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Protein

Transmembrane protein 43

Gene

Tmem43

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 43
Alternative name(s):
Protein LUMA
Gene namesi
Name:Tmem43
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi1549711. Tmem43.

Subcellular locationi

Endoplasmic reticulum By similarity. Nucleus inner membrane; Multi-pass membrane protein
Note: Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3130NuclearSequence AnalysisAdd
BLAST
Transmembranei32 – 5221HelicalSequence AnalysisAdd
BLAST
Topological domaini53 – 313261Perinuclear spaceSequence AnalysisAdd
BLAST
Transmembranei314 – 33421HelicalSequence AnalysisAdd
BLAST
Topological domaini335 – 34511NuclearSequence AnalysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence AnalysisAdd
BLAST
Topological domaini367 – 3682Perinuclear spaceSequence Analysis
Transmembranei369 – 38921HelicalSequence AnalysisAdd
BLAST
Topological domaini390 – 40011NuclearSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. nuclear inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 400399Transmembrane protein 43PRO_0000284501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5XIP9.
PRIDEiQ5XIP9.

Expressioni

Gene expression databases

GenevestigatoriQ5XIP9.

Interactioni

Subunit structurei

Can form oligomers through the transmembrane domains. Interacts with EMD; the interaction retains EMD at the inner nuclear membrane. Interacts with LMNA and LMNB2 (By similarity). Interacts with SUN2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi263420. 1 interaction.
IntActiQ5XIP9. 1 interaction.
STRINGi10116.ENSRNOP00000010895.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM43 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72539.
GeneTreeiENSGT00390000009671.
HOGENOMiHOG000008164.
HOVERGENiHBG062125.
InParanoidiQ5XIP9.
OMAiGDYFYHS.
OrthoDBiEOG7V766S.
PhylomeDBiQ5XIP9.
TreeFamiTF324718.

Family and domain databases

InterProiIPR012430. TMEM43_fam.
[Graphical view]
PANTHERiPTHR13416. PTHR13416. 1 hit.
PfamiPF07787. DUF1625. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIP9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAANYSSTGS RKEHVKVTSD PQPGFLERLS ETSGGMFVGL VTFLLSFYLI
60 70 80 90 100
FTNEGRALKT ANLLAEGLSL VVSPDSIHSV APENEGRLVH IIGALRTSKL
110 120 130 140 150
LSDPNYGVHL PAVKLRRHVE MYQWVETEES NEYTEDGQVK KETKYSYNTE
160 170 180 190 200
WRSEIVSSKN FDREIGHKNP SAMAVESFTA TAPFVQIGRF FLSAGLIDKI
210 220 230 240 250
DNFKPLSLAK LEDPHVDIIR RGDFFYHSEN PKYPEVGDVR VSFSYAGLSS
260 270 280 290 300
DDPDLGPAHV VTVIARQRGD QLIPYSTKSG DTLLLLHHGD FSAEEVFRRE
310 320 330 340 350
QKSNSMKTWG LRAAGWMAMF MGLNLMTRIL YTLVDWFPVF RDLVNIGLKA
360 370 380 390 400
FAFCVATSLT LLTVAAGWLF YRPLWAALLG CLALVPIIIA RTRVPTKKLE
Length:400
Mass (Da):44,774
Last modified:November 23, 2004 - v1
Checksum:i5B1C68706DFD4E59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083626 mRNA. Translation: AAH83626.1.
RefSeqiNP_001007746.1. NM_001007745.1.
UniGeneiRn.15201.

Genome annotation databases

EnsembliENSRNOT00000010895; ENSRNOP00000010895; ENSRNOG00000007519.
GeneIDi362401.
KEGGirno:362401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083626 mRNA. Translation: AAH83626.1.
RefSeqiNP_001007746.1. NM_001007745.1.
UniGeneiRn.15201.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi263420. 1 interaction.
IntActiQ5XIP9. 1 interaction.
STRINGi10116.ENSRNOP00000010895.

Proteomic databases

PaxDbiQ5XIP9.
PRIDEiQ5XIP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010895; ENSRNOP00000010895; ENSRNOG00000007519.
GeneIDi362401.
KEGGirno:362401.

Organism-specific databases

CTDi79188.
RGDi1549711. Tmem43.

Phylogenomic databases

eggNOGiNOG72539.
GeneTreeiENSGT00390000009671.
HOGENOMiHOG000008164.
HOVERGENiHBG062125.
InParanoidiQ5XIP9.
OMAiGDYFYHS.
OrthoDBiEOG7V766S.
PhylomeDBiQ5XIP9.
TreeFamiTF324718.

Miscellaneous databases

NextBioi679786.
PROiQ5XIP9.

Gene expression databases

GenevestigatoriQ5XIP9.

Family and domain databases

InterProiIPR012430. TMEM43_fam.
[Graphical view]
PANTHERiPTHR13416. PTHR13416. 1 hit.
PfamiPF07787. DUF1625. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiTMM43_RAT
AccessioniPrimary (citable) accession number: Q5XIP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 23, 2004
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.