Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5XIP9 (TMM43_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 43
Alternative name(s):
Protein LUMA
Gene names
Name:Tmem43
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane By similarity.

Subunit structure

Can form oligomers through the transmembrane domains. Interacts with EMD; the interaction retains EMD at the inner nuclear membrane. Interacts with LMNA and LMNB2 By similarity. Interacts with SUN2 By similarity.

Subcellular location

Endoplasmic reticulum By similarity. Nucleus inner membrane; Multi-pass membrane protein. Note: Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the TMEM43 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 400399Transmembrane protein 43
PRO_0000284501

Regions

Topological domain2 – 3130Nuclear Potential
Transmembrane32 – 5221Helical; Potential
Topological domain53 – 313261Perinuclear space Potential
Transmembrane314 – 33421Helical; Potential
Topological domain335 – 34511Nuclear Potential
Transmembrane346 – 36621Helical; Potential
Topological domain367 – 3682Perinuclear space Potential
Transmembrane369 – 38921Helical; Potential
Topological domain390 – 40011Nuclear Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5XIP9 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 5B1C68706DFD4E59

FASTA40044,774
        10         20         30         40         50         60 
MAANYSSTGS RKEHVKVTSD PQPGFLERLS ETSGGMFVGL VTFLLSFYLI FTNEGRALKT 

        70         80         90        100        110        120 
ANLLAEGLSL VVSPDSIHSV APENEGRLVH IIGALRTSKL LSDPNYGVHL PAVKLRRHVE 

       130        140        150        160        170        180 
MYQWVETEES NEYTEDGQVK KETKYSYNTE WRSEIVSSKN FDREIGHKNP SAMAVESFTA 

       190        200        210        220        230        240 
TAPFVQIGRF FLSAGLIDKI DNFKPLSLAK LEDPHVDIIR RGDFFYHSEN PKYPEVGDVR 

       250        260        270        280        290        300 
VSFSYAGLSS DDPDLGPAHV VTVIARQRGD QLIPYSTKSG DTLLLLHHGD FSAEEVFRRE 

       310        320        330        340        350        360 
QKSNSMKTWG LRAAGWMAMF MGLNLMTRIL YTLVDWFPVF RDLVNIGLKA FAFCVATSLT 

       370        380        390        400 
LLTVAAGWLF YRPLWAALLG CLALVPIIIA RTRVPTKKLE 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC083626 mRNA. Translation: AAH83626.1.
RefSeqNP_001007746.1. NM_001007745.1.
UniGeneRn.15201.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid263420. 1 interaction.
IntActQ5XIP9. 1 interaction.
STRING10116.ENSRNOP00000010895.

Proteomic databases

PaxDbQ5XIP9.
PRIDEQ5XIP9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000010895; ENSRNOP00000010895; ENSRNOG00000007519.
GeneID362401.
KEGGrno:362401.

Organism-specific databases

CTD79188.
RGD1549711. Tmem43.

Phylogenomic databases

eggNOGNOG72539.
GeneTreeENSGT00390000009671.
HOGENOMHOG000008164.
HOVERGENHBG062125.
InParanoidQ5XIP9.
OMAGDYFYHS.
OrthoDBEOG7V766S.
PhylomeDBQ5XIP9.
TreeFamTF324718.

Gene expression databases

GenevestigatorQ5XIP9.

Family and domain databases

InterProIPR012430. TMEM43_fam.
[Graphical view]
PANTHERPTHR13416. PTHR13416. 1 hit.
PfamPF07787. DUF1625. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio679786.
PROQ5XIP9.

Entry information

Entry nameTMM43_RAT
AccessionPrimary (citable) accession number: Q5XIP9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families