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Q5XIT0 (CDKL2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase-like 2

EC=2.7.11.22
Gene names
Name:Cdkl2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Domain

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

cyclin-dependent protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507Cyclin-dependent kinase-like 2
PRO_0000085819

Regions

Domain4 – 289286Protein kinase
Nucleotide binding10 – 189ATP By similarity
Motif45 – 517[NKR]KIAxRE

Sites

Active site1261Proton acceptor By similarity
Binding site331ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5XIT0 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 576D9A4F45A01B81

FASTA50757,135
        10         20         30         40         50         60 
MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 

        70         80         90        100        110        120 
ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LKLFPNGLDY QVVQKYLFQI INGIGFCHSH 

       130        140        150        160        170        180 
NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 

       190        200        210        220        230        240 
KAVDIWAIGC LVIEMLMGQP LFPGESDIDQ LHHIMTCLGN LIPRHQELFY KNPVFAGVRL 

       250        260        270        280        290        300 
PEIKDIEAEP LESRYPKLPE VVISLAKKCL HIDPDKRPLC ADLLHHDFFQ MDGFAERFSQ 

       310        320        330        340        350        360 
ELQLKIEKDA RNNSLPKKFQ IRKKEKDDAL GEERKTLVVQ DTNADPKTKD SKVLKVKGSK 

       370        380        390        400        410        420 
IDVEKTEKGT RASNGSCLHD NGTSHKGLSS TSLRDCSNVT IDHPRNPGTA IPPLTHNLSA 

       430        440        450        460        470        480 
VAPGINAAMG TIPGVQNYRV DEKTKKYCNP FVKPSQPSPS GIYNMNVSAS VSNCPLPRKS 

       490        500 
KHSPPLDLAV SMGARRVKLY LETESET 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC083590 mRNA. Translation: AAH83590.1.
RefSeqNP_001012035.1. NM_001012035.1.
UniGeneRn.162244.

3D structure databases

ProteinModelPortalQ5XIT0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000045371.

PTM databases

PhosphoSiteQ5XIT0.

Proteomic databases

PaxDbQ5XIT0.
PRIDEQ5XIT0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000050038; ENSRNOP00000049130; ENSRNOG00000002506.
GeneID305242.
KEGGrno:305242.
UCSCRGD:1309625. rat.

Organism-specific databases

CTD8999.
RGD1309625. Cdkl2.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00650000093115.
HOGENOMHOG000233024.
HOVERGENHBG080204.
KOK08824.

Gene expression databases

GenevestigatorQ5XIT0.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio654245.
PROQ5XIT0.

Entry information

Entry nameCDKL2_RAT
AccessionPrimary (citable) accession number: Q5XIT0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families