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Protein

LETM1 and EF-hand domain-containing protein 1, mitochondrial

Gene

Letm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi675 – 68713Sequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
LETM1 and EF-hand domain-containing protein 1, mitochondrial
Alternative name(s):
Leucine zipper-EF-hand-containing transmembrane protein 1
Gene namesi
Name:Letm1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1359678. Letm1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini115 – 20793Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei208 – 22821HelicalSequence analysisAdd
BLAST
Topological domaini229 – 739511Mitochondrial matrixSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 114114MitochondrionSequence analysisAdd
BLAST
Chaini115 – 739625LETM1 and EF-hand domain-containing protein 1, mitochondrialPRO_0000017696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei596 – 5961N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5XIN6.
PRIDEiQ5XIN6.

PTM databases

iPTMnetiQ5XIN6.
PhosphoSiteiQ5XIN6.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

GenevisibleiQ5XIN6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022540.

Structurei

3D structure databases

ProteinModelPortaliQ5XIN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini251 – 536286Letm1 RBDPROSITE-ProRule annotationAdd
BLAST
Domaini663 – 69836EF-handAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili115 – 13521Sequence analysisAdd
BLAST
Coiled coili445 – 49248Sequence analysisAdd
BLAST
Coiled coili537 – 62690Sequence analysisAdd
BLAST
Coiled coili707 – 73832Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 EF-hand domain.Curated
Contains 1 Letm1 RBD (ribosome-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1043. Eukaryota.
ENOG410XRSP. LUCA.
GeneTreeiENSGT00390000011225.
HOGENOMiHOG000290246.
HOVERGENiHBG052322.
InParanoidiQ5XIN6.
KOiK17800.
OMAiSEEIMKF.
OrthoDBiEOG79PJNQ.
PhylomeDBiQ5XIN6.
TreeFamiTF316321.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS51758. LETM1_RBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASILLRSCR GRGPARLASP RAASPRGSLR DRACLSCTRT VGLTSHESVL
60 70 80 90 100
SRCCTPANPV YLYFKSEPLS CWTQRPECQG TVARAAWTPA SARLVVTGPQ
110 120 130 140 150
YLPVRGWHSS SPLGEDSMIE KSLKSLKDKN KKLEEGGPVY SPPAQVVVKK
160 170 180 190 200
SLGQKILDEL KHYYHGFRLL WIDTKIAARM LWRILNGHTL TRRERRQFLR
210 220 230 240 250
ICADLFRLVP FLVFVVVPFM EFLLPVVVKL FPNMLPSTFE TQSIKEERLK
260 270 280 290 300
KELRVKLELA KFLQDTIEEM ALKNKAAKGN ATKDFSAFFQ KIRETGERPS
310 320 330 340 350
NEEIMRFSKL FEDELTLDNL TRPQLVALCK LLELQSIGTN NFLRFQLTMR
360 370 380 390 400
LRSIKADDKL ISEEGVDSLT VKELQAACRA RGMRALGVTE DRLKGQLKQW
410 420 430 440 450
LDLHLYHEIP TSLLILSRAM YLPDTLSPAD QLKSTLQTLP EIVAKEAQVK
460 470 480 490 500
AAEVEGEQVD NKAKLEATLQ EEAAIQQEHL EELKRAAETA KDIQPEVAEA
510 520 530 540 550
TVPGRPGAEL QPKMVDVIPP SEILKDTAPV LEGLKGEEIT KEEIDILSDA
560 570 580 590 600
CSKLKEQKKS LTKEKEELEL LKEDVQDYSE DLQEIKKELS KTGDEKYIEE
610 620 630 640 650
STASKRLSKR VQQMIGQIDG LITQLETTQQ NGKLDPAAAS SPTGESVISV
660 670 680 690 700
DELISAMKQI KHIPEHKLIS LTSALDENKD GNINIDDLVK VIDLVNKEDV
710 720 730
QISTTQVAEI VATLEKEEKV EEKEKAKEKA EKEAAEVKN
Length:739
Mass (Da):83,060
Last modified:November 23, 2004 - v1
Checksum:i726DE7D0EAB54331
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083642 mRNA. Translation: AAH83642.1.
RefSeqiNP_001005884.1. NM_001005884.1.
UniGeneiRn.162290.

Genome annotation databases

EnsembliENSRNOT00000022540; ENSRNOP00000022540; ENSRNOG00000016427.
GeneIDi305457.
KEGGirno:305457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083642 mRNA. Translation: AAH83642.1.
RefSeqiNP_001005884.1. NM_001005884.1.
UniGeneiRn.162290.

3D structure databases

ProteinModelPortaliQ5XIN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022540.

PTM databases

iPTMnetiQ5XIN6.
PhosphoSiteiQ5XIN6.

Proteomic databases

PaxDbiQ5XIN6.
PRIDEiQ5XIN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022540; ENSRNOP00000022540; ENSRNOG00000016427.
GeneIDi305457.
KEGGirno:305457.

Organism-specific databases

CTDi3954.
RGDi1359678. Letm1.

Phylogenomic databases

eggNOGiKOG1043. Eukaryota.
ENOG410XRSP. LUCA.
GeneTreeiENSGT00390000011225.
HOGENOMiHOG000290246.
HOVERGENiHBG052322.
InParanoidiQ5XIN6.
KOiK17800.
OMAiSEEIMKF.
OrthoDBiEOG79PJNQ.
PhylomeDBiQ5XIN6.
TreeFamiTF316321.

Miscellaneous databases

PROiQ5XIN6.

Gene expression databases

GenevisibleiQ5XIN6. RN.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS51758. LETM1_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Lubec G., Diao W., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 451-462 AND 492-513, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain and Hippocampus.
  3. "Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L."
    Tamai S., Iida H., Yokota S., Sayano T., Kiguchiya S., Ishihara N., Hayashi J., Mihara K., Oka T.
    J. Cell Sci. 121:2588-2600(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLETM1_RAT
AccessioniPrimary (citable) accession number: Q5XIN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.