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Q5XIS1

- SSH3_RAT

UniProt

Q5XIS1 - SSH3_RAT

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Protein

Protein phosphatase Slingshot homolog 3

Gene

Ssh3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei410 – 4101Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. actin binding Source: RefGenome
  2. DNA binding Source: InterPro
  3. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
  4. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein dephosphorylation Source: RefGenome
  2. regulation of actin polymerization or depolymerization Source: RefGenome
  3. regulation of axonogenesis Source: RefGenome
  4. regulation of lamellipodium assembly Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase Slingshot homolog 3 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
SSH-like protein 3
Short name:
SSH-3L
Gene namesi
Name:Ssh3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1308679. Ssh3.

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. cytoskeleton Source: UniProtKB-KW
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 652651Protein phosphatase Slingshot homolog 3PRO_0000094847Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei85 – 851PhosphoserineBy similarity
Modified residuei87 – 871PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ5XIS1.

PTM databases

PhosphoSiteiQ5XIS1.

Expressioni

Gene expression databases

GenevestigatoriQ5XIS1.

Interactioni

Subunit structurei

Does not bind to, or colocalize with, filamentous actin.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025546.

Structurei

3D structure databases

ProteinModelPortaliQ5XIS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini325 – 465141Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
HOGENOMiHOG000154428.
HOVERGENiHBG089321.
InParanoidiQ5XIS1.
KOiK05766.
PhylomeDBiQ5XIS1.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR014876. DEK_C.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR009057. Homeodomain-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF08766. DEK_C. 1 hit.
PF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIS1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALVTVSRSP PASGHSTPVG PTDRVIRRRG RLQRRQSFAV LRGAVLGLQD
60 70 80 90 100
GGEGNDAAEA DPEPMEKPSG EEQPAEDQTD NGQGSQSPWK QVQKRHLHLM
110 120 130 140 150
VELLRPQDDI RLAAQLEAAR PPRLRYLLVV STGEGLSEEE TILLGVDFPD
160 170 180 190 200
SSSHSCTLGL VLPLWSDTQV YLDGDGGFSV TSGGQSRIFK PVSIQTMWAT
210 220 230 240 250
LQVLHQACEV ALGSGLVPGG SALAWATHYQ EKLNSDQGCL NEWMAMSDLE
260 270 280 290 300
SFRPPNAEPG QASEQEQMEQ AILAELWQVL DASDLDSVTS KEIRQALELR
310 320 330 340 350
LGCPLQQYRD FIDNQMLLLM AQQDRASRIF PHLYLGSEWN AANLEELQRN
360 370 380 390 400
RVSHILNMAR EIDNFFPERF TYHNVRVWDE ESAQLLPHWK ETHRFIEDAR
410 420 430 440 450
AQGTRVLVHC KMGVSRSAAT VLAYAMKQYG WGLEQALIHV QELRPIVRPN
460 470 480 490 500
PGFLRQLQTY QGILTASRQS HVWEQKVGVV SPEEPLAPEV STPLPPLPPE
510 520 530 540 550
PGGSGEGMVM GQKGSQETPK EELGLRPRIN LRGVMRSISL LEPSSEPEST
560 570 580 590 600
TEAGDLPEVF SSDEEPLHPF SQLSRAKGGQ RVCKGPWPAL KSRQSVVALH
610 620 630 640 650
SAALVASRAR AFQGQGQGQG QEQRETGTSS TPRLRKVIRQ ASVDDSREEG

KA
Length:652
Mass (Da):72,071
Last modified:November 23, 2004 - v1
Checksum:i7006E3B386C91BD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083600 mRNA. Translation: AAH83600.1.
RefSeqiNP_001012217.1. NM_001012217.1.
UniGeneiRn.12068.

Genome annotation databases

GeneIDi365396.
KEGGirno:365396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083600 mRNA. Translation: AAH83600.1 .
RefSeqi NP_001012217.1. NM_001012217.1.
UniGenei Rn.12068.

3D structure databases

ProteinModelPortali Q5XIS1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000025546.

PTM databases

PhosphoSitei Q5XIS1.

Proteomic databases

PRIDEi Q5XIS1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 365396.
KEGGi rno:365396.

Organism-specific databases

CTDi 54961.
RGDi 1308679. Ssh3.

Phylogenomic databases

eggNOGi COG2453.
HOGENOMi HOG000154428.
HOVERGENi HBG089321.
InParanoidi Q5XIS1.
KOi K05766.
PhylomeDBi Q5XIS1.

Miscellaneous databases

NextBioi 687372.
PROi Q5XIS1.

Gene expression databases

Genevestigatori Q5XIS1.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR014876. DEK_C.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR009057. Homeodomain-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF08766. DEK_C. 1 hit.
PF00782. DSPc. 1 hit.
[Graphical view ]
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiSSH3_RAT
AccessioniPrimary (citable) accession number: Q5XIS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Tyrosine phosphatase activity has not been demonstrated for this protein to date.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3