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Protein

CXXC-type zinc finger protein 5

Gene

Cxxc5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri250 – 291CXXC-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
CXXC-type zinc finger protein 5
Gene namesi
Name:Cxxc5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1359466 Cxxc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175511 – 316CXXC-type zinc finger protein 5Add BLAST316

Proteomic databases

PaxDbiQ5XIQ3

PTM databases

PhosphoSitePlusiQ5XIQ3

Expressioni

Tissue specificityi

Expressed in neural stem cells (at protein level). Expressed in the dorsal telencephalon.1 Publication

Inductioni

Up-regulated by BMP4.1 Publication

Gene expression databases

BgeeiENSRNOG00000032878
GenevisibleiQ5XIQ3 RN

Interactioni

Subunit structurei

Interacts with DVL1. Interacts with RBPJ.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042976

Structurei

3D structure databases

ProteinModelPortaliQ5XIQ3
SMRiQ5XIQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi251 – 256Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 18Poly-Ser5
Compositional biasi21 – 26Poly-Ser6

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri250 – 291CXXC-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGNJ Eukaryota
ENOG4110UND LUCA
GeneTreeiENSGT00910000144072
HOGENOMiHOG000112118
HOVERGENiHBG095668
InParanoidiQ5XIQ3
OMAiRCGMCPP
OrthoDBiEOG091G0FYR
PhylomeDBiQ5XIQ3
TreeFamiTF326617

Family and domain databases

InterProiView protein in InterPro
IPR002857 Znf_CXXC
PfamiView protein in Pfam
PF02008 zf-CXXC, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XIQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLGGGSQD AGGSSSSSNT SSSSGSGQKA GGTDKSATVA ATAPASVADD
60 70 80 90 100
APPPERRNKS GIISEPLNKS LRRSRPLSHY SSFGSSGGAG SMMGGESADK
110 120 130 140 150
AAAAAASLLA NGHDLAAAMA VDKSNPTSKH KSGAVASLLS KAERATELAA
160 170 180 190 200
EGQLTLQQFA QSTEMLKRVV QEHLPLMSEA GAGLPDMEAV AGAEALNGQS
210 220 230 240 250
DFPYLGAFPI NPGLFIMTPA GVFLAESALH MAGLAEYPMQ GELASAISSG
260 270 280 290 300
KKKRKRCGMC APCRRRINCE QCSSCRNRKT GHQICKFRKC EELKKKPSAA
310
LEKVMLPSGA AFRWFQ
Length:316
Mass (Da):32,626
Last modified:November 23, 2004 - v1
Checksum:iE8E772D04A4BE97B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083622 mRNA Translation: AAH83622.1
RefSeqiNP_001007629.1, NM_001007628.2
XP_017456389.1, XM_017600900.1
XP_017456390.1, XM_017600901.1
XP_017456391.1, XM_017600902.1
XP_017456392.1, XM_017600903.1
XP_017456393.1, XM_017600904.1
UniGeneiRn.105695

Genome annotation databases

EnsembliENSRNOT00000045795; ENSRNOP00000042976; ENSRNOG00000032878
ENSRNOT00000085120; ENSRNOP00000069122; ENSRNOG00000032878
GeneIDi291670
KEGGirno:291670
UCSCiRGD:1359466 rat

Similar proteinsi

Entry informationi

Entry nameiCXXC5_RAT
AccessioniPrimary (citable) accession number: Q5XIQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health