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Protein

ATP synthase subunit s, mitochondrial

Gene

Atp5s

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H+ conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi93MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-163210. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit s, mitochondrial
Alternative name(s):
ATP synthase-coupling factor B
Mitochondrial ATP synthase regulatory component factor B
Gene namesi
Name:Atp5s
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1359208. Atp5s.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionBy similarityAdd BLAST25
ChainiPRO_000000254126 – 200ATP synthase subunit s, mitochondrialAdd BLAST175

Proteomic databases

PaxDbiQ5XIM4.
PRIDEiQ5XIM4.

PTM databases

iPTMnetiQ5XIM4.
PhosphoSitePlusiQ5XIM4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004893.
GenevisibleiQ5XIM4. RN.

Interactioni

Subunit structurei

Homotetramer. Associates with ATP synthase (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006509.

Structurei

3D structure databases

ProteinModelPortaliQ5XIM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati62 – 87LRR 1Add BLAST26
Repeati88 – 116LRR 2Add BLAST29
Repeati117 – 141LRR 3Add BLAST25
Repeati142 – 173LRR 4Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 61N-terminal domainAdd BLAST61

Sequence similaritiesi

Belongs to the ATP synthase subunit s family.Curated
Contains 4 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG3864. Eukaryota.
ENOG4110375. LUCA.
GeneTreeiENSGT00530000063680.
HOGENOMiHOG000230741.
HOVERGENiHBG050615.
InParanoidiQ5XIM4.
KOiK07554.
OMAiCDIKATK.
OrthoDBiEOG091G0WCB.
PhylomeDBiQ5XIM4.
TreeFamiTF315274.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR026063. ATP_synth_s.
IPR032675. L_dom-like.
[Graphical view]
PANTHERiPTHR13382. PTHR13382. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMMFGKISRQ LFSLKKIPWS CDSRYFWEWL NTVFNKVDYE RIKDVGPDRA
60 70 80 90 100
ASEWLLRCGA KVRYCGHQKW LQDYNKLPGG SVDRYKIQAI DATDSCIMDI
110 120 130 140 150
GFDHLVGLEH VERITLCRCH YIEDNCLQRL SQLENLRKSL LELEIIACGN
160 170 180 190 200
VTDNGVIALR HFKNLKYLFL SDLPGIKDKE YLAEVFTKAL PSLELKLNLK
Length:200
Mass (Da):23,324
Last modified:November 23, 2004 - v1
Checksum:i8EC195A78F6B3978
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083655 mRNA. Translation: AAH83655.1.
RefSeqiNP_001007750.1. NM_001007749.1.
XP_006240236.1. XM_006240174.3.
XP_006240237.1. XM_006240175.3.
XP_006240238.1. XM_006240176.3.
UniGeneiRn.106766.

Genome annotation databases

EnsembliENSRNOT00000006509; ENSRNOP00000006509; ENSRNOG00000004893.
GeneIDi362749.
KEGGirno:362749.
UCSCiRGD:1359208. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083655 mRNA. Translation: AAH83655.1.
RefSeqiNP_001007750.1. NM_001007749.1.
XP_006240236.1. XM_006240174.3.
XP_006240237.1. XM_006240175.3.
XP_006240238.1. XM_006240176.3.
UniGeneiRn.106766.

3D structure databases

ProteinModelPortaliQ5XIM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006509.

PTM databases

iPTMnetiQ5XIM4.
PhosphoSitePlusiQ5XIM4.

Proteomic databases

PaxDbiQ5XIM4.
PRIDEiQ5XIM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006509; ENSRNOP00000006509; ENSRNOG00000004893.
GeneIDi362749.
KEGGirno:362749.
UCSCiRGD:1359208. rat.

Organism-specific databases

CTDi27109.
RGDi1359208. Atp5s.

Phylogenomic databases

eggNOGiKOG3864. Eukaryota.
ENOG4110375. LUCA.
GeneTreeiENSGT00530000063680.
HOGENOMiHOG000230741.
HOVERGENiHBG050615.
InParanoidiQ5XIM4.
KOiK07554.
OMAiCDIKATK.
OrthoDBiEOG091G0WCB.
PhylomeDBiQ5XIM4.
TreeFamiTF315274.

Enzyme and pathway databases

ReactomeiR-RNO-163210. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

PROiQ5XIM4.

Gene expression databases

BgeeiENSRNOG00000004893.
GenevisibleiQ5XIM4. RN.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR026063. ATP_synth_s.
IPR032675. L_dom-like.
[Graphical view]
PANTHERiPTHR13382. PTHR13382. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiATP5S_RAT
AccessioniPrimary (citable) accession number: Q5XIM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: November 23, 2004
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.