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Protein

Zinc finger protein 143

Gene

Znf143

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 26125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri267 – 29125C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 32125C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 35125C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 38125C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri387 – 41125C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 44024C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • chromatin binding Source: RGD
  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • positive regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 143
Short name:
Zfp-143
Alternative name(s):
Selenocysteine tRNA gene transcription-activating factor
Gene namesi
Name:Znf143
Synonyms:Staf, Zfp143
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305662. Zfp143.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Zinc finger protein 143PRO_0000248072Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5XIU2.
PRIDEiQ5XIU2.

PTM databases

iPTMnetiQ5XIU2.

Expressioni

Gene expression databases

GenevisibleiQ5XIU2. RN.

Interactioni

Subunit structurei

Interacts with CHD8.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013733.

Family & Domainsi

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 26125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri267 – 29125C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 32125C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 35125C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 38125C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri387 – 41125C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 44024C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000118073.
HOVERGENiHBG053078.
InParanoidiQ5XIU2.
OMAiKMQIVLQ.
OrthoDBiEOG7WX080.
PhylomeDBiQ5XIU2.
TreeFamiTF333498.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAQINRDS QGMTEFPGGG MEAQHVTLCL TEAVTVADGD NLENMEGVSL
60 70 80 90 100
QAVTLADGST AYIQHNSKDG RLIDGQVIQL EDGSAAYVQH VPIPKSTGDS
110 120 130 140 150
LRLEDGQAVQ LEDGTTAFIH HTSKDSYDQS SLQAVQLEDG TTAYIHHAVQ
160 170 180 190 200
VPQPDTILAI QADGTVAGLH TGDATIDPDT ISALEQYAAK VSIDGSEGVT
210 220 230 240 250
STGLIGENEQ EKKMQIVLQG HATRVTPKSQ QSGEKAFRCK YDGCGKLYTT
260 270 280 290 300
AHHLKVHERS HTGDRPYQCE HSGCGKAFAT GYGLKSHFRT HTGEKPYRCS
310 320 330 340 350
EDNCTKSFKT SGDLQKHIRT HTGERPFKCP IEGCGRSFTT SNIRKVHIRT
360 370 380 390 400
HTGERPYYCT EPGCGRAFAS ATNYKNHVRI HTGEKPYVCT VPGCDKRFTE
410 420 430 440 450
YSSLYKHHVV HTHSKPYNCN HCGKTYKQIS TLAMHKRTAH NDTEPIEEEQ
460 470 480 490 500
EAFFEPPPGQ GDDVLKGSQI TYVTGVEGED IVSTQVATVT QSGLSQQVTL
510 520 530 540 550
ISQDGTQHVN ISQADMQAIG NTITMVTQDG TPITVPTHDA VISSAGTHSV
560 570 580 590 600
AMVTAEGTEG QQVAIVAQDL AAFHAASSEM GHQPHSHHLV TTETRPLTLV
610 620 630
ATSNGTQIAV QLGEQPSLEE AIRIASRIQQ GETPGLDD
Length:638
Mass (Da):68,999
Last modified:May 5, 2009 - v2
Checksum:i437CB9B2D77D37DF
GO

Sequence cautioni

The sequence AAH83578.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083578 mRNA. Translation: AAH83578.1. Different initiation.
RefSeqiNP_001012169.1. NM_001012169.1.
UniGeneiRn.105662.

Genome annotation databases

GeneIDi361627.
KEGGirno:361627.
UCSCiRGD:1305662. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083578 mRNA. Translation: AAH83578.1. Different initiation.
RefSeqiNP_001012169.1. NM_001012169.1.
UniGeneiRn.105662.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013733.

PTM databases

iPTMnetiQ5XIU2.

Proteomic databases

PaxDbiQ5XIU2.
PRIDEiQ5XIU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi361627.
KEGGirno:361627.
UCSCiRGD:1305662. rat.

Organism-specific databases

CTDi20841.
RGDi1305662. Zfp143.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000118073.
HOVERGENiHBG053078.
InParanoidiQ5XIU2.
OMAiKMQIVLQ.
OrthoDBiEOG7WX080.
PhylomeDBiQ5XIU2.
TreeFamiTF333498.

Miscellaneous databases

PROiQ5XIU2.

Gene expression databases

GenevisibleiQ5XIU2. RN.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiZN143_RAT
AccessioniPrimary (citable) accession number: Q5XIU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 5, 2009
Last modified: June 8, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.