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Q5XIP9

- TMM43_RAT

UniProt

Q5XIP9 - TMM43_RAT

Protein

Transmembrane protein 43

Gene

Tmem43

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 43
    Alternative name(s):
    Protein LUMA
    Gene namesi
    Name:Tmem43
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi1549711. Tmem43.

    Subcellular locationi

    Endoplasmic reticulum By similarity. Nucleus inner membrane; Multi-pass membrane protein
    Note: Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen By similarity.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. Golgi apparatus Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. nuclear inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 400399Transmembrane protein 43PRO_0000284501Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ5XIP9.
    PRIDEiQ5XIP9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5XIP9.

    Interactioni

    Subunit structurei

    Can form oligomers through the transmembrane domains. Interacts with EMD; the interaction retains EMD at the inner nuclear membrane. Interacts with LMNA and LMNB2 By similarity. Interacts with SUN2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi263420. 1 interaction.
    IntActiQ5XIP9. 1 interaction.
    STRINGi10116.ENSRNOP00000010895.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 3130NuclearSequence AnalysisAdd
    BLAST
    Topological domaini53 – 313261Perinuclear spaceSequence AnalysisAdd
    BLAST
    Topological domaini335 – 34511NuclearSequence AnalysisAdd
    BLAST
    Topological domaini367 – 3682Perinuclear spaceSequence Analysis
    Topological domaini390 – 40011NuclearSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei314 – 33421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei346 – 36621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei369 – 38921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM43 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG72539.
    GeneTreeiENSGT00390000009671.
    HOGENOMiHOG000008164.
    HOVERGENiHBG062125.
    InParanoidiQ5XIP9.
    OMAiGDYFYHS.
    OrthoDBiEOG7V766S.
    PhylomeDBiQ5XIP9.
    TreeFamiTF324718.

    Family and domain databases

    InterProiIPR012430. TMEM43_fam.
    [Graphical view]
    PANTHERiPTHR13416. PTHR13416. 1 hit.
    PfamiPF07787. DUF1625. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5XIP9-1 [UniParc]FASTAAdd to Basket

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    MAANYSSTGS RKEHVKVTSD PQPGFLERLS ETSGGMFVGL VTFLLSFYLI    50
    FTNEGRALKT ANLLAEGLSL VVSPDSIHSV APENEGRLVH IIGALRTSKL 100
    LSDPNYGVHL PAVKLRRHVE MYQWVETEES NEYTEDGQVK KETKYSYNTE 150
    WRSEIVSSKN FDREIGHKNP SAMAVESFTA TAPFVQIGRF FLSAGLIDKI 200
    DNFKPLSLAK LEDPHVDIIR RGDFFYHSEN PKYPEVGDVR VSFSYAGLSS 250
    DDPDLGPAHV VTVIARQRGD QLIPYSTKSG DTLLLLHHGD FSAEEVFRRE 300
    QKSNSMKTWG LRAAGWMAMF MGLNLMTRIL YTLVDWFPVF RDLVNIGLKA 350
    FAFCVATSLT LLTVAAGWLF YRPLWAALLG CLALVPIIIA RTRVPTKKLE 400
    Length:400
    Mass (Da):44,774
    Last modified:November 23, 2004 - v1
    Checksum:i5B1C68706DFD4E59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083626 mRNA. Translation: AAH83626.1.
    RefSeqiNP_001007746.1. NM_001007745.1.
    UniGeneiRn.15201.

    Genome annotation databases

    EnsembliENSRNOT00000010895; ENSRNOP00000010895; ENSRNOG00000007519.
    GeneIDi362401.
    KEGGirno:362401.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC083626 mRNA. Translation: AAH83626.1 .
    RefSeqi NP_001007746.1. NM_001007745.1.
    UniGenei Rn.15201.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 263420. 1 interaction.
    IntActi Q5XIP9. 1 interaction.
    STRINGi 10116.ENSRNOP00000010895.

    Proteomic databases

    PaxDbi Q5XIP9.
    PRIDEi Q5XIP9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000010895 ; ENSRNOP00000010895 ; ENSRNOG00000007519 .
    GeneIDi 362401.
    KEGGi rno:362401.

    Organism-specific databases

    CTDi 79188.
    RGDi 1549711. Tmem43.

    Phylogenomic databases

    eggNOGi NOG72539.
    GeneTreei ENSGT00390000009671.
    HOGENOMi HOG000008164.
    HOVERGENi HBG062125.
    InParanoidi Q5XIP9.
    OMAi GDYFYHS.
    OrthoDBi EOG7V766S.
    PhylomeDBi Q5XIP9.
    TreeFami TF324718.

    Miscellaneous databases

    NextBioi 679786.
    PROi Q5XIP9.

    Gene expression databases

    Genevestigatori Q5XIP9.

    Family and domain databases

    InterProi IPR012430. TMEM43_fam.
    [Graphical view ]
    PANTHERi PTHR13416. PTHR13416. 1 hit.
    Pfami PF07787. DUF1625. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiTMM43_RAT
    AccessioniPrimary (citable) accession number: Q5XIP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3