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Protein

Transmembrane protein 43

Gene

Tmem43

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 43
Alternative name(s):
Protein LUMA
Gene namesi
Name:Tmem43
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1549711 Tmem43

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 31NuclearSequence analysisAdd BLAST30
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 313Perinuclear spaceSequence analysisAdd BLAST261
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 345NuclearSequence analysisAdd BLAST11
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Topological domaini367 – 368Perinuclear spaceSequence analysis2
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Topological domaini390 – 400NuclearSequence analysisAdd BLAST11

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002845012 – 400Transmembrane protein 43Add BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5XIP9
PRIDEiQ5XIP9

Expressioni

Gene expression databases

BgeeiENSRNOG00000007519
GenevisibleiQ5XIP9 RN

Interactioni

Subunit structurei

Can form oligomers through the transmembrane domains. Interacts with EMD; the interaction retains EMD at the inner nuclear membrane. Interacts with LMNA and LMNB2 (By similarity). Interacts with SUN2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi263420, 1 interactor
IntActiQ5XIP9, 1 interactor
STRINGi10116.ENSRNOP00000010895

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM43 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEFK Eukaryota
ENOG410Z3TK LUCA
GeneTreeiENSGT00390000009671
HOGENOMiHOG000008164
HOVERGENiHBG062125
InParanoidiQ5XIP9
OMAiGDYFYHS
OrthoDBiEOG091G0A4D
PhylomeDBiQ5XIP9
TreeFamiTF324718

Family and domain databases

InterProiView protein in InterPro
IPR012430 TMEM43_fam
PANTHERiPTHR13416 PTHR13416, 1 hit
PfamiView protein in Pfam
PF07787 TMEM43, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANYSSTGS RKEHVKVTSD PQPGFLERLS ETSGGMFVGL VTFLLSFYLI
60 70 80 90 100
FTNEGRALKT ANLLAEGLSL VVSPDSIHSV APENEGRLVH IIGALRTSKL
110 120 130 140 150
LSDPNYGVHL PAVKLRRHVE MYQWVETEES NEYTEDGQVK KETKYSYNTE
160 170 180 190 200
WRSEIVSSKN FDREIGHKNP SAMAVESFTA TAPFVQIGRF FLSAGLIDKI
210 220 230 240 250
DNFKPLSLAK LEDPHVDIIR RGDFFYHSEN PKYPEVGDVR VSFSYAGLSS
260 270 280 290 300
DDPDLGPAHV VTVIARQRGD QLIPYSTKSG DTLLLLHHGD FSAEEVFRRE
310 320 330 340 350
QKSNSMKTWG LRAAGWMAMF MGLNLMTRIL YTLVDWFPVF RDLVNIGLKA
360 370 380 390 400
FAFCVATSLT LLTVAAGWLF YRPLWAALLG CLALVPIIIA RTRVPTKKLE
Length:400
Mass (Da):44,774
Last modified:November 23, 2004 - v1
Checksum:i5B1C68706DFD4E59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083626 mRNA Translation: AAH83626.1
RefSeqiNP_001007746.1, NM_001007745.1
UniGeneiRn.15201

Genome annotation databases

EnsembliENSRNOT00000010895; ENSRNOP00000010895; ENSRNOG00000007519
GeneIDi362401
KEGGirno:362401

Similar proteinsi

Entry informationi

Entry nameiTMM43_RAT
AccessioniPrimary (citable) accession number: Q5XIP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 23, 2004
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health