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Protein

Ubiquitin-associated protein 1

Gene

Ubap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-associated protein 1
Short name:
UBAP-1
Gene namesi
Name:Ubap1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1305186. Ubap1.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Endosome By similarity

  • Note: Predominantly cytosolic. Recruited to endosomes as part of the ESCRT-I complex (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Ubiquitin-associated protein 1PRO_0000211019Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei146 – 1461PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XIS7.
PRIDEiQ5XIS7.

Expressioni

Gene expression databases

GenevisibleiQ5XIS7. RN.

Interactioni

Subunit structurei

Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoechiometry. Can be a component of ESCRT-I complexes containing VPS37B, VPS37C and VPS37D (in vitro), but may have a preference for the ESCRT-I complex containing VPS37A. Interacts with PTPN23. Interacts (via UBA domains) with ubiquitinated proteins (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062034.

Structurei

3D structure databases

ProteinModelPortaliQ5XIS7.
SMRiQ5XIS7. Positions 381-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 6347UMAPROSITE-ProRule annotationAdd
BLAST
Domaini389 – 43042UBA 1PROSITE-ProRule annotationAdd
BLAST
Domaini451 – 49848UBA 2PROSITE-ProRule annotationAdd
BLAST

Domaini

The UMA domain mediates association with the ESCRT-I complex.By similarity

Sequence similaritiesi

Contains 2 UBA domains.PROSITE-ProRule annotation
Contains 1 UMA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IG52. Eukaryota.
ENOG410ZK9H. LUCA.
GeneTreeiENSGT00390000008092.
HOGENOMiHOG000231678.
HOVERGENiHBG060426.
InParanoidiQ5XIS7.
OMAiQCVETVV.
OrthoDBiEOG75MVWG.
PhylomeDBiQ5XIS7.

Family and domain databases

InterProiIPR015940. UBA.
IPR009060. UBA-like.
IPR023340. UMA.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 2 hits.
PROSITEiPS50030. UBA. 2 hits.
PS51497. UMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKKLGTDF HGTFSYLDDV PFKIGDKFKT PAKVGLPIGF SLPDCLQVVR
60 70 80 90 100
EMQYDFSLEK KAIEWAEDIR LIQEAQQEAE RKSEEAEAKV NSKSGPEGDS
110 120 130 140 150
KVSFSKTHSP ATMPPPINPI LASLQHNNIL TPTRVSSSAT KQKVLSPPHT
160 170 180 190 200
KADFNPADFE CEEDPFDNLE LKTIDEKEEL RNILVGTTGP IMAQLLDSNT
210 220 230 240 250
PRGNSGSVLQ DEEVLASLEQ ATLDFKPLHK PNGFITLPQL GNCEKMSLSS
260 270 280 290 300
KVSLPPIPTV SNIKSLSFPK LDSDDSSQKT VRLASTFHST SCLRSGASRN
310 320 330 340 350
FLKPSTQSSA SELNGDHALG LSALNLNSGT EVPALTSSQM PSLSILSVCT
360 370 380 390 400
EESSPPSTCP TVTPLNFSVS QVPTMPSCPQ AYLELQALSP SERQCVETVV
410 420 430 440 450
NMGYSYDCVL RAMKKKGENI EQILDYLFAH GQLCEKGFDP LLVEEALEMH
460 470 480 490 500
QCSEEKMMEF LQLMSKFKEM GFELKDIKEV LLLHNNDQDN ALEDLMARAE

AS
Length:502
Mass (Da):55,140
Last modified:November 23, 2004 - v1
Checksum:iB2E04C7E8C36A37F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083594 mRNA. Translation: AAH83594.1.
RefSeqiNP_001012190.1. NM_001012190.1.
UniGeneiRn.98217.

Genome annotation databases

EnsembliENSRNOT00000063849; ENSRNOP00000062034; ENSRNOG00000012004.
GeneIDi362502.
KEGGirno:362502.
UCSCiRGD:1305186. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083594 mRNA. Translation: AAH83594.1.
RefSeqiNP_001012190.1. NM_001012190.1.
UniGeneiRn.98217.

3D structure databases

ProteinModelPortaliQ5XIS7.
SMRiQ5XIS7. Positions 381-430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062034.

Proteomic databases

PaxDbiQ5XIS7.
PRIDEiQ5XIS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000063849; ENSRNOP00000062034; ENSRNOG00000012004.
GeneIDi362502.
KEGGirno:362502.
UCSCiRGD:1305186. rat.

Organism-specific databases

CTDi51271.
RGDi1305186. Ubap1.

Phylogenomic databases

eggNOGiENOG410IG52. Eukaryota.
ENOG410ZK9H. LUCA.
GeneTreeiENSGT00390000008092.
HOGENOMiHOG000231678.
HOVERGENiHBG060426.
InParanoidiQ5XIS7.
OMAiQCVETVV.
OrthoDBiEOG75MVWG.
PhylomeDBiQ5XIS7.

Miscellaneous databases

NextBioi680145.
PROiQ5XIS7.

Gene expression databases

GenevisibleiQ5XIS7. RN.

Family and domain databases

InterProiIPR015940. UBA.
IPR009060. UBA-like.
IPR023340. UMA.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 2 hits.
PROSITEiPS50030. UBA. 2 hits.
PS51497. UMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiUBAP1_RAT
AccessioniPrimary (citable) accession number: Q5XIS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 23, 2004
Last modified: December 9, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.