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Protein

Dynein intermediate chain 1, axonemal

Gene

Dnai1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the dynein complex of respiratory cilia.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein intermediate chain 1, axonemal
Alternative name(s):
Axonemal dynein intermediate chain 1
Gene namesi
Name:Dnai1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1565671. Dnai1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 705705Dynein intermediate chain 1, axonemalPRO_0000254656Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei124 – 1241PhosphoserineCombined sources
Modified residuei127 – 1271PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XIL8.
PRIDEiQ5XIL8.

Expressioni

Gene expression databases

GenevisibleiQ5XIL8. RN.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains. Interacts with BICD2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059516.

Structurei

3D structure databases

ProteinModelPortaliQ5XIL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati386 – 42641WD 1Add
BLAST
Repeati435 – 47844WD 2Add
BLAST
Repeati543 – 58341WD 3Add
BLAST
Repeati585 – 62541WD 4Add
BLAST
Repeati633 – 67240WD 5Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi136 – 18146Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the dynein intermediate chain family.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410KDU1. Eukaryota.
ENOG410YQQE. LUCA.
GeneTreeiENSGT00730000110228.
HOGENOMiHOG000231705.
HOVERGENiHBG005545.
InParanoidiQ5XIL8.
KOiK10409.
OMAiVSWNPYH.
OrthoDBiEOG751NDV.
PhylomeDBiQ5XIL8.
TreeFamiTF300553.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5XIL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKQIRKQS VILTRGARKR EEDSGTDVGE GADDWAQSKA AVRPPDQLEL
60 70 80 90 100
TDAELKEEFT RILTANNPHA PQNIVRYSFK ERTYKLIGFV NQMAIHFSQV
110 120 130 140 150
GNLIPKDSDE GRRQHYRDEL VAGSQESVKV VTSDTEILEE EEEPKEGEGE
160 170 180 190 200
GEGEAEGEAE AGSQTDVPAA AETTEKVIEE ELMAPVQPKE RKLTNQFNFS
210 220 230 240 250
ERASQTFNNP LRDRECQMEP PPRTNFSATA NQWEIYDAYV DELEKLEKTK
260 270 280 290 300
EKEKTKTPVA KKTEKMAMRK LTSMESQSDD ITKVTQAAKI VERMVNQNTY
310 320 330 340 350
DDVAQDFKYY EDAADEYRDQ EGTLLPLWKF QNDKAKRLAV TALCWNPKYK
360 370 380 390 400
DLFAVGHGSY DFMKQSRGML LLYSMKNPSF PEYMFSSESG IMCLDMHMDH
410 420 430 440 450
PYLVVVGYYD GNVAIYNLKK PHSQPCFRST SKSGKHTDPV WQVKWQKDDM
460 470 480 490 500
DHNLNFFSVS SDGRIVSWTL VKSELVHIDV IKLKDEGSTT EIPEGLQLHT
510 520 530 540 550
VGCGTAFDFH KEIDYLFLVG TEEGKIYKCS KSYSSQFLDT YDAHNMAVDA
560 570 580 590 600
VLWNPYHARV FISCSSDWTV KIWDHAIKTP MFIYDLNAAV GDVAWAPYSS
610 620 630 640 650
TVFAAVTTDG KAHVFDLAVN KYEAICNQPV VAKKKNKITH VQFNPIHPII
660 670 680 690 700
IVGDDRGHIT CLKLSPNLRK MPKEKKGQEV QKGPAVEIAK LDKLLNLVRE

VKTKT
Length:705
Mass (Da):80,073
Last modified:November 23, 2004 - v1
Checksum:iC71AC5FC006295E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083662 mRNA. Translation: AAH83662.1.
RefSeqiNP_001019513.1. NM_001024342.1.
UniGeneiRn.93980.

Genome annotation databases

EnsembliENSRNOT00000067657; ENSRNOP00000059516; ENSRNOG00000013734.
GeneIDi500442.
KEGGirno:500442.
UCSCiRGD:1565671. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083662 mRNA. Translation: AAH83662.1.
RefSeqiNP_001019513.1. NM_001024342.1.
UniGeneiRn.93980.

3D structure databases

ProteinModelPortaliQ5XIL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059516.

Proteomic databases

PaxDbiQ5XIL8.
PRIDEiQ5XIL8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067657; ENSRNOP00000059516; ENSRNOG00000013734.
GeneIDi500442.
KEGGirno:500442.
UCSCiRGD:1565671. rat.

Organism-specific databases

CTDi27019.
RGDi1565671. Dnai1.

Phylogenomic databases

eggNOGiENOG410KDU1. Eukaryota.
ENOG410YQQE. LUCA.
GeneTreeiENSGT00730000110228.
HOGENOMiHOG000231705.
HOVERGENiHBG005545.
InParanoidiQ5XIL8.
KOiK10409.
OMAiVSWNPYH.
OrthoDBiEOG751NDV.
PhylomeDBiQ5XIL8.
TreeFamiTF300553.

Miscellaneous databases

NextBioi706209.
PROiQ5XIL8.

Gene expression databases

GenevisibleiQ5XIL8. RN.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124 AND SER-127, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDNAI1_RAT
AccessioniPrimary (citable) accession number: Q5XIL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.