Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5XIT0

- CDKL2_RAT

UniProt

Q5XIT0 - CDKL2_RAT

Protein

Cyclin-dependent kinase-like 2

Gene

Cdkl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase-like 2 (EC:2.7.11.22)
    Gene namesi
    Name:Cdkl2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 14

    Organism-specific databases

    RGDi1309625. Cdkl2.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507Cyclin-dependent kinase-like 2PRO_0000085819Add
    BLAST

    Proteomic databases

    PaxDbiQ5XIT0.
    PRIDEiQ5XIT0.

    PTM databases

    PhosphoSiteiQ5XIT0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5XIT0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000045371.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XIT0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 289286Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi45 – 517[NKR]KIAxRE

    Domaini

    The [NKR]KIAxRE motif seems to be a cyclin-binding region.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00650000093115.
    HOGENOMiHOG000233024.
    HOVERGENiHBG080204.
    KOiK08824.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5XIT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR    50
    EIKLLKQLRH ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LKLFPNGLDY 100
    QVVQKYLFQI INGIGFCHSH NIIHRDIKPE NILVSQSGVV KLCDFGFART 150
    LAAPGEVYTD YVATRWYRAP ELLVGDVKYG KAVDIWAIGC LVIEMLMGQP 200
    LFPGESDIDQ LHHIMTCLGN LIPRHQELFY KNPVFAGVRL PEIKDIEAEP 250
    LESRYPKLPE VVISLAKKCL HIDPDKRPLC ADLLHHDFFQ MDGFAERFSQ 300
    ELQLKIEKDA RNNSLPKKFQ IRKKEKDDAL GEERKTLVVQ DTNADPKTKD 350
    SKVLKVKGSK IDVEKTEKGT RASNGSCLHD NGTSHKGLSS TSLRDCSNVT 400
    IDHPRNPGTA IPPLTHNLSA VAPGINAAMG TIPGVQNYRV DEKTKKYCNP 450
    FVKPSQPSPS GIYNMNVSAS VSNCPLPRKS KHSPPLDLAV SMGARRVKLY 500
    LETESET 507
    Length:507
    Mass (Da):57,135
    Last modified:November 23, 2004 - v1
    Checksum:i576D9A4F45A01B81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083590 mRNA. Translation: AAH83590.1.
    RefSeqiNP_001012035.1. NM_001012035.1.
    UniGeneiRn.162244.

    Genome annotation databases

    EnsembliENSRNOT00000050038; ENSRNOP00000049130; ENSRNOG00000002506.
    GeneIDi305242.
    KEGGirno:305242.
    UCSCiRGD:1309625. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083590 mRNA. Translation: AAH83590.1 .
    RefSeqi NP_001012035.1. NM_001012035.1.
    UniGenei Rn.162244.

    3D structure databases

    ProteinModelPortali Q5XIT0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000045371.

    PTM databases

    PhosphoSitei Q5XIT0.

    Proteomic databases

    PaxDbi Q5XIT0.
    PRIDEi Q5XIT0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000050038 ; ENSRNOP00000049130 ; ENSRNOG00000002506 .
    GeneIDi 305242.
    KEGGi rno:305242.
    UCSCi RGD:1309625. rat.

    Organism-specific databases

    CTDi 8999.
    RGDi 1309625. Cdkl2.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00650000093115.
    HOGENOMi HOG000233024.
    HOVERGENi HBG080204.
    KOi K08824.

    Miscellaneous databases

    NextBioi 654245.
    PROi Q5XIT0.

    Gene expression databases

    Genevestigatori Q5XIT0.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiCDKL2_RAT
    AccessioniPrimary (citable) accession number: Q5XIT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3