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Protein

Dynein intermediate chain 1, axonemal

Gene

Dnai1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the dynein complex of respiratory cilia.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein intermediate chain 1, axonemal
Alternative name(s):
Axonemal dynein intermediate chain 1
Gene namesi
Name:Dnai1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1565671. Dnai1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546561 – 705Dynein intermediate chain 1, axonemalAdd BLAST705

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XIL8.
PRIDEiQ5XIL8.

PTM databases

iPTMnetiQ5XIL8.
PhosphoSitePlusiQ5XIL8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013734.
GenevisibleiQ5XIL8. RN.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains. Interacts with BICD2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059516.

Structurei

3D structure databases

ProteinModelPortaliQ5XIL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati386 – 426WD 1Add BLAST41
Repeati435 – 478WD 2Add BLAST44
Repeati543 – 583WD 3Add BLAST41
Repeati585 – 625WD 4Add BLAST41
Repeati633 – 672WD 5Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi136 – 181Glu-richAdd BLAST46

Sequence similaritiesi

Belongs to the dynein intermediate chain family.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410KDU1. Eukaryota.
ENOG410YQQE. LUCA.
GeneTreeiENSGT00730000110228.
HOGENOMiHOG000231705.
HOVERGENiHBG005545.
InParanoidiQ5XIL8.
KOiK10409.
OMAiVSWNPYH.
OrthoDBiEOG091G0CPJ.
PhylomeDBiQ5XIL8.
TreeFamiTF300553.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKQIRKQS VILTRGARKR EEDSGTDVGE GADDWAQSKA AVRPPDQLEL
60 70 80 90 100
TDAELKEEFT RILTANNPHA PQNIVRYSFK ERTYKLIGFV NQMAIHFSQV
110 120 130 140 150
GNLIPKDSDE GRRQHYRDEL VAGSQESVKV VTSDTEILEE EEEPKEGEGE
160 170 180 190 200
GEGEAEGEAE AGSQTDVPAA AETTEKVIEE ELMAPVQPKE RKLTNQFNFS
210 220 230 240 250
ERASQTFNNP LRDRECQMEP PPRTNFSATA NQWEIYDAYV DELEKLEKTK
260 270 280 290 300
EKEKTKTPVA KKTEKMAMRK LTSMESQSDD ITKVTQAAKI VERMVNQNTY
310 320 330 340 350
DDVAQDFKYY EDAADEYRDQ EGTLLPLWKF QNDKAKRLAV TALCWNPKYK
360 370 380 390 400
DLFAVGHGSY DFMKQSRGML LLYSMKNPSF PEYMFSSESG IMCLDMHMDH
410 420 430 440 450
PYLVVVGYYD GNVAIYNLKK PHSQPCFRST SKSGKHTDPV WQVKWQKDDM
460 470 480 490 500
DHNLNFFSVS SDGRIVSWTL VKSELVHIDV IKLKDEGSTT EIPEGLQLHT
510 520 530 540 550
VGCGTAFDFH KEIDYLFLVG TEEGKIYKCS KSYSSQFLDT YDAHNMAVDA
560 570 580 590 600
VLWNPYHARV FISCSSDWTV KIWDHAIKTP MFIYDLNAAV GDVAWAPYSS
610 620 630 640 650
TVFAAVTTDG KAHVFDLAVN KYEAICNQPV VAKKKNKITH VQFNPIHPII
660 670 680 690 700
IVGDDRGHIT CLKLSPNLRK MPKEKKGQEV QKGPAVEIAK LDKLLNLVRE

VKTKT
Length:705
Mass (Da):80,073
Last modified:November 23, 2004 - v1
Checksum:iC71AC5FC006295E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083662 mRNA. Translation: AAH83662.1.
RefSeqiNP_001019513.1. NM_001024342.1.
UniGeneiRn.93980.

Genome annotation databases

EnsembliENSRNOT00000067657; ENSRNOP00000059516; ENSRNOG00000013734.
GeneIDi500442.
KEGGirno:500442.
UCSCiRGD:1565671. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083662 mRNA. Translation: AAH83662.1.
RefSeqiNP_001019513.1. NM_001024342.1.
UniGeneiRn.93980.

3D structure databases

ProteinModelPortaliQ5XIL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059516.

PTM databases

iPTMnetiQ5XIL8.
PhosphoSitePlusiQ5XIL8.

Proteomic databases

PaxDbiQ5XIL8.
PRIDEiQ5XIL8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067657; ENSRNOP00000059516; ENSRNOG00000013734.
GeneIDi500442.
KEGGirno:500442.
UCSCiRGD:1565671. rat.

Organism-specific databases

CTDi27019.
RGDi1565671. Dnai1.

Phylogenomic databases

eggNOGiENOG410KDU1. Eukaryota.
ENOG410YQQE. LUCA.
GeneTreeiENSGT00730000110228.
HOGENOMiHOG000231705.
HOVERGENiHBG005545.
InParanoidiQ5XIL8.
KOiK10409.
OMAiVSWNPYH.
OrthoDBiEOG091G0CPJ.
PhylomeDBiQ5XIL8.
TreeFamiTF300553.

Miscellaneous databases

PROiQ5XIL8.

Gene expression databases

BgeeiENSRNOG00000013734.
GenevisibleiQ5XIL8. RN.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAI1_RAT
AccessioniPrimary (citable) accession number: Q5XIL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.