Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin-associated domain-containing protein 1

Gene

Ubac1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-associated domain-containing protein 1
Short name:
UBA domain-containing protein 1
Alternative name(s):
E3 ubiquitin-protein ligase subunit KPC2
Kip1 ubiquitination-promoting complex protein 2
Gene namesi
Name:Ubac1
Synonyms:Kpc2, Ubadc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1359542. Ubac1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Ubiquitin-associated domain-containing protein 1PRO_0000250451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5XIR9.
PRIDEiQ5XIR9.

PTM databases

iPTMnetiQ5XIR9.
PhosphoSiteiQ5XIR9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017983.
GenevisibleiQ5XIR9. RN.

Interactioni

Subunit structurei

Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with RNF123 via its N-terminal domain. Interacts with the proteasome via its N-terminal domain (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024352.

Structurei

3D structure databases

ProteinModelPortaliQ5XIR9.
SMRiQ5XIR9. Positions 172-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 9885Ubiquitin-likeAdd
BLAST
Domaini187 – 23145UBA 1PROSITE-ProRule annotationAdd
BLAST
Domaini292 – 33241UBA 2PROSITE-ProRule annotationAdd
BLAST
Domaini357 – 39640STI1Add
BLAST

Sequence similaritiesi

Contains 1 STI1 domain.Curated
Contains 2 UBA domains.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHU5. Eukaryota.
ENOG410Y2UN. LUCA.
GeneTreeiENSGT00390000014658.
HOGENOMiHOG000231457.
HOVERGENiHBG053148.
InParanoidiQ5XIR9.
KOiK12174.
OMAiFQAILEN.
OrthoDBiEOG091G05QY.
PhylomeDBiQ5XIR9.
TreeFamiTF324579.

Family and domain databases

InterProiIPR006636. STI1_HS-bd.
IPR015940. UBA.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00627. UBA. 2 hits.
[Graphical view]
SMARTiSM00727. STI1. 1 hit.
SM00165. UBA. 2 hits.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50030. UBA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVQEEKIFA GKVLRLHICA ADGSEWLEEA TEDTSVEKLK ESCLKHGAHG
60 70 80 90 100
SLEDPKNVTH HKLIHAASER VLSDSKTILE ENIQDQDVLL LIKKRAPSPI
110 120 130 140 150
PKMADVSAEE KKKQEQKAPD KDAILRATAN LPACSTDRTA VQTTMRDFQT
160 170 180 190 200
ELRKILVSLI EVAQKLLALN PDAVELFKKA NAMLDEDEDE RVDETALRQL
210 220 230 240 250
TEMGFPESRA SKALRLNHMS VPQAMEWLIE HSEDPAIDTP LPGHAAQAEA
260 270 280 290 300
SAAAATSSSS SEAAVGTSVE DEESRDELTE IFKKIRRKKE FRADARAVIS
310 320 330 340 350
LMEMGFDEKE VIDALRVNNN QQNAACEWLL GDRKPSPEEL DQGIDPNSPL
360 370 380 390 400
FQAILDNPVV QLGLTNPKTL LAFEDMLENP LNSTQWMNDP ETGPVMLQIS

RIFQTLNRT
Length:409
Mass (Da):45,546
Last modified:November 23, 2004 - v1
Checksum:i73FF7C00C0554929
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083603 mRNA. Translation: AAH83603.1.
RefSeqiNP_001007743.1. NM_001007742.1.
UniGeneiRn.6512.

Genome annotation databases

EnsembliENSRNOT00000024352; ENSRNOP00000024352; ENSRNOG00000017983.
GeneIDi362087.
KEGGirno:362087.
UCSCiRGD:1359542. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083603 mRNA. Translation: AAH83603.1.
RefSeqiNP_001007743.1. NM_001007742.1.
UniGeneiRn.6512.

3D structure databases

ProteinModelPortaliQ5XIR9.
SMRiQ5XIR9. Positions 172-246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024352.

PTM databases

iPTMnetiQ5XIR9.
PhosphoSiteiQ5XIR9.

Proteomic databases

PaxDbiQ5XIR9.
PRIDEiQ5XIR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024352; ENSRNOP00000024352; ENSRNOG00000017983.
GeneIDi362087.
KEGGirno:362087.
UCSCiRGD:1359542. rat.

Organism-specific databases

CTDi10422.
RGDi1359542. Ubac1.

Phylogenomic databases

eggNOGiENOG410IHU5. Eukaryota.
ENOG410Y2UN. LUCA.
GeneTreeiENSGT00390000014658.
HOGENOMiHOG000231457.
HOVERGENiHBG053148.
InParanoidiQ5XIR9.
KOiK12174.
OMAiFQAILEN.
OrthoDBiEOG091G05QY.
PhylomeDBiQ5XIR9.
TreeFamiTF324579.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ5XIR9.

Gene expression databases

BgeeiENSRNOG00000017983.
GenevisibleiQ5XIR9. RN.

Family and domain databases

InterProiIPR006636. STI1_HS-bd.
IPR015940. UBA.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00627. UBA. 2 hits.
[Graphical view]
SMARTiSM00727. STI1. 1 hit.
SM00165. UBA. 2 hits.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50030. UBA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBAC1_RAT
AccessioniPrimary (citable) accession number: Q5XIR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.