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Q5XIS1

- SSH3_RAT

UniProt

Q5XIS1 - SSH3_RAT

Protein

Protein phosphatase Slingshot homolog 3

Gene

Ssh3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei410 – 4101Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. actin binding Source: RefGenome
    2. DNA binding Source: InterPro
    3. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    4. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein dephosphorylation Source: RefGenome
    2. regulation of actin polymerization or depolymerization Source: RefGenome
    3. regulation of axonogenesis Source: RefGenome
    4. regulation of lamellipodium assembly Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase Slingshot homolog 3 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    SSH-like protein 3
    Short name:
    SSH-3L
    Gene namesi
    Name:Ssh3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1308679. Ssh3.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. cytoskeleton Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 652651Protein phosphatase Slingshot homolog 3PRO_0000094847Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei85 – 851PhosphoserineBy similarity
    Modified residuei87 – 871PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ5XIS1.

    PTM databases

    PhosphoSiteiQ5XIS1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5XIS1.

    Interactioni

    Subunit structurei

    Does not bind to, or colocalize with, filamentous actin.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000025546.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5XIS1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini325 – 465141Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    HOGENOMiHOG000154428.
    HOVERGENiHBG089321.
    InParanoidiQ5XIS1.
    KOiK05766.
    PhylomeDBiQ5XIS1.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR014876. DEK_C.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR009057. Homeodomain-like.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF08766. DEK_C. 1 hit.
    PF00782. DSPc. 1 hit.
    [Graphical view]
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5XIS1-1 [UniParc]FASTAAdd to Basket

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    MALVTVSRSP PASGHSTPVG PTDRVIRRRG RLQRRQSFAV LRGAVLGLQD    50
    GGEGNDAAEA DPEPMEKPSG EEQPAEDQTD NGQGSQSPWK QVQKRHLHLM 100
    VELLRPQDDI RLAAQLEAAR PPRLRYLLVV STGEGLSEEE TILLGVDFPD 150
    SSSHSCTLGL VLPLWSDTQV YLDGDGGFSV TSGGQSRIFK PVSIQTMWAT 200
    LQVLHQACEV ALGSGLVPGG SALAWATHYQ EKLNSDQGCL NEWMAMSDLE 250
    SFRPPNAEPG QASEQEQMEQ AILAELWQVL DASDLDSVTS KEIRQALELR 300
    LGCPLQQYRD FIDNQMLLLM AQQDRASRIF PHLYLGSEWN AANLEELQRN 350
    RVSHILNMAR EIDNFFPERF TYHNVRVWDE ESAQLLPHWK ETHRFIEDAR 400
    AQGTRVLVHC KMGVSRSAAT VLAYAMKQYG WGLEQALIHV QELRPIVRPN 450
    PGFLRQLQTY QGILTASRQS HVWEQKVGVV SPEEPLAPEV STPLPPLPPE 500
    PGGSGEGMVM GQKGSQETPK EELGLRPRIN LRGVMRSISL LEPSSEPEST 550
    TEAGDLPEVF SSDEEPLHPF SQLSRAKGGQ RVCKGPWPAL KSRQSVVALH 600
    SAALVASRAR AFQGQGQGQG QEQRETGTSS TPRLRKVIRQ ASVDDSREEG 650
    KA 652
    Length:652
    Mass (Da):72,071
    Last modified:November 23, 2004 - v1
    Checksum:i7006E3B386C91BD4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083600 mRNA. Translation: AAH83600.1.
    RefSeqiNP_001012217.1. NM_001012217.1.
    UniGeneiRn.12068.

    Genome annotation databases

    GeneIDi365396.
    KEGGirno:365396.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083600 mRNA. Translation: AAH83600.1 .
    RefSeqi NP_001012217.1. NM_001012217.1.
    UniGenei Rn.12068.

    3D structure databases

    ProteinModelPortali Q5XIS1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000025546.

    PTM databases

    PhosphoSitei Q5XIS1.

    Proteomic databases

    PRIDEi Q5XIS1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 365396.
    KEGGi rno:365396.

    Organism-specific databases

    CTDi 54961.
    RGDi 1308679. Ssh3.

    Phylogenomic databases

    eggNOGi COG2453.
    HOGENOMi HOG000154428.
    HOVERGENi HBG089321.
    InParanoidi Q5XIS1.
    KOi K05766.
    PhylomeDBi Q5XIS1.

    Miscellaneous databases

    NextBioi 687372.
    PROi Q5XIS1.

    Gene expression databases

    Genevestigatori Q5XIS1.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR014876. DEK_C.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR009057. Homeodomain-like.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF08766. DEK_C. 1 hit.
    PF00782. DSPc. 1 hit.
    [Graphical view ]
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiSSH3_RAT
    AccessioniPrimary (citable) accession number: Q5XIS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Tyrosine phosphatase activity has not been demonstrated for this protein to date.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3