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Protein

Ankyrin repeat and BTB/POZ domain-containing protein 1

Gene

Abtb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and BTB/POZ domain-containing protein 1
Gene namesi
Name:Abtb1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1359363 Abtb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002482691 – 478Ankyrin repeat and BTB/POZ domain-containing protein 1Add BLAST478

Proteomic databases

PaxDbiQ5XIU1
PRIDEiQ5XIU1

PTM databases

SwissPalmiQ5XIU1

Expressioni

Gene expression databases

BgeeiENSRNOG00000015762
GenevisibleiQ5XIU1 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021445

Structurei

3D structure databases

ProteinModelPortaliQ5XIU1
SMRiQ5XIU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 31ANK 1Sequence analysisAdd BLAST31
Repeati35 – 64ANK 2Sequence analysisAdd BLAST30
Domaini115 – 182BTB 1PROSITE-ProRule annotationAdd BLAST68
Domaini272 – 346BTB 2PROSITE-ProRule annotationAdd BLAST75

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili450 – 478Sequence analysisAdd BLAST29

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0511 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000017131
HOGENOMiHOG000253956
HOVERGENiHBG059559
InParanoidiQ5XIU1
KOiK10520
OMAiMLDTKWK
OrthoDBiEOG091G08AD
PhylomeDBiQ5XIU1
TreeFamiTF329194

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00651 BTB, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00225 BTB, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF54695 SSF54695, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50097 BTB, 2 hits

Sequencei

Sequence statusi: Complete.

Q5XIU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSDLFASC RKGDVGRVRY LLEQRDVEVN VRDKWDSTPL YYACLCGHEE
60 70 80 90 100
LVRYLLANGA RCEANTFDGE RCLYGALSDP IRRALRDYKQ VTASCRRRDY
110 120 130 140 150
YDDFLQRLLE QGIHSDVVFV VHGKPFRAHR CILGARSTYF ANMLDTKWKG
160 170 180 190 200
KSVVVLRHPL INPVAFGALL QYLYTGRLDI GVEHVSDCER LAKQCQLWDL
210 220 230 240 250
LDDLEAKCEK VSEFVASKPG TCVKVLTIEP PPADPRLRAD MALLADCALP
260 270 280 290 300
PELRGDLGEL PFPCPDGFSS CPDICFRVAD SSFLCHKAFF CGRSDYFRAL
310 320 330 340 350
LDDHFRESEE PVASGDPPVV TLHDISPDIF THVLYYVYSD HTELPPELAY
360 370 380 390 400
DVLSVADMYL LPGLKRLCGR SLAQLLEEDS VVGVWRIAKL FRLARLEDQC
410 420 430 440 450
TEYMAKVIEK LVEREDFVEA VREEAAAVAA RQETDSIPLV DDIRFHVAST
460 470
VQTYSAIEEA QQQLRALENL LVSIGLDC
Length:478
Mass (Da):54,065
Last modified:November 23, 2004 - v1
Checksum:iD5A5553BD87325A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083579 mRNA Translation: AAH83579.1
RefSeqiNP_001005902.1, NM_001005902.1
UniGeneiRn.40721

Genome annotation databases

EnsembliENSRNOT00000021445; ENSRNOP00000021445; ENSRNOG00000015762
GeneIDi297432
KEGGirno:297432
UCSCiRGD:1359363 rat

Similar proteinsi

Entry informationi

Entry nameiABTB1_RAT
AccessioniPrimary (citable) accession number: Q5XIU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 23, 2004
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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