Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein pelota homolog

Gene

Pelo

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential).By similarityCurated

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processCell cycle, Cell division
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein pelota homolog (EC:3.1.-.-)
Gene namesi
Name:Pelo
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1359591 Pelo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002328361 – 385Protein pelota homologAdd BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei374PhosphoserineCombined sources1
Modified residuei380PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei382PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5XIP1
PRIDEiQ5XIP1

PTM databases

iPTMnetiQ5XIP1
PhosphoSitePlusiQ5XIP1

Expressioni

Gene expression databases

BgeeiENSRNOG00000061128
GenevisibleiQ5XIP1 RN

Interactioni

Protein-protein interaction databases

IntActiQ5XIP1, 1 interactor
STRINGi10116.ENSRNOP00000038406

Structurei

3D structure databases

ProteinModelPortaliQ5XIP1
SMRiQ5XIP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain has the RNA-binding Sm fold. It may harbor the endoribonuclease activity (Potential).Curated

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2869 Eukaryota
COG1537 LUCA
GeneTreeiENSGT00390000016326
HOGENOMiHOG000184162
HOVERGENiHBG053560
InParanoidiQ5XIP1
KOiK06965
OMAiDNLFRCQ
OrthoDBiEOG091G0AVP
PhylomeDBiQ5XIP1
TreeFamiTF105733

Family and domain databases

Gene3Di2.30.30.870, 1 hit
3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR005140 eRF1_1_Pelota
IPR005141 eRF1_2
IPR005142 eRF1_3
IPR029064 L30e-like
IPR038069 Pelota/DOM34_N
IPR004405 Transl-rel_pelota
PANTHERiPTHR10853 PTHR10853, 1 hit
PfamiView protein in Pfam
PF03463 eRF1_1, 1 hit
PF03464 eRF1_2, 1 hit
PF03465 eRF1_3, 1 hit
SMARTiView protein in SMART
SM01194 eRF1_1, 1 hit
SUPFAMiSSF159065 SSF159065, 1 hit
SSF55315 SSF55315, 1 hit
TIGRFAMsiTIGR00111 pelota, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XIP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVRKDIEK DNAGQVTLVP EEPEDMWHTY NLVQVGDSLR ASTIRKVQTE
60 70 80 90 100
SSTGSVGSNR VRTTLTLCVE AIDFDSQACQ LRVKGTNIQE NEYVKMGAYH
110 120 130 140 150
TIELEPNRQF TLAKKQWDSV VLERIEQACD PAWSADVAAV VMQEGLAHVC
160 170 180 190 200
LVTPSMTLTR AKVEVNIPRK RKGNCSQHDR ALERFYEQVV QAIQRHINFE
210 220 230 240 250
VVKCILVASP GFVREQFCDY MFQQAVKTDN KVLLENRSKF LQVHASSGHK
260 270 280 290 300
YSLKEVLCDP TVASRLSDTK AAGEVKALDD FYKMLQHEPD RAFYGLKQVE
310 320 330 340 350
RANEALAIDT LLISDELFRH QDVATRSRYV RLVDSVKENA GTVRIFSSLH
360 370 380
VSGEQLGQLT GVAAILRFPV PELSDQEDDS SSEED
Length:385
Mass (Da):43,407
Last modified:November 23, 2004 - v1
Checksum:i7C50D96BA28C48E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083637 mRNA Translation: AAH83637.1
RefSeqiNP_001007635.1, NM_001007634.1
UniGeneiRn.3842

Genome annotation databases

EnsembliENSRNOT00000091499; ENSRNOP00000075562; ENSRNOG00000061128
GeneIDi294754
KEGGirno:294754

Similar proteinsi

Entry informationi

Entry nameiPELO_RAT
AccessioniPrimary (citable) accession number: Q5XIP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health