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Protein

TRAF3-interacting protein 1

Gene

Traf3ip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-RNO-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
TRAF3-interacting protein 1
Alternative name(s):
Intraflagellar transport protein 54 homolog
Microtubule-interacting protein associated with TRAF3
Short name:
MIP-T3
Gene namesi
Name:Traf3ip1
Synonyms:Ift54, Mipt3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1309252. Traf3ip1.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Cell projectioncilium By similarity
  • Cytoplasmcytoskeletoncilium axoneme By similarity
  • Cytoplasmcytoskeletoncilium basal body By similarity

  • Note: Microtubules. In the cilium, it is observed at the ciliary base, ciliary transition zone and ciliary tip.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 653653TRAF3-interacting protein 1PRO_0000299546Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei437 – 4371PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XIN3.
PRIDEiQ5XIN3.

PTM databases

iPTMnetiQ5XIN3.

Expressioni

Gene expression databases

ExpressionAtlasiQ5XIN3. baseline.

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity). Interacts with IL13RA1. Binds to microtubules, TRAF3 and DISC1 (By similarity). Interacts with MAP4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053451.

Structurei

3D structure databases

ProteinModelPortaliQ5XIN3.
SMRiQ5XIN3. Positions 1-133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 306306Abolishes microtubules binding when missingBy similarityAdd
BLAST
Regioni229 – 653425DISC1-interaction domainBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili533 – 62896Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi207 – 29589Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the TRAF3IP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3809. Eukaryota.
ENOG410ZHUT. LUCA.
GeneTreeiENSGT00720000108822.
HOGENOMiHOG000007159.
HOVERGENiHBG101388.
InParanoidiQ5XIN3.
KOiK19680.
PhylomeDBiQ5XIN3.

Family and domain databases

InterProiIPR018799. TRAF3IP1.
[Graphical view]
PANTHERiPTHR31363. PTHR31363. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5XIN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAAVVRRTQ EALGKVIRRP PLTEKLLNKP PFRYLHDIIT EVIRITGFMK
60 70 80 90 100
GLYTDAEMKS DNVKDKDAKI SFLQKAIDVV MMVSGEPLAA KPARIVAGHE
110 120 130 140 150
PERTNELLQL IGKCCLSKLS SDEAVKRVLA GEKGDSRGRV LRTSKAQEPD
160 170 180 190 200
NKSVKEEESR TQKEEKRSSE VKERSSSAEH KQKEELKEDS KPREKERDKE
210 220 230 240 250
KAKEADRDRH REPDRDRNRD GEREKARARA KQDRDRNNKD RDRETERDRD
260 270 280 290 300
RDRRSDGGKE KERQKDRDRD KGKDRERRKS KNGEHTRDPD REKSRDADKS
310 320 330 340 350
EKKADISVGA SKSSTLKASK RRSKNSLEGR KEDNISAKIL DSIVSGLNDE
360 370 380 390 400
PDQETTAPEI DDNSASLWRE NAEPEPAVKQ KGDSPSDAEG EAVPTSQDKL
410 420 430 440 450
EVTENAEVSN ELPSSLRRIP RPGSARPAPP RVKRQESTET LAGDRSGSGK
460 470 480 490 500
TVSTVIIDSQ NSDNEDDEQF VVEAAPQLSE IAEIEMVPSG DLEDEEKHGG
510 520 530 540 550
LVKKILETKK DYEKLQQSPK PGEKERSLIF ESAWKKEKDI VSKEIEKLRV
560 570 580 590 600
SIQTLCKSAL PLGKIMDYIQ EDVDAMQNEL QLWHSENRQH AEALSKEQSI
610 620 630 640 650
TDSAVEPLKA ELSELEQQIK DQQDKICAVK ANILKNEEKI QKMVHSINLS

SRR
Length:653
Mass (Da):74,114
Last modified:November 23, 2004 - v1
Checksum:i3D9F9B9727F04351
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083645 mRNA. Translation: AAH83645.1.
RefSeqiNP_001012204.1. NM_001012204.1.
UniGeneiRn.82985.

Genome annotation databases

EnsembliENSRNOT00000056612; ENSRNOP00000053451; ENSRNOG00000024468.
GeneIDi363286.
KEGGirno:363286.
UCSCiRGD:1309252. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083645 mRNA. Translation: AAH83645.1.
RefSeqiNP_001012204.1. NM_001012204.1.
UniGeneiRn.82985.

3D structure databases

ProteinModelPortaliQ5XIN3.
SMRiQ5XIN3. Positions 1-133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053451.

PTM databases

iPTMnetiQ5XIN3.

Proteomic databases

PaxDbiQ5XIN3.
PRIDEiQ5XIN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000056612; ENSRNOP00000053451; ENSRNOG00000024468.
GeneIDi363286.
KEGGirno:363286.
UCSCiRGD:1309252. rat.

Organism-specific databases

CTDi26146.
RGDi1309252. Traf3ip1.

Phylogenomic databases

eggNOGiKOG3809. Eukaryota.
ENOG410ZHUT. LUCA.
GeneTreeiENSGT00720000108822.
HOGENOMiHOG000007159.
HOVERGENiHBG101388.
InParanoidiQ5XIN3.
KOiK19680.
PhylomeDBiQ5XIN3.

Enzyme and pathway databases

ReactomeiR-RNO-5620924. Intraflagellar transport.

Miscellaneous databases

PROiQ5XIN3.

Gene expression databases

ExpressionAtlasiQ5XIN3. baseline.

Family and domain databases

InterProiIPR018799. TRAF3IP1.
[Graphical view]
PANTHERiPTHR31363. PTHR31363. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMIPT3_RAT
AccessioniPrimary (citable) accession number: Q5XIN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 23, 2004
Last modified: July 6, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.