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Protein

Ubiquitin-associated domain-containing protein 1

Gene

Ubac1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-associated domain-containing protein 1
Short name:
UBA domain-containing protein 1
Alternative name(s):
E3 ubiquitin-protein ligase subunit KPC2
Kip1 ubiquitination-promoting complex protein 2
Gene namesi
Name:Ubac1
Synonyms:Kpc2, Ubadc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1359542 Ubac1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002504511 – 409Ubiquitin-associated domain-containing protein 1Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5XIR9
PRIDEiQ5XIR9

PTM databases

iPTMnetiQ5XIR9
PhosphoSitePlusiQ5XIR9

Expressioni

Gene expression databases

BgeeiENSRNOG00000017983
GenevisibleiQ5XIR9 RN

Interactioni

Subunit structurei

Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with RNF123 via its N-terminal domain. Interacts with the proteasome via its N-terminal domain (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024352

Structurei

3D structure databases

ProteinModelPortaliQ5XIR9
SMRiQ5XIR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 98Ubiquitin-likeAdd BLAST85
Domaini187 – 231UBA 1PROSITE-ProRule annotationAdd BLAST45
Domaini292 – 332UBA 2PROSITE-ProRule annotationAdd BLAST41
Domaini357 – 396STI1Add BLAST40

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHU5 Eukaryota
ENOG410Y2UN LUCA
GeneTreeiENSGT00390000014658
HOGENOMiHOG000231457
HOVERGENiHBG053148
InParanoidiQ5XIR9
KOiK12174
OMAiNIRDFQT
OrthoDBiEOG091G05QY
PhylomeDBiQ5XIR9
TreeFamiTF324579

Family and domain databases

InterProiView protein in InterPro
IPR006636 STI1_HS-bd
IPR015940 UBA
IPR009060 UBA-like_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00627 UBA, 2 hits
SMARTiView protein in SMART
SM00727 STI1, 1 hit
SM00165 UBA, 2 hits
SUPFAMiSSF46934 SSF46934, 2 hits
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 2 hits

Sequencei

Sequence statusi: Complete.

Q5XIR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVQEEKIFA GKVLRLHICA ADGSEWLEEA TEDTSVEKLK ESCLKHGAHG
60 70 80 90 100
SLEDPKNVTH HKLIHAASER VLSDSKTILE ENIQDQDVLL LIKKRAPSPI
110 120 130 140 150
PKMADVSAEE KKKQEQKAPD KDAILRATAN LPACSTDRTA VQTTMRDFQT
160 170 180 190 200
ELRKILVSLI EVAQKLLALN PDAVELFKKA NAMLDEDEDE RVDETALRQL
210 220 230 240 250
TEMGFPESRA SKALRLNHMS VPQAMEWLIE HSEDPAIDTP LPGHAAQAEA
260 270 280 290 300
SAAAATSSSS SEAAVGTSVE DEESRDELTE IFKKIRRKKE FRADARAVIS
310 320 330 340 350
LMEMGFDEKE VIDALRVNNN QQNAACEWLL GDRKPSPEEL DQGIDPNSPL
360 370 380 390 400
FQAILDNPVV QLGLTNPKTL LAFEDMLENP LNSTQWMNDP ETGPVMLQIS

RIFQTLNRT
Length:409
Mass (Da):45,546
Last modified:November 23, 2004 - v1
Checksum:i73FF7C00C0554929
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083603 mRNA Translation: AAH83603.1
RefSeqiNP_001007743.1, NM_001007742.1
UniGeneiRn.6512

Genome annotation databases

EnsembliENSRNOT00000024352; ENSRNOP00000024352; ENSRNOG00000017983
GeneIDi362087
KEGGirno:362087
UCSCiRGD:1359542 rat

Similar proteinsi

Entry informationi

Entry nameiUBAC1_RAT
AccessioniPrimary (citable) accession number: Q5XIR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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