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Q5XIP9

- TMM43_RAT

UniProt

Q5XIP9 - TMM43_RAT

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Protein

Transmembrane protein 43

Gene
Tmem43
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 43
Alternative name(s):
Protein LUMA
Gene namesi
Name:Tmem43
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi1549711. Tmem43.

Subcellular locationi

Endoplasmic reticulum By similarity. Nucleus inner membrane; Multi-pass membrane protein
Note: Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3130Nuclear Reviewed predictionAdd
BLAST
Transmembranei32 – 5221Helical; Reviewed predictionAdd
BLAST
Topological domaini53 – 313261Perinuclear space Reviewed predictionAdd
BLAST
Transmembranei314 – 33421Helical; Reviewed predictionAdd
BLAST
Topological domaini335 – 34511Nuclear Reviewed predictionAdd
BLAST
Transmembranei346 – 36621Helical; Reviewed predictionAdd
BLAST
Topological domaini367 – 3682Perinuclear space Reviewed prediction
Transmembranei369 – 38921Helical; Reviewed predictionAdd
BLAST
Topological domaini390 – 40011Nuclear Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
  2. Golgi apparatus Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. nuclear inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 400399Transmembrane protein 43PRO_0000284501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5XIP9.
PRIDEiQ5XIP9.

Expressioni

Gene expression databases

GenevestigatoriQ5XIP9.

Interactioni

Subunit structurei

Can form oligomers through the transmembrane domains. Interacts with EMD; the interaction retains EMD at the inner nuclear membrane. Interacts with LMNA and LMNB2 By similarity. Interacts with SUN2 By similarity.

Protein-protein interaction databases

BioGridi263420. 1 interaction.
IntActiQ5XIP9. 1 interaction.
STRINGi10116.ENSRNOP00000010895.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM43 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72539.
GeneTreeiENSGT00390000009671.
HOGENOMiHOG000008164.
HOVERGENiHBG062125.
InParanoidiQ5XIP9.
OMAiGDYFYHS.
OrthoDBiEOG7V766S.
PhylomeDBiQ5XIP9.
TreeFamiTF324718.

Family and domain databases

InterProiIPR012430. TMEM43_fam.
[Graphical view]
PANTHERiPTHR13416. PTHR13416. 1 hit.
PfamiPF07787. DUF1625. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIP9-1 [UniParc]FASTAAdd to Basket

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MAANYSSTGS RKEHVKVTSD PQPGFLERLS ETSGGMFVGL VTFLLSFYLI    50
FTNEGRALKT ANLLAEGLSL VVSPDSIHSV APENEGRLVH IIGALRTSKL 100
LSDPNYGVHL PAVKLRRHVE MYQWVETEES NEYTEDGQVK KETKYSYNTE 150
WRSEIVSSKN FDREIGHKNP SAMAVESFTA TAPFVQIGRF FLSAGLIDKI 200
DNFKPLSLAK LEDPHVDIIR RGDFFYHSEN PKYPEVGDVR VSFSYAGLSS 250
DDPDLGPAHV VTVIARQRGD QLIPYSTKSG DTLLLLHHGD FSAEEVFRRE 300
QKSNSMKTWG LRAAGWMAMF MGLNLMTRIL YTLVDWFPVF RDLVNIGLKA 350
FAFCVATSLT LLTVAAGWLF YRPLWAALLG CLALVPIIIA RTRVPTKKLE 400
Length:400
Mass (Da):44,774
Last modified:November 23, 2004 - v1
Checksum:i5B1C68706DFD4E59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC083626 mRNA. Translation: AAH83626.1.
RefSeqiNP_001007746.1. NM_001007745.1.
UniGeneiRn.15201.

Genome annotation databases

EnsembliENSRNOT00000010895; ENSRNOP00000010895; ENSRNOG00000007519.
GeneIDi362401.
KEGGirno:362401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC083626 mRNA. Translation: AAH83626.1 .
RefSeqi NP_001007746.1. NM_001007745.1.
UniGenei Rn.15201.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 263420. 1 interaction.
IntActi Q5XIP9. 1 interaction.
STRINGi 10116.ENSRNOP00000010895.

Proteomic databases

PaxDbi Q5XIP9.
PRIDEi Q5XIP9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000010895 ; ENSRNOP00000010895 ; ENSRNOG00000007519 .
GeneIDi 362401.
KEGGi rno:362401.

Organism-specific databases

CTDi 79188.
RGDi 1549711. Tmem43.

Phylogenomic databases

eggNOGi NOG72539.
GeneTreei ENSGT00390000009671.
HOGENOMi HOG000008164.
HOVERGENi HBG062125.
InParanoidi Q5XIP9.
OMAi GDYFYHS.
OrthoDBi EOG7V766S.
PhylomeDBi Q5XIP9.
TreeFami TF324718.

Miscellaneous databases

NextBioi 679786.
PROi Q5XIP9.

Gene expression databases

Genevestigatori Q5XIP9.

Family and domain databases

InterProi IPR012430. TMEM43_fam.
[Graphical view ]
PANTHERi PTHR13416. PTHR13416. 1 hit.
Pfami PF07787. DUF1625. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiTMM43_RAT
AccessioniPrimary (citable) accession number: Q5XIP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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