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Protein

Transmembrane protein 43

Gene

Tmem43

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 43
Alternative name(s):
Protein LUMA
Gene namesi
Name:Tmem43
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1549711. Tmem43.

Subcellular locationi

  • Endoplasmic reticulum By similarity
  • Nucleus inner membrane; Multi-pass membrane protein

  • Note: Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 31NuclearSequence analysisAdd BLAST30
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 313Perinuclear spaceSequence analysisAdd BLAST261
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 345NuclearSequence analysisAdd BLAST11
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Topological domaini367 – 368Perinuclear spaceSequence analysis2
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Topological domaini390 – 400NuclearSequence analysisAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002845012 – 400Transmembrane protein 43Add BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5XIP9.
PRIDEiQ5XIP9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007519.
GenevisibleiQ5XIP9. RN.

Interactioni

Subunit structurei

Can form oligomers through the transmembrane domains. Interacts with EMD; the interaction retains EMD at the inner nuclear membrane. Interacts with LMNA and LMNB2 (By similarity). Interacts with SUN2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi263420. 1 interactor.
IntActiQ5XIP9. 1 interactor.
STRINGi10116.ENSRNOP00000010895.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM43 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEFK. Eukaryota.
ENOG410Z3TK. LUCA.
GeneTreeiENSGT00390000009671.
HOGENOMiHOG000008164.
HOVERGENiHBG062125.
InParanoidiQ5XIP9.
OMAiGDYFYHS.
OrthoDBiEOG091G0A4D.
PhylomeDBiQ5XIP9.
TreeFamiTF324718.

Family and domain databases

InterProiIPR012430. TMEM43_fam.
[Graphical view]
PANTHERiPTHR13416. PTHR13416. 1 hit.
PfamiPF07787. TMEM43. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANYSSTGS RKEHVKVTSD PQPGFLERLS ETSGGMFVGL VTFLLSFYLI
60 70 80 90 100
FTNEGRALKT ANLLAEGLSL VVSPDSIHSV APENEGRLVH IIGALRTSKL
110 120 130 140 150
LSDPNYGVHL PAVKLRRHVE MYQWVETEES NEYTEDGQVK KETKYSYNTE
160 170 180 190 200
WRSEIVSSKN FDREIGHKNP SAMAVESFTA TAPFVQIGRF FLSAGLIDKI
210 220 230 240 250
DNFKPLSLAK LEDPHVDIIR RGDFFYHSEN PKYPEVGDVR VSFSYAGLSS
260 270 280 290 300
DDPDLGPAHV VTVIARQRGD QLIPYSTKSG DTLLLLHHGD FSAEEVFRRE
310 320 330 340 350
QKSNSMKTWG LRAAGWMAMF MGLNLMTRIL YTLVDWFPVF RDLVNIGLKA
360 370 380 390 400
FAFCVATSLT LLTVAAGWLF YRPLWAALLG CLALVPIIIA RTRVPTKKLE
Length:400
Mass (Da):44,774
Last modified:November 23, 2004 - v1
Checksum:i5B1C68706DFD4E59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083626 mRNA. Translation: AAH83626.1.
RefSeqiNP_001007746.1. NM_001007745.1.
UniGeneiRn.15201.

Genome annotation databases

EnsembliENSRNOT00000010895; ENSRNOP00000010895; ENSRNOG00000007519.
GeneIDi362401.
KEGGirno:362401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083626 mRNA. Translation: AAH83626.1.
RefSeqiNP_001007746.1. NM_001007745.1.
UniGeneiRn.15201.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi263420. 1 interactor.
IntActiQ5XIP9. 1 interactor.
STRINGi10116.ENSRNOP00000010895.

Proteomic databases

PaxDbiQ5XIP9.
PRIDEiQ5XIP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010895; ENSRNOP00000010895; ENSRNOG00000007519.
GeneIDi362401.
KEGGirno:362401.

Organism-specific databases

CTDi79188.
RGDi1549711. Tmem43.

Phylogenomic databases

eggNOGiENOG410IEFK. Eukaryota.
ENOG410Z3TK. LUCA.
GeneTreeiENSGT00390000009671.
HOGENOMiHOG000008164.
HOVERGENiHBG062125.
InParanoidiQ5XIP9.
OMAiGDYFYHS.
OrthoDBiEOG091G0A4D.
PhylomeDBiQ5XIP9.
TreeFamiTF324718.

Miscellaneous databases

PROiQ5XIP9.

Gene expression databases

BgeeiENSRNOG00000007519.
GenevisibleiQ5XIP9. RN.

Family and domain databases

InterProiIPR012430. TMEM43_fam.
[Graphical view]
PANTHERiPTHR13416. PTHR13416. 1 hit.
PfamiPF07787. TMEM43. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM43_RAT
AccessioniPrimary (citable) accession number: Q5XIP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 23, 2004
Last modified: October 5, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.