAH83577.1};
RN   [1] {ECO:0000313|EMBL:AAH83577.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis {ECO:0000313|EMBL:AAH83577.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; BC083577; AAH83577.1; -; mRNA.
DR   RefSeq; NP_001012105.1; NM_001012105.1.
DR   AlphaFoldDB; Q5XIU3; -.
DR   SMR; Q5XIU3; -.
DR   STRING; 10116.ENSRNOP00000014399; -.
DR   PhosphoSitePlus; Q5XIU3; -.
DR   PaxDb; 10116-ENSRNOP00000014399; -.
DR   GeneID; 313666; -.
DR   KEGG; rno:313666; -.
DR   AGR; RGD:1307143; -.
DR   CTD; 7709; -.
DR   RGD; 1307143; Zbtb17.
DR   VEuPathDB; HostDB:ENSRNOG00000010436; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_002678_30_1_1; -.
DR   InParanoid; Q5XIU3; -.
DR   OrthoDB; 4096362at2759; -.
DR   TreeFam; TF332047; -.
DR   Bgee; ENSRNOG00000010436; Expressed in skeletal muscle tissue and 20 other cell types or tissues.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR   GO; GO:0032993; C:protein-DNA complex; ISO:RGD.
DR   GO; GO:0001046; F:core promoter sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:0003677; F:DNA binding; ISO:RGD.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; ISO:RGD.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:0001223; F:transcription coactivator binding; ISO:RGD.
DR   GO; GO:0007398; P:ectoderm development; ISO:RGD.
DR   GO; GO:0070314; P:G1 to G0 transition; ISO:RGD.
DR   GO; GO:0001702; P:gastrulation with mouth forming second; ISO:RGD.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR   GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR   CDD; cd18206; BTB_POZ_ZBTB17_MIZ1; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 13.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24390; ZINC FINGER PROTEIN; 1.
DR   PANTHER; PTHR24390:SF240; ZINC FINGER PROTEIN 60-LIKE; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00096; zf-C2H2; 10.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00355; ZnF_C2H2; 13.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 9.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE   2: Evidence at transcript level;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   REGION          144..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          777..801
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        187..201
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..274
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   801 AA;  87652 MW;  774434964EE3E11F CRC64;
     MDFPQHSQRV LEQLNQQRQM GLLCDCTFVV DGVDFKAHKA VLAACSEYFK MLFVDQKDVV
     HLDISNAAGL GQVLEFMYTA KLHLSPENVD DVLAVASFLQ MQDIITACHT LKSLAEPTST
     TGESADASAE EVCCVLSPGG DKRAKEEKAA ATVLSRLDQA RSSSSAGPGR ELKEEWGGQA
     ESASRGAEQT EKADAPREPP PVELKPDPTS SMAAAEAEAL SESSEQEMEV EPASKGEEGQ
     EEEGPGPATV KEEGVHLENG EPPEENEESA GTDSGHELGM EGQNLRSGTY GDRTESKAYG
     SIIHKCEDCG KEFTHTGNFK RHIRIHTGEK PFSCRECSKA FSDPAACKAH EKTHSPLKPY
     GCEECGKSYR LISLLNLHKK RHSGEARYRC GDCGKLFTTS GNLKRHQLVH SGQKPYQCDY
     CGRSFSDPTS KMRHLETHDT DKEHKCPHCD KKFNQVGNLK AHLKIHIADG PLKCRECGKQ
     FTTSGNLKRH LRIHSGEKPY VCTHCQRQFA DPGALQRHVR IHTGEKPCQC VICGKAFTQA
     SSLIAHVRQH TGEKPYVCER CGKRFVQSSQ LANHIRHHDN IRPHKCSVCS KAFVNVGDLS
     KHIIIHTGEK PYLCDKCGRG FNRVDNLRSH VKTVHQGKAG IKILEPEEGG EVSVVTVDDM
     VTLATEALAA TAVTQLTVVP VGAAVTADET EVLKAEISKA VKQVQEEDPN THILYACDSC
     GDKFLDANSL AQHVRIHTAQ ALVMFQTDAD FYQQYGPGGA WPAGQMLQAG ELVFRPRDGT
     EGQPTLAETP PTAPDCLPPA E
//