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Q5XIS1 (SSH3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase Slingshot homolog 3

EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
SSH-like protein 3
Short name=SSH-3L
Gene names
Name:Ssh3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length652 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Does not bind to, or colocalize with, filamentous actin By similarity.

Subcellular location

Cytoplasmcytoskeleton By similarity. Nucleus By similarity.

Miscellaneous

Tyrosine phosphatase activity has not been demonstrated for this protein to date.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 652651Protein phosphatase Slingshot homolog 3
PRO_0000094847

Regions

Domain325 – 465141Tyrosine-protein phosphatase

Sites

Active site4101Phosphocysteine intermediate By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue851Phosphoserine By similarity
Modified residue871Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5XIS1 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 7006E3B386C91BD4

FASTA65272,071
        10         20         30         40         50         60 
MALVTVSRSP PASGHSTPVG PTDRVIRRRG RLQRRQSFAV LRGAVLGLQD GGEGNDAAEA 

        70         80         90        100        110        120 
DPEPMEKPSG EEQPAEDQTD NGQGSQSPWK QVQKRHLHLM VELLRPQDDI RLAAQLEAAR 

       130        140        150        160        170        180 
PPRLRYLLVV STGEGLSEEE TILLGVDFPD SSSHSCTLGL VLPLWSDTQV YLDGDGGFSV 

       190        200        210        220        230        240 
TSGGQSRIFK PVSIQTMWAT LQVLHQACEV ALGSGLVPGG SALAWATHYQ EKLNSDQGCL 

       250        260        270        280        290        300 
NEWMAMSDLE SFRPPNAEPG QASEQEQMEQ AILAELWQVL DASDLDSVTS KEIRQALELR 

       310        320        330        340        350        360 
LGCPLQQYRD FIDNQMLLLM AQQDRASRIF PHLYLGSEWN AANLEELQRN RVSHILNMAR 

       370        380        390        400        410        420 
EIDNFFPERF TYHNVRVWDE ESAQLLPHWK ETHRFIEDAR AQGTRVLVHC KMGVSRSAAT 

       430        440        450        460        470        480 
VLAYAMKQYG WGLEQALIHV QELRPIVRPN PGFLRQLQTY QGILTASRQS HVWEQKVGVV 

       490        500        510        520        530        540 
SPEEPLAPEV STPLPPLPPE PGGSGEGMVM GQKGSQETPK EELGLRPRIN LRGVMRSISL 

       550        560        570        580        590        600 
LEPSSEPEST TEAGDLPEVF SSDEEPLHPF SQLSRAKGGQ RVCKGPWPAL KSRQSVVALH 

       610        620        630        640        650 
SAALVASRAR AFQGQGQGQG QEQRETGTSS TPRLRKVIRQ ASVDDSREEG KA 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC083600 mRNA. Translation: AAH83600.1.
RefSeqNP_001012217.1. NM_001012217.1.
UniGeneRn.12068.

3D structure databases

ProteinModelPortalQ5XIS1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000025546.

PTM databases

PhosphoSiteQ5XIS1.

Proteomic databases

PRIDEQ5XIS1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID365396.
KEGGrno:365396.

Organism-specific databases

CTD54961.
RGD1308679. Ssh3.

Phylogenomic databases

eggNOGCOG2453.
HOGENOMHOG000154428.
HOVERGENHBG089321.
InParanoidQ5XIS1.
KOK05766.
PhylomeDBQ5XIS1.

Gene expression databases

GenevestigatorQ5XIS1.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
3.90.190.10. 1 hit.
InterProIPR014876. DEK_C.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR009057. Homeodomain-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF08766. DEK_C. 1 hit.
PF00782. DSPc. 1 hit.
[Graphical view]
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio687372.
PROQ5XIS1.

Entry information

Entry nameSSH3_RAT
AccessionPrimary (citable) accession number: Q5XIS1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families